JP2016185172A5 - - Google Patents

Download PDF

Info

Publication number
JP2016185172A5
JP2016185172A5 JP2016151681A JP2016151681A JP2016185172A5 JP 2016185172 A5 JP2016185172 A5 JP 2016185172A5 JP 2016151681 A JP2016151681 A JP 2016151681A JP 2016151681 A JP2016151681 A JP 2016151681A JP 2016185172 A5 JP2016185172 A5 JP 2016185172A5
Authority
JP
Japan
Prior art keywords
polypeptide
cell
progenitor cells
cells
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016151681A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016185172A (ja
JP6321733B2 (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2016185172A publication Critical patent/JP2016185172A/ja
Publication of JP2016185172A5 publication Critical patent/JP2016185172A5/ja
Priority to JP2018072807A priority Critical patent/JP6899792B2/ja
Application granted granted Critical
Publication of JP6321733B2 publication Critical patent/JP6321733B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016151681A 2008-03-17 2016-08-02 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 Active JP6321733B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2018072807A JP6899792B2 (ja) 2008-03-17 2018-04-05 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6995608P 2008-03-17 2008-03-17
US61/069,956 2008-03-17
US19798608P 2008-10-31 2008-10-31
US61/197,986 2008-10-31

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2015013821A Division JP2015119714A (ja) 2008-03-17 2015-01-28 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018072807A Division JP6899792B2 (ja) 2008-03-17 2018-04-05 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法

Publications (3)

Publication Number Publication Date
JP2016185172A JP2016185172A (ja) 2016-10-27
JP2016185172A5 true JP2016185172A5 (enExample) 2017-03-30
JP6321733B2 JP6321733B2 (ja) 2018-05-09

Family

ID=41091504

Family Applications (7)

Application Number Title Priority Date Filing Date
JP2011500906A Active JP5951254B2 (ja) 2008-03-17 2009-03-17 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
JP2015013821A Pending JP2015119714A (ja) 2008-03-17 2015-01-28 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
JP2016151681A Active JP6321733B2 (ja) 2008-03-17 2016-08-02 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
JP2018072807A Active JP6899792B2 (ja) 2008-03-17 2018-04-05 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
JP2021099098A Active JP7286710B2 (ja) 2008-03-17 2021-06-15 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
JP2023085020A Active JP7642712B2 (ja) 2008-03-17 2023-05-24 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
JP2024198599A Pending JP2025015628A (ja) 2008-03-17 2024-11-13 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2011500906A Active JP5951254B2 (ja) 2008-03-17 2009-03-17 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
JP2015013821A Pending JP2015119714A (ja) 2008-03-17 2015-01-28 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2018072807A Active JP6899792B2 (ja) 2008-03-17 2018-04-05 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
JP2021099098A Active JP7286710B2 (ja) 2008-03-17 2021-06-15 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
JP2023085020A Active JP7642712B2 (ja) 2008-03-17 2023-05-24 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
JP2024198599A Pending JP2025015628A (ja) 2008-03-17 2024-11-13 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法

Country Status (15)

Country Link
US (8) US9534205B2 (enExample)
EP (4) EP4578941A3 (enExample)
JP (7) JP5951254B2 (enExample)
KR (1) KR101679082B1 (enExample)
CN (2) CN102027105B (enExample)
AU (1) AU2009225665B9 (enExample)
BR (1) BRPI0908708A2 (enExample)
CA (1) CA2718904C (enExample)
ES (1) ES2690554T3 (enExample)
IL (1) IL208144B (enExample)
MX (1) MX2010010165A (enExample)
RU (1) RU2010139426A (enExample)
SG (4) SG10202103401QA (enExample)
WO (1) WO2009117439A2 (enExample)
ZA (1) ZA201006683B (enExample)

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110171185A1 (en) * 1999-06-30 2011-07-14 Klimanskaya Irina V Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
EP1984487B1 (en) 2005-08-03 2022-10-12 Astellas Institute for Regenerative Medicine Improved methods of reprogramming animal somatic cells
WO2007047583A2 (en) 2005-10-18 2007-04-26 National Jewish Medical And Research Center Conditionally immortalized long-term stem cells and methods of making and using such cells
WO2007069666A1 (ja) * 2005-12-13 2007-06-21 Kyoto University 核初期化因子
US20090227032A1 (en) * 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
US8278104B2 (en) * 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
EP3878949B1 (en) 2007-04-07 2025-06-04 Whitehead Institute for Biomedical Research Reprogramming of somatic cells
US9213999B2 (en) * 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US20140342984A1 (en) * 2007-10-19 2014-11-20 Robert G. Matheny Compositions for Regenerating Defective or Absent Myocardium
CN102027105B (zh) 2008-03-17 2015-03-11 斯克里普斯研究所 用于产生诱导的多能干细胞的组合化学遗传方法
KR20110006672A (ko) * 2008-04-07 2011-01-20 뉴포텐셜, 인크. Ｈｄａｃ 조절제의 사용을 통한 다능 유전자의 유도에 의한 세포 재프로그래밍
CA2695522C (en) * 2008-05-02 2019-01-15 Kyoto University Method of nuclear reprogramming
KR101803099B1 (ko) 2008-05-16 2017-11-30 타이가 바이오테크놀로지스, 인코포레이티드 항체 및 그 제조 방법
BRPI0915146A2 (pt) 2008-06-13 2017-12-05 Whitehead Inst Biomedical Res programação e reprodução de células
AU2009274172B2 (en) 2008-07-21 2015-08-13 Htyr Acquisition Llc Differentiated anucleated cells and method for preparing the same
US8298825B1 (en) 2008-08-25 2012-10-30 The General Hospital Corporation TGF-beta receptor inhibitors to enhance direct reprogramming
CN104353066B (zh) 2008-08-28 2017-05-10 泰加生物工艺学公司 Myc的调节剂、其使用方法和鉴别调节myc的试剂的方法
EP2376626A4 (en) 2008-12-13 2012-10-17 Dna Microarray MICRO-ENVIRONMENTAL NICHE ASSAY FOR SCREENING OF INDUCED PLURIPOTENT STEM CELLS (CIPS)
ES2645869T3 (es) 2008-12-17 2017-12-11 The Scripps Research Institute Generación y mantenimiento de células madre
CN102272142A (zh) * 2008-12-23 2011-12-07 帷幄生物技术公司 非遗传修饰性重编程细胞的组合物和方法
KR20110134939A (ko) * 2009-04-03 2011-12-15 더 맥클린 하스피털 코퍼레이션 유도된 다능성 줄기 세포
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
EP2438159B1 (en) 2009-05-29 2018-10-03 Kyoto University Method for selecting clone of induced pluripotent stem cells
JP5751548B2 (ja) * 2009-08-07 2015-07-22 国立大学法人京都大学 イヌｉＰＳ細胞及びその製造方法
AU2014250681B2 (en) * 2009-10-16 2016-12-15 The Scripps Research Institute Induction of pluripotent cells
EP4206319A1 (en) * 2009-10-16 2023-07-05 The Scripps Research Institute Induction of pluripotent cells
WO2011050470A1 (en) * 2009-10-29 2011-05-05 Mcmaster University Generating induced pluripotent stem cells and progenitor cells from fibroblasts
BR112012009921B1 (pt) * 2009-10-31 2021-06-29 New World Laboratories Inc Metodo para obter uma célula tronco neural
US9295697B2 (en) 2009-11-04 2016-03-29 Cellular Dynamics International, Inc. Episomal reprogramming with chemicals
US20130189780A1 (en) * 2009-12-31 2013-07-25 Fate Therapeutics, Inc. Reprogramming compositions
WO2011109015A1 (en) * 2010-03-02 2011-09-09 The Scripps Research Institute Improved methods of generating pluripotent stem cells
EP2366432A1 (en) * 2010-03-16 2011-09-21 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of glycogen synthase kinase 3 for use in therapeutic methods and screening method relating thereto
ES2624780T3 (es) 2010-03-31 2017-07-17 The Scripps Research Institute Reprogramación de células
CN102260646B (zh) * 2010-05-26 2015-09-16 北京瑞普晨创科技有限公司 一种制备诱导多潜能干细胞的方法,试剂盒及用途
ES2685171T3 (es) 2010-06-14 2018-10-05 The Scripps Research Institute Reprogramación de células a un nuevo destino
US9365826B2 (en) 2010-06-18 2016-06-14 Cellular Dynamics International, Inc. Cardiomyocyte medium with dialyzed serum
WO2012007725A2 (en) * 2010-07-16 2012-01-19 Plasticell Ltd Method of reprogramming a cell
WO2012030854A2 (en) 2010-09-01 2012-03-08 Whitehead Institute For Biomedical Research Compositions and methods for modulating emt and uses thereof
WO2012031288A1 (en) * 2010-09-03 2012-03-08 United States Of America As Represented By The Department Of Veterans Affairs Efficient generation of neurally-induced mesenchymal stem cells and applications thereof
US9447408B2 (en) 2010-09-14 2016-09-20 Kyoto University Method of efficiently establishing induced pluripotent stem cells
US9084746B2 (en) * 2010-09-22 2015-07-21 The Regents Of The University Of Colorado, A Body Corporate Therapeutic applications of SMAD7
BR112013017632A2 (pt) * 2010-12-17 2016-10-11 Biolamina Ab meio de cultura celular
KR20140063501A (ko) 2010-12-22 2014-05-27 페이트 세러퓨틱스, 인코포레이티드 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
KR20130131414A (ko) * 2010-12-27 2013-12-03 엘에스아이피 환도 운에이고우도우가이샤 ｉＰＳ 세포와 그 제조법
WO2012098260A1 (en) * 2011-01-21 2012-07-26 Axiogenesis Ag A non-viral system for the generation of induced pluripotent stem (ips) cells
DK2705143T3 (da) * 2011-05-02 2021-05-10 Univ Wayne State Protein-induceret pluripotent celleteknologi og anvendelse deraf
US20130064799A1 (en) 2011-06-01 2013-03-14 Tariq M. Rana Methods for promoting cell reprogramming
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
WO2013013105A2 (en) * 2011-07-19 2013-01-24 Vivoscript,Inc. Compositions and methods for re-programming cells without genetic modification for repairing cartilage damage
WO2013014929A1 (en) 2011-07-25 2013-01-31 Kyoto University Method for screening induced pluripotent stem cells
WO2013058403A1 (ja) 2011-10-21 2013-04-25 国立大学法人京都大学 層流による多能性維持単一分散細胞培養法
US20140329317A1 (en) 2011-11-25 2014-11-06 Kyoto University Method for culturing pluripotent stem cell
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
KR20250035015A (ko) 2011-12-05 2025-03-11 팩터 바이오사이언스 인크. 세포를 형질감염시키는 방법들 및 생성물들
WO2013131000A1 (en) * 2012-03-01 2013-09-06 Whitehead Institute For Biomedical Research Emt-inducing transcription factors cooperate with sox9
US9771560B2 (en) 2012-03-14 2017-09-26 Children's Medical Center Corporation High-throughput image-based chemical screening in zebrafish blastomere cell culture
DK2877189T3 (da) 2012-07-20 2021-02-22 Taiga Biotechnologies Inc Forbedret rekonstituering og autorekonstituering af det hæmopoietiske kammer
US10357517B1 (en) * 2012-10-01 2019-07-23 University Of South Florida Methods of treating epilepsy using neural stem cells that express nanog, SSEA-4, OCT-4, MIR-34B, MIR-34C and MIR-592
WO2014071219A1 (en) 2012-11-01 2014-05-08 Factor Bioscience Inc. Methods and products for expressing proteins in cells
WO2014071323A2 (en) * 2012-11-02 2014-05-08 Duke University Inhibition of histone methyltransferase for cardiac reprogramming
JP6509126B2 (ja) * 2013-01-09 2019-05-08 インターナショナル ステム セル コーポレイション 皮膚の再生を促進する小分子
WO2014123242A1 (ja) 2013-02-08 2014-08-14 国立大学法人京都大学 巨核球及び血小板の製造方法
WO2014136581A1 (ja) 2013-03-06 2014-09-12 国立大学法人京都大学 多能性幹細胞の培養システム及び多能性幹細胞の継代方法
EP2964774B1 (en) 2013-03-08 2020-05-06 The Regents of The University of Colorado, A Body Corporate Ptd-smad7 therapeutics
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
US9365825B2 (en) * 2013-03-11 2016-06-14 Taiga Biotechnologies, Inc. Expansion of adult stem cells in vitro
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
HUE049377T2 (hu) 2013-03-14 2020-09-28 Brigham & Womens Hospital Inc Készítmények és eljárások epiteliális õssejtek expanziójára és tenyésztésére
WO2014148646A1 (ja) 2013-03-21 2014-09-25 国立大学法人京都大学 神経分化誘導用の多能性幹細胞
US10072242B2 (en) 2013-03-25 2018-09-11 Foundation For Biomedical Research And Innovation At Kobe Cell sorting method
KR20140121317A (ko) * 2013-04-06 2014-10-15 서울대학교산학협력단 비신경 세포로부터 유도 신경 줄기 세포의 생산 방법 및 이에 의하여 생산되는 유도 신경 줄기 세포
EP2985344B1 (en) 2013-04-12 2018-07-18 Kyoto University Method for inducing alveolar epithelium progenitor cells
EP2998391B1 (en) 2013-05-14 2020-02-19 Kyoto University Efficient myocardial cell induction method
KR101870174B1 (ko) 2013-05-31 2018-06-22 아이하트 재팬 가부시키가이샤 하이드로겔을 포함하는 적층화된 세포 시트
CA2915085C (en) 2013-06-11 2021-04-27 Kyoto University Method for producing renal progenitor cells and drug comprising the same
CN104278008B (zh) * 2013-07-12 2020-08-21 北京宏冠再生医学科技有限公司 一种通过小分子化合物处理来制备多潜能干细胞的方法、试剂盒和用途
KR101655383B1 (ko) * 2013-07-27 2016-09-08 고려대학교 산학협력단 소분자 화합물을 포함하는 만능성 줄기세포의 염색체 안정성 유지용 조성물
JP6378183B2 (ja) 2013-08-07 2018-08-22 国立大学法人京都大学 膵ホルモン産生細胞の製造法
ES2721440T3 (es) 2013-09-05 2019-07-31 Univ Kyoto Nuevo método para inducir células precursoras neurales productoras de dopamina
CN104419683A (zh) * 2013-09-10 2015-03-18 中国科学院生物物理研究所 制备范可尼贫血症患者自体诱导多能干细胞的方法及其应用
WO2015061568A1 (en) * 2013-10-23 2015-04-30 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Reprogramming cardiomyocytes with one transcription factor
AU2014339843B2 (en) 2013-10-25 2019-04-04 Qurgen, Inc. Methods, systems and compositions relating to cell conversion via protein induced in-vivo cell reprogramming
EP3064577B1 (en) 2013-11-01 2020-09-09 Kyoto University Novel chondrocyte induction method
US9512406B2 (en) 2013-12-20 2016-12-06 The J. David Gladstone Institute, a testamentary trust established under the Will of J. David Gladstone Generating hepatocytes
AU2015210769B2 (en) 2014-01-31 2019-02-07 Factor Bioscience Inc. Methods and products for nucleic acid production and delivery
CN104894060B (zh) * 2014-03-03 2018-11-06 中国科学院上海生命科学研究院 诱导体细胞转分化为神经干细胞的方法及其应用
ES2966757T3 (es) 2014-03-04 2024-04-24 Fate Therapeutics Inc Métodos de reprogramación mejorados y plataformas de cultivo celular
EP3929302A1 (en) 2014-07-14 2021-12-29 Chugai Seiyaku Kabushiki Kaisha Method for identifying epitope on protein
EP3169770A1 (en) * 2014-07-16 2017-05-24 Fundación Pública Andaluza Progreso Y Salud Methods for generating induced pluripotent stem cells
SG10201900323SA (en) 2014-07-18 2019-02-27 Univ Kyoto Method for inducing t cells for cell-based immunotherapy from pluripotent stem cells
WO2016022472A1 (en) 2014-08-04 2016-02-11 University Of Kansas Mammalian pluripotent stem cells, methods for their production, and uses thereof
RU2565548C1 (ru) * 2014-08-05 2015-10-20 Дмитрий Андреевич Журавлёв Способ получения плюрипотентных стволовых клеток
WO2016022930A1 (en) 2014-08-07 2016-02-11 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Reversible stencils for fabricating micro-tissues
CA2959404A1 (en) * 2014-09-03 2016-03-10 The Brigham And Women's Hospital, Inc. Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss
JP7253692B2 (ja) 2014-12-26 2023-04-07 国立大学法人京都大学 肝細胞誘導方法
WO2016117139A1 (ja) 2015-01-20 2016-07-28 タカラバイオ株式会社 神経系細胞の製造方法
CN107429232B (zh) 2015-01-26 2023-01-03 菲特治疗公司 免疫调节性提高的细胞及其使用和生产方法
WO2016120493A1 (en) * 2015-01-30 2016-08-04 Centre National De La Recherche Scientifique (Cnrs) Reprogramming method for producing induced pluripotent stem cells (ipsc)
EP4406585A3 (en) 2015-02-13 2024-10-23 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
WO2016131137A1 (en) 2015-02-17 2016-08-25 University Health Network Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes
JP2016202172A (ja) 2015-04-16 2016-12-08 国立大学法人京都大学 疑似膵島の製造方法
CN108135935A (zh) 2015-07-21 2018-06-08 儿童医疗中心有限公司 表达pd-l1的造血干细胞及其用途
EP3339429B1 (en) * 2015-08-21 2020-10-07 Kyoto Prefectural Public University Corporation Osteoblasts and method for preparing same
WO2017066634A1 (en) 2015-10-16 2017-04-20 Fate Therapeutics, Inc. Platform for the induction & maintenance of ground state pluripotency
CN109072183B (zh) 2015-10-21 2023-01-20 京都府公立大学法人 细胞的制备方法
EP3401392B1 (en) * 2016-01-08 2022-02-23 Evia Life Sciences Inc. Method for producing hepatic stem/precursor cells from mature hepatic cells using low-molecular-weight compound
CA3010610A1 (en) 2016-01-08 2017-07-13 The Brigham And Women's Hospital, Inc. Production of differentiated enteroendocrine cells and insulin producing cells
JP7653759B2 (ja) 2016-01-20 2025-03-31 フェイト セラピューティクス，インコーポレイテッド 養子免疫療法における免疫細胞調節のための組成物および方法
KR102878032B1 (ko) * 2016-01-20 2025-10-28 페이트 세러퓨틱스, 인코포레이티드 입양 면역요법에서 면역 세포 조절을 위한 조성물 및 방법
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
WO2017179720A1 (ja) 2016-04-15 2017-10-19 国立大学法人京都大学 Ｃｄ８陽性ｔ細胞を誘導する方法
KR102312123B1 (ko) 2016-04-22 2021-10-13 고쿠리츠 다이가쿠 호진 교토 다이가쿠 도파민 생산 신경전구세포의 제조방법
CN105943526B (zh) * 2016-05-18 2018-08-14 上海交通大学医学院附属上海儿童医学中心 Pd0325901在维持动脉导管开放中的应用
US11149253B2 (en) 2016-06-03 2021-10-19 Institute Of Transfusion Medicine, Academy Of Military Medical Sciences, People's Libration Army Of China Small molecule compound combination for reprogramming digestive tract derived epithelial cells to endodermal stem/progenitor cells, reprogramming method and application
WO2018005799A1 (en) * 2016-06-29 2018-01-04 Georgia State University Research Foundation, Inc. Histone deacetylase and histone methyltransferase inhibitors and methods of making and use of the same
WO2018035377A1 (en) 2016-08-17 2018-02-22 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
JP7134416B2 (ja) * 2016-10-28 2022-09-12 国立研究開発法人国立がん研究センター ヒト肝前駆細胞の調製方法
IL281425B (en) 2016-12-02 2022-07-01 Taiga Biotechnologies Inc Nanoparticle formulations
US11932870B2 (en) 2016-12-05 2024-03-19 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
US20200141921A1 (en) 2016-12-27 2020-05-07 Sumitomo Chemical Company, Limited Evaluation method and selection method for induced pluripotent stem cells, and production method for induced pluripotent stem cells
CN106754655B (zh) * 2016-12-29 2020-06-19 赛业（苏州）生物科技有限公司 一种动物胚胎培养基
AU2017386417B2 (en) 2016-12-30 2022-07-14 Frequency Therapeutics, Inc. 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells
EP4053268B1 (en) 2017-01-20 2025-10-08 Kyoto University Method for producing cd8alpha+beta+cytotoxic t cells
EP3575392A4 (en) 2017-01-26 2020-08-26 Osaka University MEDIUM INTENDED TO INDUCE DIFFERENTIATION OF STEM CELLS INTO MESODERMAL CELLS AND PROCESS INTENDED TO PRODUCE MESODERMAL CELLS
EP3597734A4 (en) 2017-03-14 2021-03-03 Kyoto University METHOD FOR PRODUCING HELPER T-CELLS FROM PLURIPOTENT STEM CELLS
WO2018216743A1 (ja) 2017-05-25 2018-11-29 国立大学法人京都大学 中間中胚葉細胞から腎前駆細胞への分化誘導方法、および多能性幹細胞から腎前駆細胞への分化誘導方法
SG11201912436PA (en) 2017-06-19 2020-01-30 Foundation For Biomedical Res And Innovation At Kobe Method for predicting differentiation ability of pluripotent stem cell, and reagent for same
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
US20190062711A1 (en) * 2017-08-25 2019-02-28 So Young Life Sciences Corporation Use Of Phosphorylated TBeta4 And Other Factors To Generate Human Induced Pluripotent Stem Cells
US11879137B2 (en) 2017-09-22 2024-01-23 The Children's Medical Center Corporation Treatment of type 1 diabetes and autoimmune diseases or disorders
US20210363496A1 (en) 2017-10-17 2021-11-25 Kyoto University Method for obtaining artificial neuromuscular junction from pluripotent stem cells
KR101810008B1 (ko) 2017-10-23 2018-01-18 차의과학대학교 산학협력단 역분화-증진제를 이용한 인간-유래의 체세포로부터 역분화 만능 줄기세포의 제조방법
KR101810014B1 (ko) 2017-10-23 2018-01-18 차의과학대학교 산학협력단 히스톤 데아세틸라제 저해제 및 골 형성 단백질 경로 차단제를 이용한 인간-유래의 체세포로부터 역분화 만능 줄기세포의 제조방법
KR101998633B1 (ko) * 2017-10-31 2019-07-11 가톨릭관동대학교산학협력단 엘립티신의 줄기세포의 연골세포로의 분화 유도 용도
CN108624562B (zh) * 2018-05-18 2021-11-02 首都医科大学附属北京朝阳医院 一种制备肿瘤干细胞的方法及其专用试剂盒
KR102158783B1 (ko) * 2018-06-18 2020-09-22 한국생명공학연구원 세포 리프로그래밍 조성물 및 이를 이용한 유도만능줄기세포의 제조방법
US12391739B2 (en) 2018-07-13 2025-08-19 Kyoto University Method for producing gamma delta T cells
EP3824912A4 (en) 2018-07-19 2022-04-20 Kyoto University PLATEFORM CARTILAGE DERIVED FROM PLURIPOTENTS STEM CELLS AND METHODS FOR PRODUCTION OF PLATEFORM CARTILAGE
US20210332329A1 (en) 2018-07-23 2021-10-28 Kyoto University Novel renal progenitor cell marker and method for concentrating renal progenitor cells using same
US11617745B2 (en) 2018-08-17 2023-04-04 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating FOXO
EP3837352A1 (en) 2018-08-17 2021-06-23 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by upregulating jag-1
EP3892722A4 (en) 2018-12-06 2022-10-05 Kirin Holdings Kabushiki Kaisha Production method for t cells or nk cells, medium for culturing t cells or nk cells, method for culturing t cells or nk cells, method for maintaining undifferentiated state of undifferentiated t cells, and growth-accelerating agent for t cells or nk cells
WO2020130147A1 (ja) 2018-12-21 2020-06-25 国立大学法人京都大学 ルブリシン局在軟骨様組織、その製造方法及びそれを含む関節軟骨損傷治療用組成物
US20220062341A1 (en) 2018-12-26 2022-03-03 Kirin Holdings Kabushiki Kaisha Modified tcr and production method therefor
US12250943B2 (en) 2019-04-08 2025-03-18 Htyr Acquisition Llc Compositions and methods for the cryopreservation of immune cells
US12370217B2 (en) 2019-05-14 2025-07-29 Htyr Acquisition Llc Compositions and methods for treating T cell exhaustion
CA3140384A1 (en) 2019-05-15 2020-11-19 Ajinomoto Co., Inc. Method for purifying neural crest cells or corneal epithelial cells
CA3141455A1 (en) 2019-05-20 2020-11-26 Ajinomoto Co., Inc. Expansion culture method for cartilage or bone precursor cells
AU2020301036A1 (en) 2019-07-03 2022-02-17 Factor Bioscience Inc. Cationic lipids and uses thereof
WO2021015228A1 (ja) * 2019-07-25 2021-01-28 富士フイルム株式会社 特定の分化細胞の製造方法
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
CN112301052A (zh) * 2019-08-01 2021-02-02 浙江霍德生物工程有限公司 一种通过体细胞重编程制备诱导多功能干细胞的方法
WO2021117886A1 (ja) 2019-12-12 2021-06-17 国立大学法人千葉大学 巨核球および血小板を含む凍結乾燥製剤
KR102087084B1 (ko) * 2020-02-03 2020-03-10 주식회사 이에이치엘바이오 항노화인자를 발현하는 지방유래 줄기세포의 대량 배양방법
WO2021167703A1 (en) 2020-02-19 2021-08-26 Nammi Therapeutics, Inc. Formulated and/or co-formulated liposome compositions containing tgfb antagonist prodrugs useful in the treatment of cancer and methods thereof
MX2022010521A (es) 2020-02-28 2022-09-19 Takeda Pharmaceuticals Co Metodo para producir linfocitos citoliticos naturales a partir de celulas madre pluripotentes.
CN115885038A (zh) 2020-06-17 2023-03-31 国立大学法人京都大学 表达嵌合抗原受体的免疫活性细胞
WO2022014604A1 (ja) 2020-07-13 2022-01-20 国立大学法人京都大学 骨格筋前駆細胞及びその精製方法、筋原性疾患を治療するための組成物、並びに骨格筋前駆細胞を含む細胞群の製造方法
CN116134130A (zh) 2020-07-20 2023-05-16 学校法人爱知医科大学 多能细胞的未分化维持培养用组合物、多能细胞的未分化维持培养用培养基、多能细胞的未分化状态下的维持培养方法、和多能细胞的制造方法
CN116323917A (zh) 2020-08-18 2023-06-23 国立大学法人京都大学 人原始生殖细胞/人原始生殖细胞样细胞的维持扩增方法
WO2022196714A1 (ja) 2021-03-17 2022-09-22 アステラス製薬株式会社 塩基性繊維芽細胞増殖因子（ｂＦＧＦ）遺伝子が導入されたペリサイト
WO2022230977A1 (ja) 2021-04-30 2022-11-03 国立研究開発法人理化学研究所 網膜色素上皮細胞のひも状凝集体、それを製造するためのデバイスおよび製造方法、ならびに該ひも状凝集体を含有する治療薬
CN117413051A (zh) 2021-06-04 2024-01-16 麒麟控股株式会社 细胞组合物、细胞组合物的制造方法和含有细胞组合物的药物组合物
JPWO2022259721A1 (enExample) 2021-06-10 2022-12-15
EP4355861A1 (en) 2021-06-15 2024-04-24 Takeda Pharmaceutical Company Limited Method for producing natural killer cells from pluripotent stem cells
WO2023283631A2 (en) * 2021-07-08 2023-01-12 The Broad Institute, Inc. Methods for differentiating and screening stem cells
US20240335480A1 (en) 2021-07-15 2024-10-10 Astellas Pharma Inc. Vascular endothelial growth factor (vegf)-highly expressing pericyte-like cell
WO2023286832A1 (ja) 2021-07-15 2023-01-19 アステラス製薬株式会社 血管内皮増殖因子（ｖｅｇｆ）高発現ペリサイト様細胞の製造方法
EP4386083A4 (en) 2021-08-11 2025-11-12 Univ Kyoto METHOD FOR PRODUCING RENAL INTERSTITIAL PROGENITOR CELLS, ERYTHROPOIETIN-PRODUCING CELLS AND METHOD FOR PRODUCING RENIIN-PRODUCING CELLS
JPWO2023074648A1 (enExample) * 2021-10-25 2023-05-04
CA3238206A1 (en) 2021-11-11 2023-05-19 Healios K.K. Gene-modified pluripotent stem cell, immunocompetent cell derived therefrom, method for producing said cells, and use thereof
EP4477746A1 (en) 2022-02-09 2024-12-18 Sumitomo Pharma Co., Ltd. Method for assessing differentiation potential of cells in culture broth in differentiation of pluripotent stem cells into neural cells of midbrain floor plate region
CN116694551A (zh) * 2022-02-24 2023-09-05 清华大学 诱导性成熟肝脏细胞及其制备的方法
EP4516905A1 (en) 2022-04-27 2025-03-05 Kyoto University Epicardial cell regeneration promoter and method for promoting epicardial cell regeneration
CN114702591B (zh) * 2022-05-17 2022-09-23 诺赛联合(北京)生物医学科技有限公司 成体细胞衍生的类器官制备技术
CN119365606A (zh) 2022-06-10 2025-01-24 国立大学法人京都大学 未分化多能干细胞的检测方法和检测试剂
WO2024078118A1 (en) * 2022-10-12 2024-04-18 Peking University Chemical reprogramming and pluripotent stem cells
KR102887911B1 (ko) 2022-11-04 2025-11-19 건국대학교 글로컬산학협력단 분화된 세포의 유도만능줄기세포로의 리프로그래밍 효율 증진 방법
CN115772495B (zh) * 2022-12-02 2025-05-16 上海交通大学医学院附属第九人民医院 一种诱导胚胎干细胞定向分化为外胚层软骨祖细胞的培养基、方法及用途

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5384253A (en) 1990-12-28 1995-01-24 Dekalb Genetics Corporation Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5702932A (en) 1992-07-20 1997-12-30 University Of Florida Microinjection methods to transform arthropods with exogenous DNA
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
CA2167580A1 (en) 1993-07-22 1995-02-02 Howard Y. Chen Expression of human interleukin-1.beta. in a transgenic animal
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5656610A (en) 1994-06-21 1997-08-12 University Of Southern California Producing a protein in a mammal by injection of a DNA-sequence into the tongue
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5569588A (en) 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5780448A (en) 1995-11-07 1998-07-14 Ottawa Civic Hospital Loeb Research DNA-based vaccination of fish
GB9807935D0 (en) 1998-04-14 1998-06-10 Univ Edinburgh Lineage specific cells and progenitor cells
US5945100A (en) 1996-07-31 1999-08-31 Fbp Corporation Tumor delivery vehicles
US5981274A (en) 1996-09-18 1999-11-09 Tyrrell; D. Lorne J. Recombinant hepatitis virus vectors
EP0981352B8 (en) 1997-05-07 2009-06-17 Pharma Mar, S.A. Use of aplidine for the treatment of cardiovascular diseases
US6270994B1 (en) 1997-06-13 2001-08-07 Japanese Foundation For Cancer Research Smad6 and uses thereof
US5994624A (en) 1997-10-20 1999-11-30 Cotton Incorporated In planta method for the production of transgenic plants
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
USH1963H1 (en) 1998-01-16 2001-06-05 Dresser Industries, Inc. High pressure differential electrical connector
US20060263382A1 (en) 1998-06-20 2006-11-23 Richard Hotchkiss Membrane-permeant peptide complexes for treatment of sepsis
JP2002521025A (ja) 1998-07-24 2002-07-16 ザ カーネギー インスチチューション オブ ワシントン 増殖因子のＴＧＦ−βファミリーのメンバーを使用する、生殖系列幹細胞の維持および増殖のための方法。
GB9819912D0 (en) * 1998-09-11 1998-11-04 Univ Edinburgh Propagation and/or derivation of embryonic stem cells
CA2350234A1 (en) 1999-01-07 2000-07-13 Alexander James Bridges Treatment of asthma with mek inhibitors
US6703420B1 (en) 1999-03-19 2004-03-09 Bristol-Myers Squibb Pharma Company Amino-thio-acrylonitriles as MEK inhibitors
US6730293B1 (en) 1999-08-24 2004-05-04 Cellgate, Inc. Compositions and methods for treating inflammatory diseases of the skin
US20020142457A1 (en) 1999-12-28 2002-10-03 Akihiro Umezawa Cell having the potentiality of differentiation into cardiomyocytes
US20030180947A1 (en) * 2001-09-21 2003-09-25 J.H. David Wu Circadian control of stem/progenitor cell self-renewal and differentiation and of clock controlled gene expression
SI1456380T1 (sl) 2001-11-02 2012-11-30 Giuliani Int Ltd Smad inhibitorji za zdravljenje cns bolezni
US20030204862A1 (en) * 2002-03-05 2003-10-30 Ralf Kuehn Inbred embryonic stem-cell derived mice
GB0210539D0 (en) 2002-05-08 2002-06-19 Univ Edinburgh Control of es cell self renewal and lineage specification, and medium therefor
CA2506085A1 (en) 2002-11-15 2004-06-03 Ronald Lynn Merriman Combination chemotherapy comprising a mek inhibitor and capecitabine for treating cancer
JP2006517234A (ja) 2003-02-10 2006-07-20 アムジエン・インコーポレーテツド バニロイド受容体リガンドおよび治療におけるこれらのリガンドの使用
AU2003901099A0 (en) 2003-03-11 2003-03-27 Es Cell International Pte Ltd. Methods of inducing differentiation of stem cells
US20070010008A1 (en) 2005-06-29 2007-01-11 Tissuetech, Inc. Ex vivo expansion of primary animal cells
CA2529752A1 (en) 2003-06-20 2005-09-15 The Regents Of The University Of California Polypeptide transduction and fusogenic peptides
CN1863904B (zh) 2003-10-03 2014-05-28 福田惠一 由干细胞分化诱导心肌细胞的方法
GB2407048B (en) 2003-10-15 2007-07-11 Biotrace Internat Plc Laboratory apparatus
JP2007508026A (ja) 2003-10-16 2007-04-05 ザ・ユニバーシティ・コート・オブ・ザ・ユニバーシティ・オブ・エディンバラ Ｅｓ細胞の自己再生および系統仕様の制御ならびにそのための培地
US20070141703A1 (en) 2003-11-19 2007-06-21 Stanley Edouard G Methods for producing blood products from pluripotent cells in cell culture
US20070269412A1 (en) 2003-12-02 2007-11-22 Celavie Biosciences, Llc Pluripotent cells
JP5102030B2 (ja) 2004-08-13 2012-12-19 ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド ヒト胚性幹細胞における自己再生および分化のための組成物および方法
US20080268533A1 (en) 2004-08-25 2008-10-30 University Of Georgia Research Foundation, Inc. Methods and Compositions Utilizing Myc and Gsk3Beta to Manipulate the Pluripotency of Embryonic Stem Cells
US20060182724A1 (en) 2005-02-15 2006-08-17 Riordan Neil H Method for expansion of stem cells
KR101004634B1 (ko) 2005-08-01 2011-01-04 뉴포텐셜, 인크. 잠재력이 복원된 리프로그래밍된 세포의 제조
US20080242594A1 (en) 2005-09-08 2008-10-02 Mckay Ronald D G Methods for Promoting Stem Cell Proliferation and Survival
NZ606259A (en) * 2005-11-03 2014-06-27 Vertex Pharma Aminopyrimidines useful as kinase inhibitors
US8217042B2 (en) * 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
JP2009515515A (ja) * 2005-11-11 2009-04-16 ザ・ユニバーシティ・コート・オブ・ザ・ユニバーシティ・オブ・エディンバラ 細胞の再プログラム化および遺伝子改変
US20090227032A1 (en) 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
WO2007069666A1 (ja) 2005-12-13 2007-06-21 Kyoto University 核初期化因子
JP5024049B2 (ja) 2005-12-16 2012-09-12 株式会社明電舎 真空コンデンサ
GB0601538D0 (en) * 2006-01-26 2006-03-08 Univ Birmingham Epigenetic analysis
EP1992360A4 (en) 2006-02-01 2010-02-17 Univ Tokyo COMMON USE OF A TGF BETA SIGNAL HEMMER AND AN ANTITUMORAL AGENT
US7541186B2 (en) 2006-02-22 2009-06-02 University Of Washington Method of generating human retinal progenitors from embryonic stem cells
EP2457995A1 (en) 2006-03-30 2012-05-30 The University Court of The University of Edinburgh Culture medium containing kinase inhibitors, and uses thereof
GB0615327D0 (en) 2006-03-30 2006-09-13 Univ Edinburgh Culture medium containing kinase inhibitors and uses thereof
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
GB2452186B (en) 2006-05-02 2011-01-26 Wisconsin Alumni Res Found Method of differentiating stem cells into cells of the endoderm and pancreatic lineage
GB2437737B (en) 2006-05-04 2008-07-09 Access Products Ltd Scaffolding
US7884107B2 (en) 2006-06-30 2011-02-08 Merck Substituted piperidines that increase P53 activity and the uses thereof
JP4960450B2 (ja) 2006-07-14 2012-06-27 ノバルティス アーゲー Ａｌｋ−５阻害剤としてのピリミジン誘導体
US20080020014A1 (en) 2006-07-19 2008-01-24 Paul Consigny Implantable devices containing nuclear receptor ligands for the treatment of vascular and related disorders
GB0622395D0 (en) 2006-11-09 2006-12-20 Univ Cambridge Tech Methods relating to pluripotent cells
WO2008089351A1 (en) 2007-01-17 2008-07-24 Wisconsin Alumni Research Foundation Improved culture of stem cells
US20100172883A1 (en) 2007-01-19 2010-07-08 Bruneau Benoit Gaetan Methods of generating cardiomyocytes
CA2676044C (en) 2007-01-30 2019-10-22 University Of Georgia Research Foundation, Inc. Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc)
WO2008105630A1 (en) 2007-02-27 2008-09-04 Procell Therapeutics Inc. Combined use of cell permeable nanog and oct4 for increasing self-renewal and suppressing differentiation of stem cells
EP3449923A1 (en) 2007-03-07 2019-03-06 MEI Pharma, Inc. Combination of benzimidazole anti-cancer agent and a second anti-cancer agent
WO2008126932A2 (en) 2007-04-09 2008-10-23 Riken Epigenetical regulation of brain plasticity
EP2147094B2 (en) * 2007-04-18 2018-02-21 Hadasit Medical Research Services & Development Limited Stem cell-derived retinal pigment epithelial cells
US8648069B2 (en) 2007-06-08 2014-02-11 Abbvie Inc. 5-substituted indazoles as kinase inhibitors
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
DK2173863T3 (en) 2007-06-29 2019-01-21 Fujifilm Cellular Dynamics Inc Automated method and apparatus for embryonic stem cell culture
WO2009032456A2 (en) 2007-08-01 2009-03-12 Primegen Biotech Llc Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state
EP3078738B1 (en) * 2007-08-31 2020-05-20 Whitehead Institute for Biomedical Research Wnt pathway stimulation in reprogramming somatic cells
CN101617043B (zh) * 2007-10-31 2014-03-12 国立大学法人京都大学 核重编程方法
JP4604076B2 (ja) 2007-11-07 2010-12-22 国立大学法人静岡大学 燃料電池用電解質膜
EP2227540A4 (en) 2007-11-29 2011-11-02 Children S Hospital Of Orange County DIFFERENTIATION OF HUMAN CELLS
US20110190729A1 (en) 2007-11-30 2011-08-04 Cytomatrix Pty Ltd Methods of inducing pluripotency involving sox2 protein
AU2008329563A1 (en) 2007-11-30 2009-06-04 Cytomatrix Pty Ltd Methods of inducing pluripotency involving Oct4 protein
WO2009082184A2 (en) 2007-12-26 2009-07-02 Posdata Co., Ltd. Method for determining spurious and wireless communication system applying that method
CN102027105B (zh) 2008-03-17 2015-03-11 斯克里普斯研究所 用于产生诱导的多能干细胞的组合化学遗传方法
US8298825B1 (en) 2008-08-25 2012-10-30 The General Hospital Corporation TGF-beta receptor inhibitors to enhance direct reprogramming
ES2645869T3 (es) 2008-12-17 2017-12-11 The Scripps Research Institute Generación y mantenimiento de células madre
WO2010102267A2 (en) 2009-03-06 2010-09-10 Ipierian, Inc. Tgf-beta pathway inhibitors for enhancement of cellular reprogramming of human cells
EP2438159B1 (en) 2009-05-29 2018-10-03 Kyoto University Method for selecting clone of induced pluripotent stem cells
CN102625837B (zh) 2009-08-07 2015-01-14 国立大学法人京都大学 有效建立诱导的多能干细胞的方法
EP4206319A1 (en) 2009-10-16 2023-07-05 The Scripps Research Institute Induction of pluripotent cells
US8486701B2 (en) 2010-03-05 2013-07-16 University Of Houston ETS2 and MESP1 generate cardiac progenitors from fibroblasts
ES2624780T3 (es) 2010-03-31 2017-07-17 The Scripps Research Institute Reprogramación de células
JO3421B1 (ar) 2011-06-20 2019-10-20 H Lundbeck As طريقة لإعطاء 1-((1ار.3س)-6-كلورو-3-فينيل-اندان-1-ايل)-1.2.2-ترايميثيل- بيبيرازين واملاجها لمعالجة انفصام الشخصية
US9166832B1 (en) 2013-10-04 2015-10-20 Altera Corporation Methods and apparatus for decision feedback equalization adaptation

Similar Documents

Publication Publication Date Title
JP2016185172A5 (enExample)
Helion et al. Emotion regulation across the life span
Zhao et al. Adaptive multi‐degree‐of‐freedom in situ bioprinting robot for hair‐follicle‐inclusive skin repair: A preliminary study conducted in mice
NZ582018A (en) Multipotent/pluripotent cells and methods
ES3048007T3 (en) Human collagen 17-type polypeptide, production method therefor and use thereof
JP2011517560A5 (enExample)
IL320440A (en) Methods of in vitro differentiation of midbrain dopamine (mda) neurons
MX380817B (es) Un método eficiente y novedoso para generar células madre pluripotentes inducidas a partir de células sanguíneas.
JP2013517758A5 (enExample)
MY189035A (en) Antibody for binding to interleukin 4 receptor
SG10201806693XA (en) Anti-myostatin antibodies and methods of use
MX2016007779A (es) Formacion de fibras de queratina mediante el uso de ester de carbonato.
PH12017502283A1 (en) A method of treatment
JP2011529330A5 (enExample)
BR112017011398A2 (pt) métodos e composições que usam polipeptídeos variantes de klotho
MX2022015995A (es) Cabezales de aplicador, aparato y procedimientos cosmeticos para el tratamiento de la piel de un sujeto.
AR120348A1 (es) Método para producir células t
AR102445A1 (es) COMPOSICIONES Y MÉTODOS RELACIONADOS CON b-GLUCOSIDASA
MY196026A (en) Stem Cell Conditioned Media for Clinical and Cosmetic Applications
MX2020011153A (es) Método para el tratamiento y/o prevención de queratina dañada.
BR112021020141A2 (pt) Combinação de chir99021 e ácido valpróico para tratamento de perda auditiva
WO2020094954A3 (fr) Procédé pour évaluer la capacité d'une substance ou d'une composition à prévenir, ralentir ou éliminer les signes du vieillissement de la peau ou des lèvres
White Sullivan and treatment.
AU2019356414A8 (en) Binding proteins specific for HA-1H and uses thereof
White et al. Growth factors and cytokines in skeletal muscle development, growth, regeneration and disease