JP2011051997A5 - - Google Patents
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- Publication number
- JP2011051997A5 JP2011051997A5 JP2010237357A JP2010237357A JP2011051997A5 JP 2011051997 A5 JP2011051997 A5 JP 2011051997A5 JP 2010237357 A JP2010237357 A JP 2010237357A JP 2010237357 A JP2010237357 A JP 2010237357A JP 2011051997 A5 JP2011051997 A5 JP 2011051997A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- neisseria
- antigen
- outer membrane
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002163 immunogen Effects 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 10
- 241000588653 Neisseria Species 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 7
- 239000012528 membrane Substances 0.000 claims 7
- 241000588650 Neisseria meningitidis Species 0.000 claims 3
- 108010073429 Type V Secretion Systems Proteins 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 229920001542 oligosaccharide Polymers 0.000 claims 2
- 150000002482 oligosaccharides Chemical class 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 101000874355 Escherichia coli (strain K12) Outer membrane protein assembly factor BamA Proteins 0.000 claims 1
- 101710186862 Factor H binding protein Proteins 0.000 claims 1
- 108010031133 Transferrin-Binding Protein A Proteins 0.000 claims 1
- 229940024546 aluminum hydroxide gel Drugs 0.000 claims 1
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical group O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 claims 1
- 229940009976 deoxycholate Drugs 0.000 claims 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (24)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0218036.2 | 2002-08-02 | ||
| GB0218051A GB0218051D0 (en) | 2002-08-02 | 2002-08-02 | Vaccine composition |
| GB0218035A GB0218035D0 (en) | 2002-08-02 | 2002-08-02 | Vaccine composition |
| GB0218037.0 | 2002-08-02 | ||
| GB0218035.4 | 2002-08-02 | ||
| GB0218036A GB0218036D0 (en) | 2002-08-02 | 2002-08-02 | Vaccine |
| GB0218037A GB0218037D0 (en) | 2002-08-02 | 2002-08-02 | Vaccine composition |
| GB0218051.1 | 2002-08-02 | ||
| GB0220199.4 | 2002-08-30 | ||
| GB0220197.8 | 2002-08-30 | ||
| GBGB0220199.4A GB0220199D0 (en) | 2002-08-30 | 2002-08-30 | Mutant protein and refolding method |
| GBGB0220197.8A GB0220197D0 (en) | 2002-08-30 | 2002-08-30 | Refolding method |
| GB0225531.3 | 2002-11-01 | ||
| GB0225531A GB0225531D0 (en) | 2002-11-01 | 2002-11-01 | Vaccine |
| GB0225524A GB0225524D0 (en) | 2002-11-01 | 2002-11-01 | Vaccine composition |
| GB0225524.8 | 2002-11-01 | ||
| GB0230168A GB0230168D0 (en) | 2002-12-24 | 2002-12-24 | Vaccine composition |
| GB0230164A GB0230164D0 (en) | 2002-12-24 | 2002-12-24 | Vaccine composition |
| GB0230168.7 | 2002-12-24 | ||
| GB0230170.3 | 2002-12-24 | ||
| GB0230164.6 | 2002-12-24 | ||
| GB0230170A GB0230170D0 (en) | 2002-12-24 | 2002-12-24 | Vaccine |
| GB0305028A GB0305028D0 (en) | 2003-03-05 | 2003-03-05 | Vaccine |
| GB0305028.3 | 2003-03-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005506114A Division JP2006506467A (ja) | 2002-08-02 | 2003-07-31 | ワクチン組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012026928A Division JP5789203B2 (ja) | 2002-08-02 | 2012-02-10 | ワクチン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011051997A JP2011051997A (ja) | 2011-03-17 |
| JP2011051997A5 true JP2011051997A5 (enExample) | 2012-03-08 |
| JP5414651B2 JP5414651B2 (ja) | 2014-02-12 |
Family
ID=31722002
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005506113A Pending JP2006500963A (ja) | 2002-08-02 | 2003-07-31 | ワクチン組成物 |
| JP2005506111A Expired - Fee Related JP5409986B2 (ja) | 2002-08-02 | 2003-07-31 | グラム陰性細菌由来のトランスフェリン結合タンパク質およびＨｓｆを含んでなるワクチン組成物 |
| JP2005506114A Pending JP2006506467A (ja) | 2002-08-02 | 2003-07-31 | ワクチン組成物 |
| JP2005506112A Expired - Fee Related JP4740738B2 (ja) | 2002-08-02 | 2003-07-31 | ワクチン |
| JP2010237357A Expired - Fee Related JP5414651B2 (ja) | 2002-08-02 | 2010-10-22 | ワクチン組成物 |
| JP2011047056A Pending JP2011142916A (ja) | 2002-08-02 | 2011-03-04 | ワクチン |
| JP2012026928A Expired - Fee Related JP5789203B2 (ja) | 2002-08-02 | 2012-02-10 | ワクチン組成物 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005506113A Pending JP2006500963A (ja) | 2002-08-02 | 2003-07-31 | ワクチン組成物 |
| JP2005506111A Expired - Fee Related JP5409986B2 (ja) | 2002-08-02 | 2003-07-31 | グラム陰性細菌由来のトランスフェリン結合タンパク質およびＨｓｆを含んでなるワクチン組成物 |
| JP2005506114A Pending JP2006506467A (ja) | 2002-08-02 | 2003-07-31 | ワクチン組成物 |
| JP2005506112A Expired - Fee Related JP4740738B2 (ja) | 2002-08-02 | 2003-07-31 | ワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011047056A Pending JP2011142916A (ja) | 2002-08-02 | 2011-03-04 | ワクチン |
| JP2012026928A Expired - Fee Related JP5789203B2 (ja) | 2002-08-02 | 2012-02-10 | ワクチン組成物 |
Country Status (25)
| Country | Link |
|---|---|
| US (9) | US20060057160A1 (enExample) |
| EP (11) | EP2481419A3 (enExample) |
| JP (7) | JP2006500963A (enExample) |
| KR (6) | KR20050039839A (enExample) |
| CN (2) | CN1674933B (enExample) |
| AU (6) | AU2003253375B2 (enExample) |
| CA (4) | CA2493977A1 (enExample) |
| CO (3) | CO5680455A2 (enExample) |
| CY (3) | CY1114243T1 (enExample) |
| DE (2) | DE20321889U1 (enExample) |
| DK (2) | DK2255826T3 (enExample) |
| ES (3) | ES2537737T3 (enExample) |
| HU (1) | HUE029200T2 (enExample) |
| IL (3) | IL165660A0 (enExample) |
| IS (3) | IS7593A (enExample) |
| LU (1) | LU92262I2 (enExample) |
| MX (3) | MXPA05001349A (enExample) |
| MY (1) | MY149591A (enExample) |
| NO (3) | NO20050008L (enExample) |
| NZ (4) | NZ537904A (enExample) |
| PL (5) | PL216662B1 (enExample) |
| PT (2) | PT2255826E (enExample) |
| SI (2) | SI1524993T1 (enExample) |
| TW (1) | TWI360424B (enExample) |
| WO (4) | WO2004014417A2 (enExample) |
Families Citing this family (140)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2304065T3 (es) | 1998-05-01 | 2008-09-01 | Novartis Vaccines And Diagnostics, Inc. | Antigenos y composiciones de neisseria meningitidis. |
| US10967045B2 (en) * | 1998-11-02 | 2021-04-06 | Secretary of State for Health and Social Care | Multicomponent meningococcal vaccine |
| GB9823978D0 (en) * | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
| ES2477194T3 (es) | 1999-04-30 | 2014-07-16 | Novartis Vaccines And Diagnostics S.R.L. | Ant�genos neisseriales conservados |
| DK2270173T3 (en) * | 1999-05-19 | 2016-03-07 | Glaxosmithkline Biolog Sa | Neisserial combination compositions |
| GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| CA2864069A1 (en) | 1999-10-29 | 2001-05-03 | Novartis Vaccines And Diagnostics S.R.L. | Neisserial antigenic peptides |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| WO2001055182A1 (en) * | 2000-01-25 | 2001-08-02 | The University Of Queensland | PROTEINS COMPRISING CONSERVED REGIONS OF NEISSERIA MENINGITIDIS SURFACE ANTIGEN NhhA |
| MXPA02008313A (es) * | 2000-02-28 | 2002-12-09 | Chiron Spa | Expresion hibrida de proteinas de neisseria. |
| MXPA03000822A (es) | 2000-07-27 | 2004-11-01 | Childrens Hosp & Res Ct Oak | Vacunas para proteccion de espectro amplio contra enfermedades causadas por neisseria meningitidis. |
| GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| JP4592284B2 (ja) | 2001-07-27 | 2010-12-01 | カイロン ソチエタ ア レスポンサビリタ リミタータ | 髄膜炎菌付着因子 |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| WO2004014417A2 (en) * | 2002-08-02 | 2004-02-19 | Glaxosmithkline Biologicals Sa | Vaccine compositions comprising l2 and/or l3 immunotype lipooligosaccharides from lgtb- neisseria minigitidis |
| GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| US8663656B2 (en) * | 2002-10-11 | 2014-03-04 | Novartis Ag | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| SG155777A1 (en) | 2003-04-09 | 2009-10-29 | Neose Technologies Inc | Glycopegylation methods and proteins/peptides produced by the methods |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| AU2004274977B2 (en) | 2003-09-19 | 2011-06-23 | Epitopix, Llc | Campylobacter polypeptides and methods of use |
| SI1670506T1 (sl) | 2003-10-02 | 2013-03-29 | Novartis Ag | Tekoča cepiva proti multiplim meningokoknim seroskupinam |
| GB0323709D0 (en) * | 2003-10-09 | 2003-11-12 | Health Prot Agency | Modified whole cell,cell extract and omv-based vaccines |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US7628995B2 (en) * | 2003-12-23 | 2009-12-08 | Glaxosmithkline Biologicals S.A. | Outer membrane vesicles and uses thereof |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| CN1997392B (zh) * | 2004-05-11 | 2011-06-01 | 荷兰健康、福利与体育部部长代表的荷兰国 | 作为佐剂的脑膜炎奈瑟氏菌lgtB LOS |
| US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
| GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
| GB0419627D0 (en) | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| WO2006050247A2 (en) | 2004-10-29 | 2006-05-11 | Neose Technologies, Inc. | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| GB0428381D0 (en) * | 2004-12-24 | 2005-02-02 | Isis Innovation | Vaccine |
| WO2006074467A2 (en) | 2005-01-10 | 2006-07-13 | Neose Technologies, Inc. | Glycopegylated granulocyte colony stimulating factor |
| EP2361926A3 (en) * | 2005-01-21 | 2011-12-21 | Epitopix, LLC | Yersinia SSP. polypeptides and methods of use |
| HUE033196T2 (en) * | 2005-01-27 | 2017-11-28 | Children's Hospital & Res Center At Oakland | GNA1870-based vesicle vaccines for broad-spectrum protection against diseases caused by Neisseria meningitidis |
| US9187546B2 (en) | 2005-04-08 | 2015-11-17 | Novo Nordisk A/S | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| JP2008543907A (ja) | 2005-06-27 | 2008-12-04 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| US7955817B2 (en) | 2005-09-02 | 2011-06-07 | Glaxosmithkline Biologicals S.A. | Vaccine protection assay |
| CA2621578C (en) | 2005-09-05 | 2014-07-22 | Glaxosmithkline Biologicals S.A. | Serum bactericidal assay for n. meningitidis specific antisera |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| US20110008279A1 (en) * | 2005-12-06 | 2011-01-13 | Vega Masignani | Methods and Compositions Relating to Adhesins as Adjuvants |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| EA014107B1 (ru) | 2005-12-22 | 2010-10-29 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина, содержащая конъюгаты капсульных полисахаридов streptococcus pneumoniae |
| CU23549A1 (es) * | 2005-12-29 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Composiciones farmacéuticas que contienen la proteína nma0939 |
| EA020459B1 (ru) | 2006-03-30 | 2014-11-28 | Глаксосмитклайн Байолоджикалс С.А. | Иммуногенная композиция |
| CA2654706A1 (en) * | 2006-06-12 | 2007-12-21 | Nathalie Devos | Neisseria meningitidis lipooligosaccharide vaccine |
| WO2008011633A2 (en) | 2006-07-21 | 2008-01-24 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| HRP20120557T1 (hr) | 2006-09-07 | 2012-07-31 | GlaxoSmithKline@Biologicals@s@a | Kombinirano cjepivo sa smanjenim količinama antigena poliovirusa |
| US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
| GB0700136D0 (en) | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| KR20100016160A (ko) | 2007-04-03 | 2010-02-12 | 바이오제너릭스 에이지 | 글리코페길화 ｇ―ｃｓｆ를 이용하는 치료 방법 |
| MX2009013259A (es) | 2007-06-12 | 2010-01-25 | Novo Nordisk As | Proceso mejorado para la produccion de azucares de nucleotidos. |
| BRPI0813644B8 (pt) | 2007-06-26 | 2021-05-25 | Glaxosmithkline Biologicals Sa | composição imunogênica, vacina, processo para fabricar a mesma, e, uso da composição imunogênica ou vacina |
| EP2185576A4 (en) * | 2007-08-02 | 2011-01-12 | Childrens Hosp & Res Ct Oak | FHBP- AND LPXL1-BASED VESICIUM VACCINES FOR BROADBAND PROTECTION AGAINST NEISSERIA MENINGITIDIS-RELATED DISEASES |
| JP2010535019A (ja) * | 2007-08-02 | 2010-11-18 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | リポオリゴ糖（ｌｏｓ）生合成に関わる遺伝子の有無の決定によるナイセリア属菌株の分子タイピング |
| DK2200642T3 (da) | 2007-10-19 | 2012-07-16 | Novartis Ag | Meningococvaccinepræparater |
| AU2009215364B2 (en) | 2008-02-21 | 2014-09-18 | Glaxosmithkline Biologicals S.A. | Meningococcal fHBP polypeptides |
| CN101965200B (zh) | 2008-02-27 | 2013-06-19 | 诺沃-诺迪斯克有限公司 | 缀合的因子ⅷ分子 |
| SI2268618T1 (sl) | 2008-03-03 | 2015-09-30 | Novartis Ag | Spojine in sestavki kot modulatorji aktivnosti TLR |
| UA99659C2 (uk) * | 2008-05-30 | 2012-09-10 | Дзе Ю.Ес.Ей., Ес Репрезентед Бай Дзе Секретарі Оф Дзе Армі, Он Бехаф Оф Уолтер Рід Армі | Мультивалентна вакцина з нативних везикул зовнішньої мембрани менінгококів, способи її застосування |
| KR101042541B1 (ko) * | 2008-07-25 | 2011-06-17 | 한국생명공학연구원 | 외막소체를 생산하는 재조합 ｇ（－） 박테리아 및 이를이용한 다가항원이 실린 외막소체의 제조방법 |
| US20110182981A1 (en) * | 2008-08-25 | 2011-07-28 | Peixuan Zhu | Gonococcal vaccines |
| GB0816447D0 (en) * | 2008-09-08 | 2008-10-15 | Glaxosmithkline Biolog Sa | Vaccine |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| CA2747340A1 (en) | 2008-12-17 | 2010-06-24 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
| US8647634B2 (en) | 2008-12-25 | 2014-02-11 | The Chemo-Sero-Therapeutic Research Institute | Recombinant avian infectious coryza vaccine and process for preparing same |
| CN101759781B (zh) * | 2008-12-25 | 2013-04-03 | 上海市第六人民医院 | 一种细菌表层黏附蛋白及其用途 |
| EP2208787A1 (en) * | 2009-01-19 | 2010-07-21 | Université de Liège | A recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted |
| JP5806204B2 (ja) * | 2009-03-24 | 2015-11-10 | ノバルティス アーゲー | 肺炎球菌血清型１４の糖を含む組み合わせ |
| JP5668049B2 (ja) | 2009-03-24 | 2015-02-12 | ノバルティス アーゲー | 髄膜炎菌ｈ因子結合タンパク質および肺炎球菌糖結合体の組み合わせ |
| WO2010109323A1 (en) | 2009-03-24 | 2010-09-30 | Novartis Ag | Adjuvanting meningococcal factor h binding protein |
| NZ597007A (en) | 2009-05-14 | 2013-09-27 | Sanofi Pasteur | Meningococcus vaccine containing lipooligosaccharide (los) from modified strains of l6 immunotype neisseria meningitidis |
| US20120156281A1 (en) * | 2009-05-14 | 2012-06-21 | Sanofi Pasteur | Meningococcal Vaccine Based on Lipooligosaccharide (LOS) and Neisseria Meningitidis Protein |
| CA2761916A1 (fr) * | 2009-05-14 | 2010-11-18 | Sanofi Pasteur | Procede pour adjuver le lipopolysaccharide (lps) des bacteries a gram-negatif |
| JP5536765B2 (ja) * | 2009-05-20 | 2014-07-02 | 国立大学法人鳥取大学 | 部分糖鎖エピトープを用いた、病原性ナイセリア属細菌感染の検出方法およびそれら細菌に対するワクチン |
| EP2440245B1 (en) | 2009-06-10 | 2017-12-06 | GlaxoSmithKline Biologicals SA | Benzonaphthyridine-containing vaccines |
| GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| EP2470205A1 (en) | 2009-08-27 | 2012-07-04 | Novartis AG | Adjuvant comprising aluminium, oligonucleotide and polycation |
| US20110076300A1 (en) | 2009-08-27 | 2011-03-31 | Mariagrazia Pizza | Hybrid Polypeptides Including Meningococcal fHBP Sequences |
| WO2011027956A2 (ko) | 2009-09-04 | 2011-03-10 | 주식회사이언메딕스 | 그람 양성 박테리아에서 유래한 세포밖 소포체 및 이를 이용한 질병 모델 |
| WO2011027971A2 (ko) | 2009-09-01 | 2011-03-10 | 주식회사이언메딕스 | 장내 공생 세균유래 세포밖 소포체, 및 이를 이용한 질병모델, 백신, 후보 약물 탐색 방법, 및 진단 방법 |
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