IL165660A0 - Vaccine composition comprising transferrin bindin g protein and HSF from gram negative bacteria - Google Patents
Vaccine composition comprising transferrin bindin g protein and HSF from gram negative bacteriaInfo
- Publication number
- IL165660A0 IL165660A0 IL16566004A IL16566004A IL165660A0 IL 165660 A0 IL165660 A0 IL 165660A0 IL 16566004 A IL16566004 A IL 16566004A IL 16566004 A IL16566004 A IL 16566004A IL 165660 A0 IL165660 A0 IL 165660A0
- Authority
- IL
- Israel
- Prior art keywords
- hsf
- protein
- negative bacteria
- vaccine composition
- gram negative
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/104—Pseudomonadales, e.g. Pseudomonas
- A61K39/1045—Moraxella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0218037A GB0218037D0 (en) | 2002-08-02 | 2002-08-02 | Vaccine composition |
GB0218035A GB0218035D0 (en) | 2002-08-02 | 2002-08-02 | Vaccine composition |
GB0218051A GB0218051D0 (en) | 2002-08-02 | 2002-08-02 | Vaccine composition |
GB0218036A GB0218036D0 (en) | 2002-08-02 | 2002-08-02 | Vaccine |
GBGB0220197.8A GB0220197D0 (en) | 2002-08-30 | 2002-08-30 | Refolding method |
GBGB0220199.4A GB0220199D0 (en) | 2002-08-30 | 2002-08-30 | Mutant protein and refolding method |
GB0225524A GB0225524D0 (en) | 2002-11-01 | 2002-11-01 | Vaccine composition |
GB0225531A GB0225531D0 (en) | 2002-11-01 | 2002-11-01 | Vaccine |
GB0230164A GB0230164D0 (en) | 2002-12-24 | 2002-12-24 | Vaccine composition |
GB0230170A GB0230170D0 (en) | 2002-12-24 | 2002-12-24 | Vaccine |
GB0230168A GB0230168D0 (en) | 2002-12-24 | 2002-12-24 | Vaccine composition |
GB0305028A GB0305028D0 (en) | 2003-03-05 | 2003-03-05 | Vaccine |
PCT/EP2003/008567 WO2004014419A1 (en) | 2002-08-02 | 2003-07-31 | Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria |
Publications (1)
Publication Number | Publication Date |
---|---|
IL165660A0 true IL165660A0 (en) | 2006-01-15 |
Family
ID=31722002
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16566004A IL165660A0 (en) | 2002-08-02 | 2004-12-09 | Vaccine composition comprising transferrin bindin g protein and HSF from gram negative bacteria |
IL166433A IL166433A (en) | 2002-08-02 | 2005-01-20 | Vaccine compositions comprising l2 or l3 immunotype lipooligosaccharides from lgtb neisseria menigitidis and process for their preparation |
IL213264A IL213264A0 (en) | 2002-08-02 | 2011-05-31 | Vaccine compositions comprising l2 and/or l3 immunotype lipooligosaccharides from lgtb neisseria minigitidis |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL166433A IL166433A (en) | 2002-08-02 | 2005-01-20 | Vaccine compositions comprising l2 or l3 immunotype lipooligosaccharides from lgtb neisseria menigitidis and process for their preparation |
IL213264A IL213264A0 (en) | 2002-08-02 | 2011-05-31 | Vaccine compositions comprising l2 and/or l3 immunotype lipooligosaccharides from lgtb neisseria minigitidis |
Country Status (26)
Country | Link |
---|---|
US (9) | US7838014B2 (xx) |
EP (11) | EP2255826B1 (xx) |
JP (7) | JP2006506467A (xx) |
KR (6) | KR101237329B1 (xx) |
CN (2) | CN1674933B (xx) |
AU (6) | AU2003260357B2 (xx) |
CA (4) | CA2493124C (xx) |
CO (3) | CO5680454A2 (xx) |
CY (3) | CY1114243T1 (xx) |
DE (2) | DE20321889U1 (xx) |
DK (2) | DK2255826T3 (xx) |
ES (3) | ES2575014T3 (xx) |
HK (1) | HK1077014A1 (xx) |
HU (1) | HUE029200T2 (xx) |
IL (3) | IL165660A0 (xx) |
IS (3) | IS7593A (xx) |
LU (1) | LU92262I2 (xx) |
MX (3) | MXPA05001265A (xx) |
MY (1) | MY149591A (xx) |
NO (3) | NO20050010L (xx) |
NZ (4) | NZ574530A (xx) |
PL (5) | PL220107B1 (xx) |
PT (2) | PT1524993E (xx) |
SI (2) | SI2255826T1 (xx) |
TW (1) | TWI360424B (xx) |
WO (4) | WO2004014417A2 (xx) |
Families Citing this family (137)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU761780B2 (en) | 1998-05-01 | 2003-06-12 | Glaxosmithkline Biologicals Sa | Neisseria meningitidis antigens and compositions |
GB9823978D0 (en) * | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
US10967045B2 (en) * | 1998-11-02 | 2021-04-06 | Secretary of State for Health and Social Care | Multicomponent meningococcal vaccine |
EP1228217B1 (en) | 1999-04-30 | 2012-11-21 | Novartis Vaccines and Diagnostics S.r.l. | Conserved neisserial antigens |
MXPA01011867A (es) * | 1999-05-19 | 2002-05-06 | Chiron Spa | Composiciones neisseriales de combinacion. |
GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
AU784203B2 (en) | 1999-10-29 | 2006-02-23 | Glaxosmithkline Biologicals S.A. | Neisserial antigenic peptides |
GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
HUP0300696A3 (en) * | 2000-01-25 | 2004-10-28 | Univ Queensland Brisbane | Proteins comprising conserved regions of neisseria meningitidis surface antigen nhha |
JP4763210B2 (ja) | 2000-02-28 | 2011-08-31 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | ナイセリアのタンパク質の異種発現 |
EP1322328B1 (en) | 2000-07-27 | 2014-08-20 | Children's Hospital & Research Center at Oakland | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
ATE469915T1 (de) | 2001-07-27 | 2010-06-15 | Novartis Vaccines & Diagnostic | Antikörper gegen das meningokokken adhäsin app |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
EP2255826B1 (en) * | 2002-08-02 | 2016-04-13 | GlaxoSmithKline Biologicals S.A. | Neisserial vaccine compositions comprising a combination of antigens |
GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
PT2353608T (pt) * | 2002-10-11 | 2020-03-11 | Novartis Vaccines And Diagnostics S R L | Vacinas de polipéptidos para protecção alargada contra linhagens meningocócicas hipervirulentas |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
EP1615945B1 (en) | 2003-04-09 | 2011-09-28 | BioGeneriX AG | Glycopegylation methods and proteins/peptides produced by the methods |
GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
ES2395022T3 (es) | 2003-09-19 | 2013-02-07 | Epitopix, Llc | Polipéptidos de Campylobacter y sus métodos de uso |
SI1961426T1 (sl) | 2003-10-02 | 2011-10-28 | Novartis Ag | Kombinirana cepiva proti meningitisu |
GB0323709D0 (en) * | 2003-10-09 | 2003-11-12 | Health Prot Agency | Modified whole cell,cell extract and omv-based vaccines |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
EP1706481A2 (en) | 2003-12-23 | 2006-10-04 | GlaxoSmithKline Biologicals S.A. | Vaccine |
GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
PT1748791E (pt) * | 2004-05-11 | 2010-07-15 | Staat Der Nederlanden Vert Doo | Los de neisseria meningitidis lgtb utlizados como adjuvantes |
US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
GB0419627D0 (en) * | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
HUE026826T2 (en) | 2004-10-29 | 2016-07-28 | Ratiopharm Gmbh | Modeling and glycopegylation of fibroblast growth factor (FGF) |
GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
GB0428381D0 (en) * | 2004-12-24 | 2005-02-02 | Isis Innovation | Vaccine |
ES2449195T3 (es) | 2005-01-10 | 2014-03-18 | Ratiopharm Gmbh | Factor estimulante de colonias de granulocitos glicopegilado |
DK1848732T3 (en) | 2005-01-21 | 2016-11-14 | Epitopix Llc | YERSINIA SPP.-POLYPEPTIDES AND METHODS OF USE |
RU2432962C2 (ru) | 2005-01-27 | 2011-11-10 | Чилдрен'З Хоспитал Энд Рисерч Сентер Эт Окленд | Вакцины с использованием везикул на основе gna 1870 широкого спектра действия для профилактики заболеваний, вызываемых neisseria meningitidis |
WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
PE20110072A1 (es) * | 2005-06-27 | 2011-02-04 | Glaxosmithkline Biolog Sa | Composicion inmunogenica |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
US7955817B2 (en) | 2005-09-02 | 2011-06-07 | Glaxosmithkline Biologicals S.A. | Vaccine protection assay |
DE602005024320D1 (de) * | 2005-09-05 | 2010-12-02 | Glaxosmithkline Biolog Sa | Bakterizidie-serumtest für n. meningitidis spezifische antiseren |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
US20110008279A1 (en) * | 2005-12-06 | 2011-01-13 | Vega Masignani | Methods and Compositions Relating to Adhesins as Adjuvants |
GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
NZ569168A (en) | 2005-12-22 | 2012-02-24 | Glaxosmithkline Biolog Sa | Streptococcus pneumoniae polysaccharide conjugate vaccine comprising 19F-DT conjugate |
CU23549A1 (es) * | 2005-12-29 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Composiciones farmacéuticas que contienen la proteína nma0939 |
SG170090A1 (en) | 2006-03-30 | 2011-04-29 | Glaxosmithkline Biolog Sa | Immunogenic composition |
JP5275983B2 (ja) * | 2006-06-12 | 2013-08-28 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
ES2516694T3 (es) | 2006-07-21 | 2014-10-31 | Ratiopharm Gmbh | Glicosilación de péptidos a través de secuencias de glicosilación con unión en O |
EP2066344B2 (en) | 2006-09-07 | 2016-06-29 | GlaxoSmithKline Biologicals S.A. | Inactivated Poliovirus combination vaccine |
US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
GB0700136D0 (en) | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
PL2144923T3 (pl) | 2007-04-03 | 2013-12-31 | Biogenerix Ag | Sposoby leczenia z użyciem glikopegilowanego G-CSF |
US9493499B2 (en) | 2007-06-12 | 2016-11-15 | Novo Nordisk A/S | Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography |
KR101579947B1 (ko) | 2007-06-26 | 2015-12-28 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 스트렙토코쿠스 뉴모니애 캡슐 다당류 컨쥬게이트를 포함하는 백신 |
BRPI0814793A2 (pt) * | 2007-08-02 | 2015-02-03 | Glaxosmithkline Biolog Sa | Método de tipagem molecular los de uma cepa neisseria, kit, e, método de diagnóstico e classificação de uma colonização de neisseria e/ou infecção em um hospedeiro susceptível à colonização de neisseria. |
US20090035328A1 (en) * | 2007-08-02 | 2009-02-05 | Dan Granoff | fHbp- AND LPXL1-BASED VESICLE VACCINES FOR BROAD SPECTRUM PROTECTION AGAINST DISEASES CAUSED BY NEISSERIA MENINGITIDIS |
CN101951949B (zh) | 2007-10-19 | 2013-10-02 | 诺华股份有限公司 | 脑膜炎球菌疫苗制剂 |
EP3263591B1 (en) | 2008-02-21 | 2019-03-27 | GlaxoSmithKline Biologicals S.A. | Meningococcal fhbp polypeptides |
WO2009108806A1 (en) | 2008-02-27 | 2009-09-03 | Novo Nordisk A/S | Conjugated factor viii molecules |
NZ588191A (en) | 2008-03-03 | 2012-06-29 | Irm Llc | Compounds and compositions as tlr activity modulators |
JP5723768B2 (ja) * | 2008-05-30 | 2015-05-27 | ザ ユナイテッド ステイツ オブ アメリカ, アズ レプレゼンテッド バイ ザ セクレタリー オブ ジ アーミー, オン ビハーフ オブ ウォルター リード アーミー インスティチュート オブ リサーチ | 髄膜炎菌性多価未変性外膜小胞ワクチン、その作製方法およびその使用 |
KR101042541B1 (ko) * | 2008-07-25 | 2011-06-17 | 한국생명공학연구원 | 외막소체를 생산하는 재조합 g(-) 박테리아 및 이를이용한 다가항원이 실린 외막소체의 제조방법 |
US20110182981A1 (en) * | 2008-08-25 | 2011-07-28 | Peixuan Zhu | Gonococcal vaccines |
GB0816447D0 (en) | 2008-09-08 | 2008-10-15 | Glaxosmithkline Biolog Sa | Vaccine |
GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
WO2010070453A2 (en) | 2008-12-17 | 2010-06-24 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
CN101759781B (zh) * | 2008-12-25 | 2013-04-03 | 上海市第六人民医院 | 一种细菌表层黏附蛋白及其用途 |
KR101652060B1 (ko) | 2008-12-25 | 2016-08-29 | 잇빤 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 재조합 닭 전염성 코라이자 백신 및 그 제조방법 |
EP2208787A1 (en) * | 2009-01-19 | 2010-07-21 | Université de Liège | A recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted |
CN102438649A (zh) | 2009-03-24 | 2012-05-02 | 诺华有限公司 | 脑膜炎球菌h因子结合蛋白和肺炎球菌结合糖的组合物 |
WO2010109325A2 (en) * | 2009-03-24 | 2010-09-30 | Novartis Ag | Combinations including pneumococcal serotype 14 saccharide |
PT2411048T (pt) | 2009-03-24 | 2020-07-14 | Glaxosmithkline Biologicals Sa | Proteína de ligação ao fator h meningocócica com adjuvante |
CA2761916A1 (fr) * | 2009-05-14 | 2010-11-18 | Sanofi Pasteur | Procede pour adjuver le lipopolysaccharide (lps) des bacteries a gram-negatif |
NZ597008A (en) * | 2009-05-14 | 2013-03-28 | Sanofi Pasteur | Meningococcal vaccine based on lipooligosaccharide (los) and neisseria meningitidis protein |
EP2430151B1 (fr) | 2009-05-14 | 2014-06-18 | Sanofi Pasteur | Vaccin meningocoque a base de lipooligosaccharide (los) provenant de souches modifiees de neisseria meningitidis d'immunotype l6 |
WO2010134225A1 (ja) * | 2009-05-20 | 2010-11-25 | 国立大学法人鳥取大学 | 部分糖鎖エピトープを用いた、病原性ナイセリア属細菌感染の検出方法およびそれら細菌に対するワクチン |
WO2010144734A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
WO2011024071A1 (en) | 2009-08-27 | 2011-03-03 | Novartis Ag | Adjuvant comprising aluminium, oligonucleotide and polycation |
EP2470204B1 (en) | 2009-08-27 | 2015-12-16 | GlaxoSmithKline Biologicals SA | Hybrid polypeptides including meningococcal fhbp sequences |
WO2011027956A2 (ko) | 2009-09-04 | 2011-03-10 | 주식회사이언메딕스 | 그람 양성 박테리아에서 유래한 세포밖 소포체 및 이를 이용한 질병 모델 |
WO2011027971A2 (ko) | 2009-09-01 | 2011-03-10 | 주식회사이언메딕스 | 장내 공생 세균유래 세포밖 소포체, 및 이를 이용한 질병모델, 백신, 후보 약물 탐색 방법, 및 진단 방법 |
TWI445708B (zh) | 2009-09-02 | 2014-07-21 | Irm Llc | 作為tlr活性調節劑之化合物及組合物 |
ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
GB0917002D0 (en) * | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Improved shigella blebs |
GB0917003D0 (en) | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Purification of bacterial vesicles |
AU2010302344A1 (en) | 2009-09-30 | 2012-04-26 | Novartis Ag | Expression of meningococcal fhbp polypeptides |
MX2012004850A (es) | 2009-10-27 | 2012-05-22 | Novartis Ag | Polipeptidos fhbp meningococicos modificados. |
WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
AU2010315115B2 (en) * | 2009-11-06 | 2015-01-29 | Children's Hospital & Research Center At Oakland | T-cell stimulating protein B and methods of use |
CN102762206A (zh) | 2009-12-15 | 2012-10-31 | 诺华有限公司 | 免疫增强化合物的均匀悬液及其用途 |
CN103002910A (zh) * | 2010-03-10 | 2013-03-27 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗组合物 |
JP2013522177A (ja) * | 2010-03-11 | 2013-06-13 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | グラム陰性細菌性、例えば髄膜炎菌性の感染または疾患に対する免疫原性組成物またはワクチン |
EP2547357A1 (en) | 2010-03-18 | 2013-01-23 | Novartis AG | Adjuvanted vaccines for serogroup b meningococcus |
EA023725B1 (ru) | 2010-03-23 | 2016-07-29 | Новартис Аг | Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний |
AU2013202310C1 (en) * | 2010-03-29 | 2017-01-05 | Nationwide Children's Hospital, Inc. | Compositions and methods for the removal of biofilms |
JP6351972B2 (ja) * | 2010-03-29 | 2018-07-04 | ユニバーシティー オブ サザン カリフォルニア | バイオフィルムの除去のための組成物および方法 |
EP2585106A1 (en) | 2010-06-25 | 2013-05-01 | Novartis AG | Combinations of meningococcal factor h binding proteins |
EP2613797B1 (en) | 2010-09-09 | 2015-11-04 | University Of Southern California | Compositions and methods for the removal of biofilms |
WO2012032498A2 (en) | 2010-09-10 | 2012-03-15 | Novartis Ag | Developments in meningococcal outer membrane vesicles |
GB201015132D0 (en) | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
US9322011B2 (en) * | 2010-09-28 | 2016-04-26 | Abera Bioscience Ab | Fusion protein for secretory protein expression |
WO2012054879A1 (en) * | 2010-10-22 | 2012-04-26 | Duke University | Compositions and methods for the treatment of septic arthritis, osteomyelitis, and bacteremia |
EP2707009A1 (en) | 2011-05-12 | 2014-03-19 | Novartis AG | Antipyretics to enhance tolerability of vesicle-based vaccines |
CA2840096C (en) * | 2011-07-07 | 2021-07-06 | Bas VAN DE WATERBEEMD | A process for detergent-free production of outer membrane vesicles of a gram-negative bacterium |
EP2797624A1 (en) | 2011-12-29 | 2014-11-05 | Novartis AG | Adjuvanted combinations of meningococcal factor h binding proteins |
AU2013214105A1 (en) | 2012-02-02 | 2014-07-24 | Novartis Ag | Promoters for increased protein expression in meningococcus |
JP5698693B2 (ja) * | 2012-03-13 | 2015-04-08 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 髄膜炎菌特異的抗血清に対する血清殺菌アッセイ |
US10376573B2 (en) | 2012-06-14 | 2019-08-13 | Glaxosmithkline Biologicals Sa | Vaccines for serogroup X meningococcus |
US9526776B2 (en) | 2012-09-06 | 2016-12-27 | Glaxosmithkline Biologicals Sa | Combination vaccines with serogroup B meningococcus and D/T/P |
MX363529B (es) | 2012-09-18 | 2019-03-27 | Novartis Ag | Vesículas de membrana externa. |
CA2900454A1 (en) | 2013-02-07 | 2014-08-14 | Glaxosmithkline Biologicals Sa | Pharmaceutical compositions comprising vesicles |
WO2014138290A1 (en) * | 2013-03-05 | 2014-09-12 | Trudeau Institute, Inc. | Compositions and methods for treating bacterial infections |
US11274144B2 (en) | 2013-06-13 | 2022-03-15 | Research Institute At Nationwide Children's Hospital | Compositions and methods for the removal of biofilms |
US9745366B2 (en) | 2013-09-23 | 2017-08-29 | University Of Southern California | Compositions and methods for the prevention of microbial infections |
US10233234B2 (en) | 2014-01-13 | 2019-03-19 | Trellis Bioscience, Llc | Binding moieties for biofilm remediation |
US11248040B2 (en) | 2013-09-26 | 2022-02-15 | Trellis Bioscience, Llc | Binding moieties for biofilm remediation |
KR20160127104A (ko) | 2014-02-28 | 2016-11-02 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 변형된 수막구균 fhbp 폴리펩티드 |
EP3229835A1 (en) * | 2014-12-09 | 2017-10-18 | Sanofi Pasteur | Compositions comprising n. meningitidis proteins |
AU2016262823A1 (en) | 2015-05-18 | 2017-12-07 | Universita' Degli Studi Di Trento | Immunogenic compositions containing bacterial outer membrane vesicles and therapeutic uses thereof |
AU2016303688B2 (en) | 2015-07-31 | 2023-06-15 | Research Institute At Nationwide Children's Hospital | Peptides and antibodies for the removal of biofilms |
EP3365027B1 (en) | 2015-10-14 | 2022-03-30 | Research Institute at Nationwide Children's Hospital | Hu specific antibodies and their use in inhibiting biofilm |
KR101825439B1 (ko) * | 2016-04-15 | 2018-02-05 | 배재대학교 산학협력단 | 염산 처리에 의한 그람양성 박테리아 고스트의 제조 방법 |
US11564982B2 (en) | 2017-01-04 | 2023-01-31 | Research Institute At Nationwide Children's Hospital | DNABII vaccines and antibodies with enhanced activity |
US11746136B2 (en) | 2017-03-15 | 2023-09-05 | Research Institute At Nationwide Children's Hospital | Composition and methods for disruption of bacterial biofilms without accompanying inflammation |
EP3607967A1 (en) | 2018-08-09 | 2020-02-12 | GlaxoSmithKline Biologicals S.A. | Modified meningococcal fhbp polypeptides |
BR112021007668A2 (pt) * | 2018-11-06 | 2021-07-27 | Glaxosmithkline Biologicals S.A. | composições imunogênicas |
WO2020168146A1 (en) * | 2019-02-14 | 2020-08-20 | University Of Florida Research Foundation, Inc. | Honeybee commensal snodgrassella alvi vaccine against pathogenic neisseriaceae |
FR3099160B1 (fr) * | 2019-07-23 | 2022-05-06 | Univ Grenoble Alpes | Anticorps dirigé contre la protéine oprf depseudomonas aeruginosa, son utilisation en tant que médicament et composition pharmaceutique le contenant |
WO2023097652A1 (en) * | 2021-12-03 | 2023-06-08 | National Center For Nanoscience And Technology | An engineered cell and application thereof |
GB202203250D0 (en) | 2022-03-09 | 2022-04-20 | Glaxosmithkline Biologicals Sa | Immunogenic compositions |
Family Cites Families (131)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4239746A (en) * | 1973-06-30 | 1980-12-16 | Dezso Istvan Bartos | Complement fixation test employing reactants in a disposable package |
DE2744721A1 (de) | 1977-10-05 | 1979-04-19 | Veba Chemie Ag | Pulverfoermige ueberzugsmittel und deren anwendung |
DE2848965A1 (de) | 1978-11-11 | 1980-05-22 | Behringwerke Ag | Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine |
EP0027888B1 (en) | 1979-09-21 | 1986-04-16 | Hitachi, Ltd. | Semiconductor switch |
US4271147A (en) * | 1980-01-10 | 1981-06-02 | Behringwerke Aktiengesellschaft | Process for the isolation of membrane proteins from Neisseria meningitidis and vaccines containing same |
US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
US4695624A (en) | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
US20020146764A1 (en) * | 1985-03-28 | 2002-10-10 | Chiron Corporation | Expression using fused genes providing for protein product |
IT1187753B (it) | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
DE3622221A1 (de) * | 1986-07-02 | 1988-01-14 | Max Planck Gesellschaft | Verfahren zur gentechnologischen gewinnung von proteinen unter verwendung gramnegativer wirtszellen |
US5173294A (en) | 1986-11-18 | 1992-12-22 | Research Foundation Of State University Of New York | Dna probe for the identification of haemophilus influenzae |
JPH01125328A (ja) | 1987-07-30 | 1989-05-17 | Centro Natl De Biopreparados | 髄膜炎菌ワクチン |
EP0449856B1 (en) | 1988-12-16 | 2001-09-12 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Pneumolysin mutants and pneumococcal vaccines made therefrom |
US7118757B1 (en) * | 1988-12-19 | 2006-10-10 | Wyeth Holdings Corporation | Meningococcal class 1 outer-membrane protein vaccine |
CU22302A1 (es) * | 1990-09-07 | 1995-01-31 | Cigb | Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales |
CA2087160A1 (en) | 1990-07-16 | 1992-01-17 | P. Frederick Sparling | Antigenic iron repressible proteins from n. meningitidis related to the hemolysin family of toxins |
DE4023721A1 (de) | 1990-07-26 | 1992-01-30 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von vakzinen und ihre verwendung |
US5912336A (en) | 1990-08-23 | 1999-06-15 | University Of North Carolina At Chapel Hill | Isolated nucleic acid molecules encoding transferrin binding proteins from Neisseria gonorrhoeae and Neisseria meningitidis |
DE69133622D1 (de) | 1990-08-23 | 2009-10-01 | Univ North Carolina | Transferrin bindende Proteine aus Neisseria-Gonorrhoeae und Neisseria-Meningitidis. Ihre Verwendung in einem Impfstoff |
US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
US5652211A (en) | 1991-02-11 | 1997-07-29 | Biosynth S.R.L. | Peptides for neutralizing the toxicity of Lipid A |
US5371186A (en) | 1991-02-11 | 1994-12-06 | Biosynth S.R.L. | Synthetic peptides for detoxification of bacterial endotoxins and for the prevention and treatment of septic shock |
US5476929A (en) | 1991-02-15 | 1995-12-19 | Uab Research Foundation | Structural gene of pneumococcal protein |
US6592876B1 (en) | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
ATE174625T1 (de) * | 1991-03-14 | 1999-01-15 | Imclone Systems Inc | Rekombinante hybride porinepitope |
US5552146A (en) | 1991-08-15 | 1996-09-03 | Board Of Regents, The University Of Texas System | Methods and compositions relating to useful antigens of Moraxella catarrhalis |
FR2682041B1 (fr) | 1991-10-03 | 1994-01-14 | Pasteur Merieux Serums Vaccins | Vaccin contre les infections a neisseria meningitidis. |
JPH07503982A (ja) | 1992-01-13 | 1995-04-27 | アクゾ ノーベル ナムローゼ フェンノートシャップ | エンジニアリングプラスチックを伴うゴムの架橋 |
EP0625910B1 (en) | 1992-02-11 | 2003-07-23 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Dual carrier immunogenic construct |
FR2692592B1 (fr) * | 1992-06-19 | 1995-03-31 | Pasteur Merieux Serums Vacc | Fragments d'ADN codant pour les sous-unités du récepteur de la transferrine de Neisseria meningitidis et procédés les exprimant. |
ES2108278T3 (es) | 1992-06-25 | 1997-12-16 | Smithkline Beecham Biolog | Composicion de vacuna con coadyuvantes. |
NL9201716A (nl) * | 1992-10-02 | 1994-05-02 | Nederlanden Staat | Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat. |
GB9224584D0 (en) | 1992-11-23 | 1993-01-13 | Connaught Lab | Use of outer membrane protein d15 and its peptides as vaccine against haempohilus influenzae diseases |
ES2185658T3 (es) | 1993-05-18 | 2003-05-01 | Univ Ohio State Res Found | Vacuna para la otitis media. |
US5439808A (en) * | 1993-07-23 | 1995-08-08 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
ES2270420T3 (es) | 1993-11-08 | 2007-04-01 | Sanofi Pasteur Limited | Genes receptores de la transferrina de haemophilus. |
US6361779B1 (en) | 1993-11-08 | 2002-03-26 | Aventis Pasteur Limited | Transferrin receptor genes |
GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
ATE328890T1 (de) | 1994-07-15 | 2006-06-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
US5565204A (en) | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
US5545553A (en) | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
US6287574B1 (en) * | 1995-03-17 | 2001-09-11 | Biochem Pharma Inc. | Proteinase K resistant surface protein of neisseria meningitidis |
US6265567B1 (en) | 1995-04-07 | 2001-07-24 | University Of North Carolina At Chapel Hill | Isolated FrpB nucleic acid molecule |
UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
US6440425B1 (en) | 1995-05-01 | 2002-08-27 | Aventis Pasteur Limited | High molecular weight major outer membrane protein of moraxella |
US5843464A (en) | 1995-06-02 | 1998-12-01 | The Ohio State University | Synthetic chimeric fimbrin peptides |
KR19990022742A (ko) | 1995-06-07 | 1999-03-25 | 샤르레 아. 테시에르 | 스트렙토코커스 속 유래의 hsp70 계열의 쇼크 단백질 |
US6007838A (en) | 1995-06-07 | 1999-12-28 | The United States Of America As Represented By The Secretary Of The Army | Process for making liposome preparation |
GB9513074D0 (en) | 1995-06-27 | 1995-08-30 | Cortecs Ltd | Novel anigen |
ES2217325T5 (es) * | 1995-09-18 | 2009-04-01 | United States Army Medical Research Materiel Command (Usamrmc) | Metodos mejorados para la produccion de vacunas de subunidades multivalentes de proteosomas acomplejados no covalentemente. |
US6290970B1 (en) | 1995-10-11 | 2001-09-18 | Aventis Pasteur Limited | Transferrin receptor protein of Moraxella |
US6090576A (en) | 1996-03-08 | 2000-07-18 | Connaught Laboratories Limited | DNA encoding a transferrin receptor of Moraxella |
US6440701B1 (en) | 1996-03-08 | 2002-08-27 | Aventis Pasteur Limited | Transferrin receptor genes of Moraxella |
DE69735715T2 (de) | 1996-05-01 | 2007-03-29 | The Rockefeller University | Cholin-bindendes Protein, welches als gegen Pneumokokken gerichtetes Vakzin verwendet wird |
US7341727B1 (en) | 1996-05-03 | 2008-03-11 | Emergent Product Development Gaithersburg Inc. | M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same |
FR2751000B1 (fr) | 1996-07-12 | 1998-10-30 | Inst Nat Sante Rech Med | Adn specifiques des bacteries de l'espece neisseria meningitidis, leurs procedes d'obtention et leurs applications biologiques |
US5882871A (en) | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | Saliva binding protein |
US5882896A (en) | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | M protein |
EP0942983B2 (en) | 1996-10-31 | 2014-09-10 | Human Genome Sciences, Inc. | Streptococcus pneumoniae antigens and vaccines |
ATE380867T1 (de) | 1997-06-03 | 2007-12-15 | Sanofi Pasteur Ltd | Lactoferrinrezeptorgen von moraxella |
KR100619350B1 (ko) | 1997-07-21 | 2006-09-05 | 박스터 헬쓰케어 에스.에이. | 변형 면역성 뉴멀리신 백신조성물 |
WO1999006781A1 (de) | 1997-07-31 | 1999-02-11 | Wilo Gmbh | Latentwärmespeicher für ein kraftfahrzeug |
CN1204253C (zh) | 1997-08-15 | 2005-06-01 | 乌得勒支大学 | 奈瑟氏球菌乳铁蛋白结合蛋白 |
GB9717953D0 (en) | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
US6914131B1 (en) * | 1998-10-09 | 2005-07-05 | Chiron S.R.L. | Neisserial antigens |
GB9726398D0 (en) * | 1997-12-12 | 1998-02-11 | Isis Innovation | Polypeptide and coding sequences |
EP2278011A3 (en) * | 1998-01-14 | 2012-03-07 | Novartis Vaccines and Diagnostics S.r.l. | Neisseria meningitidis antigens |
CA2264970A1 (en) | 1998-03-10 | 1999-09-10 | American Cyanamid Company | Antigenic conjugates of conserved lipolysaccharides of gram negative bacteria |
ATE461709T1 (de) | 1998-04-07 | 2010-04-15 | Medimmune Llc | Choline-bindende proteine derivate aus pneumokoken als impfstoff |
GB9808734D0 (en) | 1998-04-23 | 1998-06-24 | Smithkline Beecham Biolog | Novel compounds |
GB9808866D0 (en) * | 1998-04-24 | 1998-06-24 | Smithkline Beecham Biolog | Novel compounds |
US20070026021A1 (en) * | 1998-05-01 | 2007-02-01 | Chiron S.R.I. | Neisseria meningitidis antigens and compositions |
AU761780B2 (en) * | 1998-05-01 | 2003-06-12 | Glaxosmithkline Biologicals Sa | Neisseria meningitidis antigens and compositions |
GB9809683D0 (en) | 1998-05-06 | 1998-07-01 | Smithkline Beecham Biolog | Novel compounds |
GB9810276D0 (en) * | 1998-05-13 | 1998-07-15 | Smithkline Beecham Biolog | Novel compounds |
GB9810285D0 (en) | 1998-05-13 | 1998-07-15 | Smithkline Beecham Biolog | Novel compounds |
GB9811260D0 (en) | 1998-05-26 | 1998-07-22 | Smithkline Beecham Biolog | Novel compounds |
US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
JP4503177B2 (ja) | 1998-06-03 | 2010-07-14 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | モラクセラ・カタラーリス(Moraxellacatarrhalis)由来のBASB027タンパク質およびBASB027遺伝子、抗原、抗体、ならびに使用 |
GB9812163D0 (en) | 1998-06-05 | 1998-08-05 | Smithkline Beecham Biolog | Novel compounds |
GB9812440D0 (en) | 1998-06-09 | 1998-08-05 | Smithkline Beecham Biolog | Novel compounds |
GB9814902D0 (en) | 1998-07-10 | 1998-09-09 | Univ Nottingham | Screening of neisserial vaccine candidates against pathogenic neisseria |
US6951652B2 (en) | 1998-07-29 | 2005-10-04 | Biosynth S.R.L. | Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases |
GB9818004D0 (en) * | 1998-08-18 | 1998-10-14 | Smithkline Beecham Biolog | Novel compounds |
GB9820003D0 (en) | 1998-09-14 | 1998-11-04 | Smithkline Beecham Biolog | Novel compounds |
GB9820002D0 (en) | 1998-09-14 | 1998-11-04 | Smithkline Beecham Biolog | Novel compounds |
MXPA01003557A (es) * | 1998-10-09 | 2004-04-05 | Chiron Corp | Secuencias genomicas de neisseria y metodos para su uso. |
EP1123398B1 (en) | 1998-10-16 | 2005-08-10 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Molecular pathogenicide mediated plant disease resistance |
CA2347849C (en) * | 1998-10-22 | 2013-06-25 | The University Of Montana | Omp85 proteins of neisseria gonorrhoeae and neisseria meningitidis, compositions containing same and methods of use thereof |
US6610306B2 (en) * | 1998-10-22 | 2003-08-26 | The University Of Montana | OMP85 protein of neisseria meningitidis, compositions containing the same and methods of use thereof |
GB9823978D0 (en) * | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
US20030215469A1 (en) * | 1998-11-02 | 2003-11-20 | Microbiological Research Authority | Multicomponent meningococcal vaccine |
EP1127137B2 (en) | 1998-11-03 | 2013-12-25 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Lps with reduced toxicity from genetically modified gram negative bacteria |
EP1228217B1 (en) * | 1999-04-30 | 2012-11-21 | Novartis Vaccines and Diagnostics S.r.l. | Conserved neisserial antigens |
AU780308B2 (en) * | 1999-04-30 | 2005-03-17 | J. Craig Venter Institute, Inc. | Neisseria genomic sequences and methods of their use |
GB9911683D0 (en) * | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
MXPA01011867A (es) * | 1999-05-19 | 2002-05-06 | Chiron Spa | Composiciones neisseriales de combinacion. |
US6632636B1 (en) | 1999-06-18 | 2003-10-14 | Elitra Pharmaceuticals Inc. | Nucleic acids encoding 3-ketoacyl-ACP reductase from Moraxella catarrahalis |
GB2351515B (en) | 1999-06-29 | 2002-09-11 | Pandrol Ltd | Adjustable railway rail fastening assembly and methods for use therewith |
GB9918038D0 (en) | 1999-07-30 | 1999-09-29 | Smithkline Beecham Biolog | Novel compounds |
GB9917977D0 (en) | 1999-07-30 | 1999-09-29 | Smithkline Beecham Biolog | Novel compounds |
GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
GB9918208D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Novel compounds |
GB9918302D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Novel compounds |
US6531131B1 (en) * | 1999-08-10 | 2003-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for Neisseria meningitidis |
AUPQ275799A0 (en) * | 1999-09-10 | 1999-10-07 | Luminis Pty Limited | Recombinant bacterium expressing an oligosaccharide receptor mimic |
EP1741784B1 (en) | 1999-11-29 | 2010-03-10 | Novartis Vaccines and Diagnostics S.r.l. | 85kDa neisserial antigen |
EP2275129A3 (en) | 2000-01-17 | 2013-11-06 | Novartis Vaccines and Diagnostics S.r.l. | Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins |
HUP0300696A3 (en) | 2000-01-25 | 2004-10-28 | Univ Queensland Brisbane | Proteins comprising conserved regions of neisseria meningitidis surface antigen nhha |
JP4763210B2 (ja) * | 2000-02-28 | 2011-08-31 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | ナイセリアのタンパク質の異種発現 |
GB0007432D0 (en) * | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
GB0011108D0 (en) * | 2000-05-08 | 2000-06-28 | Microscience Ltd | Virulence gene and protein and their use |
EP1322328B1 (en) | 2000-07-27 | 2014-08-20 | Children's Hospital & Research Center at Oakland | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
GB0103424D0 (en) * | 2001-02-12 | 2001-03-28 | Chiron Spa | Gonococcus proteins |
GB0108024D0 (en) * | 2001-03-30 | 2001-05-23 | Chiron Spa | Bacterial toxins |
GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
GB0118249D0 (en) * | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
RU2323002C2 (ru) * | 2001-07-26 | 2008-04-27 | Чирон Срл. | Вакцины, содержащие алюминиевые адъюванты и гистидин |
ATE469915T1 (de) * | 2001-07-27 | 2010-06-15 | Novartis Vaccines & Diagnostic | Antikörper gegen das meningokokken adhäsin app |
GB0121591D0 (en) * | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
JP4522699B2 (ja) * | 2001-10-03 | 2010-08-11 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | アジュバント化されたMeningococcus組成物 |
EP2255826B1 (en) * | 2002-08-02 | 2016-04-13 | GlaxoSmithKline Biologicals S.A. | Neisserial vaccine compositions comprising a combination of antigens |
PT2353608T (pt) * | 2002-10-11 | 2020-03-11 | Novartis Vaccines And Diagnostics S R L | Vacinas de polipéptidos para protecção alargada contra linhagens meningocócicas hipervirulentas |
DK1587537T3 (da) * | 2003-01-30 | 2012-07-16 | Novartis Ag | Injicerbare vacciner mod multiple meningococ-serogrupper |
GB0315021D0 (en) * | 2003-06-26 | 2003-07-30 | Chiron Srl | Immunogenic gonococcal compositions |
GB0323103D0 (en) * | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
SI1961426T1 (sl) * | 2003-10-02 | 2011-10-28 | Novartis Ag | Kombinirana cepiva proti meningitisu |
GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
GB0409748D0 (en) * | 2004-04-30 | 2004-06-09 | Chiron Srl | Lactoferrin cleavage |
US8039007B2 (en) * | 2006-06-29 | 2011-10-18 | J. Craig Venter Institute, Inc. | Polypeptides from Neisseria meningitidis |
-
2003
- 2003-07-31 EP EP10177890.0A patent/EP2255826B1/en not_active Expired - Lifetime
- 2003-07-31 NZ NZ574530A patent/NZ574530A/en not_active IP Right Cessation
- 2003-07-31 KR KR1020117004904A patent/KR101237329B1/ko not_active IP Right Cessation
- 2003-07-31 PL PL399214A patent/PL220107B1/pl unknown
- 2003-07-31 AU AU2003260357A patent/AU2003260357B2/en not_active Ceased
- 2003-07-31 EP EP03784151A patent/EP1524991A1/en not_active Withdrawn
- 2003-07-31 CA CA2493124A patent/CA2493124C/en not_active Expired - Fee Related
- 2003-07-31 PL PL399492A patent/PL399492A1/pl not_active Application Discontinuation
- 2003-07-31 AU AU2003250204A patent/AU2003250204B8/en not_active Ceased
- 2003-07-31 MY MYPI20032904A patent/MY149591A/en unknown
- 2003-07-31 PT PT37841533T patent/PT1524993E/pt unknown
- 2003-07-31 AU AU2003269864A patent/AU2003269864A1/en not_active Abandoned
- 2003-07-31 NZ NZ537904A patent/NZ537904A/en not_active IP Right Cessation
- 2003-07-31 JP JP2005506114A patent/JP2006506467A/ja active Pending
- 2003-07-31 PL PL03375408A patent/PL375408A1/xx not_active Application Discontinuation
- 2003-07-31 EP EP12157807.4A patent/EP2481419A3/en not_active Withdrawn
- 2003-07-31 EP EP03784153A patent/EP1524993B1/en not_active Revoked
- 2003-07-31 EP EP10177892A patent/EP2258387A3/en not_active Withdrawn
- 2003-07-31 US US10/523,044 patent/US7838014B2/en not_active Expired - Fee Related
- 2003-07-31 EP EP10177891A patent/EP2258386A3/en not_active Withdrawn
- 2003-07-31 PL PL03375382A patent/PL375382A1/xx not_active IP Right Cessation
- 2003-07-31 EP EP10177887A patent/EP2258385A3/en not_active Withdrawn
- 2003-07-31 KR KR1020057001941A patent/KR101140033B1/ko not_active IP Right Cessation
- 2003-07-31 CN CN038186489A patent/CN1674933B/zh not_active Expired - Fee Related
- 2003-07-31 SI SI200332485A patent/SI2255826T1/sl unknown
- 2003-07-31 CN CNA038184540A patent/CN1671413A/zh active Pending
- 2003-07-31 MX MXPA05001265A patent/MXPA05001265A/es active IP Right Grant
- 2003-07-31 KR KR1020127002482A patent/KR101239242B1/ko not_active IP Right Cessation
- 2003-07-31 US US10/523,055 patent/US20060057160A1/en not_active Abandoned
- 2003-07-31 MX MXPA05000842A patent/MXPA05000842A/es active IP Right Grant
- 2003-07-31 SI SI200332262T patent/SI1524993T1/sl unknown
- 2003-07-31 TW TW092121011A patent/TWI360424B/zh not_active IP Right Cessation
- 2003-07-31 DK DK10177890.0T patent/DK2255826T3/en active
- 2003-07-31 DE DE20321889U patent/DE20321889U1/de not_active Expired - Lifetime
- 2003-07-31 NZ NZ587398A patent/NZ587398A/en not_active IP Right Cessation
- 2003-07-31 EP EP03750408A patent/EP1524990A2/en not_active Withdrawn
- 2003-07-31 JP JP2005506112A patent/JP4740738B2/ja not_active Expired - Fee Related
- 2003-07-31 HU HUE10177890A patent/HUE029200T2/en unknown
- 2003-07-31 US US10/523,114 patent/US20060034854A1/en not_active Abandoned
- 2003-07-31 KR KR1020057001933A patent/KR20050039839A/ko not_active Application Discontinuation
- 2003-07-31 PT PT101778900T patent/PT2255826E/pt unknown
- 2003-07-31 WO PCT/EP2003/008568 patent/WO2004014417A2/en active Application Filing
- 2003-07-31 US US10/523,117 patent/US20060240045A1/en not_active Abandoned
- 2003-07-31 DE DE20321890U patent/DE20321890U1/de not_active Expired - Lifetime
- 2003-07-31 JP JP2005506113A patent/JP2006500963A/ja active Pending
- 2003-07-31 KR KR1020087019883A patent/KR101139976B1/ko not_active IP Right Cessation
- 2003-07-31 ES ES10177890.0T patent/ES2575014T3/es not_active Expired - Lifetime
- 2003-07-31 EP EP03784152.5A patent/EP1524992B1/en not_active Expired - Lifetime
- 2003-07-31 WO PCT/EP2003/008567 patent/WO2004014419A1/en active Application Filing
- 2003-07-31 JP JP2005506111A patent/JP5409986B2/ja not_active Expired - Fee Related
- 2003-07-31 WO PCT/EP2003/008571 patent/WO2004014418A2/en active Application Filing
- 2003-07-31 PL PL375407A patent/PL216662B1/pl unknown
- 2003-07-31 KR KR1020057001924A patent/KR20050028051A/ko not_active Application Discontinuation
- 2003-07-31 MX MXPA05001349A patent/MXPA05001349A/es active IP Right Grant
- 2003-07-31 CA CA002493092A patent/CA2493092A1/en not_active Abandoned
- 2003-07-31 AU AU2003253375A patent/AU2003253375B2/en not_active Ceased
- 2003-07-31 CA CA002493977A patent/CA2493977A1/en not_active Abandoned
- 2003-07-31 CA CA002489030A patent/CA2489030A1/en not_active Abandoned
- 2003-07-31 NZ NZ537181A patent/NZ537181A/en not_active IP Right Cessation
- 2003-07-31 DK DK03784153.3T patent/DK1524993T3/da active
- 2003-07-31 EP EP10177881A patent/EP2258384A3/en not_active Withdrawn
- 2003-07-31 WO PCT/EP2003/008569 patent/WO2004015099A2/en active Application Filing
- 2003-07-31 ES ES03784153T patent/ES2408251T3/es not_active Expired - Lifetime
- 2003-07-31 ES ES03784152.5T patent/ES2537737T3/es not_active Expired - Lifetime
- 2003-07-31 EP EP08153843A patent/EP1961427A3/en not_active Withdrawn
-
2004
- 2004-12-09 IL IL16566004A patent/IL165660A0/xx unknown
- 2004-12-13 IS IS7593A patent/IS7593A/is unknown
- 2004-12-16 IS IS7601A patent/IS7601A/is unknown
-
2005
- 2005-01-03 NO NO20050010A patent/NO20050010L/no not_active Application Discontinuation
- 2005-01-03 NO NO20050008A patent/NO20050008L/no not_active Application Discontinuation
- 2005-01-20 IS IS7658A patent/IS7658A/is unknown
- 2005-01-20 IL IL166433A patent/IL166433A/en active IP Right Grant
- 2005-01-25 NO NO20050421A patent/NO20050421L/no not_active Application Discontinuation
- 2005-01-28 CO CO05007265A patent/CO5680454A2/es active IP Right Grant
- 2005-01-28 CO CO05007266A patent/CO5680455A2/es not_active Application Discontinuation
- 2005-01-28 CO CO05007268A patent/CO5680456A2/es not_active Application Discontinuation
- 2005-10-13 HK HK05109073.6A patent/HK1077014A1/xx not_active IP Right Cessation
-
2008
- 2008-06-04 AU AU2008202479A patent/AU2008202479C1/en not_active Ceased
- 2008-12-12 AU AU2008255270A patent/AU2008255270A1/en not_active Abandoned
-
2010
- 2010-10-21 US US12/909,621 patent/US8221770B2/en not_active Expired - Fee Related
- 2010-10-22 JP JP2010237357A patent/JP5414651B2/ja not_active Expired - Fee Related
-
2011
- 2011-03-04 JP JP2011047056A patent/JP2011142916A/ja active Pending
- 2011-05-31 IL IL213264A patent/IL213264A0/en unknown
- 2011-09-29 US US13/248,693 patent/US20120027800A1/en not_active Abandoned
- 2011-11-17 US US13/299,041 patent/US20120064120A1/en not_active Abandoned
- 2011-11-17 US US13/299,007 patent/US20120064119A1/en not_active Abandoned
-
2012
- 2012-02-10 JP JP2012026928A patent/JP5789203B2/ja not_active Expired - Fee Related
-
2013
- 2013-05-31 CY CY20131100435T patent/CY1114243T1/el unknown
- 2013-07-31 LU LU92262C patent/LU92262I2/fr unknown
- 2013-09-05 CY CY2013036C patent/CY2013036I1/el unknown
-
2015
- 2015-09-03 US US14/844,989 patent/US20160082097A1/en not_active Abandoned
-
2016
- 2016-06-15 CY CY20161100532T patent/CY1117643T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL165660A0 (en) | Vaccine composition comprising transferrin bindin g protein and HSF from gram negative bacteria | |
EP1420829A4 (en) | IMMUNOMODULATING COMPOSITIONS, FORMULATIONS AND METHOD FOR THEIR USE | |
EP1463742A4 (en) | NEW PYRAZOLO AND PYRROLO PYRIMIDINES AND THEIR USES | |
IL161106A0 (en) | Dental prophylaxis and air appliance | |
EP1408978A4 (en) | NOVEL PHENYLAMINO-PYRIMIDINES AND THEIR USE | |
EP1576088A4 (en) | DOMINANT NEGATIVE PROTEINS AND METHOD THEREFOR | |
AU2003270779A8 (en) | Vaccine compositions and adjuvant | |
AU2002368228A8 (en) | Micro-organism mail sterilizer | |
AU2003296369A8 (en) | Imminoamines and preparation thereof | |
AU2003304180A8 (en) | Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses | |
AU2003206170A1 (en) | Organic-inorganic nanocomposite and preparation thereof | |
TW595541U (en) | Air circulatable and resilient member | |
HUP0600436A3 (en) | Catheter composition and uses thereof | |
IL161223A0 (en) | Novel bacterial poultry disease and vaccine therefor | |
EP1408985A4 (en) | NEW PYRIDOPYRIMIDONE AND ITS USES | |
EP1583557A4 (en) | VACCINE COMPOSITIONS AND METHODS | |
AU2002366809A8 (en) | Syn3 compositions and methods | |
AU2003207628A8 (en) | Structural and cytoskeleton-associated proteins | |
ZA200500377B (en) | Vaccine composition comprising transferrin binding protein and Hsf from gram negative bacteria | |
AU2003273725A1 (en) | Vaccine composition comprising interleukin-15 (il-15) | |
GB0124860D0 (en) | Composition and media | |
GB0218827D0 (en) | Anaesthetic compounds and conjugates thereof | |
GB0317376D0 (en) | Immunogenic protein and uses thereof | |
AU2003292774A1 (en) | Novel proteins and use thereof | |
AU2003280992A1 (en) | Novel proteins and use thereof |