JP2012521404A5 - - Google Patents

Info

Publication number

JP2012521404A5

JP2012521404A5 JP2012501410A JP2012501410A JP2012521404A5 JP 2012521404 A5 JP2012521404 A5 JP 2012521404A5 JP 2012501410 A JP2012501410 A JP 2012501410A JP 2012501410 A JP2012501410 A JP 2012501410A JP 2012521404 A5 JP2012521404 A5 JP 2012521404A5

Authority

JP

Japan

Prior art keywords

los

composition

composition according

item

motomeko

Prior art date

2010-03-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000004044 tetrasaccharides Chemical class 0.000 claims description 10
• 150000001720 carbohydrates Chemical class 0.000 claims description 9
• 230000002163 immunogen Effects 0.000 claims description 8
• 108010078791 Carrier Proteins Proteins 0.000 claims description 6
• 102000014914 Carrier Proteins Human genes 0.000 claims description 6
• 102000004190 Enzymes Human genes 0.000 claims description 6
• 108090000790 Enzymes Proteins 0.000 claims description 6
• 230000000694 effects Effects 0.000 claims description 6
• 241000588650 Neisseria meningitidis Species 0.000 claims description 5
• 241000124008 Mammalia Species 0.000 claims description 4
• 239000002671 adjuvant Substances 0.000 claims description 4
• 230000028993 immune response Effects 0.000 claims description 4
• AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 3
• 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims description 2
• 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims description 2
• 101710188053 Protein D Proteins 0.000 claims description 2
• 101710132893 Resolvase Proteins 0.000 claims description 2
• 108010031133 Transferrin-Binding Protein A Proteins 0.000 claims description 2
• ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 2
• 229960003983 diphtheria toxoid Drugs 0.000 claims description 2
• 101150002054 galE gene Proteins 0.000 claims description 2
• 229930182830 galactose Natural products 0.000 claims description 2
• GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical group O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 claims description 2
• 239000012528 membrane Substances 0.000 claims description 2
• 108090000623 proteins and genes Proteins 0.000 claims description 2
• 102000004169 proteins and genes Human genes 0.000 claims description 2
• 229960000814 tetanus toxoid Drugs 0.000 claims description 2
• STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 claims description 2
• 125000003275 alpha amino acid group Chemical group 0.000 description 7
• 229920001184 polypeptide Polymers 0.000 description 6
• 102000004196 processed proteins & peptides Human genes 0.000 description 6
• 108090000765 processed proteins & peptides Proteins 0.000 description 6
• 150000001413 amino acids Chemical class 0.000 description 3
• 239000012634 fragment Substances 0.000 description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• 239000000427 antigen Substances 0.000 description 1
• 102000036639 antigens Human genes 0.000 description 1
• 108091007433 antigens Proteins 0.000 description 1
• 230000021615 conjugation Effects 0.000 description 1