JP2006528936A5 - - Google Patents
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- Publication number
- JP2006528936A5 JP2006528936A5 JP2006529366A JP2006529366A JP2006528936A5 JP 2006528936 A5 JP2006528936 A5 JP 2006528936A5 JP 2006529366 A JP2006529366 A JP 2006529366A JP 2006529366 A JP2006529366 A JP 2006529366A JP 2006528936 A5 JP2006528936 A5 JP 2006528936A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- derivatized
- polysaccharide
- complex
- human patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 73
- 150000004676 glycans Chemical class 0.000 claims 40
- 229920001282 polysaccharide Polymers 0.000 claims 40
- 239000005017 polysaccharide Substances 0.000 claims 40
- 102000014914 Carrier Proteins Human genes 0.000 claims 22
- 108010078791 Carrier Proteins Proteins 0.000 claims 22
- 241000588650 Neisseria meningitidis Species 0.000 claims 9
- 201000005702 Pertussis Diseases 0.000 claims 9
- 229960005486 vaccine Drugs 0.000 claims 9
- 210000002966 serum Anatomy 0.000 claims 8
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 5
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 206010043376 Tetanus Diseases 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 206010013023 diphtheria Diseases 0.000 claims 4
- 229960003983 diphtheria toxoid Drugs 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 238000002255 vaccination Methods 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 3
- -1 diphtheria toxoid Proteins 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 101710082714 Exotoxin A Proteins 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 229940098773 bovine serum albumin Drugs 0.000 claims 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 229960000814 tetanus toxoid Drugs 0.000 claims 2
- 108010071023 Bacterial Outer Membrane Proteins Proteins 0.000 claims 1
- 231100000699 Bacterial toxin Toxicity 0.000 claims 1
- 101000812705 Gallus gallus Endoplasmin Proteins 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 108010058846 Ovalbumin Proteins 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 108010013381 Porins Proteins 0.000 claims 1
- 102000010912 Transferrin-Binding Proteins Human genes 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 239000000688 bacterial toxin Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 238000004299 exfoliation Methods 0.000 claims 1
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 208000037941 meningococcal disease Diseases 0.000 claims 1
- 229940092253 ovalbumin Drugs 0.000 claims 1
- 102000007739 porin activity proteins Human genes 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 1
- 239000001488 sodium phosphate Substances 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
- 229960001005 tuberculin Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46858103P | 2003-05-07 | 2003-05-07 | |
| PCT/US2004/014466 WO2004103400A2 (en) | 2003-05-07 | 2004-05-07 | Multivalent meningococcal derivatized polysaccharide-protein conjugates and corresponding vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010268151A Division JP2011042693A (ja) | 2003-05-07 | 2010-12-01 | 多価髄膜炎菌誘導体化多糖−タンパク質複合体およびワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006528936A JP2006528936A (ja) | 2006-12-28 |
| JP2006528936A5 true JP2006528936A5 (enExample) | 2007-06-21 |
Family
ID=33476662
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006529366A Pending JP2006528936A (ja) | 2003-05-07 | 2004-05-07 | 多価髄膜炎菌誘導体化多糖−タンパク質複合体およびワクチン |
| JP2010268151A Pending JP2011042693A (ja) | 2003-05-07 | 2010-12-01 | 多価髄膜炎菌誘導体化多糖−タンパク質複合体およびワクチン |
| JP2014138526A Pending JP2014193929A (ja) | 2003-05-07 | 2014-07-04 | 多価髄膜炎菌誘導体化多糖−タンパク質複合体およびワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010268151A Pending JP2011042693A (ja) | 2003-05-07 | 2010-12-01 | 多価髄膜炎菌誘導体化多糖−タンパク質複合体およびワクチン |
| JP2014138526A Pending JP2014193929A (ja) | 2003-05-07 | 2014-07-04 | 多価髄膜炎菌誘導体化多糖−タンパク質複合体およびワクチン |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050002957A1 (enExample) |
| EP (2) | EP1624888B1 (enExample) |
| JP (3) | JP2006528936A (enExample) |
| CN (2) | CN1852733A (enExample) |
| AU (2) | AU2004240558A1 (enExample) |
| BR (1) | BRPI0410341B8 (enExample) |
| CA (1) | CA2524860C (enExample) |
| WO (1) | WO2004103400A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| ES2411080T3 (es) | 2003-01-30 | 2013-07-04 | Novartis Ag | Vacunas inyectables contra múltiples serogrupos de meningococos |
| GB0406013D0 (en) * | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| EP2272531A3 (en) * | 2004-04-30 | 2011-04-13 | Novartis Vaccines and Diagnostics S.r.l. | Integration of meningococcal conjugate vaccination |
| EP1784214A4 (en) * | 2004-08-30 | 2009-09-23 | Sanofi Pasteur Inc | POLYSACCHARIDE / PROTEIN CONJUGATES MULTIVALENT MENINGOCOCCUS DERIVATIVE AND VACCINE |
| CN101072586A (zh) * | 2004-09-21 | 2007-11-14 | 圣诺菲·帕斯图尔公司 | 多价脑膜炎球菌源性多糖－蛋白质缀合物及疫苗 |
| KR20130122810A (ko) | 2005-06-27 | 2013-11-08 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 제조 방법 |
| GB0513071D0 (en) * | 2005-06-27 | 2005-08-03 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| US7955817B2 (en) | 2005-09-02 | 2011-06-07 | Glaxosmithkline Biologicals S.A. | Vaccine protection assay |
| ATE485516T1 (de) * | 2005-09-05 | 2010-11-15 | Glaxosmithkline Biolog Sa | Bakterizidie-serumtest für n. meningitidis spezifische antiseren |
| BRPI0708849B1 (pt) | 2006-03-17 | 2022-05-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para a preparação de conjugados imunogênicos multivalentes complexos, os referidos conjugados, e composições farmacêuticas |
| US10828361B2 (en) * | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| ES2670231T3 (es) | 2006-03-22 | 2018-05-29 | Glaxosmithkline Biologicals S.A. | Regímenes para inmunización con conjugados meningocócicos |
| WO2007116409A2 (en) | 2006-04-11 | 2007-10-18 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Improved vaccines comprising multimeric hsp60 peptide carriers |
| US7491517B2 (en) * | 2006-07-19 | 2009-02-17 | Jeeri R Reddy | Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135 |
| CN101428144A (zh) * | 2008-12-19 | 2009-05-13 | 长春长生生物科技股份有限公司 | 流脑多糖联合疫苗及制备工艺 |
| JP5967585B2 (ja) * | 2010-05-03 | 2016-08-10 | ディーシービー−ユーエスエー エルエルシーＤｃｂ−Ｕｓａ Ｌｌｃ | ワクチンとして使用される無毒化大腸菌易熱性エンテロトキシン（ｌｔ）との多糖結合 |
| CN103623401A (zh) * | 2012-08-23 | 2014-03-12 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法 |
| CN102861326A (zh) * | 2012-09-19 | 2013-01-09 | 天津康希诺生物技术有限公司 | 流脑多糖-蛋白质缀合疫苗及制备方法 |
| CN104829711B (zh) * | 2014-04-08 | 2018-04-03 | 北京天成新脉生物技术有限公司 | 脑膜炎球菌荚膜多糖单克隆抗体及其应用 |
| LT3506935T (lt) | 2016-09-02 | 2024-04-25 | Sanofi Pasteur, Inc. | Vakcina nuo neisseria meningitidis |
| CN108743936B (zh) * | 2018-06-14 | 2022-03-15 | 中国科学院过程工程研究所 | 一种细菌多糖结合疫苗及其制备方法与应用 |
| MX2022003682A (es) * | 2019-09-27 | 2022-04-25 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4619828A (en) | 1982-07-06 | 1986-10-28 | Connaught Laboratories, Inc. | Polysaccharide exotoxoid conjugate vaccines |
| CA2017507C (en) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| US5422427A (en) | 1991-09-17 | 1995-06-06 | The United States Of America As Represented By The United States Department Of Health And Human Services | Pneumococcal fimbrial protein A |
| US5445817A (en) | 1992-08-21 | 1995-08-29 | The United States Of America As Represented By The Department Of Health And Human Services | Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines |
| US5965714A (en) * | 1997-10-02 | 1999-10-12 | Connaught Laboratories, Inc. | Method for the covalent attachment of polysaccharides to protein molecules |
| US6146902A (en) | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| US20030035806A1 (en) * | 2001-05-11 | 2003-02-20 | D'ambra Anello J. | Novel meningitis conjugate vaccine |
-
2004
- 2004-05-07 EP EP04751728.9A patent/EP1624888B1/en not_active Expired - Lifetime
- 2004-05-07 EP EP10183290A patent/EP2386313A1/en not_active Withdrawn
- 2004-05-07 CA CA2524860A patent/CA2524860C/en not_active Expired - Lifetime
- 2004-05-07 AU AU2004240558A patent/AU2004240558A1/en not_active Abandoned
- 2004-05-07 BR BRPI0410341A patent/BRPI0410341B8/pt active IP Right Grant
- 2004-05-07 US US10/841,294 patent/US20050002957A1/en not_active Abandoned
- 2004-05-07 CN CNA2004800193066A patent/CN1852733A/zh not_active Withdrawn
- 2004-05-07 CN CN201410415117.6A patent/CN104225587B/zh not_active Expired - Lifetime
- 2004-05-07 JP JP2006529366A patent/JP2006528936A/ja active Pending
- 2004-05-07 WO PCT/US2004/014466 patent/WO2004103400A2/en not_active Ceased
-
2010
- 2010-12-01 JP JP2010268151A patent/JP2011042693A/ja active Pending
- 2010-12-16 AU AU2010257242A patent/AU2010257242A1/en not_active Ceased
-
2014
- 2014-07-04 JP JP2014138526A patent/JP2014193929A/ja active Pending
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