CA2524860C - Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine - Google Patents

Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine Download PDF

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Publication number
CA2524860C
CA2524860C CA2524860A CA2524860A CA2524860C CA 2524860 C CA2524860 C CA 2524860C CA 2524860 A CA2524860 A CA 2524860A CA 2524860 A CA2524860 A CA 2524860A CA 2524860 C CA2524860 C CA 2524860C
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CA
Canada
Prior art keywords
day
sba
serogroup
polysaccharide
tetramend
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CA2524860A
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English (en)
French (fr)
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CA2524860A1 (en
Inventor
Robert P. Ryall
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Sanofi Pasteur Inc
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Sanofi Pasteur Inc
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Publication of CA2524860A1 publication Critical patent/CA2524860A1/en
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Publication of CA2524860C publication Critical patent/CA2524860C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
CA2524860A 2003-05-07 2004-05-07 Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine Expired - Lifetime CA2524860C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46858103P 2003-05-07 2003-05-07
US60/468,581 2003-05-07
PCT/US2004/014466 WO2004103400A2 (en) 2003-05-07 2004-05-07 Multivalent meningococcal derivatized polysaccharide-protein conjugates and corresponding vaccines

Publications (2)

Publication Number Publication Date
CA2524860A1 CA2524860A1 (en) 2004-12-02
CA2524860C true CA2524860C (en) 2016-09-13

Family

ID=33476662

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2524860A Expired - Lifetime CA2524860C (en) 2003-05-07 2004-05-07 Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine

Country Status (8)

Country Link
US (1) US20050002957A1 (enExample)
EP (2) EP1624888B1 (enExample)
JP (3) JP2006528936A (enExample)
CN (2) CN1852733A (enExample)
AU (2) AU2004240558A1 (enExample)
BR (1) BRPI0410341B8 (enExample)
CA (1) CA2524860C (enExample)
WO (1) WO2004103400A2 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928196D0 (en) 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
PT2172213E (pt) 2003-01-30 2013-06-03 Novartis Ag Vacinas injetáveis contra múltiplos serogrupos meningocócicos
GB0406013D0 (en) * 2004-03-17 2004-04-21 Chiron Srl Analysis of saccharide vaccines without interference
PL1740217T3 (pl) 2004-04-30 2012-03-30 Novartis Ag Szczepienie koniugatem meningokokowym
GB0500787D0 (en) 2005-01-14 2005-02-23 Chiron Srl Integration of meningococcal conjugate vaccination
US20060088554A1 (en) * 2004-08-30 2006-04-27 Ryall Robert P Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine
JP2008513541A (ja) * 2004-09-21 2008-05-01 サノフィ パストゥール インコーポレイテッド 多価髄膜炎菌誘導体化多糖−タンパク質複合体およびワクチン
GB0513071D0 (en) * 2005-06-27 2005-08-03 Glaxosmithkline Biolog Sa Immunogenic composition
EP2201961B1 (en) * 2005-06-27 2018-01-24 GlaxoSmithKline Biologicals S.A. Immunogenic composition
US7955817B2 (en) 2005-09-02 2011-06-07 Glaxosmithkline Biologicals S.A. Vaccine protection assay
EP2208999B1 (en) 2005-09-05 2014-08-27 GlaxoSmithKline Biologicals SA Serum bactericidal assay for N. meningitidis specific antisera
KR101411425B1 (ko) 2006-03-17 2014-06-24 더 거버먼트 오브 더 유나이티드 스테이츠 오브 아메리카 에즈 레프리젠티드 바이 더 세크러테리 오브 더 디파트먼트 오브 헬스 앤드 휴먼 서비시즈 복합 다가 면역원성 콘쥬게이트의 제조 방법
DK2004225T3 (da) * 2006-03-22 2012-08-06 Novartis Ag Programmer for vaccination med meningocockonjugater
US10828361B2 (en) * 2006-03-22 2020-11-10 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
EP2007427A4 (en) 2006-04-11 2012-04-04 Yeda Res & Dev IMPROVED VACCINES WITH MULTIMETER HSP60 PEPTIDE SUPPORTS
US7491517B2 (en) * 2006-07-19 2009-02-17 Jeeri R Reddy Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135
CN101428144A (zh) * 2008-12-19 2009-05-13 长春长生生物科技股份有限公司 流脑多糖联合疫苗及制备工艺
WO2012023008A2 (en) * 2010-05-03 2012-02-23 Dcb-Usa Llc Polysaccharide conjugation with detoxified e. coli heat labile enterotoxin (lt) used as vaccine
CN103623401A (zh) * 2012-08-23 2014-03-12 北京科兴中维生物技术有限公司 多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法
CN102861326A (zh) * 2012-09-19 2013-01-09 天津康希诺生物技术有限公司 流脑多糖-蛋白质缀合疫苗及制备方法
CN104829711B (zh) * 2014-04-08 2018-04-03 北京天成新脉生物技术有限公司 脑膜炎球菌荚膜多糖单克隆抗体及其应用
PH12019500399B1 (en) 2016-09-02 2024-05-15 Sanofi Pasteur Inc Neisseria meningitidis vaccine
CN108743936B (zh) * 2018-06-14 2022-03-15 中国科学院过程工程研究所 一种细菌多糖结合疫苗及其制备方法与应用
KR102871663B1 (ko) * 2019-09-27 2025-10-16 화이자 인코포레이티드 네이세리아 메닌기티디스 조성물 및 그의 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356170A (en) 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4619828A (en) 1982-07-06 1986-10-28 Connaught Laboratories, Inc. Polysaccharide exotoxoid conjugate vaccines
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
US5153312A (en) 1990-09-28 1992-10-06 American Cyanamid Company Oligosaccharide conjugate vaccines
US5422427A (en) 1991-09-17 1995-06-06 The United States Of America As Represented By The United States Department Of Health And Human Services Pneumococcal fimbrial protein A
US5445817A (en) 1992-08-21 1995-08-29 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines
US5965714A (en) * 1997-10-02 1999-10-12 Connaught Laboratories, Inc. Method for the covalent attachment of polysaccharides to protein molecules
US6146902A (en) 1998-12-29 2000-11-14 Aventis Pasteur, Inc. Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions
WO2002091998A2 (en) * 2001-05-11 2002-11-21 Aventis Pasteur, Inc. Novel meningitis conjugate vaccine

Also Published As

Publication number Publication date
CN104225587A (zh) 2014-12-24
JP2006528936A (ja) 2006-12-28
AU2004240558A1 (en) 2004-12-02
CN104225587B (zh) 2017-07-21
US20050002957A1 (en) 2005-01-06
HK1204574A1 (en) 2015-11-27
AU2010257242A1 (en) 2011-01-13
WO2004103400A3 (en) 2005-03-24
BRPI0410341B1 (pt) 2019-07-16
JP2014193929A (ja) 2014-10-09
JP2011042693A (ja) 2011-03-03
BRPI0410341B8 (pt) 2021-05-25
BRPI0410341A (pt) 2006-05-30
CA2524860A1 (en) 2004-12-02
EP1624888A2 (en) 2006-02-15
EP1624888B1 (en) 2016-10-12
CN1852733A (zh) 2006-10-25
EP2386313A1 (en) 2011-11-16
WO2004103400A2 (en) 2004-12-02

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