JP2010514768A5 - - Google Patents
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- Publication number
- JP2010514768A5 JP2010514768A5 JP2009544100A JP2009544100A JP2010514768A5 JP 2010514768 A5 JP2010514768 A5 JP 2010514768A5 JP 2009544100 A JP2009544100 A JP 2009544100A JP 2009544100 A JP2009544100 A JP 2009544100A JP 2010514768 A5 JP2010514768 A5 JP 2010514768A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- pharmaceutical composition
- acceptable salt
- interferon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 24
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 8
- 125000000547 substituted alkyl group Chemical group 0.000 claims 8
- 108010050904 Interferons Proteins 0.000 claims 7
- 102000014150 Interferons Human genes 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 229940079322 interferon Drugs 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 5
- -1 hydroxyarylalkyl Chemical group 0.000 claims 5
- 239000003443 antiviral agent Substances 0.000 claims 4
- 241000700721 Hepatitis B virus Species 0.000 claims 3
- 208000005176 Hepatitis C Diseases 0.000 claims 3
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 210000004185 liver Anatomy 0.000 claims 3
- 229960000329 ribavirin Drugs 0.000 claims 3
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 3
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 claims 2
- GVEZIHKRYBHEFX-MNOVXSKESA-N 13C-Cerulenin Natural products CC=CCC=CCCC(=O)[C@H]1O[C@@H]1C(N)=O GVEZIHKRYBHEFX-MNOVXSKESA-N 0.000 claims 2
- YYVYAPXYZVYDHN-UHFFFAOYSA-N 9,10-phenanthroquinone Chemical compound C1=CC=C2C(=O)C(=O)C3=CC=CC=C3C2=C1 YYVYAPXYZVYDHN-UHFFFAOYSA-N 0.000 claims 2
- 102000053642 Catalytic RNA Human genes 0.000 claims 2
- 108090000994 Catalytic RNA Proteins 0.000 claims 2
- 101000749287 Clitocybe nebularis Clitocypin Proteins 0.000 claims 2
- 101000767029 Clitocybe nebularis Clitocypin-1 Proteins 0.000 claims 2
- 229940094664 Cysteine protease inhibitor Drugs 0.000 claims 2
- 241000710781 Flaviviridae Species 0.000 claims 2
- 229940121759 Helicase inhibitor Drugs 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 102000015696 Interleukins Human genes 0.000 claims 2
- 108010063738 Interleukins Proteins 0.000 claims 2
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 2
- 101800001838 Serine protease/helicase NS3 Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- FIVPIPIDMRVLAY-UHFFFAOYSA-N aspergillin Natural products C1C2=CC=CC(O)C2N2C1(SS1)C(=O)N(C)C1(CO)C2=O FIVPIPIDMRVLAY-UHFFFAOYSA-N 0.000 claims 2
- ZVSKZLHKADLHSD-UHFFFAOYSA-N benzanilide Chemical compound C=1C=CC=CC=1C(=O)NC1=CC=CC=C1 ZVSKZLHKADLHSD-UHFFFAOYSA-N 0.000 claims 2
- GVEZIHKRYBHEFX-UHFFFAOYSA-N caerulein A Natural products CC=CCC=CCCC(=O)C1OC1C(N)=O GVEZIHKRYBHEFX-UHFFFAOYSA-N 0.000 claims 2
- GVEZIHKRYBHEFX-NQQPLRFYSA-N cerulenin Chemical compound C\C=C\C\C=C\CCC(=O)[C@H]1O[C@H]1C(N)=O GVEZIHKRYBHEFX-NQQPLRFYSA-N 0.000 claims 2
- 229950005984 cerulenin Drugs 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- FIVPIPIDMRVLAY-RBJBARPLSA-N gliotoxin Chemical compound C1C2=CC=C[C@H](O)[C@H]2N2[C@]1(SS1)C(=O)N(C)[C@@]1(CO)C2=O FIVPIPIDMRVLAY-RBJBARPLSA-N 0.000 claims 2
- 229940103893 gliotoxin Drugs 0.000 claims 2
- 229930190252 gliotoxin Natural products 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 2
- 108091092562 ribozyme Proteins 0.000 claims 2
- 150000003548 thiazolidines Chemical class 0.000 claims 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 2
- NYPIRLYMDJMKGW-VPCXQMTMSA-N 4-amino-1-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one Chemical compound C[C@@]1(F)[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)N=C(N)C=C1 NYPIRLYMDJMKGW-VPCXQMTMSA-N 0.000 claims 1
- XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 108010005716 Interferon beta-1a Proteins 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- BVMWIXWOIGJRGE-UHFFFAOYSA-N NP(O)=O Chemical class NP(O)=O BVMWIXWOIGJRGE-UHFFFAOYSA-N 0.000 claims 1
- TVRCRTJYMVTEFS-ICGCPXGVSA-N [(2r,3r,4r,5r)-5-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)-4-methyloxolan-3-yl] (2s)-2-amino-3-methylbutanoate Chemical compound C[C@@]1(O)[C@H](OC(=O)[C@@H](N)C(C)C)[C@@H](CO)O[C@H]1N1C(=O)N=C(N)C=C1 TVRCRTJYMVTEFS-ICGCPXGVSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000005041 acyloxyalkyl group Chemical group 0.000 claims 1
- 229960001997 adefovir Drugs 0.000 claims 1
- 108010080374 albuferon Proteins 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000005097 aminocarbonylalkyl group Chemical group 0.000 claims 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 229960005338 clevudine Drugs 0.000 claims 1
- GBBJCSTXCAQSSJ-XQXXSGGOSA-N clevudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1[C@H](F)[C@@H](O)[C@H](CO)O1 GBBJCSTXCAQSSJ-XQXXSGGOSA-N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960000366 emtricitabine Drugs 0.000 claims 1
- 229960000980 entecavir Drugs 0.000 claims 1
- YXPVEXCTPGULBZ-WQYNNSOESA-N entecavir hydrate Chemical compound O.C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)C1=C YXPVEXCTPGULBZ-WQYNNSOESA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229960004461 interferon beta-1a Drugs 0.000 claims 1
- 108700027921 interferon tau Proteins 0.000 claims 1
- 229960001627 lamivudine Drugs 0.000 claims 1
- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 229940127073 nucleoside analogue Drugs 0.000 claims 1
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- BXNMTOQRYBFHNZ-UHFFFAOYSA-N resiquimod Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CC(C)(C)O)C3=C(N)N=C21 BXNMTOQRYBFHNZ-UHFFFAOYSA-N 0.000 claims 1
- 229950010550 resiquimod Drugs 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- NHKZSTHOYNWEEZ-AFCXAGJDSA-N taribavirin Chemical compound N1=C(C(=N)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NHKZSTHOYNWEEZ-AFCXAGJDSA-N 0.000 claims 1
- 229950006081 taribavirin Drugs 0.000 claims 1
- 229960005311 telbivudine Drugs 0.000 claims 1
- IQFYYKKMVGJFEH-CSMHCCOUSA-N telbivudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1O[C@@H](CO)[C@H](O)C1 IQFYYKKMVGJFEH-CSMHCCOUSA-N 0.000 claims 1
- 229960004556 tenofovir Drugs 0.000 claims 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 229950002810 valopicitabine Drugs 0.000 claims 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 claims 1
- 0 CC1(C)OC(CO*(N(*)**)OCCCSC(*)=O)=C(*)C1(*)CN(C=CC(N)=N1)C1=O Chemical compound CC1(C)OC(CO*(N(*)**)OCCCSC(*)=O)=C(*)C1(*)CN(C=CC(N)=N1)C1=O 0.000 description 2
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87794406P | 2006-12-28 | 2006-12-28 | |
| US60/877,944 | 2006-12-28 | ||
| US93629007P | 2007-06-18 | 2007-06-18 | |
| US60/936,290 | 2007-06-18 | ||
| US98589107P | 2007-11-06 | 2007-11-06 | |
| US60/985,891 | 2007-11-06 | ||
| PCT/US2007/026408 WO2008082601A2 (en) | 2006-12-28 | 2007-12-28 | Compounds and pharmaceutical compositions for the treatment of viral infections |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014060859A Division JP2014139218A (ja) | 2006-12-28 | 2014-03-24 | ウイルス感染の治療のための化合物、及び医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010514768A JP2010514768A (ja) | 2010-05-06 |
| JP2010514768A5 true JP2010514768A5 (enExample) | 2011-01-27 |
| JP5578853B2 JP5578853B2 (ja) | 2014-08-27 |
Family
ID=39589128
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009544100A Expired - Fee Related JP5578853B2 (ja) | 2006-12-28 | 2007-12-28 | ウイルス感染の治療のための化合物、及び医薬組成物 |
| JP2009544101A Pending JP2010514769A (ja) | 2006-12-28 | 2007-12-28 | 肝臓障害の治療のための化合物、及び医薬組成物。 |
| JP2014060859A Pending JP2014139218A (ja) | 2006-12-28 | 2014-03-24 | ウイルス感染の治療のための化合物、及び医薬組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009544101A Pending JP2010514769A (ja) | 2006-12-28 | 2007-12-28 | 肝臓障害の治療のための化合物、及び医薬組成物。 |
| JP2014060859A Pending JP2014139218A (ja) | 2006-12-28 | 2014-03-24 | ウイルス感染の治療のための化合物、及び医薬組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US7951789B2 (enExample) |
| EP (2) | EP2120566B1 (enExample) |
| JP (3) | JP5578853B2 (enExample) |
| KR (1) | KR101508018B1 (enExample) |
| AU (1) | AU2007339226B2 (enExample) |
| BR (1) | BRPI0720637A2 (enExample) |
| CA (2) | CA2673722A1 (enExample) |
| IL (1) | IL200116A0 (enExample) |
| ME (1) | ME00816B (enExample) |
| MX (1) | MX2009006851A (enExample) |
| MY (1) | MY169568A (enExample) |
| NO (1) | NO20092585L (enExample) |
| NZ (1) | NZ577999A (enExample) |
| RU (1) | RU2525392C2 (enExample) |
| SG (1) | SG177923A1 (enExample) |
| TW (2) | TW200844108A (enExample) |
| UA (1) | UA96975C2 (enExample) |
| WO (2) | WO2008082602A2 (enExample) |
Families Citing this family (182)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| EA200601591A1 (ru) | 2000-05-26 | 2007-02-27 | Айденикс (Кайман) Лимитед | Применение рибонуклеозидных соединений для лечения флавивирусных и пестивирусных инфекций |
| ES2624353T3 (es) | 2002-11-15 | 2017-07-13 | Idenix Pharmaceuticals Llc | 2'-Metil nucleósidos en combinación con interferón y mutación de Flaviviridae |
| CN101189249B (zh) | 2005-04-01 | 2013-04-17 | 加利福尼亚大学董事会 | 膦酰基-戊-2-烯-1-基核苷和类似物 |
| RU2008152171A (ru) | 2006-07-05 | 2010-08-10 | Интермьюн, Инк. (Us) | Новые ингибиторы вирусной репликации гепатита с |
| CN105010339B (zh) | 2006-12-11 | 2020-06-26 | 国立研究开发法人科学技术振兴机构 | 植物生长调整剂及其利用 |
| US7951789B2 (en) | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| MX2009012093A (es) | 2007-05-10 | 2010-01-25 | Intermune Inc | Nuevos peptidos inhibidores de la replicacion del virus de la hepatitis c. |
| GB0709791D0 (en) * | 2007-05-22 | 2007-06-27 | Angeletti P Ist Richerche Bio | Antiviral agents |
| WO2009113684A1 (ja) | 2008-03-14 | 2009-09-17 | トヨタ自動車株式会社 | 植物のバイオマス量及び/又は種子量を増産させる遺伝子及びその利用方法 |
| BRPI0911260A2 (pt) | 2008-04-15 | 2015-09-29 | Intermune Inc | composto, composição farmacêutica, método de inibição de atividade da protease de ns3/ns4 in, vitro e usos de compostos |
| WO2009132123A1 (en) | 2008-04-23 | 2009-10-29 | Gilead Sciences, Inc. | Carba-nucleoside analogs for antiviral treatment |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| BRPI0913677A2 (pt) * | 2008-07-02 | 2015-12-15 | Idenix Pharmaceuticals Inc | composto, metabólito purificado, método para tratar um hospedeiro infectado com um vírus flaviviridade, composição farmacêutica, método para preparar o composto purificado, e, processo para preparar o composto |
| PA8855801A1 (es) | 2008-12-23 | 2010-07-27 | Sintesis de nucleosidos de purina | |
| SG172359A1 (en) | 2008-12-23 | 2011-07-28 | Pharmasset Inc | Nucleoside phosphoramidates |
| AR074882A1 (es) | 2008-12-23 | 2011-02-16 | Pharmasset Inc | Analogos de nucleosidos |
| AU2010203416C1 (en) * | 2009-01-09 | 2013-07-25 | Inhibitex, Inc. | Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections |
| KR101724759B1 (ko) | 2009-02-10 | 2017-04-07 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 치료를 위한 카르바-뉴클레오시드 유사체 |
| AR075584A1 (es) | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| JP5604657B2 (ja) | 2009-03-12 | 2014-10-08 | トヨタ自動車株式会社 | 植物のバイオマス量及び／又は種子量を増産させる遺伝子及びその利用方法 |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI598358B (zh) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| WO2011145808A2 (ko) * | 2010-05-18 | 2011-11-24 | 부광약품 주식회사 | 클레부딘 및 아데포비어 디피복실을 함유하는 만성 ｂ형 간염 치료용 조성물 |
| JP5250807B2 (ja) | 2009-09-11 | 2013-07-31 | トヨタ自動車株式会社 | 植物のバイオマス量及び／又は種子量を増産させる方法、バイオマス量及び／又は種子量を増産できる植物の製造方法 |
| US7973013B2 (en) | 2009-09-21 | 2011-07-05 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| NZ599404A (en) | 2009-09-21 | 2014-02-28 | Gilead Sciences Inc | Processes and intermediates for the preparation of 1’-substituted carba-nucleoside analogs |
| EP3150608B1 (en) * | 2009-09-21 | 2019-04-10 | Gilead Sciences, Inc. | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment |
| US20110117055A1 (en) | 2009-11-19 | 2011-05-19 | Macdonald James E | Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds |
| KR20120116404A (ko) | 2009-12-18 | 2012-10-22 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｈｃｖ 병용 요법 |
| ES2516466T3 (es) | 2010-03-31 | 2014-10-30 | Gilead Pharmasset Llc | Síntesis estereoselectiva de agentes activos que contienen fósforo |
| CA2795054A1 (en) | 2010-04-01 | 2011-10-06 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| EP2596004B1 (en) | 2010-07-19 | 2014-09-10 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
| EP2595980B1 (en) | 2010-07-22 | 2014-09-03 | Gilead Sciences, Inc. | Methods and compounds for treating paramyxoviridae virus infections |
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| WO2012048013A2 (en) * | 2010-10-06 | 2012-04-12 | Inhibitex, Inc. | Phosphorodiamidate derivatives of guanosine nucleoside compounds for treatment of viral injections |
| WO2012051567A2 (en) | 2010-10-15 | 2012-04-19 | The Trustees Of Columbia University In The City Of New York | Obesity-related genes and their proteins and uses thereof |
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2007
- 2007-12-27 US US12/005,937 patent/US7951789B2/en active Active
- 2007-12-27 US US12/005,938 patent/US20080261913A1/en not_active Abandoned
- 2007-12-28 KR KR1020097015742A patent/KR101508018B1/ko not_active Expired - Fee Related
- 2007-12-28 EP EP07872645.2A patent/EP2120566B1/en active Active
- 2007-12-28 TW TW096150931A patent/TW200844108A/zh unknown
- 2007-12-28 RU RU2012132218/04A patent/RU2525392C2/ru not_active IP Right Cessation
- 2007-12-28 MX MX2009006851A patent/MX2009006851A/es active IP Right Grant
- 2007-12-28 CA CA002673722A patent/CA2673722A1/en not_active Abandoned
- 2007-12-28 AU AU2007339226A patent/AU2007339226B2/en not_active Ceased
- 2007-12-28 BR BRPI0720637-2A2A patent/BRPI0720637A2/pt active Search and Examination
- 2007-12-28 SG SG2011096476A patent/SG177923A1/en unknown
- 2007-12-28 UA UAA200907835A patent/UA96975C2/uk unknown
- 2007-12-28 ME MEP-2009-232A patent/ME00816B/me unknown
- 2007-12-28 NZ NZ577999A patent/NZ577999A/en not_active IP Right Cessation
- 2007-12-28 MY MYPI20092752A patent/MY169568A/en unknown
- 2007-12-28 JP JP2009544100A patent/JP5578853B2/ja not_active Expired - Fee Related
- 2007-12-28 CA CA002673776A patent/CA2673776A1/en not_active Abandoned
- 2007-12-28 EP EP07868086A patent/EP2107909A4/en not_active Withdrawn
- 2007-12-28 TW TW096150890A patent/TWI412368B/zh not_active IP Right Cessation
- 2007-12-28 WO PCT/US2007/026409 patent/WO2008082602A2/en not_active Ceased
- 2007-12-28 WO PCT/US2007/026408 patent/WO2008082601A2/en not_active Ceased
- 2007-12-28 JP JP2009544101A patent/JP2010514769A/ja active Pending
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2008
- 2008-04-25 US US12/150,327 patent/US7902202B2/en active Active
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2009
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2014
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