JP2005533824A5 - - Google Patents
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- JP2005533824A5 JP2005533824A5 JP2004518041A JP2004518041A JP2005533824A5 JP 2005533824 A5 JP2005533824 A5 JP 2005533824A5 JP 2004518041 A JP2004518041 A JP 2004518041A JP 2004518041 A JP2004518041 A JP 2004518041A JP 2005533824 A5 JP2005533824 A5 JP 2005533824A5
- Authority
- JP
- Japan
- Prior art keywords
- interferon
- compound
- pharmaceutical composition
- pharmaceutically acceptable
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 53
- 239000008194 pharmaceutical composition Substances 0.000 claims 34
- 108010050904 Interferons Proteins 0.000 claims 28
- 102000014150 Interferons Human genes 0.000 claims 28
- 229940079322 interferon Drugs 0.000 claims 28
- 150000003839 salts Chemical class 0.000 claims 24
- 239000011780 sodium chloride Substances 0.000 claims 24
- 239000003443 antiviral agent Substances 0.000 claims 20
- 239000003937 drug carrier Substances 0.000 claims 12
- 239000003112 inhibitor Substances 0.000 claims 12
- 230000002401 inhibitory effect Effects 0.000 claims 12
- CPELXLSAUQHCOX-UHFFFAOYSA-N hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 9
- 239000010452 phosphate Substances 0.000 claims 9
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 6
- 229940002612 prodrugs Drugs 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 5
- -1 albferon Proteins 0.000 claims 5
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 claims 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K 2qpq Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 4
- YYVYAPXYZVYDHN-UHFFFAOYSA-N 9,10-phenanthroquinone Chemical compound C1=CC=C2C(=O)C(=O)C3=CC=CC=C3C2=C1 YYVYAPXYZVYDHN-UHFFFAOYSA-N 0.000 claims 4
- 101710036216 ATEG_03556 Proteins 0.000 claims 4
- 229940072107 Ascorbate Drugs 0.000 claims 4
- ZVSKZLHKADLHSD-UHFFFAOYSA-N Benzanilide Chemical compound C=1C=CC=CC=1C(=O)NC1=CC=CC=C1 ZVSKZLHKADLHSD-UHFFFAOYSA-N 0.000 claims 4
- 229940050390 Benzoate Drugs 0.000 claims 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 4
- GVEZIHKRYBHEFX-NQQPLRFYSA-N CERULENIN Chemical compound C\C=C\C\C=C\CCC(=O)[C@H]1O[C@H]1C(N)=O GVEZIHKRYBHEFX-NQQPLRFYSA-N 0.000 claims 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate dianion Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 4
- 102000005927 Cysteine Proteases Human genes 0.000 claims 4
- 108010005843 Cysteine Proteases Proteins 0.000 claims 4
- FIVPIPIDMRVLAY-RBJBARPLSA-N Gliotoxin Chemical compound C1C2=CC=C[C@H](O)[C@H]2N2[C@]1(SS1)C(=O)N(C)[C@@]1(CO)C2=O FIVPIPIDMRVLAY-RBJBARPLSA-N 0.000 claims 4
- 229940103893 Gliotoxin Drugs 0.000 claims 4
- 102100008763 IFNA2 Human genes 0.000 claims 4
- 101700023446 IFNT Proteins 0.000 claims 4
- 108010078049 Interferon alpha-2 Proteins 0.000 claims 4
- 229960004461 Interferon beta-1a Drugs 0.000 claims 4
- 108010005716 Interferon beta-1a Proteins 0.000 claims 4
- 229940028862 Interferon gamma-1b Drugs 0.000 claims 4
- 102000006992 Interferon-alpha Human genes 0.000 claims 4
- 108010047761 Interferon-alpha Proteins 0.000 claims 4
- 108010074328 Interferon-gamma Proteins 0.000 claims 4
- 102000008070 Interferon-gamma Human genes 0.000 claims 4
- 102000015696 Interleukins Human genes 0.000 claims 4
- 108010063738 Interleukins Proteins 0.000 claims 4
- TYQCGQRIZGCHNB-JLAZNSOCSA-N L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 claims 4
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 claims 4
- 101710003000 ORF1/ORF2 Proteins 0.000 claims 4
- 101700030467 Pol Proteins 0.000 claims 4
- 229940076788 Pyruvate Drugs 0.000 claims 4
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 4
- 229960000329 Ribavirin Drugs 0.000 claims 4
- LSNNMFCWUKXFEE-UHFFFAOYSA-L Sulphite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 claims 4
- OGYGFUAIIOPWQD-UHFFFAOYSA-N Thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 4
- 230000000692 anti-sense Effects 0.000 claims 4
- 235000010323 ascorbic acid Nutrition 0.000 claims 4
- 239000011668 ascorbic acid Substances 0.000 claims 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-M benzoate Chemical compound [O-]C(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-M 0.000 claims 4
- 239000002775 capsule Substances 0.000 claims 4
- 229950005984 cerulenin Drugs 0.000 claims 4
- 230000001419 dependent Effects 0.000 claims 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N fumaric acid Chemical compound OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- AEMRFAOFKBGASW-UHFFFAOYSA-M glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 claims 4
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 4
- 229960003130 interferon gamma Drugs 0.000 claims 4
- 108010042414 interferon gamma-1b Proteins 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 4
- VZCYOOQTPOCHFL-UPHRSURJSA-L maleate(2-) Chemical compound [O-]C(=O)\C=C/C([O-])=O VZCYOOQTPOCHFL-UPHRSURJSA-L 0.000 claims 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 claims 4
- BDAGIHXWWSANSR-UHFFFAOYSA-M methanoate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 4
- NHNBFGGVMKEFGY-UHFFFAOYSA-N nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-L oxalate Chemical compound [O-]C(=O)C([O-])=O MUBZPKHOEPUJKR-UHFFFAOYSA-L 0.000 claims 4
- OFOBLEOULBTSOW-UHFFFAOYSA-L propanedioate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 claims 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-M propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 4
- LCTONWCANYUPML-UHFFFAOYSA-M pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 4
- 101710004466 rgy Proteins 0.000 claims 4
- 101710030364 rgy1 Proteins 0.000 claims 4
- 101710030359 rgy2 Proteins 0.000 claims 4
- 229920002033 ribozyme Polymers 0.000 claims 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims 4
- 229960001860 salicylate Drugs 0.000 claims 4
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims 4
- 229940086735 succinate Drugs 0.000 claims 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 4
- 229940095064 tartrate Drugs 0.000 claims 4
- 150000003548 thiazolidines Chemical class 0.000 claims 4
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 claims 4
- 229940107161 Cholesterol Drugs 0.000 claims 3
- 241000710831 Flavivirus Species 0.000 claims 3
- 241000710778 Pestivirus Species 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 235000014633 carbohydrates Nutrition 0.000 claims 3
- 235000012000 cholesterol Nutrition 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 3
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 241000710781 Flaviviridae Species 0.000 claims 2
- 125000005140 aralkylsulfonyl group Chemical group 0.000 claims 2
- 150000003459 sulfonic acid esters Chemical class 0.000 claims 2
- 208000004576 Flaviviridae Infections Diseases 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 108010012057 RNA Replicase Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39235102P | 2002-06-28 | 2002-06-28 | |
| US46619403P | 2003-04-28 | 2003-04-28 | |
| US47094903P | 2003-05-14 | 2003-05-14 | |
| PCT/US2003/020431 WO2004002422A2 (en) | 2002-06-28 | 2003-06-27 | 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005533824A JP2005533824A (ja) | 2005-11-10 |
| JP2005533824A5 true JP2005533824A5 (US20040097461A1-20040520-C00002.png) | 2006-08-17 |
Family
ID=30003834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004518041A Pending JP2005533824A (ja) | 2002-06-28 | 2003-06-27 | フラビウイルス科感染の治療のための２’−ｃ−メチル−３’−ｏ−ｌ−バリンエステルリボフラノシルシチジン |
Country Status (16)
Families Citing this family (186)
| Publication number | Priority date | Publication date | Assignee | Title |
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| MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| KR20030036189A (ko) * | 2000-05-26 | 2003-05-09 | 이데닉스(케이만)리미티드 | 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물 |
| US6875751B2 (en) * | 2000-06-15 | 2005-04-05 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
| AU2003248748A1 (en) * | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| CN101172993A (zh) * | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷 |
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| CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| CA2577526A1 (en) | 2004-08-23 | 2006-03-02 | Joseph Armstrong Martin | Antiviral 4'-azido-nucleosides |
| US7544632B2 (en) * | 2004-09-22 | 2009-06-09 | Exxonmobil Research And Engineering Company | Bulk Ni-Mo-W catalysts made from precursors containing an organic agent |
| WO2006121468A1 (en) * | 2004-11-22 | 2006-11-16 | Genelabs Technologies, Inc. | 5-nitro-nucleoside compounds for treating viral infections |
| CA2597213A1 (en) | 2005-02-09 | 2006-09-14 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| DE102005012681A1 (de) | 2005-03-18 | 2006-09-21 | Weber, Lutz, Dr. | Neue 1,5-Dihydro-pyrrol-2-one |
| AR056327A1 (es) | 2005-04-25 | 2007-10-03 | Genelabs Tech Inc | Compuestos de nucleosidos para el tratamiento de infecciones virales |
| US7781576B2 (en) | 2005-12-23 | 2010-08-24 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
-
2003
- 2003-06-27 AU AU2003248748A patent/AU2003248748A1/en not_active Abandoned
- 2003-06-27 WO PCT/US2003/020431 patent/WO2004002422A2/en active Search and Examination
- 2003-06-27 MX MXPA04012802A patent/MXPA04012802A/es not_active Application Discontinuation
- 2003-06-27 RS YUP-1139/04A patent/RS113904A/sr unknown
- 2003-06-27 KR KR1020047021073A patent/KR20050035194A/ko not_active Application Discontinuation
- 2003-06-27 JP JP2004518041A patent/JP2005533824A/ja active Pending
- 2003-06-27 CA CA002489552A patent/CA2489552A1/en not_active Abandoned
- 2003-06-27 PL PL03374781A patent/PL374781A1/xx not_active Application Discontinuation
- 2003-06-27 EP EP03762183A patent/EP1536804A4/en not_active Withdrawn
- 2003-06-27 AP AP2005003213A patent/AP2005003213A0/xx unknown
- 2003-06-27 US US10/607,909 patent/US7456155B2/en active Active
- 2003-06-27 BR BRPI0312278-6A patent/BR0312278A/pt not_active IP Right Cessation
- 2003-06-27 CN CNA03820701XA patent/CN1678326A/zh active Pending
- 2003-06-27 US US10/609,298 patent/US7662798B2/en not_active Expired - Fee Related
-
2004
- 2004-12-06 US US11/005,440 patent/US20070060503A1/en not_active Abandoned
- 2004-12-06 US US11/005,444 patent/US7625875B2/en not_active Expired - Fee Related
- 2004-12-06 US US11/005,442 patent/US20070037735A1/en not_active Abandoned
- 2004-12-06 US US11/005,472 patent/US20070060505A1/en not_active Abandoned
- 2004-12-06 US US11/005,471 patent/US20070042990A1/en not_active Abandoned
- 2004-12-06 US US11/005,446 patent/US20070060504A1/en not_active Abandoned
- 2004-12-06 US US11/005,466 patent/US20070060541A1/en not_active Abandoned
-
2005
- 2005-01-25 MA MA28070A patent/MA27374A1/fr unknown
- 2005-01-27 NO NO20050490A patent/NO20050490L/no not_active Application Discontinuation
-
2014
- 2014-08-07 LU LU92513C patent/LU92513I2/xx unknown
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