MA27374A1 - Ester de 2'-c-methyl-3'-o-l-valine et de ribofuranosyl cytidine pour le traitement des infections des flaviviridae - Google Patents
Ester de 2'-c-methyl-3'-o-l-valine et de ribofuranosyl cytidine pour le traitement des infections des flaviviridaeInfo
- Publication number
- MA27374A1 MA27374A1 MA28070A MA28070A MA27374A1 MA 27374 A1 MA27374 A1 MA 27374A1 MA 28070 A MA28070 A MA 28070A MA 28070 A MA28070 A MA 28070A MA 27374 A1 MA27374 A1 MA 27374A1
- Authority
- MA
- Morocco
- Prior art keywords
- valine
- ester
- methyl
- treatment
- flaviviridae infections
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39235102P | 2002-06-28 | 2002-06-28 | |
US46619403P | 2003-04-28 | 2003-04-28 | |
US47094903P | 2003-05-14 | 2003-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27374A1 true MA27374A1 (fr) | 2005-06-01 |
Family
ID=30003834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28070A MA27374A1 (fr) | 2002-06-28 | 2005-01-25 | Ester de 2'-c-methyl-3'-o-l-valine et de ribofuranosyl cytidine pour le traitement des infections des flaviviridae |
Country Status (16)
Country | Link |
---|---|
US (9) | US7662798B2 (fr) |
EP (1) | EP1536804A4 (fr) |
JP (1) | JP2005533824A (fr) |
KR (1) | KR20050035194A (fr) |
CN (1) | CN1678326A (fr) |
AP (1) | AP2005003213A0 (fr) |
AU (1) | AU2003248748A1 (fr) |
BR (1) | BR0312278A (fr) |
CA (1) | CA2489552A1 (fr) |
LU (1) | LU92513I2 (fr) |
MA (1) | MA27374A1 (fr) |
MX (1) | MXPA04012802A (fr) |
NO (1) | NO20050490L (fr) |
PL (1) | PL374781A1 (fr) |
RS (1) | RS113904A (fr) |
WO (1) | WO2004002422A2 (fr) |
Families Citing this family (186)
Publication number | Priority date | Publication date | Assignee | Title |
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MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
NZ547204A (en) | 2000-05-26 | 2008-01-31 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
US6875751B2 (en) * | 2000-06-15 | 2005-04-05 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
NZ537662A (en) * | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
AU2003248748A1 (en) * | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
WO2004009020A2 (fr) | 2002-07-24 | 2004-01-29 | Merck & Co., Inc. | Derives de thionucleosides utilises comme inhibiteurs de l'arn-polymerase arn-dependante virale |
US7094768B2 (en) * | 2002-09-30 | 2006-08-22 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis C virus infection |
WO2004028481A2 (fr) * | 2002-09-30 | 2004-04-08 | Genelabs Technologies, Inc. | Derives nucleosidiques servant au traitement d'une infection par le virus de l'hepatite c |
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KR20050088079A (ko) | 2002-11-15 | 2005-09-01 | 이데닉스 (케이만) 리미티드 | 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이 |
CA2509687C (fr) * | 2002-12-12 | 2012-08-14 | Idenix (Cayman) Limited | Procede de production de nucleosides ramifies en position 2' |
RU2005123395A (ru) * | 2002-12-23 | 2006-01-27 | Айденикс (Кайман) Лимитед (Ky) | Способ получения 3-нуклеозидных пролекарств |
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CA2734052A1 (fr) | 2003-05-30 | 2005-01-13 | Pharmasset, Inc. | Analogues de nucleosides fluores modifies |
PL1658302T3 (pl) | 2003-07-25 | 2011-03-31 | Idenix Pharmaceuticals Inc | Analogi nukleozydów purynowych do leczenia chorób spowodowanych przez Flaviviridae obejmujących zapalenie wątroby typu C |
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US8183005B1 (en) | 2004-08-11 | 2012-05-22 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical agents for treating HCV infections |
RU2433124C2 (ru) | 2004-09-14 | 2011-11-10 | Фармассет, Инк. | Способ получения 2'-фтор-2'-алкилзамещенных или других замещенных рибофуранозилпиримидинов и пуринов и их производных |
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2003
- 2003-06-27 AU AU2003248748A patent/AU2003248748A1/en not_active Abandoned
- 2003-06-27 AP AP2005003213A patent/AP2005003213A0/xx unknown
- 2003-06-27 CA CA002489552A patent/CA2489552A1/fr not_active Abandoned
- 2003-06-27 US US10/609,298 patent/US7662798B2/en not_active Expired - Fee Related
- 2003-06-27 PL PL03374781A patent/PL374781A1/xx not_active Application Discontinuation
- 2003-06-27 RS YUP-1139/04A patent/RS113904A/sr unknown
- 2003-06-27 JP JP2004518041A patent/JP2005533824A/ja active Pending
- 2003-06-27 US US10/607,909 patent/US7456155B2/en active Active
- 2003-06-27 CN CNA03820701XA patent/CN1678326A/zh active Pending
- 2003-06-27 BR BRPI0312278-6A patent/BR0312278A/pt not_active IP Right Cessation
- 2003-06-27 WO PCT/US2003/020431 patent/WO2004002422A2/fr active Search and Examination
- 2003-06-27 EP EP03762183A patent/EP1536804A4/fr not_active Withdrawn
- 2003-06-27 MX MXPA04012802A patent/MXPA04012802A/es not_active Application Discontinuation
- 2003-06-27 KR KR1020047021073A patent/KR20050035194A/ko not_active Application Discontinuation
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2004
- 2004-12-06 US US11/005,471 patent/US20070042990A1/en not_active Abandoned
- 2004-12-06 US US11/005,446 patent/US20070060504A1/en not_active Abandoned
- 2004-12-06 US US11/005,442 patent/US20070037735A1/en not_active Abandoned
- 2004-12-06 US US11/005,444 patent/US7625875B2/en not_active Expired - Fee Related
- 2004-12-06 US US11/005,466 patent/US20070060541A1/en not_active Abandoned
- 2004-12-06 US US11/005,440 patent/US20070060503A1/en not_active Abandoned
- 2004-12-06 US US11/005,472 patent/US20070060505A1/en not_active Abandoned
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2005
- 2005-01-25 MA MA28070A patent/MA27374A1/fr unknown
- 2005-01-27 NO NO20050490A patent/NO20050490L/no not_active Application Discontinuation
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2014
- 2014-08-07 LU LU92513C patent/LU92513I2/fr unknown
Also Published As
Publication number | Publication date |
---|---|
US20070060541A1 (en) | 2007-03-15 |
BR0312278A (pt) | 2007-06-19 |
CN1678326A (zh) | 2005-10-05 |
US20070037735A1 (en) | 2007-02-15 |
JP2005533824A (ja) | 2005-11-10 |
WO2004002422A3 (fr) | 2005-04-07 |
LU92513I2 (fr) | 2015-11-02 |
EP1536804A2 (fr) | 2005-06-08 |
EP1536804A4 (fr) | 2007-10-31 |
US20070060504A1 (en) | 2007-03-15 |
US20040077587A1 (en) | 2004-04-22 |
US7625875B2 (en) | 2009-12-01 |
US20070015905A1 (en) | 2007-01-18 |
US20070060498A1 (en) | 2007-03-15 |
AP2005003213A0 (en) | 2005-03-31 |
WO2004002422A2 (fr) | 2004-01-08 |
RS113904A (en) | 2007-02-05 |
US20070042990A1 (en) | 2007-02-22 |
US7456155B2 (en) | 2008-11-25 |
KR20050035194A (ko) | 2005-04-15 |
US20070060503A1 (en) | 2007-03-15 |
US20070060505A1 (en) | 2007-03-15 |
PL374781A1 (en) | 2005-10-31 |
AU2003248748A1 (en) | 2004-01-19 |
NO20050490L (no) | 2005-01-27 |
CA2489552A1 (fr) | 2004-01-08 |
MXPA04012802A (es) | 2005-04-19 |
US7662798B2 (en) | 2010-02-16 |
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