|
US6897220B2
(en)
*
|
2001-09-14 |
2005-05-24 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
CN101851173A
(zh)
|
2001-09-14 |
2010-10-06 |
梅特希尔基因公司 |
组蛋白脱乙酰化酶抑制剂
|
|
US7868204B2
(en)
*
|
2001-09-14 |
2011-01-11 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
|
MXPA04007590A
(es)
|
2002-02-05 |
2004-12-06 |
Yamanouchi Pharma Co Ltd |
Derivado de 2,4,6-triamino-1,3,5-triacina.
|
|
TWI319387B
(en)
|
2002-04-05 |
2010-01-11 |
Astrazeneca Ab |
Benzamide derivatives
|
|
GB0209715D0
(en)
*
|
2002-04-27 |
2002-06-05 |
Astrazeneca Ab |
Chemical compounds
|
|
US7154002B1
(en)
|
2002-10-08 |
2006-12-26 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
US7250514B1
(en)
|
2002-10-21 |
2007-07-31 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
US7351719B2
(en)
|
2002-10-31 |
2008-04-01 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
|
|
US7375228B2
(en)
|
2003-03-17 |
2008-05-20 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
WO2004104003A1
(de)
|
2003-05-23 |
2004-12-02 |
Zentaris Gmbh |
Neue pyridopyrazine und deren verwendung als modulatoren von kinasen
|
|
DE10323345A1
(de)
|
2003-05-23 |
2004-12-16 |
Zentaris Gmbh |
Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren
|
|
PL1651612T3
(pl)
|
2003-07-22 |
2012-09-28 |
Astex Therapeutics Ltd |
Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3)
|
|
WO2005019188A1
(ja)
*
|
2003-08-22 |
2005-03-03 |
Takeda Pharmaceutical Company Limited |
縮合ピリミジン誘導体およびその用途
|
|
US7868205B2
(en)
*
|
2003-09-24 |
2011-01-11 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
|
GB0322409D0
(en)
*
|
2003-09-25 |
2003-10-29 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
US20050085531A1
(en)
*
|
2003-10-03 |
2005-04-21 |
Hodge Carl N. |
Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
|
|
US7432281B2
(en)
|
2003-10-07 |
2008-10-07 |
Renovis, Inc. |
Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
|
|
CA2542096A1
(en)
*
|
2003-10-09 |
2005-04-21 |
Aton Pharma, Inc. |
Thiophene and benzothiophene hydroxamic acid derivatives
|
|
AU2004281154A1
(en)
*
|
2003-10-16 |
2005-04-28 |
Novartis Vaccines And Diagnostics, Inc. |
2,6-disubstituted quinazolines, quinoxalines, quinolines and isoquinolines as inhibitors of Raf kinase for treatment of cancer
|
|
US20050137234A1
(en)
*
|
2003-12-19 |
2005-06-23 |
Syrrx, Inc. |
Histone deacetylase inhibitors
|
|
WO2005065681A1
(en)
*
|
2003-12-19 |
2005-07-21 |
Takeda San Diego, Inc. |
N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer
|
|
US7592373B2
(en)
|
2003-12-23 |
2009-09-22 |
Boehringer Ingelheim International Gmbh |
Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
|
|
AU2005208938A1
(en)
*
|
2004-01-29 |
2005-08-11 |
Elixir Pharmaceuticals, Inc |
Anti-viral therapeutics
|
|
US20080275062A1
(en)
*
|
2004-01-30 |
2008-11-06 |
David Harold Drewry |
Chemical Compounds
|
|
EP1725528B1
(en)
|
2004-03-11 |
2013-05-29 |
4Sc Ag |
Sulphonylpyrroles as hdac inhibitors
|
|
JP5319113B2
(ja)
*
|
2004-03-26 |
2013-10-16 |
メチルジーン インコーポレイテッド |
ヒストンデアセチラーゼの阻害剤
|
|
TWI415606B
(zh)
*
|
2004-03-26 |
2013-11-21 |
Methylgene Inc |
組蛋白去乙醯基酶之抑制劑
|
|
US7253204B2
(en)
*
|
2004-03-26 |
2007-08-07 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
|
AU2005231507B2
(en)
|
2004-04-08 |
2012-03-01 |
Targegen, Inc. |
Benzotriazine inhibitors of kinases
|
|
AR050926A1
(es)
*
|
2004-09-03 |
2006-12-06 |
Astrazeneca Ab |
Derivados de benzamida como inhibidores de la histonadesacetilasa(hdac)
|
|
US7776869B2
(en)
|
2004-10-18 |
2010-08-17 |
Amgen Inc. |
Heteroaryl-substituted alkyne compounds and method of use
|
|
WO2006066133A2
(en)
*
|
2004-12-16 |
2006-06-22 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
GB0501146D0
(en)
*
|
2005-01-20 |
2005-02-23 |
Astrazeneca Ab |
Novel benzamide derivatives
|
|
US8404718B2
(en)
|
2005-01-21 |
2013-03-26 |
Astex Therapeutics Limited |
Combinations of pyrazole kinase inhibitors
|
|
AR054425A1
(es)
|
2005-01-21 |
2007-06-27 |
Astex Therapeutics Ltd |
Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
|
|
RU2440996C2
(ru)
|
2005-01-25 |
2012-01-27 |
Галенеа Корп. |
Замещенные ариламины и их применение в качестве модуляторов 5-ht6-рецептора
|
|
US7576099B2
(en)
|
2005-02-28 |
2009-08-18 |
Renovis, Inc. |
Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
|
|
WO2006097474A1
(en)
|
2005-03-15 |
2006-09-21 |
Nycomed Gmbh |
N-sulphonylpyrroles and their use as histone deacetylase inhibitors
|
|
AU2006240258A1
(en)
*
|
2005-04-20 |
2006-11-02 |
Merck Sharp & Dohme Corp. |
Benzothiophene derivatives
|
|
US7772238B2
(en)
*
|
2005-04-20 |
2010-08-10 |
Merck Sharp & Dohme Corp. |
Benzothiophene hydroxamic acid derivatives
|
|
CN101163471A
(zh)
*
|
2005-04-20 |
2008-04-16 |
默克公司 |
含有氨基甲酸酯、脲、酰胺和磺酰胺取代的苯并噻吩异羟肟酸衍生物
|
|
JP2008540574A
(ja)
*
|
2005-05-11 |
2008-11-20 |
タケダ サン ディエゴ インコーポレイテッド |
ヒストンデアセチラーゼ阻害剤
|
|
NZ563245A
(en)
*
|
2005-05-19 |
2011-04-29 |
Prometic Biosciences Inc |
Triazine compounds and compositions thereof for the treatment of cancers
|
|
KR101378716B1
(ko)
|
2005-05-20 |
2014-04-10 |
메틸진 인코포레이티드 |
Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제
|
|
DE102005027274A1
(de)
*
|
2005-06-08 |
2006-12-14 |
Schering Ag |
Inhibitoren der löslichen Adenylatzyklase
|
|
US7417066B2
(en)
|
2005-06-08 |
2008-08-26 |
Schering Ag |
Inhibitors of soluble adenylate cyclase
|
|
JP5118029B2
(ja)
|
2005-06-14 |
2013-01-16 |
タイゲン バイオテクノロジー カンパニー，リミテッド |
ピリミジン化合物
|
|
US8193206B2
(en)
|
2005-06-14 |
2012-06-05 |
Taigen Biotechnology Co., Ltd. |
Pyrimidine compounds
|
|
JP4528918B2
(ja)
*
|
2005-06-21 |
2010-08-25 |
学校法人 関西大学 |
カルボキサミド誘導体
|
|
CA2612420A1
(en)
|
2005-06-24 |
2007-01-04 |
Merck & Co., Inc. |
Modified malonate derivatives
|
|
AU2006270322A1
(en)
*
|
2005-07-14 |
2007-01-25 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
EP2275096A3
(en)
|
2005-08-26 |
2011-07-13 |
Braincells, Inc. |
Neurogenesis via modulation of the muscarinic receptors
|
|
EP2258358A3
(en)
|
2005-08-26 |
2011-09-07 |
Braincells, Inc. |
Neurogenesis with acetylcholinesterase inhibitor
|
|
ATE549333T1
(de)
|
2005-09-21 |
2012-03-15 |
4Sc Ag |
Neue sulfonylpyrrole als hdac-inhibitoren
|
|
AU2006298881A1
(en)
|
2005-09-21 |
2007-04-12 |
4Sc Ag |
Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
|
|
GB0521244D0
(en)
|
2005-10-19 |
2005-11-30 |
Astrazeneca Ab |
Benzamide compounds
|
|
AU2006304787A1
(en)
|
2005-10-21 |
2007-04-26 |
Braincells, Inc. |
Modulation of neurogenesis by PDE inhibition
|
|
CA2625210A1
(en)
|
2005-10-31 |
2007-05-10 |
Braincells, Inc. |
Gaba receptor mediated modulation of neurogenesis
|
|
JP5191391B2
(ja)
|
2005-11-01 |
2013-05-08 |
ターゲジェン インコーポレーティッド |
キナーゼのビ−アリールメタ−ピリミジン阻害剤
|
|
EP1790342A1
(de)
|
2005-11-11 |
2007-05-30 |
Zentaris GmbH |
Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
|
|
US8217042B2
(en)
|
2005-11-11 |
2012-07-10 |
Zentaris Gmbh |
Pyridopyrazines and their use as modulators of kinases
|
|
AU2006313701B2
(en)
|
2005-11-11 |
2012-05-31 |
Aeterna Zentaris Gmbh |
Novel pyridopyrazines and their use as modulators of kinases
|
|
AR057579A1
(es)
|
2005-11-23 |
2007-12-05 |
Merck & Co Inc |
Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac)
|
|
WO2007100657A2
(en)
|
2006-02-28 |
2007-09-07 |
Merck & Co., Inc. |
Inhibitors of histone deacetylase
|
|
US20100216734A1
(en)
|
2006-03-08 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
|
KR101495611B1
(ko)
|
2006-04-07 |
2015-02-25 |
메틸진 인코포레이티드 |
히스톤 데아세틸라아제의 억제제
|
|
JP2009535333A
(ja)
|
2006-04-26 |
2009-10-01 |
メルク エンド カムパニー インコーポレーテッド |
二置換アニリン化合物
|
|
AU2007249435A1
(en)
|
2006-05-09 |
2007-11-22 |
Braincells, Inc. |
5 HT receptor mediated neurogenesis
|
|
AU2007249399A1
(en)
|
2006-05-09 |
2007-11-22 |
Braincells, Inc. |
Neurogenesis by modulating angiotensin
|
|
US8119652B2
(en)
|
2006-05-18 |
2012-02-21 |
Merck Sharp & Dohme Corp. |
Aryl-fused spirocyclic compounds
|
|
US7981874B2
(en)
|
2006-07-20 |
2011-07-19 |
Merck Sharp & Dohme Corp. |
Phosphorus derivatives as histone deacetylase inhibitors
|
|
BRPI0716604A2
(pt)
|
2006-09-08 |
2013-04-09 |
Braincells Inc |
combinaÇÕes contendo um derivado de 4-acilaminopiridina
|
|
US20100184806A1
(en)
|
2006-09-19 |
2010-07-22 |
Braincells, Inc. |
Modulation of neurogenesis by ppar agents
|
|
CN101573333B
(zh)
|
2006-10-28 |
2013-06-12 |
梅特希尔基因公司 |
组蛋白脱乙酰酶抑制剂
|
|
CA2672893C
(en)
|
2006-12-15 |
2016-02-23 |
Abraxis Bioscience, Inc. |
Triazine derivatives and their therapeutical applications
|
|
CA2679198C
(en)
|
2007-02-26 |
2011-07-12 |
Pfizer Products Inc. |
Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases
|
|
US8030344B2
(en)
|
2007-03-13 |
2011-10-04 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
|
AU2008271170A1
(en)
|
2007-06-27 |
2009-01-08 |
Merck Sharp & Dohme Corp. |
Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors
|
|
WO2009002495A1
(en)
|
2007-06-27 |
2008-12-31 |
Merck & Co., Inc. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
|
JP5322477B2
(ja)
*
|
2007-09-28 |
2013-10-23 |
富士フイルム株式会社 |
新規アセチレン化合物、その塩、その製造方法、それを構成単位として含むポリマー、該ポリマーの製造方法、該ポリマーの組成物、該ポリマー組成物を硬化させてなる硬化物
|
|
CA2700058A1
(en)
|
2007-09-19 |
2009-03-26 |
4Sc Ag |
Novel tetrahydrofusedpyridines
|
|
WO2009040290A1
(en)
|
2007-09-27 |
2009-04-02 |
F. Hoffmann-La Roche Ag |
Quinoline derivatives as 5ht5a receptor antagonists
|
|
EP2205563A4
(en)
*
|
2007-10-10 |
2012-01-25 |
Orchid Res Lab Ltd |
NEW HISTONDEACETYLASE INHIBITORS
|
|
BRPI0817860A2
(pt)
*
|
2007-10-22 |
2019-09-24 |
Orchid Res Laboratories Limited |
inibidores de histona deacetilase
|
|
EP2060565A1
(en)
*
|
2007-11-16 |
2009-05-20 |
4Sc Ag |
Novel bifunctional compounds which inhibit protein kinases and histone deacetylases
|
|
CA2711995A1
(en)
*
|
2008-01-29 |
2009-08-06 |
F. Hoffmann-La Roche Ag |
Novel n-(2-amino-phenyl)-amide derivatives
|
|
EA019289B1
(ru)
|
2008-04-21 |
2014-02-28 |
Тайджен Байотекнолоджи Ко., Лтд. |
Производные аминопиридина, аминопиримидина и амино-1,3,5-триазина
|
|
KR20100132553A
(ko)
*
|
2008-05-16 |
2010-12-17 |
에프. 호프만-라 로슈 아게 |
신규한 ｎ-(2-아미노-페닐)-아크릴아미드
|
|
JP5351254B2
(ja)
|
2008-05-23 |
2013-11-27 |
ノバルティス アーゲー |
キノキサリン−およびキノリン−カルボキシアミド誘導体
|
|
CA2724357A1
(en)
*
|
2008-05-23 |
2009-11-26 |
Santen Pharmaceutical Co., Ltd. |
Novel thiophenediamine derivative having urea structure
|
|
EP2303862B1
(en)
|
2008-05-27 |
2016-08-24 |
The Board of Regents of The University of Texas System |
Wnt protein signalling inhibitors
|
|
ES2620027T3
(es)
|
2008-09-03 |
2017-06-27 |
Biomarin Pharmaceutical Inc. |
Composiciones que incluyen derivados del ácido 6-aminohexanoico como inhibidores de HDAC
|
|
US8202866B2
(en)
*
|
2008-09-17 |
2012-06-19 |
Hoffmann-La Roche Inc. |
Ortho-aminoanilides for the treatment of cancer
|
|
SMT202000257T1
(it)
*
|
2008-10-10 |
2020-07-08 |
Vm Discovery Inc |
Composizioni e metodi per il trattamento dei disturbi da uso di alcol, dolore e altre malattie
|
|
KR20110075016A
(ko)
|
2008-10-14 |
2011-07-05 |
닝 시 |
화합물 및 사용 방법
|
|
WO2010056847A2
(en)
|
2008-11-13 |
2010-05-20 |
Taigen Biotechnology Co., Ltd. |
Lyophilization formulation
|
|
EP2942346B1
(en)
|
2009-02-17 |
2020-05-06 |
Syntrix Biosystems, Inc. |
Pyridinecarboxamides as cxcr2 modulators
|
|
US20100216805A1
(en)
|
2009-02-25 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis using d-cycloserine combinations
|
|
CN101906076B
(zh)
*
|
2009-06-04 |
2013-03-13 |
深圳微芯生物科技有限责任公司 |
作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用
|
|
JP2012529518A
(ja)
*
|
2009-06-09 |
2012-11-22 |
アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー |
ヘッジホッグシグナル伝達のピリジル−トリアジン阻害剤
|
|
CA2765044A1
(en)
|
2009-06-09 |
2010-12-16 |
California Capital Equity, Llc |
Benzyl substituted triazine derivatives and their therapeutical applications
|
|
CN102573480B
(zh)
|
2009-06-09 |
2015-06-10 |
加利福尼亚资本权益有限责任公司 |
三嗪衍生物及其治疗应用
|
|
US8784873B2
(en)
*
|
2009-07-22 |
2014-07-22 |
Naturewise Biotech & Medicals Corporation |
Use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly
|
|
JP2011057661A
(ja)
*
|
2009-08-14 |
2011-03-24 |
Bayer Cropscience Ag |
殺虫性カルボキサミド類
|
|
IN2012DN03807A
(cg-RX-API-DMAC7.html)
|
2009-10-30 |
2015-08-28 |
Massachusetts Inst Technology |
|
|
RU2528386C2
(ru)
|
2010-05-21 |
2014-09-20 |
Кемилиа Аб |
Новые производные пиримидина
|
|
AU2011293612B2
(en)
*
|
2010-08-23 |
2015-11-26 |
Syntrix Biosystems Inc. |
Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators
|
|
AU2010363329A1
(en)
|
2010-11-07 |
2013-05-09 |
Targegen, Inc. |
Compositions and methods for treating myelofibrosis
|
|
CA2820709C
(en)
|
2011-02-28 |
2016-02-16 |
Sunshine Lake Pharma Co., Ltd. |
Substituted quinoline compounds and methods of use
|
|
US8957066B2
(en)
|
2011-02-28 |
2015-02-17 |
Biomarin Pharmaceutical Inc. |
Histone deacetylase inhibitors
|
|
CA2828524C
(en)
*
|
2011-02-28 |
2020-01-07 |
Repligen Corporation |
Histone deacetylase inhibitors
|
|
US10059723B2
(en)
|
2011-02-28 |
2018-08-28 |
Biomarin Pharmaceutical Inc. |
Histone deacetylase inhibitors
|
|
DK2688883T3
(en)
|
2011-03-24 |
2016-09-05 |
Noviga Res Ab |
pyrimidine
|
|
EP2508184A1
(en)
|
2011-04-06 |
2012-10-10 |
Æterna Zentaris GmbH |
Pyridopyrazine derivatives and their use
|
|
CN102775356B
(zh)
*
|
2011-05-13 |
2015-07-22 |
江苏恒谊药业有限公司 |
4-氨基喹唑啉衍生物及其应用
|
|
CN102807526B
(zh)
*
|
2011-06-21 |
2015-12-02 |
寿光富康制药有限公司 |
组蛋白去乙酰化酶抑制剂ZYJ-D08a及其差向异构体的制备方法与应用
|
|
CN102838625B
(zh)
*
|
2011-06-22 |
2015-04-15 |
中国科学院上海药物研究所 |
四氢吡啶并噻唑类化合物、其制备方法、包含该化合物的药物组合物及其用途
|
|
CN102276554B
(zh)
*
|
2011-06-28 |
2013-10-30 |
四川大学 |
4-（（2-氨基-5-巯基-1,3,4-噻二唑）-甲基）-苯甲酰胺衍生物及其制备方法和用途
|
|
EA201490228A1
(ru)
*
|
2011-07-08 |
2014-08-29 |
Новартис Аг |
Новые производные трифторметилоксадиазола и их применение для лечения заболевания
|
|
UA115532C2
(uk)
|
2011-07-29 |
2017-11-27 |
Каріофарм Терапеутікс, Інк. |
Модулятори нуклеарного транспорту, що містять гідразид, і їхнє застосування
|
|
WO2013019561A1
(en)
*
|
2011-07-29 |
2013-02-07 |
Karyopharm Therapeutics, Inc. |
Nuclear transport modulators and uses thereof
|
|
KR20140097459A
(ko)
*
|
2011-11-28 |
2014-08-06 |
노파르티스 아게 |
신규 트리플루오로메틸-옥사디아졸 유도체 및 질환의 치료에서의 그의 용도
|
|
JP5881460B2
(ja)
*
|
2012-02-23 |
2016-03-09 |
公立大学法人名古屋市立大学 |
新規アミド化合物及びその用途
|
|
JPWO2013137371A1
(ja)
*
|
2012-03-15 |
2015-08-03 |
興和株式会社 |
新規ピリミジン化合物及びそれらを含有する医薬
|
|
KR102163377B1
(ko)
|
2012-05-09 |
2020-10-08 |
바이오젠 엠에이 인코포레이티드 |
핵 수송 조절인자 및 이의 용도
|
|
EP2854780B1
(en)
|
2012-06-05 |
2017-08-30 |
University Of Kansas |
Inhibitors of respiratory syncytial virus
|
|
US8969388B1
(en)
|
2012-07-28 |
2015-03-03 |
Sunshine Lake Pharma Co., Ltd. |
Substituted pyrazolone compounds and methods of use
|
|
TWI574962B
(zh)
|
2012-11-14 |
2017-03-21 |
加拓科學公司 |
作爲ｐｉ３激酶調節劑的芳雜環化合物及其使用方法和用途
|
|
AU2013363957B2
(en)
|
2012-12-21 |
2018-03-22 |
Celgene Quanticel Research, Inc. |
Histone demethylase inhibitors
|
|
EP2951153B1
(en)
|
2013-02-01 |
2019-04-03 |
Regenacy Pharmaceuticals, LLC |
Selective hdac3 inhibitors
|
|
US9139583B2
(en)
|
2013-02-01 |
2015-09-22 |
Acetylon Pharmaceuticals, Inc. |
Selective HDAC3 inhibitors
|
|
MX2015010700A
(es)
|
2013-02-21 |
2017-01-23 |
Calitor Sciences Llc |
Compuestos heteroaromaticos como moduladores de la p13 cinasa.
|
|
EP2968278B8
(en)
|
2013-03-15 |
2019-05-22 |
Karyopharm Therapeutics Inc. |
Methods of promoting wound healing using crm1 inhibitors
|
|
BR112015023399A8
(pt)
|
2013-03-15 |
2019-12-03 |
Biomarin Pharm Inc |
inibidores de hdac, seu uso e composição farmacêutica
|
|
AU2014284168B2
(en)
|
2013-06-21 |
2018-10-25 |
Karyopharm Therapeutics Inc. |
Nuclear transport modulators and uses thereof
|
|
US10561676B2
(en)
|
2013-08-02 |
2020-02-18 |
Syntrix Biosystems Inc. |
Method for treating cancer using dual antagonists of CXCR1 and CXCR2
|
|
US10046002B2
(en)
|
2013-08-02 |
2018-08-14 |
Syntrix Biosystems Inc. |
Method for treating cancer using chemokine antagonists
|
|
US8969365B2
(en)
|
2013-08-02 |
2015-03-03 |
Syntrix Biosystems, Inc. |
Thiopyrimidinecarboxamides as CXCR1/2 modulators
|
|
EP2853532B1
(en)
*
|
2013-09-28 |
2020-12-09 |
Instytut Farmakologii Polskiej Akademii Nauk |
1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III
|
|
EP3626717A1
(en)
|
2013-10-14 |
2020-03-25 |
Eisai R&D Management Co., Ltd. |
Selectively substituted quinoline compounds
|
|
US9663486B2
(en)
|
2013-10-14 |
2017-05-30 |
Eisai R&D Management Co., Ltd. |
Selectively substituted quinoline compounds
|
|
EP3769757A3
(en)
|
2013-10-18 |
2021-10-06 |
The General Hospital Corporation |
Imaging histone deacetylases with a radiotracer using positron emission tomography
|
|
US9988343B2
(en)
*
|
2013-11-05 |
2018-06-05 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of histone deacetylase
|
|
US9636298B2
(en)
|
2014-01-17 |
2017-05-02 |
Methylgene Inc. |
Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs
|
|
EP3738960A1
(en)
|
2014-06-25 |
2020-11-18 |
Celgene Quanticel Research, Inc. |
Histone demethylase inhibitors
|
|
JP6785217B2
(ja)
*
|
2014-07-31 |
2020-11-18 |
インスティチュート パスツール コリア |
２−アミノ−ベンゾイミダゾール誘導体ならびにこれらの５−リポキシゲナーゼおよび／またはプロスタグランジンｅシンターゼ阻害剤としての使用
|
|
WO2016025904A1
(en)
|
2014-08-15 |
2016-02-18 |
Karyopharm Therapeutics Inc. |
Polymorphs of selinexor
|
|
SG10201913192VA
(en)
*
|
2015-07-02 |
2020-03-30 |
Biomarin Pharm Inc |
Histone deacetylase inhibitors
|
|
JP6812426B2
(ja)
|
2015-10-19 |
2021-01-13 |
サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． |
Ｅｇｆｒ阻害剤の塩、結晶形及びその使用
|
|
US10526295B2
(en)
|
2015-12-31 |
2020-01-07 |
Karyopharm Therapeutics Inc. |
Nuclear transport modulators and uses thereof
|
|
EP3397634A1
(en)
|
2015-12-31 |
2018-11-07 |
Karyopharm Therapeutics, Inc. |
Nuclear transport modulators and uses thereof
|
|
CN109311825B
(zh)
*
|
2016-05-12 |
2022-03-22 |
南京世其医药科技有限公司 |
2,4,6-三取代均三嗪化合物及其制备方法和应用
|
|
CN106242992A
(zh)
*
|
2016-07-25 |
2016-12-21 |
北京化工大学 |
一种苯甲酰胺类化合物及其在制备抑制癌细胞增殖和/或治疗癌症的药物中的应用
|
|
CN106496053B
(zh)
*
|
2016-09-22 |
2018-01-05 |
潍坊医学院 |
一种组蛋白去乙酰酶抑制剂n‑(2’‑胺基苯基)‑4‑(双(2‑氯乙基)胺基)苯甲酰胺及其制备方法和应用
|
|
US10660909B2
(en)
|
2016-11-17 |
2020-05-26 |
Syntrix Biosystems Inc. |
Method for treating cancer using chemokine antagonists
|
|
US11602530B2
(en)
|
2016-11-28 |
2023-03-14 |
Biogen Ma Inc. |
CRM1 inhibitors for treating epilepsy
|
|
TW201829381A
(zh)
*
|
2016-12-22 |
2018-08-16 |
美商拜奧馬林製藥公司 |
組蛋白脫乙醯基酶抑制劑
|
|
US10357493B2
(en)
|
2017-03-10 |
2019-07-23 |
Selenity Therapeutics (Bermuda), Ltd. |
Metalloenzyme inhibitor compounds
|
|
CN107141244B
(zh)
*
|
2017-05-08 |
2019-11-19 |
潍坊医学院 |
吲哚丁酸类组蛋白去乙酰酶抑制剂及其制备方法和应用
|
|
US11535598B2
(en)
*
|
2017-05-16 |
2022-12-27 |
Annji Pharmaceutical Co., Ltd. |
Histone deacetylases (HDACs) inhibitors
|
|
US11230524B2
(en)
*
|
2017-08-17 |
2022-01-25 |
Standard Llc |
Myocyte enhancer factor 2 (MEF2) modulators
|
|
CN107459480A
(zh)
*
|
2017-09-05 |
2017-12-12 |
镇江斯格派医疗器械有限公司 |
一种双芳基脲类组蛋白去乙酰化酶抑制剂
|
|
KR101964810B1
(ko)
|
2017-10-12 |
2019-04-02 |
충북대학교 산학협력단 |
Hdac 억제제로서 신규한 퀴나졸린-4(3h)-원 기반 n-하이드록시벤즈아미드 또는 n-하이드록시프로펜아미드 및 이를 유효성분으로 포함하는 항암제 조성물
|
|
MX2020004994A
(es)
|
2017-11-15 |
2020-10-12 |
Metabomed Ltd |
Inhibidores de acss2 y metodos de uso de los mismos.
|
|
US12133852B2
(en)
|
2017-11-15 |
2024-11-05 |
Epivario, Inc. |
ACSS2 inhibitors and methods of use thereof
|
|
CN108570012B
(zh)
*
|
2018-05-23 |
2021-11-12 |
中南大学 |
1,3-苯并噁嗪-2,4(3h)-二酮衍生物及其合成方法和用途
|
|
CN109020951B
(zh)
*
|
2018-08-24 |
2020-06-02 |
大连理工大学 |
含三取代三聚氯氰的萘酰亚胺类衍生物及其合成方法和应用
|
|
CN109336876A
(zh)
*
|
2018-10-31 |
2019-02-15 |
南京先进生物材料与过程装备研究院有限公司 |
二苯并[b,d]噻吩类STAT3抑制剂的酒石酸盐及其制备方法与用途
|
|
CN109293647A
(zh)
*
|
2018-10-31 |
2019-02-01 |
南京先进生物材料与过程装备研究院有限公司 |
二苯并[b,d]噻吩类STAT3抑制剂的M晶型及其制备方法
|
|
CN109180656A
(zh)
*
|
2018-10-31 |
2019-01-11 |
南京先进生物材料与过程装备研究院有限公司 |
一类stat3抑制剂及其应用
|
|
CN109336877A
(zh)
*
|
2018-10-31 |
2019-02-15 |
南京先进生物材料与过程装备研究院有限公司 |
二苯并[b,d]噻吩类STAT3抑制剂的甲磺酸盐及其制备方法与用途
|
|
CN109336871A
(zh)
*
|
2018-10-31 |
2019-02-15 |
南京先进生物材料与过程装备研究院有限公司 |
一种stat3抑制剂的马来酸盐及其制备方法与用途
|
|
CN109369626A
(zh)
*
|
2018-10-31 |
2019-02-22 |
南京先进生物材料与过程装备研究院有限公司 |
咔唑类stat3抑制剂p晶型及其制备方法
|
|
CN110078722A
(zh)
*
|
2018-10-31 |
2019-08-02 |
南京先进生物材料与过程装备研究院有限公司 |
一种噻吨酮类stat3抑制剂马来酸盐晶型a及其应用
|
|
CN109336867A
(zh)
*
|
2018-10-31 |
2019-02-15 |
南京先进生物材料与过程装备研究院有限公司 |
咔唑类stat3抑制剂晶型a及其制备方法
|
|
CN109336870A
(zh)
*
|
2018-10-31 |
2019-02-15 |
南京先进生物材料与过程装备研究院有限公司 |
咔唑类stat3抑制剂晶型i及其制备方法
|
|
CN109369628A
(zh)
*
|
2018-10-31 |
2019-02-22 |
南京先进生物材料与过程装备研究院有限公司 |
咔唑类stat3抑制剂晶型ii及其制备方法
|
|
CN109336869A
(zh)
*
|
2018-10-31 |
2019-02-15 |
南京先进生物材料与过程装备研究院有限公司 |
一种stat3抑制剂的甲磺酸盐及其制备方法与用途
|
|
CA3136083A1
(en)
*
|
2019-05-14 |
2020-11-19 |
Metabomed Ltd |
Acss2 inhibitors and methods of use thereof
|
|
GB201918404D0
(en)
*
|
2019-12-13 |
2020-01-29 |
Z Factor Ltd |
Compounds and their use for the treatment of aplha1-antitrypsin deficiency
|
|
CN111116469A
(zh)
*
|
2019-12-27 |
2020-05-08 |
北京鑫开元医药科技有限公司 |
一种hdac抑制剂、制备方法、药物组合物及其用途
|
|
CN113549057B
(zh)
*
|
2020-04-24 |
2023-01-31 |
中国药科大学 |
Snail抑制剂及其衍生物，制备方法、药物组合物和应用
|
|
CN115403483B
(zh)
*
|
2021-07-02 |
2024-01-26 |
河南省儿童医院郑州儿童医院 |
含二苯乙烯或二苯甲酮骨架的ca-4衍生物、药物组合物及其制备方法和应用
|
|
CN114539180B
(zh)
*
|
2021-12-24 |
2025-02-07 |
贵州大学 |
一种含异噁唑啉的双酰胺类化合物及其制备方法和用途
|
|
CN118745163A
(zh)
*
|
2024-06-06 |
2024-10-08 |
四川省医学科学院·四川省人民医院 |
苯并呋喃类化合物、其制备方法及其应用和pdgfr激酶抑制剂
|