JP7442439B2 - Kdm4阻害剤 - Google Patents
Kdm4阻害剤 Download PDFInfo
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- JP7442439B2 JP7442439B2 JP2020503253A JP2020503253A JP7442439B2 JP 7442439 B2 JP7442439 B2 JP 7442439B2 JP 2020503253 A JP2020503253 A JP 2020503253A JP 2020503253 A JP2020503253 A JP 2020503253A JP 7442439 B2 JP7442439 B2 JP 7442439B2
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
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- Molecular Biology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pyridine Compounds (AREA)
Description
本出願は、2017年3月30日出願の米国仮特許出願第62/478,785号、および2017年6月1日出願の米国仮特許出願62/513,875号の優先権の利益を主張し、これら双方の全体があらゆる目的のために本明細書に組み込まれる。
XはOまたはCH2であり、
R6はN(R1)(R2)またはO(R2)であり、
R1はHまたはC1-C6アルキルであり、および
R2は、随意に置換されたアリール、ヘテロアリール、シクリル、またはヘテロシクリルである。
Claims (1)
- リジンデメチラーゼ4(KDM4)活性に関連する癌(KDM4関連癌)を阻害するための薬剤の製造における、以下の構造の3-([[(4R)-7-[メチル[4-プロパン-2-イル)フェニル]アミノ]-3,4-ジヒドロ-2H-1-ベンゾピラン-4-イル]メチル]アミノ)ピリジン-4-カルボン酸である化合物、あるいはその立体異性体または薬学的に許容可能な塩の使用であって、
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762478785P | 2017-03-30 | 2017-03-30 | |
US62/478,785 | 2017-03-30 | ||
US201762513875P | 2017-06-01 | 2017-06-01 | |
US62/513,875 | 2017-06-01 | ||
PCT/US2018/024624 WO2018183370A2 (en) | 2017-03-30 | 2018-03-27 | Kdm4 inhibitors |
Publications (3)
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JP2020515645A JP2020515645A (ja) | 2020-05-28 |
JP2020515645A5 JP2020515645A5 (ja) | 2021-05-06 |
JP7442439B2 true JP7442439B2 (ja) | 2024-03-04 |
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JP2020503253A Active JP7442439B2 (ja) | 2017-03-30 | 2018-03-27 | Kdm4阻害剤 |
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US (3) | US20180290977A1 (ja) |
EP (1) | EP3600301A4 (ja) |
JP (1) | JP7442439B2 (ja) |
TW (1) | TWI814723B (ja) |
WO (1) | WO2018183370A2 (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US9242968B2 (en) * | 2014-06-25 | 2016-01-26 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
CN113876953B (zh) * | 2020-07-02 | 2022-12-09 | 中国科学院上海营养与健康研究所 | 新型细胞衰老干预靶点及其在化疗抗癌中的靶向应用 |
WO2023023112A1 (en) * | 2021-08-18 | 2023-02-23 | Celgene Corporation | Process for preparing histone demethylase inhibitors |
WO2023122221A1 (en) * | 2021-12-23 | 2023-06-29 | Tachyon Therapeutics, Inc. | Pharmaceutical formulations comprising 3-({[(4r)-7-{methyl[4-(propan-2-yl)phenyl]amino}-3,4-dihydro-2h-l-benzopyran-4-yl]methyl}amino)pyridine-4-carboxylic acid |
WO2024064734A1 (en) * | 2022-09-21 | 2024-03-28 | Celgene Corporation | Crystalline forms of 3-({[(4r)-7-{methyl[4-(propan-2- yl)phenyl]amino}-3,4-dihydro-2h-l-benzopyran-4- yl]methyl}amino)pyridine-4-carboxylic acid l-lysine salt, a histone demethylase inhibitor |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014100818A1 (en) | 2012-12-21 | 2014-06-26 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
WO2015200709A1 (en) | 2014-06-25 | 2015-12-30 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
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US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
CA3148196A1 (en) | 2013-10-18 | 2015-04-23 | Celgene Quanticel Research, Inc. | Bromodomain inhibitors |
US9890434B2 (en) * | 2014-03-19 | 2018-02-13 | National Tsing Hua University | Method for identifying compound for inhibiting an activity of a histone lysine demethylase |
BR112016025248B1 (pt) | 2014-05-01 | 2022-12-13 | Celgene Quanticel Research, Inc | Compostos inibidores de demetilase lisina-específica-1, composição farmacêutica e seus usos |
JP6883913B2 (ja) * | 2015-12-28 | 2021-06-09 | セルジーン クオンティセル リサーチ,インク. | ヒストンデメチラーゼ阻害剤 |
-
2018
- 2018-03-27 US US15/936,811 patent/US20180290977A1/en not_active Abandoned
- 2018-03-27 US US16/498,714 patent/US20200039938A1/en not_active Abandoned
- 2018-03-27 WO PCT/US2018/024624 patent/WO2018183370A2/en unknown
- 2018-03-27 JP JP2020503253A patent/JP7442439B2/ja active Active
- 2018-03-27 EP EP18774276.2A patent/EP3600301A4/en active Pending
- 2018-03-29 TW TW107110863A patent/TWI814723B/zh active
-
2022
- 2022-05-20 US US17/749,233 patent/US20240076271A1/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014100818A1 (en) | 2012-12-21 | 2014-06-26 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
WO2015200709A1 (en) | 2014-06-25 | 2015-12-30 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
Non-Patent Citations (1)
Title |
---|
Breast Cancer: Basic and Clinical Research,2016年,Vol. 10,pp. 169-175 |
Also Published As
Publication number | Publication date |
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WO2018183370A2 (en) | 2018-10-04 |
EP3600301A4 (en) | 2020-08-12 |
EP3600301A2 (en) | 2020-02-05 |
US20200039938A1 (en) | 2020-02-06 |
US20240076271A1 (en) | 2024-03-07 |
JP2020515645A (ja) | 2020-05-28 |
US20180290977A1 (en) | 2018-10-11 |
TWI814723B (zh) | 2023-09-11 |
TW201840537A (zh) | 2018-11-16 |
WO2018183370A3 (en) | 2018-12-20 |
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