HRP970473B1 - 6-0-substituted ketolides having antibacterial activity - Google Patents

6-0-substituted ketolides having antibacterial activity

Info

Publication number
HRP970473B1
HRP970473B1 HR970473A HRP970473A HRP970473B1 HR P970473 B1 HRP970473 B1 HR P970473B1 HR 970473 A HR970473 A HR 970473A HR P970473 A HRP970473 A HR P970473A HR P970473 B1 HRP970473 B1 HR P970473B1
Authority
HR
Croatia
Prior art keywords
substituted
alkyl
aryl
heteroaryl
group
Prior art date
Application number
HR970473A
Other languages
English (en)
Croatian (hr)
Inventor
Sun Or Yat
T. Chu Daniel
Ma Zhenkun
J. Plattner Jacob
F. Clark Richard
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP970473(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/888,350 external-priority patent/US5866549A/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of HRP970473A2 publication Critical patent/HRP970473A2/hr
Publication of HRP970473B1 publication Critical patent/HRP970473B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR970473A 1996-09-04 1997-09-03 6-0-substituted ketolides having antibacterial activity HRP970473B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70777696A 1996-09-04 1996-09-04
US08/888,350 US5866549A (en) 1996-09-04 1997-07-03 6-O-substituted ketolides having antibacterial activity

Publications (2)

Publication Number Publication Date
HRP970473A2 HRP970473A2 (en) 1998-08-31
HRP970473B1 true HRP970473B1 (en) 2007-02-28

Family

ID=27107953

Family Applications (5)

Application Number Title Priority Date Filing Date
HR970473A HRP970473B1 (en) 1996-09-04 1997-09-03 6-0-substituted ketolides having antibacterial activity
HRP20060275AA HRP20060275B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja
HRP20060277AA HRP20060277B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja
HRP20060276AA HRP20060276B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja
HRP20060278AA HRP20060278B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja

Family Applications After (4)

Application Number Title Priority Date Filing Date
HRP20060275AA HRP20060275B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja
HRP20060277AA HRP20060277B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja
HRP20060276AA HRP20060276B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja
HRP20060278AA HRP20060278B1 (hr) 1996-09-04 2006-08-11 6-0-supstituirani ketolidi antibakterijskog djelovanja

Country Status (27)

Country Link
US (4) US6028181A (cs)
EP (5) EP1291351B1 (cs)
JP (1) JP4597274B2 (cs)
KR (5) KR100523679B1 (cs)
CN (4) CN100441591C (cs)
AT (5) ATE296307T1 (cs)
BG (1) BG63547B1 (cs)
BR (1) BR9711661A (cs)
CA (1) CA2263972C (cs)
CZ (1) CZ300106B6 (cs)
DE (5) DE69733369T2 (cs)
DK (5) DK1291352T3 (cs)
ES (5) ES2242812T3 (cs)
HR (5) HRP970473B1 (cs)
HU (1) HU230166B1 (cs)
ID (1) ID19406A (cs)
IL (1) IL128681A0 (cs)
NO (1) NO314230B1 (cs)
NZ (1) NZ334274A (cs)
PL (1) PL188173B1 (cs)
PT (5) PT1291351E (cs)
RO (1) RO121473B1 (cs)
RU (1) RU2192427C2 (cs)
SI (1) SI20023B (cs)
SK (5) SK285536B6 (cs)
TR (1) TR199901127T2 (cs)
WO (1) WO1998009978A1 (cs)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
ES2199524T3 (es) 1998-04-24 2004-02-16 Pfizer Products Inc. Derivados 9a,11b-deshidro de 9-oxima-3-ceto-6-o-metileritromicina.
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2792637B1 (fr) * 1999-04-26 2001-06-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2780977B1 (fr) * 1998-07-09 2000-09-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
HK1049010A1 (zh) 1998-11-03 2003-04-25 辉瑞产品公司 新的大环内酯抗生素
HUP0201067A3 (en) * 1999-03-15 2004-07-28 Abbott Lab 6-o-substituted macrolides having antibacterial activity, pharmaceutical compositions containing them, their use and process for preparation of the compounds
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
AU773678B2 (en) * 1999-04-16 2004-06-03 Kosan Biosciences, Inc. Macrolide antiinfective agents
MXPA01012661A (es) * 1999-06-07 2002-07-22 Abbott Lab Derivados de 6-o-carbamato quetolida.
US6420535B1 (en) * 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
EP1101769A3 (en) 1999-11-18 2001-10-24 Pfizer Products Inc. Nitrogen containing erythromycin derivatives
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
CA2451391A1 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
WO2003024986A1 (en) 2001-09-17 2003-03-27 Ortho-Mcneil Pharmaceutical, Inc. 6-o-carbamate-11,12-lacto-ketolide antimicrobials
US6673774B2 (en) * 2001-12-03 2004-01-06 Enanta Pharmaceuticals, Inc. 11-O-substituted macrolides and their descladinose derivatives
NZ533282A (en) 2001-12-05 2006-09-29 Ortho Mcneil Pharm Inc 6-O-Acyl ketolide derivatives of erythromycine useful as antibacterials
US20030162729A1 (en) * 2002-02-13 2003-08-28 Zhenkun Ma Macrolides with activity against methicillin-resistant staphylococcus aureus
US6831068B2 (en) * 2002-02-13 2004-12-14 Abbott Laboratories Macrolide antibacterial compounds
EP1474431A2 (en) * 2002-02-13 2004-11-10 Abbott Laboratories Macrolide antibacterial compounds
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
CA2487918A1 (en) * 2002-05-31 2003-12-11 Janssen Pharmaceutica N.V. 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents
JPWO2004078771A1 (ja) * 2003-03-07 2006-06-08 大正製薬株式会社 ２−フルオロ−６−ｏ−置換ケトライド誘導体
CA2801100A1 (en) * 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Macrolides and processes for their preparation
CA2523541A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Novel ketolide derivatives
US6790835B1 (en) * 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
US20040254126A1 (en) * 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
US20050101548A1 (en) * 2003-09-12 2005-05-12 Xiaodong Lin Antimicrobial derivatives
GB0327720D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
WO2005067564A2 (en) * 2004-01-07 2005-07-28 Enanta Pharmaceuticals, Inc. 6-11 bicyclic erythromycin derivatives
US7265094B2 (en) * 2004-01-09 2007-09-04 Enanta Pharmaceuticals, Inc. 9N-substituted 6-11 bicyclic erythromycin derivatives
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
JP2008508322A (ja) * 2004-07-28 2008-03-21 ランバクシー ラボラトリーズ リミテッド 抗菌剤としてのケトライド誘導体
BRPI0514381A (pt) * 2004-07-30 2008-06-10 Palumed Sa compostos hìbridos de aminoquinolina-antibiótico, composições farmacêuticas, método de preparação e uso destes
FR2874922A1 (fr) * 2004-07-30 2006-03-10 Palumed Sa Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
US7312201B2 (en) * 2004-12-13 2007-12-25 Enanta Pharmaceuticals, Inc. Tetracyclic bicyclolides
MX2007007598A (es) * 2004-12-21 2007-07-25 Pfizer Prod Inc Macrolidos.
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US7517859B2 (en) * 2005-05-04 2009-04-14 Enanta Pharmaceuticals, Inc. Spirocyclic bicyclolides
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
JP5015016B2 (ja) 2006-02-07 2012-08-29 大正製薬株式会社 １０ａ−アザライド化合物
WO2008023248A2 (en) 2006-08-24 2008-02-28 Wockhardt Research Centre Novel macrolides and ketolides having antimicrobial activity
JPWO2009019868A1 (ja) 2007-08-06 2010-10-28 大正製薬株式会社 １０ａ、１２位架橋型１０ａ−アザライド化合物
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
EP2203435B1 (en) * 2007-09-17 2018-07-18 Enanta Pharmaceuticals, Inc. 6, 11-bridged biaryl macrolides
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
CN101917850B (zh) 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
WO2009139181A1 (ja) 2008-05-15 2009-11-19 大正製薬株式会社 ４員環構造を有する１０ａ－アザライド化合物
JP5602748B2 (ja) * 2008-10-24 2014-10-08 センプラ ファーマシューティカルズ，インコーポレイテッド トリアゾール含有マクロライドを用いた生体防御
AU2010252641B2 (en) 2009-05-27 2015-09-17 Wockhardt Research Centre Ketolide compounds having antimicrobial activity
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN102724874B (zh) 2009-09-10 2018-06-01 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
HRP20160168T1 (hr) 2010-03-22 2016-03-25 Cempra Pharmaceuticals Inc Kristalne forme makrolida i njihova uporaba
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
NZ623574A (en) 2010-12-09 2015-07-31 Wockhardt Ltd Ketolide compounds
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
JP5718488B2 (ja) 2011-03-01 2015-05-13 ウォックハート リミテッド ケトライド中間体の調製方法
US8993739B2 (en) 2011-03-22 2015-03-31 Wockhardt Ltd. Process for preparation of ketolide compounds
CN102766181A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 6-o-取代的红霉素衍生物的制备方法
CN102766089A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 3-(3-喹啉基)-2-丙烯-1-卤代物及其制备方法
CA2868262A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
GB201217310D0 (en) 2012-09-27 2012-11-14 C10 Pharma As Compounds
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
WO2018067663A2 (en) * 2016-10-04 2018-04-12 Biopharmati Sa Ketolides having antibacterial activity
WO2018161039A1 (en) * 2017-03-03 2018-09-07 Synovo Gmbh Novel anti-infective and anti-inflammatory compounds
CN109942653B (zh) * 2019-02-27 2021-06-25 北京理工大学 一种红霉素衍生物及其制备方法
AU2020395150A1 (en) 2019-12-02 2022-06-23 AliquantumRx, Inc. Salts and polymorphs of cethromycin for the treatment of disease salts and polymorphs of cethromycin
CN113817008B (zh) * 2021-07-15 2023-05-23 湖州师范学院 新型琥珀酰基十六元大环内酯的制备方法及用途

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
KR930702369A (ko) * 1990-10-15 1993-09-08 우에노 아키라 에리쓰로마이신 또는 그의 유도체의 2'위치 수식 화합물
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
EP0559896B1 (en) * 1990-11-28 1997-08-27 Taisho Pharmaceutical Co. Ltd 6-o-methylerythromycin a derivative
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
CA2093303C (en) * 1992-04-09 1998-11-24 Abraham Araya Aluminosilicates
ES2087737T3 (es) * 1992-04-22 1996-07-16 Taisho Pharmaceutical Co Ltd Un derivado 5-o-desosaminil-eritronoluro a.
JP3259429B2 (ja) * 1992-04-22 2002-02-25 大正製薬株式会社 ５−ｏ−デソサミニルエリスロノライドａ誘導体
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2713226B1 (fr) * 1993-12-03 1996-01-05 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732684B1 (fr) * 1995-04-06 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2738571B1 (fr) * 1995-09-11 1997-10-17 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
US6274715B1 (en) * 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
KR19990067492A (ko) * 1995-11-08 1999-08-25 스티븐 에프. 웨인스톡 트리사이클릭 에리트로마이신 유도체
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AU4472797A (en) * 1996-10-31 1998-05-22 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6171807B1 (en) * 1996-11-13 2001-01-09 Associates Of Cape Cod, Inc. Detection and quantitation of endotoxin by fluorescence polarization

Also Published As

Publication number Publication date
TR199901127T2 (xx) 1999-07-21
DE69733723T2 (de) 2006-04-20
KR100568455B1 (ko) 2006-04-07
DK1291351T3 (da) 2005-10-24
HRP20060276A2 (en) 2007-10-31
ES2242983T3 (es) 2005-11-16
KR20050044815A (ko) 2005-05-12
USRE39591E1 (en) 2007-04-24
ATE299508T1 (de) 2005-07-15
PT1291352E (pt) 2005-09-30
HRP20060275B1 (hr) 2014-04-11
US6147197A (en) 2000-11-14
SK286181B6 (sk) 2008-04-07
IL128681A0 (en) 2000-01-31
CN100441591C (zh) 2008-12-10
PL188173B1 (pl) 2004-12-31
DK1291352T3 (da) 2005-09-19
CA2263972A1 (en) 1998-03-12
HRP20060276B1 (hr) 2014-04-25
US6028181A (en) 2000-02-22
HRP970473A2 (en) 1998-08-31
RU2192427C2 (ru) 2002-11-10
HRP20060275A2 (en) 2007-10-31
DE69733439D1 (de) 2005-07-07
DE69733370T2 (de) 2006-02-02
NZ334274A (en) 2001-02-23
CN1237183A (zh) 1999-12-01
BG63547B1 (bg) 2002-04-30
RO121473B1 (ro) 2007-06-29
ES2242811T3 (es) 2005-11-16
ID19406A (id) 1998-07-09
KR20050044816A (ko) 2005-05-12
CA2263972C (en) 2008-01-29
EP1291350B1 (en) 2005-05-25
SK285536B6 (sk) 2007-03-01
US6075133A (en) 2000-06-13
HK1021537A1 (en) 2000-06-16
SK28699A3 (en) 2000-03-13
DK0929563T3 (da) 2005-10-03
DE69733439T2 (de) 2006-05-04
CN1680418A (zh) 2005-10-12
SK285535B6 (sk) 2007-03-01
HUP9902869A3 (en) 2001-04-28
KR20050043993A (ko) 2005-05-11
CN1273475C (zh) 2006-09-06
DE69733369T2 (de) 2006-01-26
CZ68599A3 (cs) 1999-08-11
EP1291351A1 (en) 2003-03-12
KR20000068435A (ko) 2000-11-25
EP1291350A1 (en) 2003-03-12
EP1291352A1 (en) 2003-03-12
ES2244716T3 (es) 2005-12-16
ATE296308T1 (de) 2005-06-15
ATE296307T1 (de) 2005-06-15
ATE296832T1 (de) 2005-06-15
JP2001500855A (ja) 2001-01-23
EP1291353A1 (en) 2003-03-12
DK1291350T3 (da) 2005-09-26
DE69733422T2 (de) 2006-05-04
HU230166B1 (hu) 2015-09-28
CN1680420A (zh) 2005-10-12
SI20023B (en) 2001-02-28
SK285533B6 (sk) 2007-03-01
PT929563E (pt) 2005-10-31
CZ300106B6 (cs) 2009-02-11
SK285534B6 (sk) 2007-03-01
HUP9902869A2 (hu) 2000-02-28
DE69733422D1 (de) 2005-07-07
AU4178097A (en) 1998-03-26
PT1291350E (pt) 2005-09-30
DE69733723D1 (de) 2005-08-18
EP1291352B1 (en) 2005-05-25
DE69733369D1 (de) 2005-06-30
SI20023A (sl) 2000-02-29
NO314230B1 (no) 2003-02-17
PT1291353E (pt) 2005-10-31
BG103292A (en) 1999-12-30
AU729348B2 (en) 2001-02-01
ATE296831T1 (de) 2005-06-15
KR100576988B1 (ko) 2006-05-10
NO991022D0 (no) 1999-03-02
EP0929563B1 (en) 2005-06-01
WO1998009978A1 (en) 1998-03-12
HRP20060278B1 (hr) 2014-04-11
HRP20060278A2 (en) 2007-10-31
HRP20060277B1 (hr) 2014-04-11
PL332009A1 (en) 1999-08-16
JP4597274B2 (ja) 2010-12-15
EP0929563A1 (en) 1999-07-21
CN100460415C (zh) 2009-02-11
KR20050043994A (ko) 2005-05-11
EP1291351B1 (en) 2005-07-13
HRP20060277A2 (en) 2007-10-31
BR9711661A (pt) 1999-08-24
EP1291353B1 (en) 2005-06-01
KR100523679B1 (ko) 2005-10-26
DE69733370D1 (de) 2005-06-30
CN1680419A (zh) 2005-10-12
PT1291351E (pt) 2005-11-30
KR100610043B1 (ko) 2006-08-08
ES2242813T3 (es) 2005-11-16
NO991022L (no) 1999-05-03
ES2242812T3 (es) 2005-11-16
DK1291353T3 (da) 2005-10-03

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