YU178391A - Jedinjenja 7-acil-3(supstituisanih karbamoiloksi) cefema i postupak za njihovo dobijanje - Google Patents

Jedinjenja 7-acil-3(supstituisanih karbamoiloksi) cefema i postupak za njihovo dobijanje

Info

Publication number
YU178391A
YU178391A YU178391A YU178391A YU178391A YU 178391 A YU178391 A YU 178391A YU 178391 A YU178391 A YU 178391A YU 178391 A YU178391 A YU 178391A YU 178391 A YU178391 A YU 178391A
Authority
YU
Yugoslavia
Prior art keywords
compounds
cefema
acyl
obtaining
substituted carbamoyloxy
Prior art date
Application number
YU178391A
Other languages
English (en)
Other versions
YU48399B (sh
Inventor
S. Negi
M. Yamanaka
K. Katsu
J. Sugiyama
Y. Komatu
A. Kamata
A. Tsuruoka
Y. Machida
Original Assignee
Eisai Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2302783A external-priority patent/JPH04178392A/ja
Priority claimed from JP3040747A external-priority patent/JPH05331174A/ja
Priority claimed from JP6770991A external-priority patent/JPH04282388A/ja
Priority claimed from JP16951291A external-priority patent/JPH05331173A/ja
Application filed by Eisai Co. Ltd. filed Critical Eisai Co. Ltd.
Publication of YU178391A publication Critical patent/YU178391A/sh
Publication of YU48399B publication Critical patent/YU48399B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Jedinjenja 7-acil-3-supstituisanih karbamoiloksi cefema predstavljeno sledećom formulom (I): u kooj A označava -CH= ili -N= grupu; R1 označava hidroksil, niži alkoksil, fluor-supstituisan niži alkoksil, ili zaštićenu hidroksil grupu; R2 i R3 su isti ili različiti i pojedinačno predstavljaju niži alkil, hidroksil-supstituisan niži alkil, karbamoil-supstituisanu nižu alkil grupu, ili cijano-supstituisanu nižu alkil grupu, R2 je atom vodonika i R3 je niži alkoksil ili alkil grupa neobavezno supstituisana sa jednim ili više halogenih atoma, ili grupa -N R2 koja označava 4-6-očlanu heterocikličnu grupu, koja sadrži jedan atom azota, ili morfolin grupu, pomenuta heterociklična grupa, ili morfolin grupa bivaju neobavezno supstituisane sa jednim ili više nižih alkila, hidroksil i/ili hidroksil-supstituisanim nižim alkil grupama i R4 označava karboksil ili zaštićenu karboksil grupu ili njegovu farmaceutski prihvatljivu so i postupak za njihovo pripremanje isto kao i jedan antibakterijski sastav koji sadrži gornje cefem jedinjenje.
YU178391A 1990-11-09 1991-11-08 Jedinjenja 7-acil-3-(supstituisanih karbamoiloksi) cefema i postupak za njihovo dobijanje YU48399B (sh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2302783A JPH04178392A (ja) 1990-11-09 1990-11-09 ７―アシル―３―置換カルバモイルオキシセフェム化合物およびその製造法
JP3040747A JPH05331174A (ja) 1991-02-14 1991-02-14 ７−アシル−３−置換カルバモイルオキシセフェム化合物およびその製造法
JP6770991A JPH04282388A (ja) 1991-03-08 1991-03-08 ７−置換−３−ジメチルカルバモイルオキシメチル−３−セフェム化合物の製造法およびその中間体
JP16951291A JPH05331173A (ja) 1991-04-12 1991-04-12 ７−置換−３−アリールオキシカルボニルオキシメチル−３−セフェム化合物及びその製造法

Publications (2)

Publication Number Publication Date
YU178391A true YU178391A (sh) 1994-01-20
YU48399B YU48399B (sh) 1998-07-10

Family

ID=27460944

Family Applications (1)

Application Number Title Priority Date Filing Date
YU178391A YU48399B (sh) 1990-11-09 1991-11-08 Jedinjenja 7-acil-3-(supstituisanih karbamoiloksi) cefema i postupak za njihovo dobijanje

Country Status (20)

Country Link
US (5) US5559225A (sh)
EP (4) EP1074553A1 (sh)
JP (2) JP2867192B2 (sh)
KR (1) KR0166378B1 (sh)
CN (2) CN1038589C (sh)
AT (2) ATE200492T1 (sh)
AU (2) AU654300B2 (sh)
CA (1) CA2054895C (sh)
DE (2) DE69132580T2 (sh)
DK (1) DK0484966T3 (sh)
ES (1) ES2155433T3 (sh)
FI (1) FI915245A (sh)
GR (1) GR3036157T3 (sh)
HU (1) HU221429B (sh)
IL (3) IL99898A (sh)
NO (1) NO302417B1 (sh)
NZ (1) NZ240441A (sh)
PT (1) PT99468B (sh)
RU (1) RU2091378C1 (sh)
YU (1) YU48399B (sh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05230068A (ja) * 1992-02-07 1993-09-07 Kyoto Yakuhin Kogyo Kk ３−ジ置換カルバモイルオキシメチルセファロスポリン化合物、その製造法および中間体化合物
AT401651B (de) * 1994-06-14 1996-11-25 Biochemie Gmbh 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroximinoacetamido)-3-n,n- dimethylcarbamoyloxymethyl-3-cephem-4-
KR100197788B1 (ko) * 1995-06-30 1999-06-15 김충환 세펨 유도체의 제조방법
US6093814A (en) * 1995-12-27 2000-07-25 Hanmi Pharmaceutical Co., Ltd. Process for preparation of cefdinir
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
CA2491503A1 (en) * 2003-12-24 2005-06-24 Chic Optic Inc. Eyeglasses with living hinge
CN102633816A (zh) * 2012-03-30 2012-08-15 李莎 头孢西丁酯化前体药物化合物及口服制剂
US11222768B2 (en) * 2018-09-07 2022-01-11 Varian Semiconductor Equipment Associates, Inc. Foam in ion implantation system
CN112321606B (zh) * 2020-11-04 2022-05-17 福安药业集团重庆博圣制药有限公司 头孢唑肟钠及其中间体的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7412541A (nl) * 1973-10-12 1975-04-15 Merck & Co Inc Werkwijze voor het bereiden van cefalosporinen, ijze ter bereiding van farmaceutische raten, alsmede de door toepassing daarvan ardigde voorwerpen.
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2760484C2 (sh) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
US4327093A (en) * 1978-10-24 1982-04-27 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds
JPS60190783A (ja) * 1983-12-21 1985-09-28 Sumitomo Seiyaku Kk セフエム系化合物
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
US4705704A (en) * 1985-10-01 1987-11-10 General Electric Company Novel aminofunctional polysiloxane emulsions for treating textiles
FI872879A (fi) * 1986-07-21 1988-01-22 Sankei Yakuhin Kk --laktamfoerening, foerfarande foer dess framstaellning, denna innehaollande laekemedelskomposition foer behandling av sjukdom med bakterieinfektion samt mellanprodukter foer dess syntes.
GB8623211D0 (en) * 1986-09-26 1986-10-29 Glaxo Group Ltd Chemical compounds
AU1630988A (en) * 1987-05-30 1988-12-01 Kyoto Pharmaceutical Industries, Ltd. Cephalosporin compound and pharmaceutical composition thereof
JPH0796240B2 (ja) 1987-08-13 1995-10-18 小島プレス工業株式会社 表皮を有する複合成形体
GB2210876A (en) * 1987-10-14 1989-06-21 Glaxo Group Ltd Cephalosporins
DK637888A (da) * 1987-11-24 1989-05-25 Hoffmann La Roche Carboxylsyreestere
CN1018091B (zh) * 1988-01-11 1992-09-02 吉林工业大学 晶体管噪声成份分析与测试系统
CN1015637B (zh) * 1988-02-25 1992-02-26 中国石油化工总公司石油化工科学研究院 含β沸石的烃重整催化剂
GB8907617D0 (en) * 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
JPH0346474A (ja) 1989-07-14 1991-02-27 Victor Co Of Japan Ltd 情報信号記録円盤及びその記録装置
EP0531875B1 (de) * 1991-09-07 2004-03-24 Aventis Pharma Deutschland GmbH Diastereomer des 3-Cephem-4-carbonsäure-1-(-isopropoxycarbonyloxy)ethylesters und Verfahren zu dessen Herstellung

Also Published As

Publication number Publication date
IL99898A0 (en) 1992-08-18
CN1056847C (zh) 2000-09-27
NO914375L (no) 1992-05-11
KR920009834A (ko) 1992-06-25
EP1074553A1 (en) 2001-02-07
CN1038589C (zh) 1998-06-03
PT99468A (pt) 1992-10-30
ATE200291T1 (de) 2001-04-15
IL99898A (en) 1996-10-31
DE69132580D1 (de) 2001-05-17
PT99468B (pt) 1999-04-30
US5587473A (en) 1996-12-24
CA2054895A1 (en) 1992-05-10
FI915245A0 (fi) 1991-11-06
JPH0692969A (ja) 1994-04-05
DE69132580T2 (de) 2001-10-25
JPH1067784A (ja) 1998-03-10
EP0484966A3 (en) 1993-03-10
KR0166378B1 (ko) 1999-01-15
US5604217A (en) 1997-02-18
DK0484966T3 (da) 2001-05-07
AU8709691A (en) 1992-05-14
JP3143829B2 (ja) 2001-03-07
IL113744A (en) 1998-06-15
HUT60275A (en) 1992-08-28
IL113744A0 (en) 1995-08-31
ATE200492T1 (de) 2001-04-15
EP1074554A2 (en) 2001-02-07
CN1140175A (zh) 1997-01-15
CA2054895C (en) 2001-02-13
NO914375D0 (no) 1991-11-08
HU913520D0 (en) 1992-01-28
CN1061602A (zh) 1992-06-03
EP0484966B1 (en) 2001-04-11
YU48399B (sh) 1998-07-10
DE69132578D1 (de) 2001-05-10
RU2091378C1 (en) 1997-09-27
DE69132578T2 (de) 2001-08-23
NZ240441A (en) 1993-03-26
HU221429B (en) 2002-10-28
US5559225A (en) 1996-09-24
US5741902A (en) 1998-04-21
NO302417B1 (no) 1998-03-02
EP0761671B1 (en) 2001-04-04
EP1074554A3 (en) 2001-02-28
EP0484966A2 (en) 1992-05-13
GR3036157T3 (en) 2001-09-28
AU654300B2 (en) 1994-11-03
EP0761671A1 (en) 1997-03-12
AU5057193A (en) 1994-01-20
JP2867192B2 (ja) 1999-03-08
FI915245A (fi) 1992-05-10
AU671310B2 (en) 1996-08-22
US5563265A (en) 1996-10-08
ES2155433T3 (es) 2001-05-16

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