PE20010750A1 - Derivados de espiro [2h-1-benzopiran-2,4`-piperidina] - Google Patents

Derivados de espiro [2h-1-benzopiran-2,4`-piperidina]

Info

Publication number
PE20010750A1
PE20010750A1 PE2000001227A PE0012272000A PE20010750A1 PE 20010750 A1 PE20010750 A1 PE 20010750A1 PE 2000001227 A PE2000001227 A PE 2000001227A PE 0012272000 A PE0012272000 A PE 0012272000A PE 20010750 A1 PE20010750 A1 PE 20010750A1
Authority
PE
Peru
Prior art keywords
alkyl
benzopyran
piperidine
cfo2
nr3so2r4
Prior art date
Application number
PE2000001227A
Other languages
English (en)
Inventor
David John Miller
Samuel George Gibson
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of PE20010750A1 publication Critical patent/PE20010750A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS ESPIRO[2H-1-BENZOPIRAN-2,4`-PIPERIDINA] DE FORMULA I, DONDE Y ES H, HALOGENO, ALQUILO C1-C6, ALQUILOXI C1-C6, ALQUENILOXI C2-C6, ALQUINILOXI C2-C6, CICLOALQUILOXI C3-C6, ARILOXI C6-C12, ARILALQUILOXI C7-C15, HETEROARILOXI, HETEROARILALQUILOXI, SR3, NR3R4, OSO2R5, NR3SO2R4, DOS SUSTITUYENTES FORMAN O-(CH2)n-O, O-(CF2)n-O; n ES 1-2; X ES H, HALOGENO, OH, ALQUILOXI C1-C4, SR3, NR3SO2R4, ALQUILO C1-C4; R1 ES H, ALQUILO C1-C4, ARILO C6-C12; R2, R3, R4 SON H, ALQUILO C1-C4; R5 ES ALQUILO C1-C4, ARILO C6-C12. LOS COMPUESTOS INHIBEN SELECTIVAMENTE EL TRANSPORTE DE GLICINA POR EL TRANSPORTADOR GLYT-1 HUMANO Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE LA ESQUIZOFRENIA, DEPRESION, DEMENCIA, DETERIORO COGNITIVO
PE2000001227A 1999-11-17 2000-11-16 Derivados de espiro [2h-1-benzopiran-2,4`-piperidina] PE20010750A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99309137 1999-11-17

Publications (1)

Publication Number Publication Date
PE20010750A1 true PE20010750A1 (es) 2001-07-19

Family

ID=8241739

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001227A PE20010750A1 (es) 1999-11-17 2000-11-16 Derivados de espiro [2h-1-benzopiran-2,4`-piperidina]

Country Status (29)

Country Link
US (2) US6645973B1 (es)
EP (1) EP1232160B1 (es)
JP (1) JP4825386B2 (es)
KR (1) KR100776226B1 (es)
CN (1) CN1199974C (es)
AR (1) AR026487A1 (es)
AT (1) ATE398622T1 (es)
AU (1) AU779518B2 (es)
BR (1) BR0015586A (es)
CA (1) CA2389491C (es)
CO (1) CO5261618A1 (es)
CY (1) CY1108339T1 (es)
CZ (1) CZ293920B6 (es)
DE (1) DE60039247D1 (es)
DK (1) DK1232160T3 (es)
ES (1) ES2307536T3 (es)
HK (1) HK1047282B (es)
HU (1) HUP0204162A3 (es)
IL (2) IL149286A0 (es)
NO (1) NO327743B1 (es)
NZ (1) NZ518671A (es)
PE (1) PE20010750A1 (es)
PL (1) PL206071B1 (es)
PT (1) PT1232160E (es)
RU (1) RU2250211C2 (es)
SK (1) SK287040B6 (es)
TW (1) TWI243173B (es)
WO (1) WO2001036423A1 (es)
ZA (1) ZA200203320B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
FR2842804B1 (fr) * 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
KR101255074B1 (ko) 2003-10-01 2013-04-16 아돌로 코포레이션 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법
CN100413865C (zh) * 2004-01-08 2008-08-27 弗·哈夫曼-拉罗切有限公司 二氮杂-螺哌啶衍生物
AU2004313692B2 (en) * 2004-01-08 2011-07-28 F. Hoffmann-La Roche Ag Diaza-spiropiperidine derivatives as inhibitors of glycine transporter 1 and glycine transporter 2
WO2005092442A2 (en) * 2004-03-22 2005-10-06 Apkarian Vania A Method and compositions for treatment of chronic neuropathic pain
CN101184749B (zh) * 2005-03-31 2012-12-05 阿得罗公司 螺环杂环衍生物及其使用方法
US7598261B2 (en) * 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US20090186901A1 (en) * 2006-05-05 2009-07-23 Ulrich Reiser Chemical compounds
JP2010503669A (ja) * 2006-09-12 2010-02-04 アドラー コーポレーション 認知機能の強化のためのｎ含有スピロ化合物の使用
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
KR100888468B1 (ko) * 2007-08-31 2009-03-11 한국화학연구원 항암활성을 갖는1'-알킬피페리딘-4'-스피로-2-6-(아미도)-2ｈ-벤조피란유도체
US20100317679A1 (en) * 2007-09-21 2010-12-16 Ligand Pharmaceuticals, Inc. Substituted aryl-fused spirocyclic amines
EP2380595A1 (en) 2010-04-19 2011-10-26 Nlife Therapeutics S.L. Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
TW201643169A (zh) * 2010-07-09 2016-12-16 艾伯維股份有限公司 作為s1p調節劑的螺-哌啶衍生物
US20170143681A1 (en) 2015-11-02 2017-05-25 Apkarian Technologies Llc Methods and compositions for treating pain
CN116621187B (zh) * 2023-07-24 2023-09-22 江苏泓顺硅基半导体科技有限公司 一种用于高温氯化提纯石英砂的设备

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
FR2689509B1 (fr) * 1992-04-01 1994-06-03 Adir Nouveaux derives spiraniques du 3-amino chromane, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DK78692D0 (da) 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
IL107881A0 (en) 1992-12-05 1994-04-12 Fisons Corp Furanone derivatives and pharmaceutical compositions containing them
CA2155108A1 (en) * 1993-02-12 1994-08-18 John J. Baldwin Nitrogen-containing spirocycles
US5484923A (en) * 1993-06-10 1996-01-16 Merck & Co., Inc. Process of making spirocycles and analogs thereof
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
GB9421003D0 (en) * 1994-10-18 1994-12-07 Smithkline Beecham Plc Novel compounds
US5654316A (en) * 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
PT871440E (pt) 1995-12-07 2006-07-31 Daniel C Javitt Tratamento de sintomas negativos e cognitivos de esquizofrenia com antagonistas da captacao de glicina
HUP9600928A3 (en) 1996-04-10 1999-03-29 Richter Gedeon Vegyeszet Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation
SI1014966T1 (sl) 1996-05-31 2006-10-31 Allelix Neuroscience Inc Zdravilo za zdravljenje nevroloskih in nevripsihiatricnih bolezni
WO1997045423A1 (en) 1996-05-31 1997-12-04 Trophix Neuroscience Inc. Pharmaceutical for treating of neurological and neuropsychiatric disorders
US5919653A (en) 1996-08-20 1999-07-06 Allelix Neuroscience Inc. Nucleic acids encoding a human glycine transporter
AU2030999A (en) 1998-01-09 1999-07-26 Allelix Neuroscience, Inc. Glycine transport inhibitors
TW555757B (en) 1998-07-31 2003-10-01 Akzo Nobel Nv Aminomethylcarboxylic acid derivatives
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
DE60107832T2 (de) * 2000-04-27 2005-06-16 Basilea Pharmaceutica Ag Chromenylmethylpyrimidindiamine als antibakterielle wirkstoffe

Also Published As

Publication number Publication date
JP4825386B2 (ja) 2011-11-30
US7507824B2 (en) 2009-03-24
CA2389491C (en) 2010-11-02
KR20020050287A (ko) 2002-06-26
ES2307536T3 (es) 2008-12-01
IL149286A0 (en) 2002-11-10
CZ293920B6 (cs) 2004-08-18
US20040029904A1 (en) 2004-02-12
HUP0204162A3 (en) 2006-01-30
PL206071B1 (pl) 2010-06-30
CA2389491A1 (en) 2001-05-25
PT1232160E (pt) 2008-09-30
AU1521901A (en) 2001-05-30
EP1232160B1 (en) 2008-06-18
CO5261618A1 (es) 2003-03-31
IL149286A (en) 2008-08-07
JP2003527340A (ja) 2003-09-16
CZ20021724A3 (cs) 2002-08-14
DE60039247D1 (de) 2008-07-31
NZ518671A (en) 2003-10-31
HUP0204162A2 (hu) 2003-04-28
WO2001036423A1 (en) 2001-05-25
NO327743B1 (no) 2009-09-14
AR026487A1 (es) 2003-02-12
HK1047282B (zh) 2008-08-29
BR0015586A (pt) 2002-07-09
RU2250211C2 (ru) 2005-04-20
EP1232160A1 (en) 2002-08-21
TWI243173B (en) 2005-11-11
SK287040B6 (sk) 2009-10-07
SK8432002A3 (en) 2002-10-08
PL355975A1 (en) 2004-05-31
HK1047282A1 (en) 2003-02-14
CN1390221A (zh) 2003-01-08
DK1232160T3 (da) 2008-10-06
US6645973B1 (en) 2003-11-11
CY1108339T1 (el) 2014-02-12
KR100776226B1 (ko) 2007-11-16
AU779518B2 (en) 2005-01-27
NO20022320D0 (no) 2002-05-15
ZA200203320B (en) 2003-08-27
NO20022320L (no) 2002-05-15
ATE398622T1 (de) 2008-07-15
CN1199974C (zh) 2005-05-04

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed