IL149286A0 - Spiro(2h-1-benzopyran-2,4'-piperidine) derivatives as glycine transport inhibitors - Google Patents

Spiro(2h-1-benzopyran-2,4'-piperidine) derivatives as glycine transport inhibitors

Info

Publication number
IL149286A0
IL149286A0 IL14928600A IL14928600A IL149286A0 IL 149286 A0 IL149286 A0 IL 149286A0 IL 14928600 A IL14928600 A IL 14928600A IL 14928600 A IL14928600 A IL 14928600A IL 149286 A0 IL149286 A0 IL 149286A0
Authority
IL
Israel
Prior art keywords
benzopyran
spiro
piperidine
derivatives
transport inhibitors
Prior art date
Application number
IL14928600A
Other languages
English (en)
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of IL149286A0 publication Critical patent/IL149286A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL14928600A 1999-11-17 2000-11-13 Spiro(2h-1-benzopyran-2,4'-piperidine) derivatives as glycine transport inhibitors IL149286A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99309137 1999-11-17
PCT/EP2000/011351 WO2001036423A1 (en) 1999-11-17 2000-11-13 Spiro(2h-1-benzopyran-2,4'-piperidine) derivates as glycine transport inhibitors

Publications (1)

Publication Number Publication Date
IL149286A0 true IL149286A0 (en) 2002-11-10

Family

ID=8241739

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14928600A IL149286A0 (en) 1999-11-17 2000-11-13 Spiro(2h-1-benzopyran-2,4'-piperidine) derivatives as glycine transport inhibitors
IL149286A IL149286A (en) 1999-11-17 2002-04-23 History of Spiro (H2 1 - Benzopyran - 4,2 '- Piperidine) as Glycine Transfer Inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL149286A IL149286A (en) 1999-11-17 2002-04-23 History of Spiro (H2 1 - Benzopyran - 4,2 '- Piperidine) as Glycine Transfer Inhibitors

Country Status (29)

Country Link
US (2) US6645973B1 (xx)
EP (1) EP1232160B1 (xx)
JP (1) JP4825386B2 (xx)
KR (1) KR100776226B1 (xx)
CN (1) CN1199974C (xx)
AR (1) AR026487A1 (xx)
AT (1) ATE398622T1 (xx)
AU (1) AU779518B2 (xx)
BR (1) BR0015586A (xx)
CA (1) CA2389491C (xx)
CO (1) CO5261618A1 (xx)
CY (1) CY1108339T1 (xx)
CZ (1) CZ293920B6 (xx)
DE (1) DE60039247D1 (xx)
DK (1) DK1232160T3 (xx)
ES (1) ES2307536T3 (xx)
HK (1) HK1047282B (xx)
HU (1) HUP0204162A3 (xx)
IL (2) IL149286A0 (xx)
NO (1) NO327743B1 (xx)
NZ (1) NZ518671A (xx)
PE (1) PE20010750A1 (xx)
PL (1) PL206071B1 (xx)
PT (1) PT1232160E (xx)
RU (1) RU2250211C2 (xx)
SK (1) SK287040B6 (xx)
TW (1) TWI243173B (xx)
WO (1) WO2001036423A1 (xx)
ZA (1) ZA200203320B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
FR2842804B1 (fr) * 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
JP4976134B2 (ja) * 2003-10-01 2012-07-18 アドラー コーポレーション スピロ環複素環誘導体及びそれらを使用する方法
BRPI0418375A (pt) * 2004-01-08 2007-05-22 Hoffmann La Roche derivados de diaza-espiropiperidina
RU2351599C2 (ru) * 2004-01-08 2009-04-10 Ф.Хоффманн-Ля Рош Аг Диазаспиропиперидиновые производные в качестве ингибиторов глицинового переносчика 1 и глицинового переносчика 2
US20050209317A1 (en) * 2004-03-22 2005-09-22 Apkarian A V Method and compositions for treatment of chronic neuropathic pain
US7598261B2 (en) * 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
CN101184749B (zh) * 2005-03-31 2012-12-05 阿得罗公司 螺环杂环衍生物及其使用方法
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
CA2648831A1 (en) * 2006-05-05 2007-11-15 Ulrich Reiser Spiro- (tho) benzopyran-2, 4' -piperidine-and cyclohexane derivatives as inhibitors of specific cell cycle enzymes
CN101534819A (zh) * 2006-09-12 2009-09-16 阿得罗公司 含氮的螺环化合物用于增强认知功能的应用
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
KR100888468B1 (ko) * 2007-08-31 2009-03-11 한국화학연구원 항암활성을 갖는1'-알킬피페리딘-4'-스피로-2-6-(아미도)-2ｈ-벤조피란유도체
US20100317679A1 (en) * 2007-09-21 2010-12-16 Ligand Pharmaceuticals, Inc. Substituted aryl-fused spirocyclic amines
EP2380595A1 (en) 2010-04-19 2011-10-26 Nlife Therapeutics S.L. Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
TWI543984B (zh) * 2010-07-09 2016-08-01 艾伯維公司 作為s1p調節劑的螺-哌啶衍生物
US20170143681A1 (en) 2015-11-02 2017-05-25 Apkarian Technologies Llc Methods and compositions for treating pain
CN116621187B (zh) * 2023-07-24 2023-09-22 江苏泓顺硅基半导体科技有限公司 一种用于高温氯化提纯石英砂的设备

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
FR2689509B1 (fr) * 1992-04-01 1994-06-03 Adir Nouveaux derives spiraniques du 3-amino chromane, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
IL107881A0 (en) * 1992-12-05 1994-04-12 Fisons Corp Furanone derivatives and pharmaceutical compositions containing them
WO1994018204A1 (en) * 1993-02-12 1994-08-18 Merck & Co., Inc. Spiro (2h-1-benzopyran-2, 4' piperidine) class iii antiarrhythmics
US5484923A (en) * 1993-06-10 1996-01-16 Merck & Co., Inc. Process of making spirocycles and analogs thereof
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
GB9421003D0 (en) * 1994-10-18 1994-12-07 Smithkline Beecham Plc Novel compounds
US5654316A (en) 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
PT871440E (pt) 1995-12-07 2006-07-31 Daniel C Javitt Tratamento de sintomas negativos e cognitivos de esquizofrenia com antagonistas da captacao de glicina
HUP9600928A3 (en) * 1996-04-10 1999-03-29 Richter Gedeon Vegyeszet Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation
DK1014966T3 (da) 1996-05-31 2006-12-04 Allelix Neuroscience Inc Farmaceutisk præparat til behandling af neurologiske og neuropsykiatriske lidelser
CA2255727A1 (en) 1996-05-31 1997-12-04 Trophix Pharmaceuticals, Inc. Pharmaceutical for treating of neurological and neuropsychiatric disorders
US5919653A (en) 1996-08-20 1999-07-06 Allelix Neuroscience Inc. Nucleic acids encoding a human glycine transporter
AU2030999A (en) 1998-01-09 1999-07-26 Allelix Neuroscience, Inc. Glycine transport inhibitors
TW555757B (en) 1998-07-31 2003-10-01 Akzo Nobel Nv Aminomethylcarboxylic acid derivatives
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
MXPA02010518A (es) * 2000-04-27 2003-03-10 Basilea Pharmaceutica Ag Cromenilmetilpirimidindiaminas como agentes antibacterianos.

Also Published As

Publication number Publication date
DK1232160T3 (da) 2008-10-06
EP1232160B1 (en) 2008-06-18
HK1047282A1 (en) 2003-02-14
NO20022320D0 (no) 2002-05-15
AU1521901A (en) 2001-05-30
ZA200203320B (en) 2003-08-27
SK8432002A3 (en) 2002-10-08
IL149286A (en) 2008-08-07
PT1232160E (pt) 2008-09-30
US7507824B2 (en) 2009-03-24
KR20020050287A (ko) 2002-06-26
NO327743B1 (no) 2009-09-14
BR0015586A (pt) 2002-07-09
HK1047282B (zh) 2008-08-29
CY1108339T1 (el) 2014-02-12
HUP0204162A2 (hu) 2003-04-28
DE60039247D1 (de) 2008-07-31
JP2003527340A (ja) 2003-09-16
CA2389491C (en) 2010-11-02
AR026487A1 (es) 2003-02-12
SK287040B6 (sk) 2009-10-07
CN1390221A (zh) 2003-01-08
PL355975A1 (en) 2004-05-31
JP4825386B2 (ja) 2011-11-30
CZ20021724A3 (cs) 2002-08-14
NO20022320L (no) 2002-05-15
ES2307536T3 (es) 2008-12-01
ATE398622T1 (de) 2008-07-15
EP1232160A1 (en) 2002-08-21
US20040029904A1 (en) 2004-02-12
CN1199974C (zh) 2005-05-04
CO5261618A1 (es) 2003-03-31
AU779518B2 (en) 2005-01-27
TWI243173B (en) 2005-11-11
RU2250211C2 (ru) 2005-04-20
US6645973B1 (en) 2003-11-11
CZ293920B6 (cs) 2004-08-18
KR100776226B1 (ko) 2007-11-16
CA2389491A1 (en) 2001-05-25
HUP0204162A3 (en) 2006-01-30
PL206071B1 (pl) 2010-06-30
PE20010750A1 (es) 2001-07-19
WO2001036423A1 (en) 2001-05-25
NZ518671A (en) 2003-10-31

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