HUP0101736A2 - Izoxazolo[3,4-c]kinolin-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Izoxazolo[3,4-c]kinolin-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0101736A2 HUP0101736A2 HU0101736A HUP0101736A HUP0101736A2 HU P0101736 A2 HUP0101736 A2 HU P0101736A2 HU 0101736 A HU0101736 A HU 0101736A HU P0101736 A HUP0101736 A HU P0101736A HU P0101736 A2 HUP0101736 A2 HU P0101736A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- general formula
- substituted
- heterocyclic
- isoxazolo
- Prior art date
Links
- PPWRLAMDBATQMH-UHFFFAOYSA-N [1,2]oxazolo[3,4-c]quinoline Chemical class C1=CC=C2C3=CON=C3C=NC2=C1 PPWRLAMDBATQMH-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004343 1-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 101100496169 Arabidopsis thaliana CLH1 gene Proteins 0.000 abstract 1
- 101100044057 Mesocricetus auratus SYCP3 gene Proteins 0.000 abstract 1
- 101100080600 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nse6 gene Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 101150111293 cor-1 gene Proteins 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- -1 norbornan-2-yl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
A találmány tárgyát az (I) általános képletű vegyületek, ahol m értéke1-6, R jelentése hidrogénatom, COR1 általános képletű csoport,aminocsoport, NH-Pg vagy NHCOR2 általános képletű csoport, R1hidroxicsoport, 1-6 szénatomos alkoxi vagy NR3R4 általános képletűcsoport, Pg jelentése aminovédőcsoport, R2 jelentése 1-6 szénatomosalkilcsoport, szubsztituált 1-4 szénatomos alkilcsoport, arilcsoport,szubsztituált arilcsoport, (CH2)n-heterociklusos csoport vagyszubsztituált (CH2)n-heterociklusos csoport, R3 jelentése bármelymegjelenése esetén, egymástól függetlenül hidrogénatom vagy 1-6szénatomos alkilcsoport, R4 1-6 szénatomos alkilcsoport, norbornan-2-il-csoport, arilcsoport, szubsztituált arilcsoport, CH2(CH(CH3)-fenil-csoport, (CH2)n- heterociklusos csoport vagy szubsztituált (CH2)n-heterociklusos csoport; n értéke 0, 1 vagy 2 valamint ezen vegyületekgyógyászatilag elfogadható sói illetve szolvátjai képezik. Szintén atalálmány tárgyát képezik az ezen vegyületeket tartalmazógyógyszerkészítmények, illetve ezen vegyületek alkalmazása rákelleneskemoterápiás gyógyszerek előállításánál. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8107798P | 1998-04-08 | 1998-04-08 | |
| PCT/US1999/007343 WO1999051227A1 (en) | 1998-04-08 | 1999-04-07 | Methods for inhibiting mrp1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0101736A2 true HUP0101736A2 (hu) | 2001-11-28 |
| HUP0101736A3 HUP0101736A3 (en) | 2002-04-29 |
Family
ID=22161958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0101736A HUP0101736A3 (en) | 1998-04-08 | 1999-04-07 | Isoxazolo[3,4-c]quinoline derivatives, their use and pharmaceutical compositions containing them |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6417193B1 (hu) |
| EP (1) | EP1069897A1 (hu) |
| JP (1) | JP2002510624A (hu) |
| KR (1) | KR20010042482A (hu) |
| CN (1) | CN1296408A (hu) |
| AU (1) | AU3468099A (hu) |
| BR (1) | BR9909497A (hu) |
| CA (1) | CA2327706A1 (hu) |
| EA (1) | EA200001036A1 (hu) |
| HU (1) | HUP0101736A3 (hu) |
| ID (1) | ID27048A (hu) |
| IL (1) | IL138391A0 (hu) |
| NO (1) | NO20005042D0 (hu) |
| PL (1) | PL343312A1 (hu) |
| SK (1) | SK15002000A3 (hu) |
| TR (1) | TR200002803T2 (hu) |
| WO (1) | WO1999051227A1 (hu) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6743794B2 (en) | 1999-12-22 | 2004-06-01 | Eli Lilly And Company | Methods and compounds for inhibiting MRP1 |
| PT1250340E (pt) * | 1999-12-22 | 2005-04-29 | Lilly Co Eli | Metodos e compostos para inibicao de mrp1 |
| WO2001096346A1 (en) * | 2000-06-14 | 2001-12-20 | Eli Lilly And Company | Tricyclic compounds as mrp1-inhibitors |
| WO2002000624A2 (en) * | 2000-06-23 | 2002-01-03 | Eli Lilly And Company | Methods and compounds for inhibiting mrp1 |
| JP2004509897A (ja) * | 2000-09-22 | 2004-04-02 | イーライ・リリー・アンド・カンパニー | シクロヘキシルアミン誘導体の立体選択的製造方法 |
| US7037921B2 (en) | 2001-04-09 | 2006-05-02 | Eli Lilly And Company | Compounds and methods for inhibiting MRP1 |
| CN1281210C (zh) * | 2003-11-29 | 2006-10-25 | 胡汛 | 五味子乙素在制备治疗肿瘤药物中的应用 |
| CN104002843A (zh) * | 2014-05-29 | 2014-08-27 | 安徽银龙泵阀股份有限公司 | 一种减震效果好易于放置的双泵移动车 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
| US5717092A (en) | 1996-03-29 | 1998-02-10 | Vertex Pharmaceuticals Inc. | Compounds with improved multi-drug resistance activity |
-
1999
- 1999-04-07 TR TR2000/02803T patent/TR200002803T2/xx unknown
- 1999-04-07 PL PL99343312A patent/PL343312A1/xx not_active Application Discontinuation
- 1999-04-07 IL IL13839199A patent/IL138391A0/xx unknown
- 1999-04-07 KR KR1020007011102A patent/KR20010042482A/ko not_active Application Discontinuation
- 1999-04-07 ID IDW20002009A patent/ID27048A/id unknown
- 1999-04-07 HU HU0101736A patent/HUP0101736A3/hu unknown
- 1999-04-07 EP EP99916334A patent/EP1069897A1/en not_active Withdrawn
- 1999-04-07 US US09/646,074 patent/US6417193B1/en not_active Expired - Fee Related
- 1999-04-07 WO PCT/US1999/007343 patent/WO1999051227A1/en not_active Application Discontinuation
- 1999-04-07 JP JP2000541998A patent/JP2002510624A/ja not_active Withdrawn
- 1999-04-07 CA CA002327706A patent/CA2327706A1/en not_active Abandoned
- 1999-04-07 EA EA200001036A patent/EA200001036A1/ru unknown
- 1999-04-07 CN CN99804810A patent/CN1296408A/zh active Pending
- 1999-04-07 SK SK1500-2000A patent/SK15002000A3/sk unknown
- 1999-04-07 AU AU34680/99A patent/AU3468099A/en not_active Abandoned
- 1999-04-07 BR BR9909497-5A patent/BR9909497A/pt not_active Application Discontinuation
-
2000
- 2000-10-06 NO NO20005042A patent/NO20005042D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20005042L (no) | 2000-10-06 |
| EP1069897A1 (en) | 2001-01-24 |
| NO20005042D0 (no) | 2000-10-06 |
| CA2327706A1 (en) | 1999-10-14 |
| US6417193B1 (en) | 2002-07-09 |
| ID27048A (id) | 2001-02-22 |
| KR20010042482A (ko) | 2001-05-25 |
| BR9909497A (pt) | 2000-12-12 |
| JP2002510624A (ja) | 2002-04-09 |
| IL138391A0 (en) | 2001-10-31 |
| SK15002000A3 (sk) | 2001-06-11 |
| WO1999051227A1 (en) | 1999-10-14 |
| PL343312A1 (en) | 2001-08-13 |
| TR200002803T2 (tr) | 2000-12-21 |
| EA200001036A1 (ru) | 2001-04-23 |
| HUP0101736A3 (en) | 2002-04-29 |
| AU3468099A (en) | 1999-10-25 |
| CN1296408A (zh) | 2001-05-23 |
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