BR9909497A - Métodos para inibição da mrp1 - Google Patents
Métodos para inibição da mrp1Info
- Publication number
- BR9909497A BR9909497A BR9909497-5A BR9909497A BR9909497A BR 9909497 A BR9909497 A BR 9909497A BR 9909497 A BR9909497 A BR 9909497A BR 9909497 A BR9909497 A BR 9909497A
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- mrp1
- inhibiting
- inhibiting mrp1
- conferred
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: <B>"MéTODOS PARA INIBIçãO DA MRP1"<D>. A presente invenção refere-se a um composto de fórmula I: que é de utilidade para inibição de neoplasmas resistentes, em que a resistência é conferida em parte ou totalmente pela MRP1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8107798P | 1998-04-08 | 1998-04-08 | |
PCT/US1999/007343 WO1999051227A1 (en) | 1998-04-08 | 1999-04-07 | Methods for inhibiting mrp1 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9909497A true BR9909497A (pt) | 2000-12-12 |
Family
ID=22161958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9909497-5A BR9909497A (pt) | 1998-04-08 | 1999-04-07 | Métodos para inibição da mrp1 |
Country Status (17)
Country | Link |
---|---|
US (1) | US6417193B1 (pt) |
EP (1) | EP1069897A1 (pt) |
JP (1) | JP2002510624A (pt) |
KR (1) | KR20010042482A (pt) |
CN (1) | CN1296408A (pt) |
AU (1) | AU3468099A (pt) |
BR (1) | BR9909497A (pt) |
CA (1) | CA2327706A1 (pt) |
EA (1) | EA200001036A1 (pt) |
HU (1) | HUP0101736A3 (pt) |
ID (1) | ID27048A (pt) |
IL (1) | IL138391A0 (pt) |
NO (1) | NO20005042L (pt) |
PL (1) | PL343312A1 (pt) |
SK (1) | SK15002000A3 (pt) |
TR (1) | TR200002803T2 (pt) |
WO (1) | WO1999051227A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6743794B2 (en) | 1999-12-22 | 2004-06-01 | Eli Lilly And Company | Methods and compounds for inhibiting MRP1 |
CA2395513A1 (en) * | 1999-12-22 | 2001-06-28 | Rosanne Bonjouklian | Methods and compounds for inhibiting mrp1 |
EP1301518A1 (en) * | 2000-06-14 | 2003-04-16 | Eli Lilly And Company | Tricyclic compounds as mrp1-inhibitors |
CA2413579A1 (en) * | 2000-06-23 | 2002-01-03 | Eli Lilly And Company | Methods and compounds for inhibiting mrp1 |
WO2002024705A1 (en) * | 2000-09-22 | 2002-03-28 | Eli Lilly And Company | Stereoselective process for preparing cyclohexyl amine derivatives |
EP1392702B1 (en) * | 2001-04-09 | 2005-11-30 | Eli Lilly And Company | Compounds and methods for inhibiting mrp1 |
CN1281210C (zh) * | 2003-11-29 | 2006-10-25 | 胡汛 | 五味子乙素在制备治疗肿瘤药物中的应用 |
CN104002843A (zh) * | 2014-05-29 | 2014-08-27 | 安徽银龙泵阀股份有限公司 | 一种减震效果好易于放置的双泵移动车 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
US5717092A (en) | 1996-03-29 | 1998-02-10 | Vertex Pharmaceuticals Inc. | Compounds with improved multi-drug resistance activity |
-
1999
- 1999-04-07 JP JP2000541998A patent/JP2002510624A/ja not_active Withdrawn
- 1999-04-07 SK SK1500-2000A patent/SK15002000A3/sk unknown
- 1999-04-07 IL IL13839199A patent/IL138391A0/xx unknown
- 1999-04-07 WO PCT/US1999/007343 patent/WO1999051227A1/en not_active Application Discontinuation
- 1999-04-07 CN CN99804810A patent/CN1296408A/zh active Pending
- 1999-04-07 AU AU34680/99A patent/AU3468099A/en not_active Abandoned
- 1999-04-07 PL PL99343312A patent/PL343312A1/xx not_active Application Discontinuation
- 1999-04-07 CA CA002327706A patent/CA2327706A1/en not_active Abandoned
- 1999-04-07 EP EP99916334A patent/EP1069897A1/en not_active Withdrawn
- 1999-04-07 HU HU0101736A patent/HUP0101736A3/hu unknown
- 1999-04-07 US US09/646,074 patent/US6417193B1/en not_active Expired - Fee Related
- 1999-04-07 EA EA200001036A patent/EA200001036A1/ru unknown
- 1999-04-07 TR TR2000/02803T patent/TR200002803T2/xx unknown
- 1999-04-07 KR KR1020007011102A patent/KR20010042482A/ko not_active Application Discontinuation
- 1999-04-07 ID IDW20002009A patent/ID27048A/id unknown
- 1999-04-07 BR BR9909497-5A patent/BR9909497A/pt not_active Application Discontinuation
-
2000
- 2000-10-06 NO NO20005042A patent/NO20005042L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1999051227A1 (en) | 1999-10-14 |
CA2327706A1 (en) | 1999-10-14 |
KR20010042482A (ko) | 2001-05-25 |
HUP0101736A2 (hu) | 2001-11-28 |
SK15002000A3 (sk) | 2001-06-11 |
CN1296408A (zh) | 2001-05-23 |
US6417193B1 (en) | 2002-07-09 |
EP1069897A1 (en) | 2001-01-24 |
JP2002510624A (ja) | 2002-04-09 |
AU3468099A (en) | 1999-10-25 |
IL138391A0 (en) | 2001-10-31 |
ID27048A (id) | 2001-02-22 |
PL343312A1 (en) | 2001-08-13 |
TR200002803T2 (tr) | 2000-12-21 |
HUP0101736A3 (en) | 2002-04-29 |
NO20005042D0 (no) | 2000-10-06 |
EA200001036A1 (ru) | 2001-04-23 |
NO20005042L (no) | 2000-10-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |