PT885210E - Compostos triciclicos que possuem afinidade de ligacao para receptores de melatonina sua producao e utilizacao - Google Patents

Compostos triciclicos que possuem afinidade de ligacao para receptores de melatonina sua producao e utilizacao

Info

Publication number
PT885210E
PT885210E PT97905450T PT97905450T PT885210E PT 885210 E PT885210 E PT 885210E PT 97905450 T PT97905450 T PT 97905450T PT 97905450 T PT97905450 T PT 97905450T PT 885210 E PT885210 E PT 885210E
Authority
PT
Portugal
Prior art keywords
group
optionally substituted
ligacation
melatonine
affinity
Prior art date
Application number
PT97905450T
Other languages
English (en)
Inventor
Shigenori Ohkawa
Osamu Uchikawa
Masaomi Miyamoto
Kohji Fukatsu
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27286462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT885210(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of PT885210E publication Critical patent/PT885210E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
PT97905450T 1996-03-08 1997-03-05 Compostos triciclicos que possuem afinidade de ligacao para receptores de melatonina sua producao e utilizacao PT885210E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5149196 1996-03-08
JP18366796 1996-07-12
JP2918597 1997-02-13

Publications (1)

Publication Number Publication Date
PT885210E true PT885210E (pt) 2002-09-30

Family

ID=27286462

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97905450T PT885210E (pt) 1996-03-08 1997-03-05 Compostos triciclicos que possuem afinidade de ligacao para receptores de melatonina sua producao e utilizacao

Country Status (20)

Country Link
US (1) US6218429B1 (pt)
EP (2) EP1550655A1 (pt)
JP (1) JP4358917B2 (pt)
KR (1) KR100494214B1 (pt)
CN (3) CN100441574C (pt)
AT (1) ATE219071T1 (pt)
CA (1) CA2241666C (pt)
CZ (1) CZ291626B6 (pt)
DE (1) DE69713294T3 (pt)
DK (1) DK0885210T5 (pt)
ES (1) ES2175350T5 (pt)
HK (1) HK1087112A1 (pt)
HU (1) HU224220B1 (pt)
NO (1) NO322205B1 (pt)
NZ (1) NZ330656A (pt)
PL (1) PL188093B1 (pt)
PT (1) PT885210E (pt)
SK (1) SK283970B6 (pt)
TW (1) TW562803B (pt)
WO (1) WO1997032871A1 (pt)

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WO2001014385A1 (fr) * 1999-08-20 2001-03-01 Takeda Chemical Industries, Ltd. Derives de dihydrobenzofuran, leur procede de preparation et agents
JP4632499B2 (ja) * 1999-08-26 2011-02-16 武田薬品工業株式会社 鼻粘膜付着マトリックス
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WO2002040054A1 (fr) * 2000-11-17 2002-05-23 Takeda Chemical Industries, Ltd. Preparation pharmaceutique contenant de la copolyvidone
WO2002040053A1 (fr) * 2000-11-17 2002-05-23 Takeda Chemical Industries, Ltd. Preparation pharmaceutique contenant du talc/ du sulfate de baryum
US6800648B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
IL149377A (en) * 2002-04-28 2012-10-31 Neurim Pharma 1991 Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds
TW200626137A (en) * 2004-12-13 2006-08-01 Takeda Pharmaceuticals Co Preventive or therapeutic agent for sleep disorder
PE20061355A1 (es) * 2005-04-04 2007-01-15 Takeda Pharmaceutical Composicion farmaceutica que comprende ramelteon
EP1900368B1 (en) * 2005-06-22 2011-05-11 Takeda Pharmaceutical Company Limited Tablet containing hardly soluble active ingredient
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RU2008141305A (ru) 2006-03-20 2010-04-27 Такеда Фармасьютикал Компани Лимитед (Jp) Профилактическое или терапевтическое средство против синдрома раздраженного кишечника
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KR20100017297A (ko) 2007-04-26 2010-02-16 다케다 야쿠힌 고교 가부시키가이샤 ２환식 화합물 및 이의 약학적 용도
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WO2009060318A2 (en) * 2007-07-12 2009-05-14 Teva Pharmaceutical Industries Ltd. Polymorphic forms of ramelteon and processes for preparation thereof
ES2324849A1 (es) * 2007-10-25 2009-08-17 Ferrer Internacional, S.A. Compuestos de indano.
US7470814B1 (en) * 2007-10-31 2008-12-30 Ferrer Internacional, S.A. Process for the preparation of substituted 7-allyl-6-hydroxy-indanes
WO2009056993A2 (en) * 2007-11-01 2009-05-07 Teva Pharmaceutical Industries Ltd. A process for the synthesis of ramelteon and its intermediates
ES2507517T3 (es) * 2008-01-31 2014-10-15 Takeda Pharmaceutical Company Limited Agente profiláctico o terapéutico para trastorno de déficit de atención con hiperactividad
US8871807B2 (en) 2008-03-28 2014-10-28 Ecolab Usa Inc. Detergents capable of cleaning, bleaching, sanitizing and/or disinfecting textiles including sulfoperoxycarboxylic acids
CN102105443B (zh) 2008-03-28 2014-05-28 埃科莱布有限公司 磺基过氧羧酸、它们的制备和用作漂白剂和抗微生物剂的方法
US8809392B2 (en) 2008-03-28 2014-08-19 Ecolab Usa Inc. Sulfoperoxycarboxylic acids, their preparation and methods of use as bleaching and antimicrobial agents
KR20110041495A (ko) 2008-07-30 2011-04-21 페레르 인터내쇼날 에스.에이. 1,6-디하이드로-2ｈ-3-옥사-6-아자-ａｓ-인다세네 화합물
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CN102321056B (zh) * 2011-07-29 2014-05-14 宁波人健药业集团股份有限公司 一种合成雷美替胺的方法
CN102391220A (zh) * 2011-10-10 2012-03-28 四川大学 三环乙醇类化合物及其制备方法和用途
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CN103724357B (zh) * 2012-10-11 2016-06-08 中国药科大学 一种3,4-二氢吡喃并[3,2-b]吲哚-2-酮类化合物的合成方法
CN102924410A (zh) * 2012-10-29 2013-02-13 华润赛科药业有限责任公司 一种雷美替胺的制备方法及其中间体
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US20140256811A1 (en) 2013-03-05 2014-09-11 Ecolab Usa Inc. Efficient stabilizer in controlling self accelerated decomposition temperature of peroxycarboxylic acid compositions with mineral acids
KR20160100998A (ko) 2014-01-14 2016-08-24 아스테라스 세이야쿠 가부시키가이샤 인돌 화합물
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US5661186A (en) 1995-02-24 1997-08-26 Bristol-Myers Squibb Co. Tetralinyl-and indanyl-ethylamides

Also Published As

Publication number Publication date
CZ291626B6 (cs) 2003-04-16
DE69713294T2 (de) 2003-02-13
HU224220B1 (hu) 2005-06-28
CZ277598A3 (cs) 1998-12-16
DE69713294D1 (de) 2002-07-18
SK283970B6 (sk) 2004-06-08
HUP9900616A3 (en) 2002-11-28
CN1900067A (zh) 2007-01-24
AU2231897A (en) 1997-09-22
CN100441574C (zh) 2008-12-10
EP0885210B2 (en) 2008-06-18
DK0885210T4 (da) 2008-09-08
NO983970L (no) 1998-08-28
JP4358917B2 (ja) 2009-11-04
DK0885210T3 (da) 2002-10-07
PL328726A1 (en) 1999-02-15
ES2175350T3 (es) 2002-11-16
US6218429B1 (en) 2001-04-17
HK1087112A1 (en) 2006-10-06
SK115098A3 (en) 1999-03-12
JPH11152281A (ja) 1999-06-08
NO322205B1 (no) 2006-08-28
EP1550655A1 (en) 2005-07-06
CN1727339A (zh) 2006-02-01
ATE219071T1 (de) 2002-06-15
HUP9900616A2 (hu) 1999-06-28
EP0885210A1 (en) 1998-12-23
EP0885210B1 (en) 2002-06-12
TW562803B (en) 2003-11-21
CN100443480C (zh) 2008-12-17
ES2175350T5 (es) 2008-12-16
CA2241666A1 (en) 1997-09-12
DE69713294T3 (de) 2009-01-15
CN1212691A (zh) 1999-03-31
KR19990087628A (ko) 1999-12-27
NZ330656A (en) 1999-06-29
NO983970D0 (no) 1998-08-28
AU706610B2 (en) 1999-06-17
PL188093B1 (pl) 2004-12-31
DK0885210T5 (da) 2008-10-13
WO1997032871A1 (en) 1997-09-12
KR100494214B1 (ko) 2005-11-25
CA2241666C (en) 2007-11-06

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