BR9909446A - Métodos para inibição de mrp1 - Google Patents

Métodos para inibição de mrp1

Info

Publication number
BR9909446A
BR9909446A BR9909446-0A BR9909446A BR9909446A BR 9909446 A BR9909446 A BR 9909446A BR 9909446 A BR9909446 A BR 9909446A BR 9909446 A BR9909446 A BR 9909446A
Authority
BR
Brazil
Prior art keywords
methods
mrp1
inhibiting mrp1
inhibiting
inhibition
Prior art date
Application number
BR9909446-0A
Other languages
English (en)
Inventor
Joseph Michael Gruber
Bryan Hurst Norman
Sean Patrick Hollinshead
Joseph Wendell Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9909446A publication Critical patent/BR9909446A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Patente de Invenção: <B>"MéTODOS PARA INIBIçãO DE MRP1"<D>. A presente invenção refere-se a um composto da fórmula (I) o qual é útil para a inibição de neoplasmas resistentes, onde a resistência é conferida em parte ou totalmente pela MRP1.
BR9909446-0A 1998-04-08 1999-04-07 Métodos para inibição de mrp1 BR9909446A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8108898P 1998-04-08 1998-04-08
PCT/US1999/007615 WO1999051236A1 (en) 1998-04-08 1999-04-07 Methods for inhibiting mrp1

Publications (1)

Publication Number Publication Date
BR9909446A true BR9909446A (pt) 2000-12-12

Family

ID=22162031

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909446-0A BR9909446A (pt) 1998-04-08 1999-04-07 Métodos para inibição de mrp1

Country Status (17)

Country Link
US (1) US6221876B1 (pt)
EP (1) EP1067932A4 (pt)
JP (1) JP2002510632A (pt)
KR (1) KR20010042481A (pt)
CN (1) CN1296410A (pt)
AU (1) AU3550299A (pt)
BR (1) BR9909446A (pt)
CA (1) CA2327452A1 (pt)
EA (1) EA200001035A1 (pt)
HU (1) HUP0102548A2 (pt)
ID (1) ID26804A (pt)
IL (1) IL138393A0 (pt)
NO (1) NO20005041L (pt)
PL (1) PL343320A1 (pt)
SK (1) SK14992000A3 (pt)
TR (1) TR200002804T2 (pt)
WO (1) WO1999051236A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2255294T3 (es) * 1998-08-07 2006-06-16 Chiron Corporation Derivados de isoxazol sustituidos como moduladores del receptor de estrogenos.
US6743794B2 (en) 1999-12-22 2004-06-01 Eli Lilly And Company Methods and compounds for inhibiting MRP1
DE60016039T2 (de) * 1999-12-22 2005-08-11 Eli Lilly And Co., Indianapolis Verfahren und verbindungen für die hemmung von mrp1
WO2001096346A1 (en) * 2000-06-14 2001-12-20 Eli Lilly And Company Tricyclic compounds as mrp1-inhibitors
US7064131B2 (en) 2001-04-09 2006-06-20 Eli Lilly And Company Compounds and methods for inhibiting MRP1
CN1281210C (zh) * 2003-11-29 2006-10-25 胡汛 五味子乙素在制备治疗肿瘤药物中的应用
WO2005113004A2 (en) * 2004-05-14 2005-12-01 The Cleveland Clinic Founfation Small molecule inhibitors for mrp1 and other multidrug transporters

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182290A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain oxazoloquinolinones; a new class of GABA brain receptor ligands

Also Published As

Publication number Publication date
NO20005041D0 (no) 2000-10-06
KR20010042481A (ko) 2001-05-25
CA2327452A1 (en) 1999-10-14
JP2002510632A (ja) 2002-04-09
EP1067932A4 (en) 2001-11-14
NO20005041L (no) 2000-10-06
TR200002804T2 (tr) 2001-02-21
SK14992000A3 (sk) 2001-06-11
AU3550299A (en) 1999-10-25
US6221876B1 (en) 2001-04-24
IL138393A0 (en) 2001-10-31
CN1296410A (zh) 2001-05-23
HUP0102548A2 (hu) 2001-11-28
ID26804A (id) 2001-02-08
PL343320A1 (en) 2001-08-13
WO1999051236A1 (en) 1999-10-14
EA200001035A1 (ru) 2001-04-23
EP1067932A1 (en) 2001-01-17

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4O,5O,6O, 7O E 8O ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.