DE69132578T2 - Cephemderivate - Google Patents

Cephemderivate

Info

Publication number
DE69132578T2
DE69132578T2 DE69132578T DE69132578T DE69132578T2 DE 69132578 T2 DE69132578 T2 DE 69132578T2 DE 69132578 T DE69132578 T DE 69132578T DE 69132578 T DE69132578 T DE 69132578T DE 69132578 T2 DE69132578 T2 DE 69132578T2
Authority
DE
Germany
Prior art keywords
cephem derivatives
preparation
cephem
derivatives
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69132578T
Other languages
English (en)
Other versions
DE69132578D1 (de
Inventor
Shigeto Negi
Motosuke Yamanaka
Kanemasa Katsu
Isao Sugiyama
Yuuki Komatu
Atsushi Kamata
Akihiko Tsuruoka
Yoshimasa Machida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2302783A external-priority patent/JPH04178392A/ja
Priority claimed from JP3040747A external-priority patent/JPH05331174A/ja
Priority claimed from JP6770991A external-priority patent/JPH04282388A/ja
Priority claimed from JP16951291A external-priority patent/JPH05331173A/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of DE69132578D1 publication Critical patent/DE69132578D1/de
Application granted granted Critical
Publication of DE69132578T2 publication Critical patent/DE69132578T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69132578T 1990-11-09 1991-11-08 Cephemderivate Expired - Fee Related DE69132578T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2302783A JPH04178392A (ja) 1990-11-09 1990-11-09 ７―アシル―３―置換カルバモイルオキシセフェム化合物およびその製造法
JP3040747A JPH05331174A (ja) 1991-02-14 1991-02-14 ７−アシル−３−置換カルバモイルオキシセフェム化合物およびその製造法
JP6770991A JPH04282388A (ja) 1991-03-08 1991-03-08 ７−置換−３−ジメチルカルバモイルオキシメチル−３−セフェム化合物の製造法およびその中間体
JP16951291A JPH05331173A (ja) 1991-04-12 1991-04-12 ７−置換−３−アリールオキシカルボニルオキシメチル−３−セフェム化合物及びその製造法

Publications (2)

Publication Number Publication Date
DE69132578D1 DE69132578D1 (de) 2001-05-10
DE69132578T2 true DE69132578T2 (de) 2001-08-23

Family

ID=27460944

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69132578T Expired - Fee Related DE69132578T2 (de) 1990-11-09 1991-11-08 Cephemderivate
DE69132580T Expired - Fee Related DE69132580T2 (de) 1990-11-09 1991-11-08 7-Acyl-3-(substituierte carbamoyloxy) Cephem Verbindungen, Verfahren zu ihrer Herstellung und Anwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69132580T Expired - Fee Related DE69132580T2 (de) 1990-11-09 1991-11-08 7-Acyl-3-(substituierte carbamoyloxy) Cephem Verbindungen, Verfahren zu ihrer Herstellung und Anwendung

Country Status (20)

Country Link
US (5) US5559225A (de)
EP (4) EP1074553A1 (de)
JP (2) JP2867192B2 (de)
KR (1) KR0166378B1 (de)
CN (2) CN1038589C (de)
AT (2) ATE200492T1 (de)
AU (2) AU654300B2 (de)
CA (1) CA2054895C (de)
DE (2) DE69132578T2 (de)
DK (1) DK0484966T3 (de)
ES (1) ES2155433T3 (de)
FI (1) FI915245A (de)
GR (1) GR3036157T3 (de)
HU (1) HU221429B (de)
IL (3) IL99898A (de)
NO (1) NO302417B1 (de)
NZ (1) NZ240441A (de)
PT (1) PT99468B (de)
RU (1) RU2091378C1 (de)
YU (1) YU48399B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05230068A (ja) * 1992-02-07 1993-09-07 Kyoto Yakuhin Kogyo Kk ３−ジ置換カルバモイルオキシメチルセファロスポリン化合物、その製造法および中間体化合物
AT401651B (de) * 1994-06-14 1996-11-25 Biochemie Gmbh 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroximinoacetamido)-3-n,n- dimethylcarbamoyloxymethyl-3-cephem-4-
KR100197788B1 (ko) * 1995-06-30 1999-06-15 김충환 세펨 유도체의 제조방법
DE69621649T2 (de) * 1995-12-27 2002-09-19 Hanmi Pharmaceutical Co Verfahren zur herstellung von cefdinir
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
CA2491503A1 (en) * 2003-12-24 2005-06-24 Chic Optic Inc. Eyeglasses with living hinge
CN102633816A (zh) * 2012-03-30 2012-08-15 李莎 头孢西丁酯化前体药物化合物及口服制剂
US11222768B2 (en) * 2018-09-07 2022-01-11 Varian Semiconductor Equipment Associates, Inc. Foam in ion implantation system
CN112321606B (zh) * 2020-11-04 2022-05-17 福安药业集团重庆博圣制药有限公司 头孢唑肟钠及其中间体的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7412541A (nl) * 1973-10-12 1975-04-15 Merck & Co Inc Werkwijze voor het bereiden van cefalosporinen, ijze ter bereiding van farmaceutische raten, alsmede de door toepassing daarvan ardigde voorwerpen.
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
GR63088B (en) * 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
JPS6011713B2 (ja) 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
US4327093A (en) * 1978-10-24 1982-04-27 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds
JPS60190783A (ja) * 1983-12-21 1985-09-28 Sumitomo Seiyaku Kk セフエム系化合物
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
US4705704A (en) * 1985-10-01 1987-11-10 General Electric Company Novel aminofunctional polysiloxane emulsions for treating textiles
FI872879A (fi) * 1986-07-21 1988-01-22 Sankei Yakuhin Kk --laktamfoerening, foerfarande foer dess framstaellning, denna innehaollande laekemedelskomposition foer behandling av sjukdom med bakterieinfektion samt mellanprodukter foer dess syntes.
GB8623211D0 (en) * 1986-09-26 1986-10-29 Glaxo Group Ltd Chemical compounds
AU1630988A (en) * 1987-05-30 1988-12-01 Kyoto Pharmaceutical Industries, Ltd. Cephalosporin compound and pharmaceutical composition thereof
JPH0796240B2 (ja) 1987-08-13 1995-10-18 小島プレス工業株式会社 表皮を有する複合成形体
GB2210876A (en) * 1987-10-14 1989-06-21 Glaxo Group Ltd Cephalosporins
DK637888A (da) * 1987-11-24 1989-05-25 Hoffmann La Roche Carboxylsyreestere
CN1018091B (zh) * 1988-01-11 1992-09-02 吉林工业大学 晶体管噪声成份分析与测试系统
CN1015637B (zh) * 1988-02-25 1992-02-26 中国石油化工总公司石油化工科学研究院 含β沸石的烃重整催化剂
GB8907617D0 (en) * 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
JPH0346474A (ja) 1989-07-14 1991-02-27 Victor Co Of Japan Ltd 情報信号記録円盤及びその記録装置
EP0531875B1 (de) * 1991-09-07 2004-03-24 Aventis Pharma Deutschland GmbH Diastereomer des 3-Cephem-4-carbonsäure-1-(-isopropoxycarbonyloxy)ethylesters und Verfahren zu dessen Herstellung

Also Published As

Publication number Publication date
NO914375D0 (no) 1991-11-08
US5559225A (en) 1996-09-24
DK0484966T3 (da) 2001-05-07
DE69132580D1 (de) 2001-05-17
NZ240441A (en) 1993-03-26
FI915245A (fi) 1992-05-10
JPH1067784A (ja) 1998-03-10
DE69132578D1 (de) 2001-05-10
EP1074553A1 (de) 2001-02-07
GR3036157T3 (en) 2001-09-28
CN1061602A (zh) 1992-06-03
EP1074554A3 (de) 2001-02-28
EP0761671A1 (de) 1997-03-12
HUT60275A (en) 1992-08-28
IL99898A0 (en) 1992-08-18
CN1140175A (zh) 1997-01-15
YU178391A (sh) 1994-01-20
PT99468B (pt) 1999-04-30
IL113744A0 (en) 1995-08-31
US5741902A (en) 1998-04-21
JP2867192B2 (ja) 1999-03-08
ATE200492T1 (de) 2001-04-15
ATE200291T1 (de) 2001-04-15
NO302417B1 (no) 1998-03-02
KR0166378B1 (ko) 1999-01-15
US5604217A (en) 1997-02-18
AU8709691A (en) 1992-05-14
IL99898A (en) 1996-10-31
NO914375L (no) 1992-05-11
CA2054895A1 (en) 1992-05-10
AU671310B2 (en) 1996-08-22
KR920009834A (ko) 1992-06-25
DE69132580T2 (de) 2001-10-25
CN1038589C (zh) 1998-06-03
CA2054895C (en) 2001-02-13
EP0484966A3 (en) 1993-03-10
EP0484966A2 (de) 1992-05-13
RU2091378C1 (en) 1997-09-27
HU913520D0 (en) 1992-01-28
EP0484966B1 (de) 2001-04-11
EP0761671B1 (de) 2001-04-04
PT99468A (pt) 1992-10-30
YU48399B (sh) 1998-07-10
CN1056847C (zh) 2000-09-27
AU5057193A (en) 1994-01-20
IL113744A (en) 1998-06-15
ES2155433T3 (es) 2001-05-16
US5563265A (en) 1996-10-08
US5587473A (en) 1996-12-24
FI915245A0 (fi) 1991-11-06
AU654300B2 (en) 1994-11-03
JPH0692969A (ja) 1994-04-05
EP1074554A2 (de) 2001-02-07
HU221429B (en) 2002-10-28
JP3143829B2 (ja) 2001-03-07

Similar Documents

Publication Publication Date Title
BR9303993A (pt) Composto, processo para preparar o mesmo e composição farmacêutica
AU1608692A (en) Amidinophenylalanine derivatives, a process for the preparation thereof, use thereof and agents containing these as anticoagulants
AU8599091A (en) Antimicrobial agents as well as substituted 2-cyclohexan-1-y1-amine derivatives and their preparation
FI931031A (fi) Mometasonfuroatmonohydrat, foerfarande foer dess framstaellning och farmaceutiska sammansaettningar
ES2013067A6 (es) Un procedimiento para producir un derivado de piperazina.
MX9708696A (es) Cefalosporinas antibacterianas.
ATE200291T1 (de) Cephemderivate
LV10949A (lv) Aizvietoti 4-fenil-4piperidinkarboksamidi to iegusanas panemiens farmaceitiska kompozicija
KR960703863A (ko) 암 치료용 신규 비스-나프탈이미드(New Bis-naphthalimides for the Treatment of Cancer)
FI911138A0 (fi) Ny substituerad aminfoerening och foerfarande foer dess framstaellning.
ES2021515A6 (es) Procedimiento para la preparacion de compuestos derivados de isotiazolo-piridona azetidinil substituidos.
SE9203824L (sv) Bensofuranylimidazol-derivat, foerfarande foer framstaellning daerav och terapeutiska kompositioner innehaallande desamma
DE69528984T2 (de) Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
ES482083A1 (es) Un procedimiento para la preparacion de un derivado de teta-hidro-2h-benzo-c-pirrol.

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee