SE7509861L - Forfarande for framstellning av n-acylamino-alfa-arylacetamido-cefalosporiner - Google Patents
Forfarande for framstellning av n-acylamino-alfa-arylacetamido-cefalosporinerInfo
- Publication number
- SE7509861L SE7509861L SE7509861A SE7509861A SE7509861L SE 7509861 L SE7509861 L SE 7509861L SE 7509861 A SE7509861 A SE 7509861A SE 7509861 A SE7509861 A SE 7509861A SE 7509861 L SE7509861 L SE 7509861L
- Authority
- SE
- Sweden
- Prior art keywords
- group
- formula
- substituted
- derivative
- substituents
- Prior art date
Links
- 125000001424 substituent group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP49103183A JPS5132576A (en) | 1974-09-06 | 1974-09-06 | Nn ashiruamino arufua ariiruasetoamidosefuarosuhorinruinoseiho |
| JP49108429A JPS5136488A (en) | 1974-09-19 | 1974-09-19 | Nn ashiruamino arufua ariiruasetoamidosefuarosuhorinrui no seizohoho |
| JP49108428A JPS5136487A (en) | 1974-09-19 | 1974-09-19 | Nn ashiruamino arufua ariiruasetoamidosefuarosuhorinrui no seizoho |
| JP3382475A JPS51108086A (en) | 1975-03-20 | 1975-03-20 | nn ashiruamino arufua ariiruasetoamidosefuarosuhorinruinoseizohoho |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7509861L true SE7509861L (sv) | 1976-03-08 |
| SE431211B SE431211B (sv) | 1984-01-23 |
Family
ID=27459847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7509861A SE431211B (sv) | 1974-09-06 | 1975-09-04 | Forfarande for framstellning av n-acylamino-alfa-arylacetamido-cefalosporiner |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4156724A (sv) |
| AR (1) | AR213728A1 (sv) |
| AT (1) | AT347034B (sv) |
| CA (1) | CA1074784A (sv) |
| CH (1) | CH616682A5 (sv) |
| DD (1) | DD122252A5 (sv) |
| DE (1) | DE2539664A1 (sv) |
| DK (1) | DK157246C (sv) |
| ES (3) | ES440739A1 (sv) |
| FR (1) | FR2283688A1 (sv) |
| GB (1) | GB1510730A (sv) |
| HU (1) | HU170897B (sv) |
| NL (1) | NL7510486A (sv) |
| NO (1) | NO153573C (sv) |
| SE (1) | SE431211B (sv) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51115491A (en) * | 1975-04-03 | 1976-10-12 | Sumitomo Chem Co Ltd | Method for preparing 77* *44hydroxyy1*5 naphthyridinee33carboxyamino ** phenylacetamido*cephalosporins |
| US4302454A (en) * | 1976-03-03 | 1981-11-24 | Sumitomo Chemical Company, Limited | Cephalosporins |
| FR2362146A1 (fr) * | 1976-08-17 | 1978-03-17 | Fujisawa Pharmaceutical Co | Procede de preparation de composes d'acide 7-(n-substitue-2-phenylglycinamido)-3-substitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, a activite antibacterienne |
| JPS545974A (en) * | 1977-06-16 | 1979-01-17 | Ajinomoto Co Inc | Imidazoledicaroboxylic acid derivatives |
| JPS5572195A (en) * | 1978-11-28 | 1980-05-30 | Mitsui Toatsu Chem Inc | Novel cephalosporin and antibacterial comprising it as active constituent |
| GB2045238B (en) * | 1978-11-28 | 1982-12-01 | Mitsui Toatsu Chemicals | Cephalosporins |
| JPS55139389A (en) * | 1979-04-19 | 1980-10-31 | Mitsui Toatsu Chem Inc | Novel cephalosporin |
| JPS55129287A (en) * | 1979-03-27 | 1980-10-06 | Ajinomoto Co Inc | Imidazole-dicarboxylic acid derivative |
| US4311699A (en) * | 1979-03-12 | 1982-01-19 | Haskell Theodore H | Aminoacid derivatives of cephalosporin compounds |
| US4267180A (en) * | 1979-03-12 | 1981-05-12 | Warner-Lambert Company | Novel antibacterial amide compounds and process means for producing the same |
| JPS5643288A (en) * | 1979-09-18 | 1981-04-21 | Meiji Seika Kaisha Ltd | Cephalosporin derivative and its preparation |
| US4288590A (en) * | 1980-02-14 | 1981-09-08 | Bristol-Myers Company | 7-[Dα-(4-Hydroxy-1,5-naphthyridine-3-carboxamido)-α-arylacetamido]-3-(N,N-dimethyl-aminomethylpyridinium) methyl-3-cephem-4-carboxylates |
| CA1152489A (en) * | 1980-03-05 | 1983-08-23 | Takao Okuda | ANTIMICROBIAL 7- (.alpha.-ACYLAMINO-.alpha.-ARYLACETAMIDO)-3- (SUBSTITUTED METHYL) CEPHALOSPORIN COMPOUNDS, THEIR COMPOSITIONS AND PRODUCTION THEREOF |
| JPS56158791A (en) * | 1980-05-10 | 1981-12-07 | Taisho Pharmaceut Co Ltd | Cephalosporin compound |
| US4468394A (en) * | 1981-04-02 | 1984-08-28 | Eisai Co., Ltd. | Cephalosporin compounds |
| US4404201A (en) * | 1981-11-13 | 1983-09-13 | Warner-Lambert Company | Cephalosporins |
| US7358249B2 (en) | 2002-08-13 | 2008-04-15 | Shionogi & Co., Ltd. | Heterocyclic compounds having inhibitory activity against HIV integrase |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA873869A (en) * | 1971-06-22 | Bristol-Myers Squibb Company | Phenylacetic acid derivatives | |
| US3634416A (en) * | 1969-03-21 | 1972-01-11 | Glaxo Lab Ltd | Purification of 7alpha-aminoarylacetamido delta**3-4-carboxy-cephalosporins |
| US3641021A (en) * | 1969-04-18 | 1972-02-08 | Lilly Co Eli | 3 7-(ring-substituted) cephalosporin compounds |
| US3634418A (en) * | 1969-08-20 | 1972-01-11 | Bristol Myers Co | 3 - azidomethyl - 7-(alpha-aminophenyl(or thienyl)acetamido)ceph - 3 -em-4-oic acids |
| US3867380A (en) * | 1971-02-18 | 1975-02-18 | Smithkline Corp | 3-Heterocyclic thiomethylcephalosporins |
| ZA728331B (en) * | 1971-12-23 | 1974-06-26 | Lilly Co Eli | Preparation of 3-alkylthiomethyl cephalosporins |
| CA1003405A (en) * | 1972-06-14 | 1977-01-11 | Smith Kline And French Canada Ltd. | P-hydroxymethylphenylacetamidocephalosporins |
| CA1076560A (en) * | 1972-06-14 | 1980-04-29 | Smith Kline And French Canada Ltd. | 3-heterocyclic thiomethylcephalosporins |
| CA999574A (en) * | 1972-06-14 | 1976-11-09 | Smith Kline And French Canada Ltd. | 7-hydroxyhalophenylacetamido-3-h heterocyclicthiomethyl cephalosporins |
| AR208171A1 (es) * | 1972-09-29 | 1976-12-09 | Ciba Geigy Ag | Procedimiento para la obtencion de nuevos derivados del acido cef-3-em-4-carboxilico |
| JPS5417754B2 (sv) * | 1972-12-15 | 1979-07-02 | ||
| CA1022544A (en) * | 1972-12-21 | 1977-12-13 | Yukiyasu Murakami | Process of preparing a heterocyclic acyl group-substituted cephalosporin derivative |
| JPS5751837B2 (sv) * | 1973-04-05 | 1982-11-04 | ||
| GB1509074A (en) * | 1974-04-05 | 1978-04-26 | Yamanouchi Pharma Co Ltd | Cephalosporin derivatives |
| CH606001A5 (sv) * | 1974-05-13 | 1978-10-13 | Ciba Geigy Ag | |
| US3931160A (en) * | 1974-05-15 | 1976-01-06 | Smithkline Corporation | α-Amino-α-(acylamidophenyl)acetamidocephalosporins |
-
1975
- 1975-09-03 CA CA234,729A patent/CA1074784A/en not_active Expired
- 1975-09-04 SE SE7509861A patent/SE431211B/sv not_active IP Right Cessation
- 1975-09-04 AR AR260264A patent/AR213728A1/es active
- 1975-09-04 DK DK398375A patent/DK157246C/da not_active IP Right Cessation
- 1975-09-05 NO NO753054A patent/NO153573C/no unknown
- 1975-09-05 AT AT686375A patent/AT347034B/de not_active IP Right Cessation
- 1975-09-05 HU HU75SU00000901A patent/HU170897B/hu unknown
- 1975-09-05 CH CH1155575A patent/CH616682A5/fr not_active IP Right Cessation
- 1975-09-05 NL NL7510486A patent/NL7510486A/xx active Search and Examination
- 1975-09-05 DE DE19752539664 patent/DE2539664A1/de active Granted
- 1975-09-05 GB GB36761/75A patent/GB1510730A/en not_active Expired
- 1975-09-05 DD DD188216A patent/DD122252A5/xx unknown
- 1975-09-05 ES ES440739A patent/ES440739A1/es not_active Expired
- 1975-09-05 FR FR7527357A patent/FR2283688A1/fr active Granted
- 1975-09-08 US US05/611,104 patent/US4156724A/en not_active Expired - Lifetime
-
1977
- 1977-03-01 ES ES456651A patent/ES456651A1/es not_active Expired
- 1977-03-01 ES ES456652A patent/ES456652A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ATA686375A (de) | 1978-04-15 |
| AU8461875A (en) | 1977-03-17 |
| CH616682A5 (sv) | 1980-04-15 |
| NO153573B (no) | 1986-01-06 |
| DE2539664C2 (sv) | 1988-09-29 |
| AR213728A1 (es) | 1979-03-15 |
| DD122252A5 (sv) | 1976-09-20 |
| FR2283688B1 (sv) | 1978-11-10 |
| US4156724A (en) | 1979-05-29 |
| DE2539664A1 (de) | 1976-03-18 |
| SE431211B (sv) | 1984-01-23 |
| GB1510730A (en) | 1978-05-17 |
| DK157246B (da) | 1989-11-27 |
| CA1074784A (en) | 1980-04-01 |
| NL7510486A (nl) | 1976-03-09 |
| ES440739A1 (es) | 1977-06-16 |
| FR2283688A1 (fr) | 1976-04-02 |
| NO153573C (no) | 1986-04-16 |
| AT347034B (de) | 1978-12-11 |
| DK398375A (da) | 1976-03-07 |
| ES456651A1 (es) | 1978-07-01 |
| HU170897B (hu) | 1977-09-28 |
| ES456652A1 (es) | 1978-07-01 |
| DK157246C (da) | 1990-05-07 |
| NO753054L (sv) | 1976-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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