HRP20220893T1 - Cd20 terapije, cd22 terapije, i kombinirane terapije sa stanicom koja eksprimira cd19 kimerni antigenski receptor - Google Patents

Cd20 terapije, cd22 terapije, i kombinirane terapije sa stanicom koja eksprimira cd19 kimerni antigenski receptor Download PDF

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Publication number
HRP20220893T1
HRP20220893T1 HRP20220893TT HRP20220893T HRP20220893T1 HR P20220893 T1 HRP20220893 T1 HR P20220893T1 HR P20220893T T HRP20220893T T HR P20220893TT HR P20220893 T HRP20220893 T HR P20220893T HR P20220893 T1 HRP20220893 T1 HR P20220893T1
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HR
Croatia
Prior art keywords
seq
car
cell
cdr1
cdr2
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HRP20220893TT
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English (en)
Croatian (hr)
Inventor
Hans Bitter
Jennifer Mary Bordeaux
Barbara Brannetti
Jennifer BROGDON
Naveen Kumar Dakappagari
Saar GILL
Steven HIGHFILL
Lu Huang
Carl H. June
Ju Young Kim
Lei Ming
Na Li
Andreas Loew
Elena ORLANDO
Marco RUELLA
Thai Tran
Jimin Zhang
Li Zhou
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Novartis Ag
The Trustees Of The University Of Pennsylvania
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Application filed by Novartis Ag, The Trustees Of The University Of Pennsylvania filed Critical Novartis Ag
Publication of HRP20220893T1 publication Critical patent/HRP20220893T1/hr

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/36—Immune checkpoint inhibitors
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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HRP20220893TT 2015-04-08 2016-04-08 Cd20 terapije, cd22 terapije, i kombinirane terapije sa stanicom koja eksprimira cd19 kimerni antigenski receptor HRP20220893T1 (hr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562144497P 2015-04-08 2015-04-08
US201562144615P 2015-04-08 2015-04-08
US201562144639P 2015-04-08 2015-04-08
US201562207255P 2015-08-19 2015-08-19
US201562263423P 2015-12-04 2015-12-04
PCT/US2016/026655 WO2016164731A2 (en) 2015-04-08 2016-04-08 Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell
EP16719611.2A EP3280729B1 (en) 2015-04-08 2016-04-08 Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell

Publications (1)

Publication Number Publication Date
HRP20220893T1 true HRP20220893T1 (hr) 2022-10-14

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HRP20220893TT HRP20220893T1 (hr) 2015-04-08 2016-04-08 Cd20 terapije, cd22 terapije, i kombinirane terapije sa stanicom koja eksprimira cd19 kimerni antigenski receptor

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US (4) US10253086B2 (cg-RX-API-DMAC7.html)
EP (3) EP4491715A3 (cg-RX-API-DMAC7.html)
JP (3) JP6961490B2 (cg-RX-API-DMAC7.html)
KR (1) KR20170134642A (cg-RX-API-DMAC7.html)
CN (3) CN114958764A (cg-RX-API-DMAC7.html)
AU (2) AU2016245958B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017021500A2 (cg-RX-API-DMAC7.html)
CA (1) CA2981751A1 (cg-RX-API-DMAC7.html)
CO (1) CO2017010190A2 (cg-RX-API-DMAC7.html)
DK (1) DK3280729T3 (cg-RX-API-DMAC7.html)
ES (2) ES2923894T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20220893T1 (cg-RX-API-DMAC7.html)
HU (1) HUE059218T2 (cg-RX-API-DMAC7.html)
IL (2) IL254817B2 (cg-RX-API-DMAC7.html)
LT (1) LT3280729T (cg-RX-API-DMAC7.html)
MX (2) MX2017012939A (cg-RX-API-DMAC7.html)
PL (1) PL3280729T3 (cg-RX-API-DMAC7.html)
PT (1) PT3280729T (cg-RX-API-DMAC7.html)
RU (2) RU2752918C2 (cg-RX-API-DMAC7.html)
SG (2) SG10201913731UA (cg-RX-API-DMAC7.html)
SI (1) SI3280729T1 (cg-RX-API-DMAC7.html)
TW (1) TWI746437B (cg-RX-API-DMAC7.html)
WO (1) WO2016164731A2 (cg-RX-API-DMAC7.html)

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ES2760023T3 (es) 2013-02-20 2020-05-12 Univ Pennsylvania Tratamiento del cáncer utilizando receptor de antígeno quimérico anti-EGFRvIII humanizado
EP2958942B1 (en) 2013-02-20 2020-06-03 Novartis AG Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells
ES2769574T3 (es) 2013-03-15 2020-06-26 Michael C Milone Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
BR112016013187A2 (pt) 2013-12-19 2017-09-26 Novartis Ag receptores de antígenos quiméricos de mesotelina humanos e usos dos mesmos
EP4420663A3 (en) 2013-12-20 2024-10-30 Novartis AG Regulatable chimeric antigen receptor
EP4303229A3 (en) 2014-01-21 2024-04-17 Novartis AG Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
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