HRP20211563T1 - Pripravci koji sadrže sintetske polinukleotide koji kodiraju proteine srodne crispr-u i sintetske sgrna, te postupci njihove uporabe - Google Patents

Pripravci koji sadrže sintetske polinukleotide koji kodiraju proteine srodne crispr-u i sintetske sgrna, te postupci njihove uporabe Download PDF

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Publication number
HRP20211563T1
HRP20211563T1 HRP20211563TT HRP20211563T HRP20211563T1 HR P20211563 T1 HRP20211563 T1 HR P20211563T1 HR P20211563T T HRP20211563T T HR P20211563TT HR P20211563 T HRP20211563 T HR P20211563T HR P20211563 T1 HRP20211563 T1 HR P20211563T1
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Croatia
Prior art keywords
synthetic polynucleotide
sgrna
synthetic
gene
region
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HRP20211563TT
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English (en)
Croatian (hr)
Inventor
Stephen G. HOGE
Eric Yi-Chun Huang
Tirtha Chakraborty
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Modernatx, Inc.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52280736&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20211563(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Modernatx, Inc. filed Critical Modernatx, Inc.
Publication of HRP20211563T1 publication Critical patent/HRP20211563T1/hr

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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Genetics & Genomics (AREA)
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  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
HRP20211563TT 2013-07-11 2014-07-11 Pripravci koji sadrže sintetske polinukleotide koji kodiraju proteine srodne crispr-u i sintetske sgrna, te postupci njihove uporabe HRP20211563T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361844890P 2013-07-11 2013-07-11
US201361886545P 2013-10-03 2013-10-03
PCT/US2014/046434 WO2015006747A2 (en) 2013-07-11 2014-07-11 Compositions comprising synthetic polynucleotides encoding crispr related proteins and synthetic sgrnas and methods of use.
EP14823392.7A EP3019619B1 (en) 2013-07-11 2014-07-11 Compositions comprising synthetic polynucleotides encoding crispr related proteins and synthetic sgrnas and methods of use

Publications (1)

Publication Number Publication Date
HRP20211563T1 true HRP20211563T1 (hr) 2022-01-07

Family

ID=52280736

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20211563TT HRP20211563T1 (hr) 2013-07-11 2014-07-11 Pripravci koji sadrže sintetske polinukleotide koji kodiraju proteine srodne crispr-u i sintetske sgrna, te postupci njihove uporabe

Country Status (17)

Country Link
US (2) US11027025B2 (enExample)
EP (2) EP3971287A1 (enExample)
JP (4) JP7019233B2 (enExample)
AU (2) AU2014287009B2 (enExample)
CA (1) CA2917348A1 (enExample)
CY (1) CY1124740T1 (enExample)
DK (1) DK3019619T3 (enExample)
ES (1) ES2896755T3 (enExample)
HR (1) HRP20211563T1 (enExample)
HU (1) HUE056760T2 (enExample)
LT (1) LT3019619T (enExample)
PL (1) PL3019619T3 (enExample)
PT (1) PT3019619T (enExample)
RS (1) RS62529B1 (enExample)
SI (1) SI3019619T1 (enExample)
SM (1) SMT202100691T1 (enExample)
WO (1) WO2015006747A2 (enExample)

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SI3019619T1 (sl) 2021-12-31
EP3019619A2 (en) 2016-05-18
RS62529B1 (sr) 2021-11-30
AU2014287009B2 (en) 2020-10-29
AU2021200486B2 (en) 2023-08-31
JP7019233B2 (ja) 2022-02-15
AU2014287009A1 (en) 2016-02-11
EP3019619A4 (en) 2017-01-11
JP2022115896A (ja) 2022-08-09
ES2896755T3 (es) 2022-02-25
JP7225456B2 (ja) 2023-02-20
WO2015006747A2 (en) 2015-01-15
JP2016523564A (ja) 2016-08-12
JP2022164843A (ja) 2022-10-27
CA2917348A1 (en) 2015-01-15
PT3019619T (pt) 2021-11-11
JP2020108379A (ja) 2020-07-16
LT3019619T (lt) 2021-12-10
US11027025B2 (en) 2021-06-08
US20160367702A1 (en) 2016-12-22
EP3971287A1 (en) 2022-03-23
US20220111079A1 (en) 2022-04-14
DK3019619T3 (da) 2021-10-11
JP7136826B2 (ja) 2022-09-13
PL3019619T3 (pl) 2022-01-10
CY1124740T1 (el) 2022-07-22
EP3019619B1 (en) 2021-08-25
SMT202100691T1 (it) 2022-01-10
HUE056760T2 (hu) 2022-03-28
WO2015006747A3 (en) 2015-04-23

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