CY1124740T1 - Συνθεσεις που περιλαμβανουν συνθετiκα πολυνουκλεοτιδια που κωδικοποιουν crispr σχετικες πρωτεϊνες και συνθετικα sgrnas και μεθοδοι χρησης - Google Patents

Συνθεσεις που περιλαμβανουν συνθετiκα πολυνουκλεοτιδια που κωδικοποιουν crispr σχετικες πρωτεϊνες και συνθετικα sgrnas και μεθοδοι χρησης

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Publication number
CY1124740T1
CY1124740T1 CY20211100957T CY211100957T CY1124740T1 CY 1124740 T1 CY1124740 T1 CY 1124740T1 CY 20211100957 T CY20211100957 T CY 20211100957T CY 211100957 T CY211100957 T CY 211100957T CY 1124740 T1 CY1124740 T1 CY 1124740T1
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Cyprus
Prior art keywords
synthetic
methods
compositions
polynucleotides encoding
related proteins
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CY20211100957T
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English (en)
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Stephen G. HOGE
Eric Yi-Chun Huang
Tirtha Chakraborty
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Modernatx, Inc.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52280736&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1124740(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Modernatx, Inc. filed Critical Modernatx, Inc.
Publication of CY1124740T1 publication Critical patent/CY1124740T1/el

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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

Abstract

Η παρούσα εφεύρεση αφορά συνθέσεις που περιλαμβάνουν και μεθόδους που χρησιμοποιούν συνθετικά πολυνουκλεοτίδια, π.χ. τροποποιημένο mRNA, που κωδικοποιεί CRISPR σχετικές πρωτεΐνες που συμπεριλαμβάνουν dCAS9 και συνθετικά sgRNAs που στοχεύουν ένα γονίδιο ενδιαφέροντος.
CY20211100957T 2013-07-11 2021-11-05 Συνθεσεις που περιλαμβανουν συνθετiκα πολυνουκλεοτιδια που κωδικοποιουν crispr σχετικες πρωτεϊνες και συνθετικα sgrnas και μεθοδοι χρησης CY1124740T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361844890P 2013-07-11 2013-07-11
US201361886545P 2013-10-03 2013-10-03
PCT/US2014/046434 WO2015006747A2 (en) 2013-07-11 2014-07-11 Compositions comprising synthetic polynucleotides encoding crispr related proteins and synthetic sgrnas and methods of use.

Publications (1)

Publication Number Publication Date
CY1124740T1 true CY1124740T1 (el) 2022-07-22

Family

ID=52280736

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CY20211100957T CY1124740T1 (el) 2013-07-11 2021-11-05 Συνθεσεις που περιλαμβανουν συνθετiκα πολυνουκλεοτιδια που κωδικοποιουν crispr σχετικες πρωτεϊνες και συνθετικα sgrnas και μεθοδοι χρησης

Country Status (16)

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US (2) US11027025B2 (el)
EP (2) EP3019619B1 (el)
JP (4) JP7019233B2 (el)
AU (2) AU2014287009B2 (el)
CA (1) CA2917348A1 (el)
CY (1) CY1124740T1 (el)
DK (1) DK3019619T3 (el)
ES (1) ES2896755T3 (el)
HR (1) HRP20211563T1 (el)
HU (1) HUE056760T2 (el)
LT (1) LT3019619T (el)
PL (1) PL3019619T3 (el)
PT (1) PT3019619T (el)
RS (1) RS62529B1 (el)
SI (1) SI3019619T1 (el)
WO (1) WO2015006747A2 (el)

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