DK3019619T3 - Sammensætninger, der omfatter syntetiske polynukleotider, som koder for crispr-beslægtede proteiner, og syntetiske sgrna'er, og anvendelsesfremgangsmåder - Google Patents

Sammensætninger, der omfatter syntetiske polynukleotider, som koder for crispr-beslægtede proteiner, og syntetiske sgrna'er, og anvendelsesfremgangsmåder Download PDF

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Publication number
DK3019619T3
DK3019619T3 DK14823392.7T DK14823392T DK3019619T3 DK 3019619 T3 DK3019619 T3 DK 3019619T3 DK 14823392 T DK14823392 T DK 14823392T DK 3019619 T3 DK3019619 T3 DK 3019619T3
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synthetic
related proteins
compositions including
sgrnas
polynucleotides coding
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DK14823392.7T
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Danish (da)
English (en)
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Stephen G Hoge
Eric Yi-Chun Huang
Tirtha Chakraborty
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Modernatx Inc
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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK14823392.7T 2013-07-11 2014-07-11 Sammensætninger, der omfatter syntetiske polynukleotider, som koder for crispr-beslægtede proteiner, og syntetiske sgrna'er, og anvendelsesfremgangsmåder DK3019619T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361844890P 2013-07-11 2013-07-11
US201361886545P 2013-10-03 2013-10-03
PCT/US2014/046434 WO2015006747A2 (en) 2013-07-11 2014-07-11 Compositions comprising synthetic polynucleotides encoding crispr related proteins and synthetic sgrnas and methods of use.

Publications (1)

Publication Number Publication Date
DK3019619T3 true DK3019619T3 (da) 2021-10-11

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DK14823392.7T DK3019619T3 (da) 2013-07-11 2014-07-11 Sammensætninger, der omfatter syntetiske polynukleotider, som koder for crispr-beslægtede proteiner, og syntetiske sgrna'er, og anvendelsesfremgangsmåder

Country Status (17)

Country Link
US (2) US11027025B2 (enExample)
EP (2) EP3019619B1 (enExample)
JP (4) JP7019233B2 (enExample)
AU (2) AU2014287009B2 (enExample)
CA (1) CA2917348A1 (enExample)
CY (1) CY1124740T1 (enExample)
DK (1) DK3019619T3 (enExample)
ES (1) ES2896755T3 (enExample)
HR (1) HRP20211563T1 (enExample)
HU (1) HUE056760T2 (enExample)
LT (1) LT3019619T (enExample)
PL (1) PL3019619T3 (enExample)
PT (1) PT3019619T (enExample)
RS (1) RS62529B1 (enExample)
SI (1) SI3019619T1 (enExample)
SM (1) SMT202100691T1 (enExample)
WO (1) WO2015006747A2 (enExample)

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JP2020108379A (ja) 2020-07-16
AU2021200486B2 (en) 2023-08-31
SI3019619T1 (sl) 2021-12-31
EP3019619A4 (en) 2017-01-11
JP2022164843A (ja) 2022-10-27
EP3019619A2 (en) 2016-05-18

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