HK1068811A1 - Substituted oxazolidinones for combinational therapy - Google Patents
Substituted oxazolidinones for combinational therapyInfo
- Publication number
- HK1068811A1 HK1068811A1 HK05101508.8A HK05101508A HK1068811A1 HK 1068811 A1 HK1068811 A1 HK 1068811A1 HK 05101508 A HK05101508 A HK 05101508A HK 1068811 A1 HK1068811 A1 HK 1068811A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- substituted oxazolidinones
- combinational therapy
- oxazolidinones
- combinations
- combinational
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10129725A DE10129725A1 (de) | 2001-06-20 | 2001-06-20 | Kombinationstherapie substituierter Oxazolidinone |
PCT/EP2002/006237 WO2003000256A1 (fr) | 2001-06-20 | 2002-06-07 | Combinaisons therapeutiques d'oxazolidinones substituees |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1068811A1 true HK1068811A1 (en) | 2005-05-06 |
Family
ID=7688824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05101508.8A HK1068811A1 (en) | 2001-06-20 | 2005-02-23 | Substituted oxazolidinones for combinational therapy |
Country Status (33)
Country | Link |
---|---|
US (2) | US7767702B2 (fr) |
EP (1) | EP1411932B1 (fr) |
JP (1) | JP4667744B2 (fr) |
KR (1) | KR100904138B1 (fr) |
CN (1) | CN100577162C (fr) |
AT (1) | ATE457171T1 (fr) |
AU (1) | AU2002312982B2 (fr) |
BG (1) | BG66354B1 (fr) |
BR (1) | BRPI0210941B8 (fr) |
CA (1) | CA2451258C (fr) |
CO (1) | CO5550434A2 (fr) |
CU (1) | CU23366B7 (fr) |
CY (1) | CY1110019T1 (fr) |
CZ (1) | CZ303715B6 (fr) |
DE (2) | DE10129725A1 (fr) |
DK (1) | DK1411932T3 (fr) |
EC (1) | ECSP034916A (fr) |
EE (1) | EE05419B1 (fr) |
ES (1) | ES2338997T3 (fr) |
HK (1) | HK1068811A1 (fr) |
HR (1) | HRP20040042B1 (fr) |
HU (1) | HU230120B1 (fr) |
IL (2) | IL159257A0 (fr) |
MX (1) | MXPA03011519A (fr) |
NO (1) | NO334821B1 (fr) |
NZ (1) | NZ530223A (fr) |
PL (1) | PL206803B1 (fr) |
PT (1) | PT1411932E (fr) |
RU (1) | RU2321407C9 (fr) |
SI (1) | SI1411932T1 (fr) |
SK (1) | SK287904B6 (fr) |
UA (1) | UA82986C2 (fr) |
WO (1) | WO2003000256A1 (fr) |
Families Citing this family (66)
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DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
DE10300111A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
US7429603B2 (en) * | 2003-04-25 | 2008-09-30 | 3-Dimensional Pharmaceuticals, Inc. | C-fms kinase inhibitors |
WO2004101552A1 (fr) * | 2003-05-14 | 2004-11-25 | Orchid Chemicals & Pharmaceuticals Ltd | Derives d'oxazolidinone utiles comme agents antibacteriens |
DE10336716A1 (de) | 2003-08-11 | 2005-03-10 | Merck Patent Gmbh | Verfahren zur Herstellung von N-Aryl-morpholinonen |
US7687627B2 (en) * | 2003-09-08 | 2010-03-30 | Wockhardt Limited | Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy |
DE10342570A1 (de) * | 2003-09-15 | 2005-04-14 | Bayer Healthcare Ag | Verfahren zur Herstellung von 4-(4-Aminophenyl)-3-morpholinon |
WO2005027896A1 (fr) * | 2003-09-19 | 2005-03-31 | Kissei Pharmaceutical Co., Ltd. | Medicaments combines |
DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
DE102004002044A1 (de) * | 2004-01-15 | 2005-08-04 | Bayer Healthcare Ag | Herstellverfahren |
US7371743B2 (en) * | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
JP5020073B2 (ja) | 2004-06-18 | 2012-09-05 | ミレニアム ファーマシューティカルズ インク. | 第Xa因子阻害剤 |
DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
EP1685841A1 (fr) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention et traitement de troubles thromboemboliques |
DE102005018690A1 (de) * | 2005-04-22 | 2006-10-26 | Bayer Healthcare Ag | Imino-oxazolidine und ihre Verwendung |
JP5214096B2 (ja) * | 2005-06-17 | 2013-06-19 | 富士フイルムファインケミカルズ株式会社 | 新規なビピリジン誘導体 |
DE102005045518A1 (de) | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
DE102005047564A1 (de) * | 2005-10-04 | 2007-05-31 | Bayer Healthcare Ag | Amorphe Form von 5-Chlor-N-({(5S)2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl)-methyl)-2-thiophencarboxamid |
DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
DE102005047558A1 (de) * | 2005-10-04 | 2008-02-07 | Bayer Healthcare Ag | Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen |
DE502006009169D1 (en) * | 2005-10-04 | 2011-05-05 | Bayer Schering Pharma Ag | NEUE POLYMORPHE FORM VON 5-CHLOR-N-(ä ( 5S )-2-0X0-3-Ä4-( 3-OXO-4-MORPHOLINYL)-PHENYLÜ-1,3-OXAZOLIDIN-5-YLü -METHYL)-2-THIOPHENCARBOXAMID |
DE102005052174A1 (de) | 2005-11-02 | 2007-06-06 | Bayer Healthcare Ag | Phenylen-bis-oxazolidin-Derivate und ihre Verwendung |
US7700590B2 (en) | 2006-02-09 | 2010-04-20 | University Of New Orleans Research And Technology Foundation, Inc. | Antibacterial agents |
DE102006007146A1 (de) * | 2006-02-16 | 2007-08-23 | Bayer Healthcare Ag | Aminoacyl-Prodrugs |
AR060768A1 (es) * | 2006-05-05 | 2008-07-10 | Millennium Pharm Inc | Compuestos de imidazol sustituidos inhibidores del factor x, composiciones farmaceuticas que los contienen y usos como agentes antitromboticos. |
DE102006039589A1 (de) * | 2006-08-24 | 2008-03-06 | Bayer Healthcare Ag | Aminoacyl-Prodrugs II |
DE102006051625A1 (de) * | 2006-11-02 | 2008-05-08 | Bayer Materialscience Ag | Kombinationstherapie substituierter Oxazolidinone |
JPWO2008120655A1 (ja) | 2007-03-30 | 2010-07-15 | 株式会社医薬分子設計研究所 | I型11βヒドロキシステロイド脱水素酵素阻害活性を有するオキサゾリジノン誘導体 |
KR101009594B1 (ko) * | 2007-05-09 | 2011-01-20 | 주식회사 레고켐 바이오사이언스 | P4 위치에 사이클릭 아미딘을 가지는 FXa 저해제, 이의유도체, 제조방법 및 이를 함유하는 의약 조성물 |
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DE102007028407A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
DE102007028320A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
DE102007028406A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
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KR100898361B1 (ko) * | 2008-07-03 | 2009-05-20 | 주식회사 레고켐 바이오사이언스 | P4 위치에 사이클릭 아미독심 또는 사이클릭 아미드라존기를 가지는 FXa 저해제, 이의 유도체, 제조방법 및이를 함유하는 의약 조성물 |
SI2459555T1 (sl) | 2009-07-31 | 2022-03-31 | Krka, D.D., Novo Mesto | Postopek kristalizacije rivaroksabana |
CN102050819B (zh) * | 2009-11-10 | 2012-05-23 | 天津药物研究院 | 噁唑烷酮衍生物及其制备方法和用途 |
CN102762550B (zh) * | 2009-12-17 | 2015-04-01 | 米伦纽姆医药公司 | Xa因子抑制剂的盐和结晶形式 |
WO2011075602A1 (fr) | 2009-12-17 | 2011-06-23 | Millennium Pharmaceuticals, Inc. | Procédés de préparation d'inhibiteurs du facteur xa et de leurs sels |
DE102010028362A1 (de) | 2010-04-29 | 2011-11-03 | Bayer Schering Pharma Aktiengesellschaft | Herstellverfahren |
CN102311400A (zh) * | 2010-06-29 | 2012-01-11 | 翔真生物科技股份有限公司 | 制备5-左旋-氨甲基-3-芳基-2-恶唑烷酮类的方法 |
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WO2013098833A2 (fr) * | 2011-09-08 | 2013-07-04 | Cadila Healthcare Limited | Procédés et intermédiaires destinés à la préparation de rivaroxaban |
EP2766373B1 (fr) * | 2011-10-11 | 2016-08-17 | Council of Scientific & Industrial Research | Sila-analogues de dérivés d'oxazolidinone et synthèse de ceux-ci |
PL2935255T3 (pl) | 2012-12-21 | 2018-01-31 | Farma Grs D O O | Sposób wytwarzania rywaroksabanu |
KR20150100661A (ko) * | 2012-12-26 | 2015-09-02 | 완버리 엘티디. | 치환된 옥사졸리디논의 알데히드 유도체 |
CN103936763B (zh) * | 2013-01-18 | 2017-10-31 | 中国科学院上海药物研究所 | 噁唑烷酮类化合物及其制备方法和用途 |
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EP3213749B1 (fr) | 2014-10-30 | 2020-08-12 | Chengdu Baiyu Pharmaceutical Co., Ltd. | Composition pharmaceutique contenant un ginkgolide b et un inhibiteur du facteur xa, son procédé de préparation et ses applications |
CN104402876A (zh) * | 2014-11-25 | 2015-03-11 | 沈阳药科大学 | 噁唑烷酮类化合物及其应用 |
CN104447729A (zh) * | 2014-12-05 | 2015-03-25 | 广东东阳光药业有限公司 | 噁唑烷酮类化合物及其在药物中的应用 |
CN104447728B (zh) * | 2014-12-05 | 2017-01-04 | 广东东阳光药业有限公司 | 噁唑烷酮类化合物及其在药物中的应用 |
CN104478866B (zh) * | 2014-12-05 | 2017-07-07 | 广东东阳光药业有限公司 | 噁唑烷酮类化合物及其在药物中的应用 |
CN104497008B (zh) * | 2014-12-09 | 2016-11-16 | 广东东阳光药业有限公司 | 取代噁唑烷酮类化合物及其使用方法和用途 |
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US11608320B2 (en) | 2020-02-02 | 2023-03-21 | Kuwait University | Oxazolidinone hydroxamic acid derivatives |
CN111253383A (zh) * | 2020-03-27 | 2020-06-09 | 南京国星生物技术研究院有限公司 | 一种利伐沙班的合成方法 |
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-
2001
- 2001-06-20 DE DE10129725A patent/DE10129725A1/de not_active Withdrawn
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2002
- 2002-06-07 CA CA2451258A patent/CA2451258C/fr not_active Expired - Lifetime
- 2002-06-07 US US10/481,297 patent/US7767702B2/en not_active Expired - Fee Related
- 2002-06-07 PT PT02738154T patent/PT1411932E/pt unknown
- 2002-06-07 IL IL15925702A patent/IL159257A0/xx unknown
- 2002-06-07 CZ CZ20033451A patent/CZ303715B6/cs not_active IP Right Cessation
- 2002-06-07 SK SK1530-2003A patent/SK287904B6/sk unknown
- 2002-06-07 MX MXPA03011519A patent/MXPA03011519A/es active IP Right Grant
- 2002-06-07 RU RU2004101404/15A patent/RU2321407C9/ru active
- 2002-06-07 ES ES02738154T patent/ES2338997T3/es not_active Expired - Lifetime
- 2002-06-07 HU HU0400240A patent/HU230120B1/hu unknown
- 2002-06-07 EP EP02738154A patent/EP1411932B1/fr not_active Expired - Lifetime
- 2002-06-07 WO PCT/EP2002/006237 patent/WO2003000256A1/fr active IP Right Grant
- 2002-06-07 JP JP2003506901A patent/JP4667744B2/ja not_active Expired - Lifetime
- 2002-06-07 NZ NZ530223A patent/NZ530223A/en not_active IP Right Cessation
- 2002-06-07 AT AT02738154T patent/ATE457171T1/de active
- 2002-06-07 EE EEP200400020A patent/EE05419B1/xx unknown
- 2002-06-07 CN CN02812411A patent/CN100577162C/zh not_active Expired - Lifetime
- 2002-06-07 AU AU2002312982A patent/AU2002312982B2/en not_active Expired
- 2002-06-07 KR KR1020037016596A patent/KR100904138B1/ko active IP Right Grant
- 2002-06-07 DE DE50214206T patent/DE50214206D1/de not_active Expired - Lifetime
- 2002-06-07 DK DK02738154.0T patent/DK1411932T3/da active
- 2002-06-07 SI SI200230892T patent/SI1411932T1/sl unknown
- 2002-06-07 PL PL368079A patent/PL206803B1/pl unknown
- 2002-06-07 BR BRPI0210941A patent/BRPI0210941B8/pt not_active IP Right Cessation
- 2002-07-06 UA UA2004010387A patent/UA82986C2/uk unknown
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- 2003-12-09 IL IL159257A patent/IL159257A/en active IP Right Grant
- 2003-12-12 BG BG108443A patent/BG66354B1/bg unknown
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- 2003-12-19 NO NO20035743A patent/NO334821B1/no not_active IP Right Cessation
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2004
- 2004-01-19 CO CO04003298A patent/CO5550434A2/es not_active Application Discontinuation
- 2004-01-19 HR HRP20040042AA patent/HRP20040042B1/hr not_active IP Right Cessation
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2005
- 2005-02-23 HK HK05101508.8A patent/HK1068811A1/xx not_active IP Right Cessation
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