EE05419B1 - Asendatud oksasolidinoonid kombineeritud raviks - Google Patents
Asendatud oksasolidinoonid kombineeritud raviksInfo
- Publication number
- EE05419B1 EE05419B1 EEP200400020A EEP200400020A EE05419B1 EE 05419 B1 EE05419 B1 EE 05419B1 EE P200400020 A EEP200400020 A EE P200400020A EE P200400020 A EEP200400020 A EE P200400020A EE 05419 B1 EE05419 B1 EE 05419B1
- Authority
- EE
- Estonia
- Prior art keywords
- combination therapy
- substituted oxazolidinones
- oxazolidinones
- combinations
- substituted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10129725A DE10129725A1 (de) | 2001-06-20 | 2001-06-20 | Kombinationstherapie substituierter Oxazolidinone |
PCT/EP2002/006237 WO2003000256A1 (de) | 2001-06-20 | 2002-06-07 | Kombinationstherapie substituierter oxazolidinone |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200400020A EE200400020A (et) | 2004-04-15 |
EE05419B1 true EE05419B1 (et) | 2011-06-15 |
Family
ID=7688824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200400020A EE05419B1 (et) | 2001-06-20 | 2002-06-07 | Asendatud oksasolidinoonid kombineeritud raviks |
Country Status (33)
Country | Link |
---|---|
US (2) | US7767702B2 (xx) |
EP (1) | EP1411932B1 (xx) |
JP (1) | JP4667744B2 (xx) |
KR (1) | KR100904138B1 (xx) |
CN (1) | CN100577162C (xx) |
AT (1) | ATE457171T1 (xx) |
AU (1) | AU2002312982B2 (xx) |
BG (1) | BG66354B1 (xx) |
BR (1) | BRPI0210941B8 (xx) |
CA (1) | CA2451258C (xx) |
CO (1) | CO5550434A2 (xx) |
CU (1) | CU23366B7 (xx) |
CY (1) | CY1110019T1 (xx) |
CZ (1) | CZ303715B6 (xx) |
DE (2) | DE10129725A1 (xx) |
DK (1) | DK1411932T3 (xx) |
EC (1) | ECSP034916A (xx) |
EE (1) | EE05419B1 (xx) |
ES (1) | ES2338997T3 (xx) |
HK (1) | HK1068811A1 (xx) |
HR (1) | HRP20040042B1 (xx) |
HU (1) | HU230120B1 (xx) |
IL (2) | IL159257A0 (xx) |
MX (1) | MXPA03011519A (xx) |
NO (1) | NO334821B1 (xx) |
NZ (1) | NZ530223A (xx) |
PL (1) | PL206803B1 (xx) |
PT (1) | PT1411932E (xx) |
RU (1) | RU2321407C9 (xx) |
SI (1) | SI1411932T1 (xx) |
SK (1) | SK287904B6 (xx) |
UA (1) | UA82986C2 (xx) |
WO (1) | WO2003000256A1 (xx) |
Families Citing this family (66)
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DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
DE10129725A1 (de) * | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
DE10300111A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
US7429603B2 (en) * | 2003-04-25 | 2008-09-30 | 3-Dimensional Pharmaceuticals, Inc. | C-fms kinase inhibitors |
WO2004101552A1 (en) * | 2003-05-14 | 2004-11-25 | Orchid Chemicals & Pharmaceuticals Ltd | Oxazolidinone derivatives as antibacterial agents |
DE10336716A1 (de) * | 2003-08-11 | 2005-03-10 | Merck Patent Gmbh | Verfahren zur Herstellung von N-Aryl-morpholinonen |
US7687627B2 (en) * | 2003-09-08 | 2010-03-30 | Wockhardt Limited | Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy |
DE10342570A1 (de) * | 2003-09-15 | 2005-04-14 | Bayer Healthcare Ag | Verfahren zur Herstellung von 4-(4-Aminophenyl)-3-morpholinon |
EP1679067A4 (en) * | 2003-09-19 | 2010-04-07 | Kissei Pharmaceutical | COMBINED MEDICINES |
DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
DE102004002044A1 (de) * | 2004-01-15 | 2005-08-04 | Bayer Healthcare Ag | Herstellverfahren |
US7371743B2 (en) * | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
WO2006002099A2 (en) | 2004-06-18 | 2006-01-05 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
DE102005018690A1 (de) * | 2005-04-22 | 2006-10-26 | Bayer Healthcare Ag | Imino-oxazolidine und ihre Verwendung |
JP5214096B2 (ja) * | 2005-06-17 | 2013-06-19 | 富士フイルムファインケミカルズ株式会社 | 新規なビピリジン誘導体 |
DE102005045518A1 (de) | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
DE102005047564A1 (de) * | 2005-10-04 | 2007-05-31 | Bayer Healthcare Ag | Amorphe Form von 5-Chlor-N-({(5S)2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl)-methyl)-2-thiophencarboxamid |
DE102005047558A1 (de) * | 2005-10-04 | 2008-02-07 | Bayer Healthcare Ag | Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen |
DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
EP1934208B1 (de) * | 2005-10-04 | 2011-03-23 | Bayer Schering Pharma Aktiengesellschaft | Neue polymorphe form von 5-chlor-n-({ ( 5s )-2-0x0-3-[4-( 3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl} -methyl)-2-thiophencarboxamid |
DE102005052174A1 (de) | 2005-11-02 | 2007-06-06 | Bayer Healthcare Ag | Phenylen-bis-oxazolidin-Derivate und ihre Verwendung |
US7700590B2 (en) | 2006-02-09 | 2010-04-20 | University Of New Orleans Research And Technology Foundation, Inc. | Antibacterial agents |
DE102006007146A1 (de) | 2006-02-16 | 2007-08-23 | Bayer Healthcare Ag | Aminoacyl-Prodrugs |
WO2007131179A1 (en) * | 2006-05-05 | 2007-11-15 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
DE102006039589A1 (de) * | 2006-08-24 | 2008-03-06 | Bayer Healthcare Ag | Aminoacyl-Prodrugs II |
DE102006051625A1 (de) * | 2006-11-02 | 2008-05-08 | Bayer Materialscience Ag | Kombinationstherapie substituierter Oxazolidinone |
EP2141154A4 (en) | 2007-03-30 | 2011-06-01 | Inst Med Molecular Design Inc | OXAZOLIDINONE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11-HYDROXYSTEOID DEHYDROGENASE TYPE I |
KR101009594B1 (ko) * | 2007-05-09 | 2011-01-20 | 주식회사 레고켐 바이오사이언스 | P4 위치에 사이클릭 아미딘을 가지는 FXa 저해제, 이의유도체, 제조방법 및 이를 함유하는 의약 조성물 |
WO2008140220A1 (en) * | 2007-05-09 | 2008-11-20 | Legochem Bioscience Ltd. | Fxa inhibitors with cyclic amidines as p4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof |
DE102007028407A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
DE102007028319A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
DE102007028320A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
DE102007028406A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
ES2425183T3 (es) * | 2007-08-14 | 2013-10-11 | Concert Pharmaceuticals Inc. | Derivados de oxazolidinonas sustituidas |
JP2011506363A (ja) * | 2007-12-11 | 2011-03-03 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | 心不全の処置および/または予防用のオキサゾリジノン類 |
KR100898361B1 (ko) * | 2008-07-03 | 2009-05-20 | 주식회사 레고켐 바이오사이언스 | P4 위치에 사이클릭 아미독심 또는 사이클릭 아미드라존기를 가지는 FXa 저해제, 이의 유도체, 제조방법 및이를 함유하는 의약 조성물 |
SI2459555T1 (sl) | 2009-07-31 | 2022-03-31 | Krka, D.D., Novo Mesto | Postopek kristalizacije rivaroksabana |
CN102050819B (zh) * | 2009-11-10 | 2012-05-23 | 天津药物研究院 | 噁唑烷酮衍生物及其制备方法和用途 |
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US8530501B2 (en) | 2009-12-17 | 2013-09-10 | Millennium Pharmaceuticals, Inc. | Salts and crystalline forms of a factor Xa inhibitor |
DE102010028362A1 (de) | 2010-04-29 | 2011-11-03 | Bayer Schering Pharma Aktiengesellschaft | Herstellverfahren |
CN102311400A (zh) * | 2010-06-29 | 2012-01-11 | 翔真生物科技股份有限公司 | 制备5-左旋-氨甲基-3-芳基-2-恶唑烷酮类的方法 |
US20130172554A1 (en) * | 2010-09-07 | 2013-07-04 | Symed Labs Limited | Processes for the preparation of 4-morpholin-3-one |
CN104693139B (zh) * | 2011-01-07 | 2017-04-19 | 浙江九洲药业股份有限公司 | 一种合成利伐沙班中间体的新工艺 |
JP6325978B2 (ja) * | 2011-05-06 | 2018-05-16 | エギシュ ヂョヂセルヂャール ザートケルエン ミケデ レースヴェーニタールササーグ | リバロキサバンの製法及び該方法において形成される中間体 |
EP2753619A2 (en) * | 2011-09-08 | 2014-07-16 | Cadila Healthcare Limited | Processes and intermediates for preparing rivaroxaban |
US9233989B2 (en) * | 2011-10-11 | 2016-01-12 | Council Of Scientific & Industrial Research | Sila analogs of oxazolidinone derivatives and synthesis thereof |
EP3309158B1 (en) | 2012-12-21 | 2022-03-16 | Krka, tovarna zdravil, d.d. | Crystalline form k of rivaroxaban and process for its preparation |
BR112015011033A2 (pt) * | 2012-12-26 | 2017-07-11 | Wanbury Ltd | derivado aldeído de oxazolidinonas substituídas |
CN103936763B (zh) * | 2013-01-18 | 2017-10-31 | 中国科学院上海药物研究所 | 噁唑烷酮类化合物及其制备方法和用途 |
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JP6389009B2 (ja) * | 2014-10-30 | 2018-09-12 | チェンデュ バイユ ファーマシューティカル カンパニー リミテッドChengdu Baiyu Pharmaceutical Co.,Ltd. | ギンコライドBと第Xa因子阻害剤とを含有する薬物組成物及びその製造方法と用途 |
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CN104497008B (zh) * | 2014-12-09 | 2016-11-16 | 广东东阳光药业有限公司 | 取代噁唑烷酮类化合物及其使用方法和用途 |
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CN111253383A (zh) * | 2020-03-27 | 2020-06-09 | 南京国星生物技术研究院有限公司 | 一种利伐沙班的合成方法 |
CN112159402B (zh) * | 2020-10-28 | 2022-04-05 | 南京法恩化学有限公司 | 一种利伐沙班的制备方法 |
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2001
- 2001-06-20 DE DE10129725A patent/DE10129725A1/de not_active Withdrawn
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2002
- 2002-06-07 EP EP02738154A patent/EP1411932B1/de not_active Expired - Lifetime
- 2002-06-07 NZ NZ530223A patent/NZ530223A/en not_active IP Right Cessation
- 2002-06-07 DK DK02738154.0T patent/DK1411932T3/da active
- 2002-06-07 CN CN02812411A patent/CN100577162C/zh not_active Expired - Lifetime
- 2002-06-07 CZ CZ20033451A patent/CZ303715B6/cs not_active IP Right Cessation
- 2002-06-07 CA CA2451258A patent/CA2451258C/en not_active Expired - Lifetime
- 2002-06-07 PT PT02738154T patent/PT1411932E/pt unknown
- 2002-06-07 AT AT02738154T patent/ATE457171T1/de active
- 2002-06-07 IL IL15925702A patent/IL159257A0/xx unknown
- 2002-06-07 BR BRPI0210941A patent/BRPI0210941B8/pt not_active IP Right Cessation
- 2002-06-07 AU AU2002312982A patent/AU2002312982B2/en not_active Expired
- 2002-06-07 WO PCT/EP2002/006237 patent/WO2003000256A1/de active IP Right Grant
- 2002-06-07 KR KR1020037016596A patent/KR100904138B1/ko active IP Right Grant
- 2002-06-07 HU HU0400240A patent/HU230120B1/hu unknown
- 2002-06-07 SK SK1530-2003A patent/SK287904B6/sk unknown
- 2002-06-07 EE EEP200400020A patent/EE05419B1/xx unknown
- 2002-06-07 DE DE50214206T patent/DE50214206D1/de not_active Expired - Lifetime
- 2002-06-07 MX MXPA03011519A patent/MXPA03011519A/es active IP Right Grant
- 2002-06-07 ES ES02738154T patent/ES2338997T3/es not_active Expired - Lifetime
- 2002-06-07 SI SI200230892T patent/SI1411932T1/sl unknown
- 2002-06-07 US US10/481,297 patent/US7767702B2/en not_active Expired - Fee Related
- 2002-06-07 JP JP2003506901A patent/JP4667744B2/ja not_active Expired - Lifetime
- 2002-06-07 PL PL368079A patent/PL206803B1/pl unknown
- 2002-06-07 RU RU2004101404/15A patent/RU2321407C9/ru active
- 2002-07-06 UA UA2004010387A patent/UA82986C2/uk unknown
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- 2003-12-09 IL IL159257A patent/IL159257A/en active IP Right Grant
- 2003-12-12 BG BG108443A patent/BG66354B1/bg unknown
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- 2003-12-19 NO NO20035743A patent/NO334821B1/no not_active IP Right Cessation
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2004
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- 2004-01-19 HR HRP20040042AA patent/HRP20040042B1/hr not_active IP Right Cessation
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2005
- 2005-02-23 HK HK05101508.8A patent/HK1068811A1/xx not_active IP Right Cessation
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