GB201007286D0 - New compounds - Google Patents

New compounds

Info

Publication number
GB201007286D0
GB201007286D0 GB201007286A GB201007286A GB201007286D0 GB 201007286 D0 GB201007286 D0 GB 201007286D0 GB 201007286 A GB201007286 A GB 201007286A GB 201007286 A GB201007286 A GB 201007286A GB 201007286 D0 GB201007286 D0 GB 201007286D0
Authority
GB
United Kingdom
Prior art keywords
new compounds
compounds
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GB201007286A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astex Therapeutics Ltd
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Priority to GB201007286A priority Critical patent/GB201007286D0/en
Publication of GB201007286D0 publication Critical patent/GB201007286D0/en
Priority to JOP/2011/0133A priority patent/JO3366B1/ar
Priority to TW100114665A priority patent/TWI545122B/zh
Priority to RS20211397A priority patent/RS62570B1/sr
Priority to SM20170193T priority patent/SMT201700193T1/it
Priority to PL11724710T priority patent/PL2563775T3/pl
Priority to ARP110101476 priority patent/AR080982A1/es
Priority to PT16207610T priority patent/PT3178818T/pt
Priority to EP19175481.1A priority patent/EP3590934B1/en
Priority to KR1020127031310A priority patent/KR101889565B1/ko
Priority to SI201132013T priority patent/SI3590934T1/sl
Priority to US13/643,741 priority patent/US8895601B2/en
Priority to CN201180021785.5A priority patent/CN102858765B/zh
Priority to HRP20170410TT priority patent/HRP20170410T1/hr
Priority to HUE16207610A priority patent/HUE045893T2/hu
Priority to MX2015012476A priority patent/MX365702B/es
Priority to LTEP16207610.3T priority patent/LT3178818T/lt
Priority to SG10201708578QA priority patent/SG10201708578QA/en
Priority to EA201291143A priority patent/EA023222B8/ru
Priority to PL19175481T priority patent/PL3590934T3/pl
Priority to MYPI2012004699A priority patent/MY189427A/en
Priority to ES11724710.6T priority patent/ES2621461T3/es
Priority to MYPI2016001863A priority patent/MY191669A/en
Priority to DK11724710.6T priority patent/DK2563775T3/en
Priority to SM20210662T priority patent/SMT202100662T1/it
Priority to HUE19175481A priority patent/HUE056999T2/hu
Priority to DK16207610.3T priority patent/DK3178818T3/da
Priority to MX2012012414A priority patent/MX2012012414A/es
Priority to EP11724710.6A priority patent/EP2563775B1/en
Priority to PH1/2012/501993A priority patent/PH12012501993A1/en
Priority to LTEP11724710.6T priority patent/LT2563775T/lt
Priority to PT117247106T priority patent/PT2563775T/pt
Priority to CR20180339A priority patent/CR20180339A/es
Priority to ES19175481T priority patent/ES2899937T3/es
Priority to AP2012006490A priority patent/AP3210A/xx
Priority to BR112012027509-7A priority patent/BR112012027509B1/pt
Priority to IN2591MUN2012 priority patent/IN2012MN02591A/en
Priority to PL16207610T priority patent/PL3178818T3/pl
Priority to JP2013506755A priority patent/JP5639261B2/ja
Priority to SG2012078085A priority patent/SG184966A1/en
Priority to SM20190469T priority patent/SMT201900469T1/it
Priority to SI201131112A priority patent/SI2563775T1/sl
Priority to RSP20191045 priority patent/RS59196B1/sr
Priority to HUE11724710A priority patent/HUE033702T2/en
Priority to HRP20211675TT priority patent/HRP20211675T1/hr
Priority to MEP-2013-123A priority patent/ME01825B/me
Priority to CN201510087109.8A priority patent/CN104725362B/zh
Priority to AU2011247047A priority patent/AU2011247047B2/en
Priority to EA201500278A priority patent/EA028599B1/ru
Priority to KR1020187023217A priority patent/KR101933843B1/ko
Priority to SI201131755T priority patent/SI3178818T1/sl
Priority to LTEP19175481.1T priority patent/LT3590934T/lt
Priority to RS20170353A priority patent/RS55863B1/sr
Priority to DK19175481.1T priority patent/DK3590934T3/da
Priority to NZ602726A priority patent/NZ602726A/en
Priority to PT191754811T priority patent/PT3590934T/pt
Priority to EP16207610.3A priority patent/EP3178818B1/en
Priority to ES16207610T priority patent/ES2742409T3/es
Priority to PCT/GB2011/050851 priority patent/WO2011135376A1/en
Priority to CA2796204A priority patent/CA2796204C/en
Priority to IL222600A priority patent/IL222600A/en
Priority to NI201200162A priority patent/NI201200162A/es
Priority to CL2012003048A priority patent/CL2012003048A1/es
Priority to CR20120576A priority patent/CR20120576A/es
Priority to ECSP12012318 priority patent/ECSP12012318A/es
Priority to US14/505,020 priority patent/US9464071B2/en
Priority to HK15112661.6A priority patent/HK1211922B/xx
Priority to IL244032A priority patent/IL244032B/en
Priority to US15/141,061 priority patent/US9850228B2/en
Priority to CY20171100400T priority patent/CY1118804T1/el
Priority to AU2017202512A priority patent/AU2017202512B2/en
Priority to ZA2017/06763A priority patent/ZA201706763B/en
Priority to US15/810,521 priority patent/US10519137B2/en
Priority to HRP20191224TT priority patent/HRP20191224T1/hr
Priority to CY20191100858T priority patent/CY1121882T1/el
Priority to US16/663,579 priority patent/US20200131153A1/en
Priority to US17/451,601 priority patent/US20220135544A1/en
Priority to CY20211101014T priority patent/CY1124928T1/el
Priority to FR25C1006C priority patent/FR25C1006I2/fr
Priority to NL301318C priority patent/NL301318I2/nl
Priority to NO2025011C priority patent/NO2025011I1/no
Priority to LTPA2025509C priority patent/LTPA2025509I1/lt
Priority to FIC20250009C priority patent/FIC20250009I1/fi
Priority to HUS2500011C priority patent/HUS2500011I1/hu
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
GB201007286A 2010-04-30 2010-04-30 New compounds Ceased GB201007286D0 (en)

Priority Applications (84)

Application Number Priority Date Filing Date Title
GB201007286A GB201007286D0 (en) 2010-04-30 2010-04-30 New compounds
JOP/2011/0133A JO3366B1 (ar) 2010-04-30 2011-04-19 مثبطات بيرازوليل كوينوكزالين كاينيز
TW100114665A TWI545122B (zh) 2010-04-30 2011-04-27 吡唑喹噁啉激酶抑制劑
RS20211397A RS62570B1 (sr) 2010-04-30 2011-04-28 Inhibitori kinaze pirazolil hinoksalina
SM20170193T SMT201700193T1 (it) 2010-04-30 2011-04-28 INIBITORI DI CHINASI PIRAZOLlLCHINOSSALINICI
PL11724710T PL2563775T3 (pl) 2010-04-30 2011-04-28 Pirazolilo-chinoksalinowe inhibitory kinazy
ARP110101476 AR080982A1 (es) 2010-04-30 2011-04-28 Derivados de quinoxalina
PT16207610T PT3178818T (pt) 2010-04-30 2011-04-28 Inibidores de pirazolil quinoxalina quinase
EP19175481.1A EP3590934B1 (en) 2010-04-30 2011-04-28 Pyrazolyl quinoxaline kinase inhibitors
KR1020127031310A KR101889565B1 (ko) 2010-04-30 2011-04-28 피라졸릴 퀴녹살린 키나제 억제제
SI201132013T SI3590934T1 (sl) 2010-04-30 2011-04-28 Inhibitorji pirazolil kinoksalin kinaze
US13/643,741 US8895601B2 (en) 2010-04-30 2011-04-28 Pyrazolyl quinoxaline kinase inhibitors
CN201180021785.5A CN102858765B (zh) 2010-04-30 2011-04-28 吡唑基喹喔啉激酶抑制剂
HRP20170410TT HRP20170410T1 (hr) 2010-04-30 2011-04-28 Inhibitori kinaze priazolil kinoksalina
HUE16207610A HUE045893T2 (hu) 2010-04-30 2011-04-28 Pirazolil-kinoxalin-kináz inhibitorok
MX2015012476A MX365702B (es) 2010-04-30 2011-04-28 Inhibidores de pirazolil quinoxalina cinasa.
LTEP16207610.3T LT3178818T (lt) 2010-04-30 2011-04-28 Pirazolilo chinoksalino kinazės inhibitoriai
SG10201708578QA SG10201708578QA (en) 2010-04-30 2011-04-28 Pyrazolyl quinoxaline kinase inhibitors
EA201291143A EA023222B8 (ru) 2010-04-30 2011-04-28 Пиразолилхиноксалиновые ингибиторы киназы
PL19175481T PL3590934T3 (pl) 2010-04-30 2011-04-28 Pirazolilo-chinoksalinowe inhibitory kinazy
MYPI2012004699A MY189427A (en) 2010-04-30 2011-04-28 Pyrazolyl quinoxaline kinase inhibitors
ES11724710.6T ES2621461T3 (es) 2010-04-30 2011-04-28 Inhibidores de quinasa de pirazolilquinoxalina
MYPI2016001863A MY191669A (en) 2010-04-30 2011-04-28 Pyrazolyl quinoxaline kinase inihibitors
DK11724710.6T DK2563775T3 (en) 2010-04-30 2011-04-28 PYRAZOLYLQUINOXALINKINASE INHIBITORS
SM20210662T SMT202100662T1 (it) 2010-04-30 2011-04-28 Inibitori di chinasi pirazolilchinossalinici
HUE19175481A HUE056999T2 (hu) 2010-04-30 2011-04-28 Pirazolil-kinoxalin kináz inhibitorok
DK16207610.3T DK3178818T3 (da) 2010-04-30 2011-04-28 Pyrazolylquinoxalinkinasehæmmere
MX2012012414A MX2012012414A (es) 2010-04-30 2011-04-28 Inhibidores de pirazoll quinazolina cinasa.
EP11724710.6A EP2563775B1 (en) 2010-04-30 2011-04-28 Pyrazolyl quinoxaline kinase inhibitors
PH1/2012/501993A PH12012501993A1 (en) 2010-04-30 2011-04-28 Pyrazolyl quinazoline kinase ihibitors
LTEP11724710.6T LT2563775T (lt) 2010-04-30 2011-04-28 Pirazolilo chinoksalino kinazės inhibitoriai
PT117247106T PT2563775T (pt) 2010-04-30 2011-04-28 Inibidores de pirazolil quinoxalina quinase
CR20180339A CR20180339A (es) 2010-04-30 2011-04-28 INHIBIDORES DE PIRAZOLIL QUINAZOLINA CINASA (Divisional 2012-0576)
ES19175481T ES2899937T3 (es) 2010-04-30 2011-04-28 Inhibidores de quinasa de pirazolilquinoxalina
AP2012006490A AP3210A (en) 2010-04-30 2011-04-28 Pyrazolyt quinazoline kinase inhibitors
BR112012027509-7A BR112012027509B1 (pt) 2010-04-30 2011-04-28 Composto pirazolil-quinoxalina inibidor de quinase, combinação, produto, processo para a preparação de um composto, composição farmacêutica, e, uso de um composto
IN2591MUN2012 IN2012MN02591A (enExample) 2010-04-30 2011-04-28
PL16207610T PL3178818T3 (pl) 2010-04-30 2011-04-28 Inhibitory kinazy pirazolilochinoksalinowej
JP2013506755A JP5639261B2 (ja) 2010-04-30 2011-04-28 ピラゾリルキノキサリンキナーゼ阻害剤
SG2012078085A SG184966A1 (en) 2010-04-30 2011-04-28 Pyrazolyl quinazoline kinase inhibitors
SM20190469T SMT201900469T1 (it) 2010-04-30 2011-04-28 Inibitori di ghinasi pirazolilchinossalinici
SI201131112A SI2563775T1 (sl) 2010-04-30 2011-04-28 Pirazolil kinoksalin inhibitorji kinaze
RSP20191045 RS59196B1 (sr) 2010-04-30 2011-04-28 Inhibitori kinaze pirazolil hinoksalina
HUE11724710A HUE033702T2 (en) 2010-04-30 2011-04-28 Pyrazolyl quinoxaline kinase inhibitors
HRP20211675TT HRP20211675T1 (hr) 2010-04-30 2011-04-28 Inhibitori kinaze pirazolil hinoksalina
MEP-2013-123A ME01825B (me) 2010-04-30 2011-04-28 Inhibitori pirazolil hinoksalina kinaze
CN201510087109.8A CN104725362B (zh) 2010-04-30 2011-04-28 吡唑基喹喔啉激酶抑制剂
AU2011247047A AU2011247047B2 (en) 2010-04-30 2011-04-28 Pyrazolyl quinoxaline kinase inhibitors
EA201500278A EA028599B1 (ru) 2010-04-30 2011-04-28 Пиразолилхиноксалиновые ингибиторы киназы
KR1020187023217A KR101933843B1 (ko) 2010-04-30 2011-04-28 피라졸릴 퀴녹살린 키나제 억제제
SI201131755T SI3178818T1 (sl) 2010-04-30 2011-04-28 Inhibitorji pirazolil kinoksalin kinaze
LTEP19175481.1T LT3590934T (lt) 2010-04-30 2011-04-28 Pirazolilchinoksalino kinazės inhibitoriai
RS20170353A RS55863B1 (sr) 2010-04-30 2011-04-28 Inhibitori kinaze pirazolil hinoksalina
DK19175481.1T DK3590934T3 (da) 2010-04-30 2011-04-28 Pyrazolylquinoxalinkinasehæmmere
NZ602726A NZ602726A (en) 2010-04-30 2011-04-28 Pyrazolyl quinoxaline kinase inhibitors
PT191754811T PT3590934T (pt) 2010-04-30 2011-04-28 Inibidores de pirazolil quinoxalina quinase
EP16207610.3A EP3178818B1 (en) 2010-04-30 2011-04-28 Pyrazolyl quinoxaline kinase inhibitors
ES16207610T ES2742409T3 (es) 2010-04-30 2011-04-28 Inhibidores de quinasa de pirazolilquinoxalina
PCT/GB2011/050851 WO2011135376A1 (en) 2010-04-30 2011-04-28 Pyrazolyl quinazoline kinase inhibitors
CA2796204A CA2796204C (en) 2010-04-30 2011-04-28 Pyrazolyl quinoxaline kinase inhibitors
IL222600A IL222600A (en) 2010-04-30 2012-10-22 Derivatives of 3- (pyrazole-4-ram) -6-phenylamino-quinoxaline, their preparation, combinations and preparations containing them and their use in the manufacture and treatment of cancer prevention drugs
NI201200162A NI201200162A (es) 2010-04-30 2012-10-29 Inhibidores de pirazolil quinoxalina cinasa
CL2012003048A CL2012003048A1 (es) 2010-04-30 2012-10-30 Compuestos derivados de n-fenil-3-(1h-pirazol-4-il)quinoxalin-6-amina, inhibidores de tirosino quinasa fgfr; proceso de preparación; composición farmacéutica; y su uso en la prevención o tratamiento de cáncer.
CR20120576A CR20120576A (es) 2010-04-30 2012-11-13 Inhibidores de pirazolil quinazolina cinasa
ECSP12012318 ECSP12012318A (es) 2010-04-30 2012-11-29 Inhibidores de pirazolil quinazolina cinasa
US14/505,020 US9464071B2 (en) 2010-04-30 2014-10-02 Pyrazolyl quinoxaline kinase inhibitors
HK15112661.6A HK1211922B (en) 2010-04-30 2015-12-24 Pyrazolyl quinoxaline kinase inhibitors
IL244032A IL244032B (en) 2010-04-30 2016-02-09 Intermediates for the preparation of pyrazolylquinoxaline kinase inhibitors
US15/141,061 US9850228B2 (en) 2010-04-30 2016-04-28 Pyrazolyl quinoxaline kinase inhibitors
CY20171100400T CY1118804T1 (el) 2010-04-30 2017-04-04 Αναστολεις πυραζολυλο κινοξαλινο κινασης
AU2017202512A AU2017202512B2 (en) 2010-04-30 2017-04-18 Pyrazolyl quinoxaline kinase inhibitors
ZA2017/06763A ZA201706763B (en) 2010-04-30 2017-10-06 Pyrazolyl quinoxaline kinase inhibitors
US15/810,521 US10519137B2 (en) 2010-04-30 2017-11-13 Pyrazolyl quinoxaline kinase inhibitors
HRP20191224TT HRP20191224T1 (hr) 2010-04-30 2019-07-08 Inhibitori kinaze pirazolil kinoksalina
CY20191100858T CY1121882T1 (el) 2010-04-30 2019-08-09 Αναστολεις πυραζολυλο κινοξαλινο κινασης
US16/663,579 US20200131153A1 (en) 2010-04-30 2019-10-25 Pyrazolyl quinoxaline kinase inhibitors
US17/451,601 US20220135544A1 (en) 2010-04-30 2021-10-20 Pyrazolyl quinoxaline kinase inhibitors
CY20211101014T CY1124928T1 (el) 2010-04-30 2021-11-23 Αναστολεις πυραζολυλο κινοξαλινο κινασης
FR25C1006C FR25C1006I2 (fr) 2010-04-30 2025-02-13 Inhibiteurs de pyrazolyl-quinoxaline kinase
NL301318C NL301318I2 (nl) 2010-04-30 2025-02-14 Erdafitinib of een farmaceutisch aanvaardbaar zout daarvan of een solvaat daarvan
NO2025011C NO2025011I1 (no) 2010-04-30 2025-02-17 Erdafitinib or a pharmaceutically acceptable salt thereof or a solvate thereof
LTPA2025509C LTPA2025509I1 (enExample) 2010-04-30 2025-02-17
FIC20250009C FIC20250009I1 (fi) 2010-04-30 2025-02-18 Erdafitinibi tai sen farmaseuttisesti hyväksyttävä suola tai solvaatti
HUS2500011C HUS2500011I1 (hu) 2010-04-30 2025-02-20 Pirazolil-kinoxalin kináz inhibitorok

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201007286A GB201007286D0 (en) 2010-04-30 2010-04-30 New compounds

Publications (1)

Publication Number Publication Date
GB201007286D0 true GB201007286D0 (en) 2010-06-16

Family

ID=42289929

Family Applications (1)

Application Number Title Priority Date Filing Date
GB201007286A Ceased GB201007286D0 (en) 2010-04-30 2010-04-30 New compounds

Country Status (41)

Country Link
US (6) US8895601B2 (enExample)
EP (3) EP2563775B1 (enExample)
JP (1) JP5639261B2 (enExample)
KR (2) KR101889565B1 (enExample)
CN (2) CN104725362B (enExample)
AP (1) AP3210A (enExample)
AR (1) AR080982A1 (enExample)
AU (2) AU2011247047B2 (enExample)
BR (1) BR112012027509B1 (enExample)
CA (1) CA2796204C (enExample)
CL (1) CL2012003048A1 (enExample)
CR (2) CR20180339A (enExample)
CY (2) CY1121882T1 (enExample)
DK (3) DK3178818T3 (enExample)
EA (2) EA028599B1 (enExample)
EC (1) ECSP12012318A (enExample)
ES (3) ES2742409T3 (enExample)
FI (1) FIC20250009I1 (enExample)
FR (1) FR25C1006I2 (enExample)
GB (1) GB201007286D0 (enExample)
HR (1) HRP20211675T1 (enExample)
HU (4) HUE045893T2 (enExample)
IL (1) IL222600A (enExample)
IN (1) IN2012MN02591A (enExample)
JO (1) JO3366B1 (enExample)
LT (4) LT2563775T (enExample)
ME (1) ME01825B (enExample)
MX (2) MX2012012414A (enExample)
MY (2) MY189427A (enExample)
NL (1) NL301318I2 (enExample)
NO (1) NO2025011I1 (enExample)
NZ (1) NZ602726A (enExample)
PH (1) PH12012501993A1 (enExample)
PL (3) PL3178818T3 (enExample)
PT (3) PT3178818T (enExample)
RS (3) RS59196B1 (enExample)
SG (2) SG10201708578QA (enExample)
SI (3) SI3590934T1 (enExample)
SM (3) SMT202100662T1 (enExample)
TW (1) TWI545122B (enExample)
WO (1) WO2011135376A1 (enExample)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009008099A (es) 2007-02-01 2009-12-14 Resverlogix Corp Compuestos para la prevencion y tratamiento de enfermedades cardiovasculares.
KR101913109B1 (ko) 2009-03-18 2018-10-31 리스버로직스 코퍼레이션 신규한 소염제
DK2421533T3 (en) 2009-04-22 2019-01-07 Resverlogix Corp Hitherto unknown anti-inflammatory agents
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
WO2013059740A1 (en) 2011-10-21 2013-04-25 Foundation Medicine, Inc. Novel alk and ntrk1 fusion molecules and uses thereof
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) * 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) * 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) * 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
US9611267B2 (en) 2012-06-13 2017-04-04 Incyte Holdings Corporation Substituted tricyclic compounds as FGFR inhibitors
DK2872491T3 (da) 2012-07-11 2021-08-09 Blueprint Medicines Corp Inhibitorer af fibroblastvækstfaktorreceptoren
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
KR101532570B1 (ko) * 2012-10-15 2015-06-30 리스버로직스 코퍼레이션 벤즈아미드 화합물의 합성에 유용한 화합물
HK1214831A1 (zh) 2012-11-05 2016-08-05 Foundation Medicine, Inc. 新型融合分子及其应用
AU2013337277B2 (en) 2012-11-05 2018-03-08 Foundation Medicine, Inc. Novel NTRK1 fusion molecules and uses thereof
US9719970B2 (en) 2012-11-30 2017-08-01 Waters Technologies Corporation Methods and apparatus for the analysis of vitamin D metabolites
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US10980804B2 (en) 2013-01-18 2021-04-20 Foundation Medicine, Inc. Methods of treating cholangiocarcinoma
AR094812A1 (es) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd Derivado de piridina monocíclico como inhibidor del fgfr
US9321786B2 (en) 2013-03-15 2016-04-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
EP3943087A1 (en) 2013-03-15 2022-01-26 Celgene CAR LLC Heteroaryl compounds and uses thereof
TWI649318B (zh) 2013-04-19 2019-02-01 英塞特控股公司 作為ｆｇｆｒ抑制劑之雙環雜環
GB201307577D0 (en) * 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
CN104163794A (zh) * 2013-10-17 2014-11-26 中国药科大学 2-氨基芳环类血管内皮生长因子受体(vegfr)抑制剂及其制备方法和用途
BR112016008849B8 (pt) 2013-10-25 2022-09-06 Blueprint Medicines Corp Compostos ou sais farmaceuticamente aceitáveis dos mesmos, uso dos referidos compostos e composições farmacêuticas
US9695165B2 (en) 2014-01-15 2017-07-04 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
MA38393B1 (fr) * 2014-03-13 2018-11-30 Sanofi Sa Composés hétéroaryle et utilisations associées
JO3512B1 (ar) * 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
KR102479696B1 (ko) * 2014-03-26 2022-12-22 아스텍스 테라퓨틱스 리미티드 Fgfr 억제제 및 igf1r 억제제의 조합물
HUE053654T2 (hu) * 2014-03-26 2021-07-28 Astex Therapeutics Ltd FGFR- és CMET-inhibitorok kombinációi a rák kezelésére
CN105017227B (zh) * 2014-07-08 2018-03-09 四川百利药业有限责任公司 N‑(1h‑吡唑‑5‑基)喹唑啉‑4‑胺类化合物
BR112017002268B1 (pt) 2014-08-18 2022-11-08 Eisai R&D Management Co., Ltd Sal de derivado de piridina monocíclica e cristal do mesmo
UA122564C2 (uk) * 2014-09-26 2020-12-10 Янссен Фармацевтика Нв Використання панелі мутантних генів fgfr для ідентифікації пацієнтів із раковим захворюванням, які піддаються лікуванню інгібітором fgfr
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
TWI695837B (zh) 2014-12-04 2020-06-11 比利時商健生藥品公司 作為激酶調節劑之三唑並嗒
JOP20200201A1 (ar) * 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
AU2016219822B2 (en) 2015-02-20 2020-07-09 Incyte Holdings Corporation Bicyclic heterocycles as FGFR inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
JP6903585B2 (ja) 2015-03-13 2021-07-14 レスバーロジックス コーポレイション 補体関連疾患の治療のための組成物および治療方法
RU2712222C2 (ru) 2015-03-25 2020-01-27 Нэшнл Кэнсер Сентер Терапевтическое средство против рака желчных протоков
TWI703984B (zh) * 2015-04-03 2020-09-11 英商阿斯特克斯治療有限公司 用於癌症治療之fgfr/pd-1組合療法
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
CA2996857C (en) * 2015-09-23 2024-05-21 Janssen Pharmaceutica Nv Quinoxaline, quinoline and quinazolinone derivative compounds for the treatment of cancer
EP3353164B1 (en) * 2015-09-23 2021-11-03 Janssen Pharmaceutica, N.V. Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
CN105596330B (zh) * 2015-12-11 2018-10-16 深圳市坤健创新药物研究院 虚拟筛选化合物在制备激酶抑制剂中的应用和药物
WO2017104739A1 (ja) 2015-12-17 2017-06-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 乳がん治療剤
CN107459519A (zh) 2016-06-06 2017-12-12 上海艾力斯医药科技有限公司 稠合嘧啶哌啶环衍生物及其制备方法和应用
WO2018049233A1 (en) 2016-09-08 2018-03-15 Nicolas Stransky Inhibitors of the fibroblast growth factor receptor in combination with cyclin-dependent kinase inhibitors
CA3039919A1 (en) * 2016-10-10 2018-04-19 Development Center For Biotechnology Quinoxaline compounds as type iii receptor tyrosine kinase inhibitors
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
JOP20190280A1 (ar) * 2017-06-02 2019-12-02 Janssen Pharmaceutica Nv مثبطات fgfr2 لعلاج سرطان الأوعية الصفراوية
CA3072735A1 (en) * 2017-08-21 2019-02-28 Celgene Corporation Processes for the preparation of (s)-tert-butyl 4,5-diamino-5-oxopentanoate
EP3716978B1 (en) 2017-12-01 2023-08-16 Board of Regents of the University of Nebraska N-(phenyl)-n'-(6-quinoxalinyl)-urea derivatives as ikkb inhibitors for the treatment of cancer
BR112020017922A2 (pt) 2018-03-28 2020-12-22 Eisai R&D Management Co., Ltd. Agente terapêutico para carcinoma hepatocelular
KR102308134B1 (ko) * 2018-04-26 2021-10-01 재단법인 의약바이오컨버젼스연구단 mTOR 저해제로서의 신규 화합물 및 이의 용도
TW201946630A (zh) 2018-05-04 2019-12-16 美商英塞特公司 Fgfr抑制劑之鹽
ES2991427T3 (es) 2018-05-04 2024-12-03 Incyte Corp Formas sólidas de un inhibidor de FGFR y procedimientos para preparar las mismas
AU2019342289A1 (en) 2018-09-21 2021-03-18 Janssen Pharmaceutica Nv Treatment of cholangiocarcinoma
CN113474337A (zh) * 2018-12-19 2021-10-01 奥瑞生物药品公司 作为fgfr抑制剂用于治疗癌症的7-((3，5-二甲氧基苯基)氨基)喹喔啉衍生物
JP2022515198A (ja) 2018-12-19 2022-02-17 アレイ バイオファーマ インコーポレイテッド ＦＧＦＲチロシンキナーゼの阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2020205493A1 (en) 2019-03-29 2020-10-08 Janssen Pharmaceutica Nv Fgfr tyrosine kinase inhibitors for the treatment of urothelial carcinoma
CA3130773A1 (en) 2019-03-29 2020-10-08 Peter Marie Z. De Porre Fgfr tyrosine kinase inhibitors for the treatment of urothelial carcinoma
WO2020208592A1 (en) * 2019-04-12 2020-10-15 Dr. Reddy’S Laboratories Limited Process for preparation of erdafitinib, its purification and amorphous solid dispersion
CN111909044A (zh) * 2019-05-09 2020-11-10 南京爱德程医药科技有限公司 2-(烷基氨基)乙基苯甲酸酯类化合物的合成方法
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
TWI759829B (zh) * 2019-08-23 2022-04-01 財團法人生物技術開發中心 作為第iii型受體酪胺酸激酶抑制劑之雜環吡唑衍生物
JP7709959B2 (ja) 2019-09-26 2025-07-17 ヤンセン ファーマシューティカ エヌ．ベー． 連続的な治療設定における免疫チェックポイント阻害剤に対する患者の応答を高めるためのｆｇｆｒ遺伝子改変癌におけるｆｇｆｒ阻害剤の使用
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
GEAP202415945A (en) 2019-10-14 2024-04-25 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN110790677B (zh) * 2019-11-05 2022-04-29 浙江工业大学 一种金刚烷甲酰胺类化合物及其制备方法和应用
CA3161008A1 (en) 2019-11-25 2021-06-03 Amgen Inc. Heterocyclic compounds as delta-5 desaturase inhibitors and methods of use
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
AU2020395185A1 (en) 2019-12-04 2022-06-02 Incyte Corporation Derivatives of an FGFR inhibitor
CN113024517A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种制备厄达替尼的方法
CN113024518A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种厄达替尼的制备方法
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JP2023512482A (ja) * 2020-01-17 2023-03-27 ベータ・ファーマ・インコーポレイテッド Ｆｇｆｒキナーゼ阻害剤としてのピリダジンおよび１，２，４－トリアジン誘導体
TWI900527B (zh) 2020-02-12 2025-10-11 比利時商健生藥品公司 用於治療尿路上皮癌的ｆｇｆｒ酪胺酸激酶抑制劑和抗ｐｄ１藥劑
JP2023513704A (ja) 2020-02-12 2023-04-03 ヤンセン ファーマシューティカ エヌ．ベー． 高リスク筋層非浸潤性膀胱癌を治療するためのｆｇｆｒチロシンキナーゼ阻害剤
US20240010632A1 (en) 2020-08-17 2024-01-11 Teva Pharmaceuticals International Gmbh Solid state forms of erdafitinib salts and processes for preparation of erdafitinib
CN112920167B (zh) * 2020-08-19 2022-08-26 四川大学华西医院 靶向fgfr和hdac的双靶点抑制剂及其制备方法和应用、药物组合物及药剂
AU2021339962A1 (en) 2020-09-14 2023-05-25 Janssen Pharmaceutica Nv Fgfr inhibitor combination therapies
EP4323405A1 (en) 2021-04-12 2024-02-21 Incyte Corporation Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
JP2024518612A (ja) 2021-05-19 2024-05-01 ヤンセン ファーマシューティカ エヌ．ベー． 進行性固形腫瘍の治療のためのｆｇｆｒチロシンキナーゼ阻害剤
AR126101A1 (es) 2021-06-09 2023-09-13 Incyte Corp Heterociclos tricíclicos como inhibidores de fgfr
CA3220274A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
CN117858872A (zh) 2021-06-22 2024-04-09 缆图药品公司 用于治疗癌症的杂环egfr抑制剂
EP4415692A1 (en) 2021-10-12 2024-08-21 TARIS Biomedical LLC Erdafitinib formulations and systems for intravesical administration
WO2023081923A1 (en) 2021-11-08 2023-05-11 Frequency Therapeutics, Inc. Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
WO2023159216A1 (en) * 2022-02-18 2023-08-24 Taris Biomedical Llc Erdafitinib formulations and osmotic systems for intravesical administration
CN115108926B (zh) * 2022-04-02 2023-06-20 上海工程技术大学 一种用于制备厄达替尼的中间体化合物及制备方法
AU2024220896A1 (en) 2023-02-13 2025-10-02 Taris Biomedical Llc Erdafitinib for intravesical administration for use in the treatment of bladder cancer
CN120813357A (zh) 2023-02-13 2025-10-17 詹森药业有限公司 用于治疗高风险非肌层浸润性膀胱癌的fgfr酪氨酸激酶抑制剂
CN119101036A (zh) * 2023-06-08 2024-12-10 广州六顺生物科技有限公司 喹喔啉类化合物及其应用
WO2025059602A1 (en) 2023-09-14 2025-03-20 Taris Biomedical Llc Methods of treating bladder cancer using intravesical administration of erdafitinib
CN119350298A (zh) * 2024-10-09 2025-01-24 沈阳药科大学 一种厄达替尼的制备方法以及用于该方法的中间体化合物

Family Cites Families (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2940972A (en) 1957-06-27 1960-06-14 Thomae Gmbh Dr K Tri-and tetra-substituted pteridine derivatives
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
GB9125001D0 (en) 1991-11-25 1992-01-22 Ici Plc Heterocyclic compounds
EP0698015A1 (en) 1993-05-14 1996-02-28 Genentech, Inc. Preparation of n-cyanodithioimino-carbonates and 3-mercapto-5-amino-1h-1,2,4-triazole
US5700823A (en) 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US6331555B1 (en) 1995-06-01 2001-12-18 University Of California Treatment of platelet derived growth factor related disorders such as cancers
US6218529B1 (en) 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
CA2744096C (en) 1996-07-31 2013-07-30 Laboratory Corporation Of America Holdings Biomarkers and targets for diagnosis, prognosis and management of prostate disease
TW472045B (en) 1996-09-25 2002-01-11 Astra Ab Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
AU747026B2 (en) 1997-05-28 2002-05-09 Aventis Pharmaceuticals Inc. Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
US6235740B1 (en) 1997-08-25 2001-05-22 Bristol-Myers Squibb Co. Imidazoquinoxaline protein tyrosine kinase inhibitors
UA71555C2 (en) 1997-10-06 2004-12-15 Zentaris Gmbh Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives
WO2000042026A1 (en) 1999-01-15 2000-07-20 Novo Nordisk A/S Non-peptide glp-1 agonists
EA005287B1 (ru) 1999-09-15 2004-12-30 Уорнер-Ламберт Компани Птеридиноны в качестве ингибиторов киназ
DE10013318A1 (de) 2000-03-17 2001-09-20 Merck Patent Gmbh Formulierung enthaltend Chinoxalinderivate
WO2002076985A1 (en) 2001-03-23 2002-10-03 Smithkline Beecham Corporation Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
JP4286146B2 (ja) 2001-12-18 2009-06-24 メルク エンド カムパニー インコーポレーテッド メタボトロピックグルタミン酸受容体−５のヘテロアリール置換ピラゾール系調節剤
ES2333702T3 (es) 2001-12-24 2010-02-26 Astrazeneca Ab Derivados de quinazolina sustituidos que actuan como unhibidores de cinasas aurora.
JP2003213463A (ja) 2002-01-17 2003-07-30 Sumitomo Chem Co Ltd 金属腐食防止剤および洗浄液
CA2480800C (en) 2002-04-08 2008-09-23 Mark T. Bilodeau Inhibitors of akt activity
US7265378B2 (en) 2002-07-10 2007-09-04 E. I. Du Pont De Nemours And Company Electronic devices made with electron transport and/or anti-quenching layers
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
CA2500727A1 (en) 2002-10-03 2004-04-15 Targegen, Inc. Vasculostatic agents and methods of use thereof
AR043059A1 (es) 2002-11-12 2005-07-13 Bayer Pharmaceuticals Corp Derivados de indolil pirazinona utiles para el tratamiento de trastornos hiper-proliferativos
US7098332B2 (en) 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
JP2006516561A (ja) 2003-01-17 2006-07-06 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 細胞増殖の阻害剤としての２−アミノピリジン置換ヘテロ環類
WO2004098494A2 (en) 2003-04-30 2004-11-18 Cytokinetics, Inc. Compounds, compositions, and methods
EP1628666B1 (en) 2003-05-14 2015-09-23 NeuroGenetic Pharmaceuticals, Inc. Compouds and uses thereof in modulating amyloid beta
ES2316985T3 (es) 2003-05-23 2009-04-16 Aterna Zentaris Gmbh Nuevas piridopirazidinas y su uso como moduladores de quinasas.
DE10323345A1 (de) 2003-05-23 2004-12-16 Zentaris Gmbh Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren
WO2005007099A2 (en) 2003-07-10 2005-01-27 Imclone Systems Incorporated Pkb inhibitors as anti-tumor agents
EP1646383A4 (en) 2003-07-21 2009-03-25 Bethesda Pharmaceuticals Inc DESIGN AND SYNTHESIS OF OPTIMIZED LIGANDS FOR PPAR
BRPI0413234A (pt) 2003-08-01 2006-10-03 Genelabs Tech Inc derivados de imidazola bicìclica contra flaviviridae
ES2293354T3 (es) 2003-10-17 2008-03-16 4 Aza Ip Nv Derivados de pteridina sustituidos por heterociclos y su uso en terapia.
WO2005047244A2 (en) 2003-11-07 2005-05-26 Chiron Corporation Inhibition of fgfr3 and treatment of multiple myeloma
EA009875B1 (ru) 2003-11-20 2008-04-28 Янссен Фармацевтика Н.В. 6-алкенил и 6-фенилалкил замещенные 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза) полимеразы
MXPA06005735A (es) 2003-11-24 2006-08-17 Hoffmann La Roche Pirazolil e imidazolil pirimidinas.
PL1706385T3 (pl) * 2003-12-23 2011-03-31 Astex Therapeutics Ltd Pochodne pirazolu jako modulatory kinazy białkowej
US7205316B2 (en) 2004-05-12 2007-04-17 Abbott Laboratories Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands
US7098222B2 (en) 2004-05-12 2006-08-29 Abbott Laboratories Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
EP1789399A1 (en) 2004-08-31 2007-05-30 AstraZeneca AB Quinazolinone derivatives and their use as b-raf inhibitors
CA2583192A1 (en) 2004-10-14 2006-04-20 F. Hoffmann-La Roche Ag 1,5-naphthyridine azolidinones having cdk1 antiproliferative activity
MX2007004480A (es) 2004-10-15 2007-05-08 Astrazeneca Ab Quinoxalinas como inhibidores b raf.
CN102861019B (zh) 2004-12-24 2016-05-25 诺华股份有限公司 治疗或预防神经性疼痛的药物
US8278290B2 (en) 2005-02-14 2012-10-02 Biononics Limited Tubulin polymerisation inhibitors
US9271963B2 (en) 2005-03-03 2016-03-01 Universitat Des Saarlandes Selective inhibitors of human corticosteroid synthases
AU2006247833A1 (en) 2005-05-12 2006-11-23 Merck & Co., Inc. Tyrosine kinase inhibitors
BRPI0611521A2 (pt) 2005-05-18 2010-09-14 Wyeth Corp inibidores de 4,6-diamino-[1,7]naftiridina-3-carbonitrila de quìnase tpl2 e métodos de fabricação e uso dos mesmos
GB0513692D0 (en) 2005-07-04 2005-08-10 Karobio Ab Novel pharmaceutical compositions
WO2007023186A1 (en) 2005-08-26 2007-03-01 Laboratoires Serono S.A. Pyrazine derivatives and use as pi3k inhibitors
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
EP1790342A1 (de) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
CA2628039A1 (en) 2005-11-11 2007-05-18 Aeterna Zentaris Gmbh Novel pyridopyrazines and their use as modulators of kinases
PT1966214T (pt) 2005-12-21 2017-02-03 Janssen Pharmaceutica Nv Triazolpiridazinas como moduladores de tirosina quinase
CA2651072A1 (en) 2006-05-01 2007-11-08 Pfizer Products Inc. Substituted 2-amino-fused heterocyclic compounds
GB0609621D0 (en) 2006-05-16 2006-06-21 Astrazeneca Ab Novel co-crystal
ATE549338T1 (de) 2006-05-24 2012-03-15 Boehringer Ingelheim Int Substituierte pteridine, die mit einem viergliedrigen heterocyclus substituiert sind
JO3235B1 (ar) 2006-05-26 2018-03-08 Astex Therapeutics Ltd مركبات بيررولوبيريميدين و استعمالاتها
WO2008003702A2 (en) 2006-07-03 2008-01-10 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg Fused bicyclic compounds interacting with the histamine h4 receptor
EP2081928B1 (en) 2006-11-10 2014-02-26 Bristol-Myers Squibb Company Pyrrolo-pyridine kinase inhibitors
JP2008127446A (ja) 2006-11-20 2008-06-05 Canon Inc １，５−ナフチリジン化合物及び有機発光素子
CN102123712B (zh) 2006-12-13 2014-03-19 默沙东公司 使用igf1r抑制剂治疗癌症的方法
US7872018B2 (en) 2006-12-21 2011-01-18 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
MX2009006706A (es) * 2006-12-22 2009-07-02 Astex Therapeutics Ltd Compuestos heterociclicos biciclicos como inhibidores del receptor del factor de crecimiento de fibroblastos.
AU2007336893A1 (en) 2006-12-22 2008-07-03 Novartis Ag Quinazolines for PDK1 inhibition
KR20080062876A (ko) 2006-12-29 2008-07-03 주식회사 대웅제약 신규한 항진균성 트리아졸 유도체
US7592342B2 (en) * 2007-05-10 2009-09-22 Smithkline Beecham Corporation Quinoxaline derivatives as PI3 kinase inhibitors
EP1990342A1 (en) 2007-05-10 2008-11-12 AEterna Zentaris GmbH Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof
WO2008150827A1 (en) 2007-05-29 2008-12-11 Smithkline Beecham Corporation Naphthyridine, derivatives as p13 kinase inhibitors
AR066879A1 (es) 2007-06-08 2009-09-16 Novartis Ag Derivados de quinoxalina como inhibidores de la actividad de cinasa de tirosina de las cinasas janus
KR20130008625A (ko) 2007-06-20 2013-01-22 미쓰비시 타나베 파마 코퍼레이션 신규한 말론산술폰아미드 유도체 및 그 의약 용도
EP2170894A1 (en) 2007-06-21 2010-04-07 Janssen Pharmaceutica N.V. Polymorphic and hydrate forms, salts and process for preparing 6-{difluoro[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline
JP2010532758A (ja) 2007-07-06 2010-10-14 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド 組み合わせ抗癌療法
ES2424977T3 (es) 2007-08-08 2013-10-10 Glaxosmithkline Intellectual Property Development Limited Derivados de 2-[(2-{fenilamino}-1H-pirrolo[2,3-D]pirimidin-4-il)amino]benzamida como inhibidores de IGF-1R para el tratamiento del cáncer
WO2009021083A1 (en) * 2007-08-09 2009-02-12 Smithkline Beecham Corporation Quinoxaline derivatives as pi3 kinase inhibitors
WO2009019518A1 (en) 2007-08-09 2009-02-12 Astrazeneca Ab Pyrimidine compounds having a fgfr inhibitory effect
US20090054304A1 (en) 2007-08-23 2009-02-26 Kalypsys, Inc. Heterocyclic modulators of tgr5 for treatment of disease
ES2569528T3 (es) 2007-11-16 2016-05-11 Incyte Holdings Corporation 4-pirazolil-N-arilpirimidin-2-aminas y 4-pirazolil-N-heteroarilpirimidin-2-aminas como inhibidores de quinasas Janus
US20110129456A1 (en) 2008-05-05 2011-06-02 Yaolin Wang Sequential Administration of Chemotherapeutic Agents for Treatment of Cancer
MY155535A (en) 2008-05-23 2015-10-30 Novartis Ag Derivatives of quinolines and quinoxalines as protien tyrosine kinase inhibitors
EP2356116A1 (en) 2008-11-20 2011-08-17 OSI Pharmaceuticals, Inc. Substituted pyrroloý2,3-b¨-pyridines and-pyrazines
US8716280B2 (en) 2009-01-21 2014-05-06 Basilea Pharmaceutica Ag Bicyclic antibiotics
WO2010088177A1 (en) 2009-02-02 2010-08-05 Merck Sharp & Dohme Corp. Inhibitors of akt activity
TW201041888A (en) 2009-05-06 2010-12-01 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
TR201910781T4 (tr) 2009-06-12 2019-08-21 Abivax Kanser tedavisi için yararlı bileşikler.
CN102656163B (zh) 2009-09-03 2016-01-13 拜奥埃内杰尼克斯公司 抑制pask的杂环化合物
CA2772790C (en) 2009-09-04 2017-06-27 Benjamin Bader Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors
US20110123545A1 (en) 2009-11-24 2011-05-26 Bristol-Myers Squibb Company Combination of vegfr2 and igf1r inhibitors for the treatment of proliferative diseases
EP2332939A1 (en) 2009-11-26 2011-06-15 Æterna Zentaris GmbH Novel Naphthyridine derivatives and the use thereof as kinase inhibitors
EP2560966B1 (en) 2010-03-30 2021-01-06 Verseon International Corporation Multisubstituted aromatic compounds as inhibitors of thrombin
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
WO2011146591A1 (en) 2010-05-19 2011-11-24 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
CN103153062B (zh) 2010-05-24 2015-07-15 因特利凯有限责任公司 杂环化合物及其用途
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
CN102532141A (zh) 2010-12-08 2012-07-04 中国科学院上海药物研究所 [1，2，4]三唑并[4，3-b][1，2，4]三嗪类化合物、其制备方法和用途
MX343706B (es) 2011-01-31 2016-11-18 Novartis Ag Derivados heterocíclicos novedosos.
US20140037642A1 (en) 2011-02-02 2014-02-06 Amgen Inc. Methods and compositions relating to inhibition of igf-1r
JP6130305B2 (ja) 2011-02-23 2017-05-17 インテリカイン， エルエルシー キナーゼ阻害剤の組み合わせおよびそれらの使用
WO2012118492A1 (en) 2011-03-01 2012-09-07 Array Biopharma Inc. Heterocyclic sulfonamides as raf inhibitors
US9896730B2 (en) 2011-04-25 2018-02-20 OSI Pharmaceuticals, LLC Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
WO2013032951A1 (en) 2011-08-26 2013-03-07 Neupharma, Inc. Certain chemical entities, compositions, and methods
EP3332785B1 (en) 2011-09-14 2020-05-06 Neupharma, Inc. Certain chemical entities, compositions, and methods
EP2757885B1 (en) 2011-09-21 2017-03-15 Neupharma, Inc. Certain chemical entites, compositions, and methods
CN104024257A (zh) 2011-10-04 2014-09-03 吉利德卡利斯托加有限责任公司 Pi3k的新的喹喔啉抑制剂
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
BR112014009890A2 (pt) 2011-10-28 2020-10-27 Novartis Ag derivados de purina e seu uso no tratamento de doença
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
JO3210B1 (ar) 2011-10-28 2018-03-08 Merck Sharp & Dohme مثبط منصهر لبروتين نقل الكوليسترليستير اوكسازوليدينون ثمائي الحلقة
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
US9481911B2 (en) 2012-03-08 2016-11-01 Astellas Pharma Inc. Methods for detecting FGFR3/TACC3 fusion genes
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
US20150203589A1 (en) 2012-07-24 2015-07-23 The Trustees Of Columbia University In The City Of New York Fusion proteins and methods thereof
US10980804B2 (en) 2013-01-18 2021-04-20 Foundation Medicine, Inc. Methods of treating cholangiocarcinoma
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
US10028956B2 (en) 2013-08-02 2018-07-24 Ignyta, Inc. Methods of treating various cancers using an AXL/cMET inhibitor in combination with other agents
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
KR102479696B1 (ko) 2014-03-26 2022-12-22 아스텍스 테라퓨틱스 리미티드 Fgfr 억제제 및 igf1r 억제제의 조합물
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
HUE053654T2 (hu) 2014-03-26 2021-07-28 Astex Therapeutics Ltd FGFR- és CMET-inhibitorok kombinációi a rák kezelésére
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
MX2017010595A (es) 2015-02-19 2018-11-12 Bioclin Therapeutics Inc Métodos, composiciones, y equipos para tratamiento de cáncer.
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer

Also Published As

Publication number Publication date
SI2563775T1 (sl) 2017-05-31
HUS2500011I1 (hu) 2025-03-28
SG184966A1 (en) 2012-11-29
DK3590934T3 (da) 2021-11-08
EP3590934B1 (en) 2021-08-25
EP2563775A1 (en) 2013-03-06
MY191669A (en) 2022-07-06
NZ602726A (en) 2014-05-30
FR25C1006I2 (fr) 2026-02-06
US20180127397A1 (en) 2018-05-10
US9850228B2 (en) 2017-12-26
BR112012027509A8 (pt) 2021-11-03
EP3178818A1 (en) 2017-06-14
MX365702B (es) 2019-06-11
IN2012MN02591A (enExample) 2015-06-12
HUE045893T2 (hu) 2020-01-28
US10519137B2 (en) 2019-12-31
IL222600A0 (en) 2012-12-31
WO2011135376A1 (en) 2011-11-03
AU2011247047A1 (en) 2013-01-10
CY1124928T1 (el) 2023-01-05
LT3590934T (lt) 2021-12-27
RS55863B1 (sr) 2017-08-31
RS59196B1 (sr) 2019-10-31
PT3178818T (pt) 2019-09-05
KR20180093134A (ko) 2018-08-20
NO2025011I1 (no) 2025-02-17
US20200131153A1 (en) 2020-04-30
US20130072457A1 (en) 2013-03-21
US20150105368A1 (en) 2015-04-16
EP3178818B1 (en) 2019-05-22
AU2017202512B2 (en) 2018-07-26
SMT201700193T1 (it) 2017-05-08
CR20180339A (es) 2018-11-12
US20160311800A1 (en) 2016-10-27
AR080982A1 (es) 2012-05-23
FIC20250009I1 (fi) 2025-02-18
HUE033702T2 (en) 2017-12-28
ECSP12012318A (es) 2013-02-28
KR101933843B1 (ko) 2018-12-28
US8895601B2 (en) 2014-11-25
ES2899937T3 (es) 2022-03-15
AU2017202512A1 (en) 2017-05-04
RS62570B1 (sr) 2021-12-31
PT2563775T (pt) 2017-04-18
EA028599B1 (ru) 2017-12-29
JP5639261B2 (ja) 2014-12-10
MX2012012414A (es) 2013-02-26
LT2563775T (lt) 2017-04-10
SMT202100662T1 (it) 2022-01-10
LT3178818T (lt) 2019-08-12
KR101889565B1 (ko) 2018-08-17
TWI545122B (zh) 2016-08-11
LTPA2025509I1 (enExample) 2025-03-10
SMT201900469T1 (it) 2019-09-09
DK3178818T3 (da) 2019-07-22
PT3590934T (pt) 2021-11-25
CN102858765B (zh) 2015-04-01
AU2011247047B2 (en) 2017-01-19
PL3590934T3 (pl) 2022-02-07
CA2796204C (en) 2020-08-25
CY1121882T1 (el) 2020-10-14
HUE056999T2 (hu) 2022-04-28
AP2012006490A0 (en) 2012-10-31
EA201500278A1 (ru) 2015-09-30
CN102858765A (zh) 2013-01-02
EA201291143A1 (ru) 2013-05-30
SG10201708578QA (en) 2017-11-29
FR25C1006I1 (fr) 2025-04-04
EP3590934A1 (en) 2020-01-08
DK2563775T3 (en) 2017-03-27
ME01825B (me) 2014-12-20
PL3178818T3 (pl) 2019-11-29
BR112012027509A2 (pt) 2017-08-08
NL301318I2 (nl) 2025-03-13
BR112012027509B1 (pt) 2022-07-05
CN104725362A (zh) 2015-06-24
JP2013528580A (ja) 2013-07-11
PH12012501993A1 (en) 2016-07-29
SI3178818T1 (sl) 2019-09-30
IL222600A (en) 2016-02-29
ES2621461T3 (es) 2017-07-04
EA023222B1 (ru) 2016-05-31
PL2563775T3 (pl) 2017-07-31
CR20120576A (es) 2013-03-04
EP2563775B1 (en) 2017-01-04
CN104725362B (zh) 2017-04-12
CL2012003048A1 (es) 2013-04-19
MY189427A (en) 2022-02-11
SI3590934T1 (sl) 2022-03-31
EA023222B8 (ru) 2017-04-28
ES2742409T3 (es) 2020-02-14
US20220135544A1 (en) 2022-05-05
AP3210A (en) 2015-04-30
KR20130108076A (ko) 2013-10-02
JO3366B1 (ar) 2019-03-13
US9464071B2 (en) 2016-10-11
HRP20211675T1 (hr) 2022-02-18
TW201204714A (en) 2012-02-01
CA2796204A1 (en) 2011-11-03

Similar Documents

Publication Publication Date Title
GB201007286D0 (en) New compounds
GB201020179D0 (en) New compounds
AP2012006641A0 (en) New compounds
IL223783A0 (en) Pro-neurogenic compounds
GB201008134D0 (en) Compounds
GB201015949D0 (en) Compounds
PL2619208T3 (pl) Związki imidazotriazynonu
PL2648516T3 (pl) Podstawione związki pirydynono-pirydynylowe
GB201007347D0 (en) Compounds
EP2649050A4 (en) LINKS
GB201002563D0 (en) Compounds
GB201008209D0 (en) Compounds
GB201001688D0 (en) Compounds
GB201002216D0 (en) Compounds
GB201001796D0 (en) Compounds
GB201015537D0 (en) Compounds
GB201008210D0 (en) Compounds
GB201021494D0 (en) Compounds
GB201013507D0 (en) Compounds
GB201004307D0 (en) New compounds
GB201016221D0 (en) New compounds
GB201012899D0 (en) New compounds
GB201022042D0 (en) Compounds
GB201005727D0 (en) Compounds
GB201014052D0 (en) Compounds

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)