MX2020002010A - Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo. - Google Patents

Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.

Info

Publication number
MX2020002010A
MX2020002010A MX2020002010A MX2020002010A MX2020002010A MX 2020002010 A MX2020002010 A MX 2020002010A MX 2020002010 A MX2020002010 A MX 2020002010A MX 2020002010 A MX2020002010 A MX 2020002010A MX 2020002010 A MX2020002010 A MX 2020002010A
Authority
MX
Mexico
Prior art keywords
processes
diamino
tert
butyl
preparation
Prior art date
Application number
MX2020002010A
Other languages
English (en)
Inventor
John F Traverse
Weihong Zhang
Maryll E Geherty
Michael J Zacuto
Kirsten Faye Johnson
Christopher Marton
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2020002010A publication Critical patent/MX2020002010A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/70—Compounds containing any of the groups, e.g. isoureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporcionan procesos para la preparación de 4,5-diamino-5-oxopentanoato de (S)-terc-butilo, o una sal, un solvato, un hidrato, un enantiómero, una mezcla de enantiómeros, o un isotopólogo de este. También se proporcionan formas sólidas de diversos productos intermedios y productos obtenidos a partir de los procesos.
MX2020002010A 2017-08-21 2018-08-20 Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo. MX2020002010A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762548268P 2017-08-21 2017-08-21
PCT/US2018/000358 WO2019040109A1 (en) 2017-08-21 2018-08-20 PROCESSES FOR THE PREPARATION OF (S) -TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE

Publications (1)

Publication Number Publication Date
MX2020002010A true MX2020002010A (es) 2020-07-13

Family

ID=63794593

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020002010A MX2020002010A (es) 2017-08-21 2018-08-20 Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.

Country Status (8)

Country Link
US (3) US10717703B2 (es)
EP (1) EP3672939A1 (es)
JP (2) JP7399846B2 (es)
CN (1) CN111032628A (es)
AU (1) AU2018321548B2 (es)
CA (1) CA3072735A1 (es)
MX (1) MX2020002010A (es)
WO (1) WO2019040109A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111606837A (zh) * 2020-06-15 2020-09-01 千辉药业（安徽）有限责任公司 一种维格列汀的合成方法
KR20240040769A (ko) * 2021-07-26 2024-03-28 아비나스 오퍼레이션스, 인코포레이티드 이작용성 화합물을 제조하는 방법
CN114478324B (zh) * 2021-12-30 2023-07-07 上海嘉莱多生物技术有限责任公司 一种活性化合物及其在侧链羧基类化合物保护的应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3989812A (en) 1974-08-09 1976-11-02 Smithkline Instruments, Inc. Folic acid derivatives and use in radio-assay
CH613709A5 (en) 1975-12-10 1979-10-15 Ciba Geigy Ag Process for the preparation of glucosamine derivatives
JPS55111499A (en) 1979-02-21 1980-08-28 Takeda Chem Ind Ltd Glucosamine derivative and its preparation
US4406889A (en) 1980-02-15 1983-09-27 Ciba-Geigy Corporation Derivatives of aldohexoses, intermediates, processes for their manufacture, preparations containing such compounds, and their use
US4481190A (en) 1982-12-21 1984-11-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
JPS611651A (ja) 1984-06-12 1986-01-07 Toyama Chem Co Ltd Ｎ−アシル酸性アミノ酸ジアミド類およびその製造法並びにそれらを含有する抗潰瘍剤
US4690916A (en) 1984-11-13 1987-09-01 Syntex (U.S.A.) Inc. Nona and decapeptide analogs of LHRH useful as LHRH antagonists
US4897255A (en) 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5556982A (en) 1985-01-14 1996-09-17 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5175343A (en) 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
HUT46044A (en) 1986-11-21 1988-09-28 Richter Gedeon Vegyeszet Process for producing immunstimulant peptides inhibiting multiplication of leukaemic cells and pharmaceutics comprising same
US4988496A (en) 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
IN173794B (es) 1988-12-15 1994-07-16 Council Of Scient & Ind Res Ra
US5270302A (en) 1988-12-21 1993-12-14 Abbott Laboratories Derivatives of tetrapeptides as CCK agonists
HU205147B (en) 1989-06-29 1992-03-30 Sandoz Ag Process for producing muramyl dipeptide derivative and pharmaceutical compostions comprising same
IN177680B (es) 1990-05-08 1997-02-15 Council Scient Ind Res
US5312831A (en) 1993-05-12 1994-05-17 American Cyanamid Company Urethanes and ureas that induce cytokine production
GB9326518D0 (en) 1993-12-29 1994-03-02 Sandoz Ltd Organic compounds
GB9408936D0 (en) 1994-05-05 1994-06-22 Cancer Res Inst Anti-cancer compounds
DE19505932B4 (de) * 1995-02-21 2005-06-23 Degussa Ag Verfahren zur Herstellung von Oxazolidinonen, neue Oxazolidinone sowie Verwendung von Oxazolidinonen
US5710129A (en) 1995-02-23 1998-01-20 Ariad Pharmaceuticals, Inc. Inhibitors of SH2-mediated processes
US5635504A (en) 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
IN184769B (es) 1995-07-20 2000-09-30 Council Scient Ind Res
JPH09165370A (ja) 1995-10-13 1997-06-24 Fuji Yakuhin Kogyo Kk ラクタム誘導体およびその塩
GB9524267D0 (en) 1995-11-28 1996-01-31 Isis Innovation Enzyme inhibitor and method
WO1997031016A2 (en) 1996-02-23 1997-08-28 Ariad Pharmaceuticals, Inc. New inhibitors of sh2-mediated processes
US6117896A (en) 1997-02-10 2000-09-12 Molecumetics Ltd. Methods for regulating transcription factors
AU5729898A (en) 1996-12-18 1998-07-15 Emory University Polycationic oligomers
ATE349462T1 (de) 1998-07-28 2007-01-15 Santen Pharmaceutical Co Ltd Thiazolidin-derivate
JP2000219663A (ja) 1998-11-24 2000-08-08 Taiho Yakuhin Kogyo Kk Ｎδ−置換アミノオルニチン誘導体及びその塩
AU2001252921A1 (en) 2000-04-18 2001-10-30 Eli Lilly And Company A glycopeptide and preparation thereof
JP2004501085A (ja) 2000-04-18 2004-01-15 イーライ・リリー・アンド・カンパニー リピドｉｉの製造方法
US7662960B2 (en) 2001-04-26 2010-02-16 Choongwae Pharma Corporation Beta-strand mimetics and method relating thereto
AU2002950136A0 (en) 2002-07-11 2002-09-12 La Trobe University N-methyl amino acids
JP4808026B2 (ja) 2002-08-22 2011-11-02 ヴィクソム ヒューマン バイオニクス インコーポレーテッド 膝上部肢切断患者用の駆動源付き義足
CN100522995C (zh) 2003-10-22 2009-08-05 中国医学科学院药物研究所 胞壁酰-丙氨酰-d-异谷氨酰胺衍生物、制法和其药物组合物与用途
US20050187138A1 (en) 2004-02-24 2005-08-25 The Regents Of The University Of California, A California Corporation Peptide beta-strand mimics based on pyridinones, pyrazinones, pyridazinones, and triazinones
WO2005100334A1 (en) 2004-04-14 2005-10-27 Pfizer Products Inc. Dipeptidyl peptidase-iv inhibitors
US7405237B2 (en) 2004-07-28 2008-07-29 Celgene Corporation Isoindoline compounds and methods of their use
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
JP5181118B2 (ja) 2005-07-11 2013-04-10 ワイス・エルエルシー グルタミン酸アグリカナーゼ阻害剤
CN1943341B (zh) 2006-08-04 2012-05-09 华南农业大学 氨基酸与农药的藕合物及其制备方法与作为农药的应用
PL2420497T3 (pl) 2006-09-26 2016-06-30 Celgene Corp 5-Podstawione pochodne chinazolinonu jako środki przeciwnowotworowe
WO2008156701A2 (en) 2007-06-13 2008-12-24 The Brigham And Women's Hospital, Inc. Hydroxamate inhibitors of insulin-degrading enzyme and uses thereof
WO2009078040A2 (en) 2007-12-17 2009-06-25 Debatosh Datta Compounds inducing reperfusion in ischaemic tissues
CA2709553A1 (en) 2007-12-17 2009-06-25 Green Cross Therapeutics Private Ltd. Compound inducing angiogenesis response in ischaemic tissues
CZ305066B6 (cs) * 2008-02-25 2015-04-22 Zentiva, K.S. Způsob výroby (3R,4S)-1-(4-fluorfenyl)-3-[(3S)-3-(4-fluorfenyl)-3-hydroxypropyl)]-4-(4-hydroxyfenyl)-2-azetidinonu
US8344115B2 (en) 2008-04-21 2013-01-01 Chan-Sui Pang, legal representative Immunoassay for specific determination of S-adenosylmethionine and analogs thereof in biological samples
JP2011525487A (ja) * 2008-06-23 2011-09-22 アストラゼネカ アクチボラグ トロンビン阻害剤としての使用のための新規複素環式カルボキサミド
WO2010048423A1 (en) 2008-10-24 2010-04-29 Ark Diagnostics, Inc. Levetiracetam immunoassays
CA2746066A1 (en) 2008-12-09 2010-06-17 Sands Innovations Pty Ltd A dispensing container
LT3202460T (lt) 2010-02-11 2019-10-10 Celgene Corporation Arilmetoksi izoindolino dariniai ir kompozicijos, apimantys ir jų panaudojimo būdus
GB201007286D0 (en) * 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
CN102219834A (zh) 2011-04-14 2011-10-19 北京市丰硕维康技术开发有限责任公司 一种制备罗莫肽的方法
WO2014025978A1 (en) 2012-08-09 2014-02-13 Celgene Corporation Processes for the preparation of (s)-3-4-((4-(morpholinomethyl) benzyl)oxy)-1-oxoisoindolin-2-yl) piperidine-2,6-dione and pharmaceutically acceptable forms thereof
US9695145B2 (en) 2013-01-22 2017-07-04 Celgene Corporation Processes for the preparation of isotopologues of 3-(4-((4- morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof
US10189805B2 (en) 2014-09-09 2019-01-29 Vanderbilt University Metabolism probes for therapy and diagnosis
PL3214081T3 (pl) 2014-10-30 2021-04-06 Kangpu Biopharmaceuticals, Ltd. Pochodna izoindoliny, półprodukt, sposób wytwarzania, kompozycja farmaceutyczna i ich zastosowanie
CN104826544B (zh) 2015-04-02 2016-09-28 中国石油大学(华东) 含有偶氮苯光敏基团的脂肽分子表面活性剂及其合成方法

Also Published As

Publication number Publication date
JP2024037802A (ja) 2024-03-19
US11912644B2 (en) 2024-02-27
JP7399846B2 (ja) 2023-12-18
US20200299228A1 (en) 2020-09-24
CA3072735A1 (en) 2019-02-28
US11505522B2 (en) 2022-11-22
WO2019040109A1 (en) 2019-02-28
JP2020531500A (ja) 2020-11-05
CN111032628A (zh) 2020-04-17
AU2018321548A1 (en) 2020-03-05
AU2018321548B2 (en) 2023-03-09
US10717703B2 (en) 2020-07-21
US20190084924A1 (en) 2019-03-21
EP3672939A1 (en) 2020-07-01
US20230234914A1 (en) 2023-07-27

Similar Documents

Publication Publication Date Title
MX2020006315A (es) Acidos carbamoil ciclohexilicos ligados a n triazol como antagonistas de acido lisofosfatidico (lpa).
EP3762498A4 (en) PROCESS FOR THE PRODUCTION OF TRYPTAMINES
MX2020001302A (es) Procesos para preparar compuestos de pirrolidina.
WO2018029711A3 (en) Process for the preparation of venetoclax
MX2020002010A (es) Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.
WO2016207914A3 (en) Methods for preparing oltipraz
IL271399A (en) Methods for the preparation of heterocyclic 3,1-benzodioxole compounds
EP3846791A4 (en) ILLUDIN ANALOGUES, THEIR USES AND PROCEDURES FOR THEIR SYNTHESIS
IL292852A (en) Method for preparing (3-chloro-2-pyridyl)hydrazine
IL291221A (en) Methods for the synthesis of wolbenzine
WO2015111085A8 (en) Processes for the preparation of eltrombopag and pharmaceutically acceptable salts, solvates and intermediates thereof
EP3548457A4 (en) IMPROVED METHOD FOR PRODUCING 2,3,3,3-TETRAFLUORPROPEN
EP3902790C0 (de) Verbessertes verfahren zur herstellung von 4,6-dihydroxypyrimidin
IL271974A (en) New intermediates useful for the synthesis of aminopyrimidine derivatives, a process for their preparation and a process for preparing aminopyrimidine derivatives using them
EP3740469A4 (en) SULFENTRAZONE SYNTHESIS PROCESS
GB2554835A (en) Stable liquid formulations of pemetrexed
EP3941911A4 (en) METHOD FOR THE SYNTHESIS OF 2,5-FURANDICARBOXYLIC ACID
PT3759082T (pt) Processo para a síntese de 6-clorometiluracilo
MX2018015871A (es) Cenicriviroc purificado e intermedios purificados para fabricar cenicriviroc.
EP3681863A4 (en) IMPROVED PROCESS FOR THE PREPARATION OF TRIFLOXYSTROBIN
UA124942C2 (uk) Спосіб одержання енантіомерів пірліндолу та їхніх солей
MX2019005504A (es) Potenciadores de bmp.
GB201715114D0 (en) 9 (11)-estosterene-16a, 17a-epoxy-3ß-ol-20-one drug intermediates synthesis method
MX2019001813A (es) Procedimiento para la preparacion de pyrazoles de 3-amino-1-(2,6-disustituido-fenilo).
PL3831816T3 (pl) Sposób syntezy 4,6-dinitrobenzofuroksanu