ES2952056T3 - Preparación de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida - Google Patents

Preparación de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida Download PDF

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Publication number
ES2952056T3
ES2952056T3 ES20208218T ES20208218T ES2952056T3 ES 2952056 T3 ES2952056 T3 ES 2952056T3 ES 20208218 T ES20208218 T ES 20208218T ES 20208218 T ES20208218 T ES 20208218T ES 2952056 T3 ES2952056 T3 ES 2952056T3
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Spain
Prior art keywords
formula
compound
salt
difluorophenyl
pyrrolidin
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ES20208218T
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English (en)
Spanish (es)
Inventor
Mark Reynolds
Charles Todd Eary
Stacey Spencer
Derrick Juengst
Bruno Hache
Yutong Jiang
Julia Haas
Steven W Andrews
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Array Biopharma Inc
Loxo Oncology Inc
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Array Biopharma Inc
Loxo Oncology Inc
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Application filed by Array Biopharma Inc, Loxo Oncology Inc filed Critical Array Biopharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES20208218T 2016-05-18 2017-05-18 Preparación de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida Active ES2952056T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662338359P 2016-05-18 2016-05-18

Publications (1)

Publication Number Publication Date
ES2952056T3 true ES2952056T3 (es) 2023-10-26

Family

ID=58794189

Family Applications (2)

Application Number Title Priority Date Filing Date
ES20208218T Active ES2952056T3 (es) 2016-05-18 2017-05-18 Preparación de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida
ES17726442T Active ES2836222T3 (es) 2016-05-18 2017-05-18 Preparación de (S)-N-(5-((R)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida

Family Applications After (1)

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ES17726442T Active ES2836222T3 (es) 2016-05-18 2017-05-18 Preparación de (S)-N-(5-((R)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida

Country Status (27)

Country Link
US (1) US11214571B2 (enExample)
EP (2) EP3800189B1 (enExample)
JP (1) JP7443057B2 (enExample)
KR (1) KR102566858B1 (enExample)
CN (1) CN110049987B (enExample)
AU (1) AU2017268371B2 (enExample)
CA (1) CA3024603A1 (enExample)
CL (1) CL2018003264A1 (enExample)
CO (1) CO2018013015A2 (enExample)
DK (2) DK3458456T3 (enExample)
ES (2) ES2952056T3 (enExample)
FI (1) FI3800189T3 (enExample)
HR (2) HRP20230704T1 (enExample)
HU (2) HUE063877T2 (enExample)
IL (1) IL262964B (enExample)
LT (2) LT3800189T (enExample)
MX (1) MX392604B (enExample)
PE (1) PE20190437A1 (enExample)
PL (2) PL3800189T3 (enExample)
PT (2) PT3458456T (enExample)
RS (2) RS64698B1 (enExample)
RU (1) RU2745953C2 (enExample)
SG (1) SG11201810245WA (enExample)
SI (2) SI3458456T1 (enExample)
UA (1) UA127826C2 (enExample)
WO (1) WO2017201241A1 (enExample)
ZA (1) ZA201808534B (enExample)

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CN109232582B (zh) * 2018-11-28 2021-02-05 安礼特（上海）医药科技有限公司 拉洛替尼硫酸氢盐晶型及其制备和应用
CN112457231A (zh) * 2019-09-09 2021-03-09 上海医药工业研究院 一种拉罗替尼（Larotrectinib）中间体的消旋化方法
CN110804059B (zh) * 2019-09-30 2024-03-12 郑州泰基鸿诺医药股份有限公司 氨基甲酸酯类化合物、药物组合物及其应用
CN111138437B (zh) * 2019-12-04 2021-03-05 杭州华东医药集团新药研究院有限公司 取代的吡唑并[1,5-a]嘧啶氨基酸衍生物及其用途
CN112624950A (zh) * 2020-12-10 2021-04-09 北京蓝博特科技有限公司 一种(r)-2-(2,5-二氟苯基)吡咯烷的合成方法
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CN113444070A (zh) * 2021-07-28 2021-09-28 深圳市真味生物科技有限公司 一种由手性叔丁基亚磺酰胺合成手性尼古丁的制备方法
CN115872905B (zh) * 2021-09-29 2024-08-09 凯特立斯（深圳）科技有限公司 一种拉罗替尼中间体的制备方法
WO2024023836A1 (en) 2022-07-27 2024-02-01 Mylan Laboratories Limited Polymorphic form of larotrectinib sulfate
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