ES2834102T3 - Variantes de alfa-amilasa - Google Patents
Variantes de alfa-amilasa Download PDFInfo
- Publication number
- ES2834102T3 ES2834102T3 ES18183123T ES18183123T ES2834102T3 ES 2834102 T3 ES2834102 T3 ES 2834102T3 ES 18183123 T ES18183123 T ES 18183123T ES 18183123 T ES18183123 T ES 18183123T ES 2834102 T3 ES2834102 T3 ES 2834102T3
- Authority
- ES
- Spain
- Prior art keywords
- variant
- amylase
- alpha
- seq
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108090000637 alpha-Amylases Proteins 0.000 title claims abstract description 109
- 102000004139 alpha-Amylases Human genes 0.000 title claims abstract description 106
- 229940024171 alpha-amylase Drugs 0.000 title claims abstract description 93
- 229920001184 polypeptide Polymers 0.000 claims abstract description 76
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 76
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 76
- 230000000694 effects Effects 0.000 claims abstract description 38
- 238000006467 substitution reaction Methods 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims description 74
- 102000040430 polynucleotide Human genes 0.000 claims description 70
- 108091033319 polynucleotide Proteins 0.000 claims description 70
- 239000002157 polynucleotide Substances 0.000 claims description 70
- 150000007523 nucleic acids Chemical class 0.000 claims description 21
- 102000039446 nucleic acids Human genes 0.000 claims description 20
- 108020004707 nucleic acids Proteins 0.000 claims description 20
- 230000014509 gene expression Effects 0.000 claims description 19
- 238000012217 deletion Methods 0.000 claims description 16
- 230000037430 deletion Effects 0.000 claims description 16
- 239000013604 expression vector Substances 0.000 claims description 13
- 102200043446 rs281875252 Human genes 0.000 claims description 12
- 102220472853 Potassium voltage-gated channel subfamily KQT member 2_S52Q_mutation Human genes 0.000 claims description 6
- 102200145344 rs104894412 Human genes 0.000 claims description 6
- 102220081916 rs863224080 Human genes 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 3
- 238000011084 recovery Methods 0.000 claims 1
- 235000006206 Balanites maughamii Nutrition 0.000 abstract 1
- 240000000400 Balanites maughamii Species 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 101
- 239000000203 mixture Substances 0.000 description 73
- 238000005406 washing Methods 0.000 description 53
- 102000013142 Amylases Human genes 0.000 description 48
- 108010065511 Amylases Proteins 0.000 description 48
- 239000003599 detergent Substances 0.000 description 47
- 235000019418 amylase Nutrition 0.000 description 45
- 238000012360 testing method Methods 0.000 description 44
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 42
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 42
- 239000004382 Amylase Substances 0.000 description 41
- 102000004190 Enzymes Human genes 0.000 description 38
- 108090000790 Enzymes Proteins 0.000 description 38
- 108090000623 proteins and genes Proteins 0.000 description 35
- 229940088598 enzyme Drugs 0.000 description 34
- 239000013598 vector Substances 0.000 description 33
- 108091026890 Coding region Proteins 0.000 description 30
- 235000001014 amino acid Nutrition 0.000 description 30
- 150000001413 amino acids Chemical class 0.000 description 27
- 239000004744 fabric Substances 0.000 description 26
- 238000009472 formulation Methods 0.000 description 22
- 241000223218 Fusarium Species 0.000 description 20
- 108010076504 Protein Sorting Signals Proteins 0.000 description 19
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 18
- 230000010076 replication Effects 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 229920002472 Starch Polymers 0.000 description 16
- 238000004140 cleaning Methods 0.000 description 16
- 230000002538 fungal effect Effects 0.000 description 16
- 239000008107 starch Substances 0.000 description 16
- 235000019698 starch Nutrition 0.000 description 16
- 108020004414 DNA Proteins 0.000 description 15
- 241000499912 Trichoderma reesei Species 0.000 description 15
- 239000007788 liquid Substances 0.000 description 15
- 241000193830 Bacillus <bacterium> Species 0.000 description 14
- 229920000742 Cotton Polymers 0.000 description 14
- 125000003275 alpha amino acid group Chemical group 0.000 description 13
- 230000001580 bacterial effect Effects 0.000 description 13
- 230000004048 modification Effects 0.000 description 13
- 238000012986 modification Methods 0.000 description 13
- 239000013612 plasmid Substances 0.000 description 13
- 230000008569 process Effects 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 12
- 229940100486 rice starch Drugs 0.000 description 12
- 125000000539 amino acid group Chemical group 0.000 description 11
- 239000000523 sample Substances 0.000 description 11
- 240000006439 Aspergillus oryzae Species 0.000 description 10
- 235000002247 Aspergillus oryzae Nutrition 0.000 description 10
- 241000233866 Fungi Species 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 230000035772 mutation Effects 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 10
- 239000000758 substrate Substances 0.000 description 10
- 241000351920 Aspergillus nidulans Species 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 238000002741 site-directed mutagenesis Methods 0.000 description 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 8
- 241000228212 Aspergillus Species 0.000 description 8
- 238000004851 dishwashing Methods 0.000 description 8
- -1 for example Substances 0.000 description 8
- 238000003780 insertion Methods 0.000 description 8
- 230000037431 insertion Effects 0.000 description 8
- 238000005215 recombination Methods 0.000 description 8
- 230000006798 recombination Effects 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 241000194108 Bacillus licheniformis Species 0.000 description 7
- 241000123346 Chrysosporium Species 0.000 description 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 7
- 241001494489 Thielavia Species 0.000 description 7
- 244000005700 microbiome Species 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 230000001105 regulatory effect Effects 0.000 description 7
- 230000009466 transformation Effects 0.000 description 7
- 244000063299 Bacillus subtilis Species 0.000 description 6
- 235000014469 Bacillus subtilis Nutrition 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 241000221779 Fusarium sambucinum Species 0.000 description 6
- 241000567178 Fusarium venenatum Species 0.000 description 6
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 6
- 102100024295 Maltase-glucoamylase Human genes 0.000 description 6
- 108010028144 alpha-Glucosidases Proteins 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 239000002299 complementary DNA Substances 0.000 description 6
- 210000001938 protoplast Anatomy 0.000 description 6
- 239000002689 soil Substances 0.000 description 6
- 238000013518 transcription Methods 0.000 description 6
- 230000035897 transcription Effects 0.000 description 6
- 241000228245 Aspergillus niger Species 0.000 description 5
- 101000757144 Aspergillus niger Glucoamylase Proteins 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 5
- 241000146406 Fusarium heterosporum Species 0.000 description 5
- 241000193385 Geobacillus stearothermophilus Species 0.000 description 5
- 239000004471 Glycine Substances 0.000 description 5
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 5
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 5
- 229940025131 amylases Drugs 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 238000003776 cleavage reaction Methods 0.000 description 5
- 238000010276 construction Methods 0.000 description 5
- 238000004520 electroporation Methods 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- 230000010354 integration Effects 0.000 description 5
- 108020004999 messenger RNA Proteins 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- 230000008488 polyadenylation Effects 0.000 description 5
- 235000018102 proteins Nutrition 0.000 description 5
- 230000007017 scission Effects 0.000 description 5
- 241001513093 Aspergillus awamori Species 0.000 description 4
- 241000193744 Bacillus amyloliquefaciens Species 0.000 description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
- 229920002261 Corn starch Polymers 0.000 description 4
- 241000567163 Fusarium cerealis Species 0.000 description 4
- 241000223194 Fusarium culmorum Species 0.000 description 4
- 241000223198 Humicola Species 0.000 description 4
- 241001480714 Humicola insolens Species 0.000 description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 241000235403 Rhizomucor miehei Species 0.000 description 4
- 241000194017 Streptococcus Species 0.000 description 4
- 241000187747 Streptomyces Species 0.000 description 4
- 241000223258 Thermomyces lanuginosus Species 0.000 description 4
- 241000223259 Trichoderma Species 0.000 description 4
- 108700015934 Triose-phosphate isomerases Proteins 0.000 description 4
- 108010048241 acetamidase Proteins 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 4
- 229910001628 calcium chloride Inorganic materials 0.000 description 4
- 235000011148 calcium chloride Nutrition 0.000 description 4
- 230000021615 conjugation Effects 0.000 description 4
- 239000008120 corn starch Substances 0.000 description 4
- 229940099112 cornstarch Drugs 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000004927 fusion Effects 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000003259 recombinant expression Methods 0.000 description 4
- 235000015067 sauces Nutrition 0.000 description 4
- 239000012085 test solution Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 238000013519 translation Methods 0.000 description 4
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 3
- 102100034044 All-trans-retinol dehydrogenase [NAD(+)] ADH1B Human genes 0.000 description 3
- 101710193111 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Proteins 0.000 description 3
- 108010037870 Anthranilate Synthase Proteins 0.000 description 3
- 239000004475 Arginine Substances 0.000 description 3
- 102000004580 Aspartic Acid Proteases Human genes 0.000 description 3
- 108010017640 Aspartic Acid Proteases Proteins 0.000 description 3
- 241000228215 Aspergillus aculeatus Species 0.000 description 3
- 241000892910 Aspergillus foetidus Species 0.000 description 3
- 241001225321 Aspergillus fumigatus Species 0.000 description 3
- 241001480052 Aspergillus japonicus Species 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 108010059892 Cellulase Proteins 0.000 description 3
- 241000223195 Fusarium graminearum Species 0.000 description 3
- 241000223221 Fusarium oxysporum Species 0.000 description 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Chemical class OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
- 240000003183 Manihot esculenta Species 0.000 description 3
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 3
- 241000235395 Mucor Species 0.000 description 3
- 108091034117 Oligonucleotide Proteins 0.000 description 3
- 102000035195 Peptidases Human genes 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- 241000235648 Pichia Species 0.000 description 3
- 241000589516 Pseudomonas Species 0.000 description 3
- 241000187432 Streptomyces coelicolor Species 0.000 description 3
- 108700005078 Synthetic Genes Proteins 0.000 description 3
- 241000223262 Trichoderma longibrachiatum Species 0.000 description 3
- 241000223261 Trichoderma viride Species 0.000 description 3
- 102000005924 Triose-Phosphate Isomerase Human genes 0.000 description 3
- IXKSXJFAGXLQOQ-XISFHERQSA-N WHWLQLKPGQPMY Chemical compound C([C@@H](C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)C1=CNC=N1 IXKSXJFAGXLQOQ-XISFHERQSA-N 0.000 description 3
- 235000004279 alanine Nutrition 0.000 description 3
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 3
- 229940091771 aspergillus fumigatus Drugs 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 235000019219 chocolate Nutrition 0.000 description 3
- 230000002759 chromosomal effect Effects 0.000 description 3
- 239000013024 dilution buffer Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 3
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 3
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 3
- 238000002744 homologous recombination Methods 0.000 description 3
- 230000006801 homologous recombination Effects 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 229910001629 magnesium chloride Inorganic materials 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000002703 mutagenesis Methods 0.000 description 3
- 231100000350 mutagenesis Toxicity 0.000 description 3
- 229920001542 oligosaccharide Polymers 0.000 description 3
- 150000002482 oligosaccharides Polymers 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 238000002708 random mutagenesis Methods 0.000 description 3
- 102220087235 rs864622622 Human genes 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 239000008399 tap water Substances 0.000 description 3
- 235000020679 tap water Nutrition 0.000 description 3
- 239000004753 textile Substances 0.000 description 3
- 230000002103 transcriptional effect Effects 0.000 description 3
- 239000012224 working solution Substances 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 241001019659 Acremonium <Plectosphaerellaceae> Species 0.000 description 2
- 102220466243 Acyl-coenzyme A thioesterase MBLAC2_R170A_mutation Human genes 0.000 description 2
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 2
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 2
- 241001489705 Aquarius Species 0.000 description 2
- 101100163849 Arabidopsis thaliana ARS1 gene Proteins 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000223651 Aureobasidium Species 0.000 description 2
- 241000193752 Bacillus circulans Species 0.000 description 2
- 241001328122 Bacillus clausii Species 0.000 description 2
- 241000193749 Bacillus coagulans Species 0.000 description 2
- 241000193747 Bacillus firmus Species 0.000 description 2
- 241000193422 Bacillus lentus Species 0.000 description 2
- 241000194107 Bacillus megaterium Species 0.000 description 2
- 241000194103 Bacillus pumilus Species 0.000 description 2
- 241000193388 Bacillus thuringiensis Species 0.000 description 2
- 241000193764 Brevibacillus brevis Species 0.000 description 2
- 241000589876 Campylobacter Species 0.000 description 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 2
- 108010008885 Cellulose 1,4-beta-Cellobiosidase Proteins 0.000 description 2
- 241000146399 Ceriporiopsis Species 0.000 description 2
- 241001556045 Chrysosporium merdarium Species 0.000 description 2
- 241000080524 Chrysosporium queenslandicum Species 0.000 description 2
- 241000193403 Clostridium Species 0.000 description 2
- 241001509964 Coptotermes Species 0.000 description 2
- 241001337994 Cryptococcus <scale insect> Species 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 108090000204 Dipeptidase 1 Proteins 0.000 description 2
- 241000194033 Enterococcus Species 0.000 description 2
- 102000010911 Enzyme Precursors Human genes 0.000 description 2
- 108010062466 Enzyme Precursors Proteins 0.000 description 2
- 241000589565 Flavobacterium Species 0.000 description 2
- 241000145614 Fusarium bactridioides Species 0.000 description 2
- 241001112697 Fusarium reticulatum Species 0.000 description 2
- 241001014439 Fusarium sarcochroum Species 0.000 description 2
- 241000223192 Fusarium sporotrichioides Species 0.000 description 2
- 241000605909 Fusobacterium Species 0.000 description 2
- 102000048120 Galactokinases Human genes 0.000 description 2
- 108700023157 Galactokinases Proteins 0.000 description 2
- 108700007698 Genetic Terminator Regions Proteins 0.000 description 2
- 241000626621 Geobacillus Species 0.000 description 2
- 101100369308 Geobacillus stearothermophilus nprS gene Proteins 0.000 description 2
- 101100080316 Geobacillus stearothermophilus nprT gene Proteins 0.000 description 2
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 2
- 239000007995 HEPES buffer Substances 0.000 description 2
- 241000589989 Helicobacter Species 0.000 description 2
- 101001129621 Homo sapiens PH domain leucine-rich repeat-containing protein phosphatase 1 Proteins 0.000 description 2
- 235000003332 Ilex aquifolium Nutrition 0.000 description 2
- 241000209027 Ilex aquifolium Species 0.000 description 2
- 241000411968 Ilyobacter Species 0.000 description 2
- 102100027612 Kallikrein-11 Human genes 0.000 description 2
- 241000235649 Kluyveromyces Species 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical class OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
- 108010029541 Laccase Proteins 0.000 description 2
- 241000186660 Lactobacillus Species 0.000 description 2
- 241000194036 Lactococcus Species 0.000 description 2
- 108090001060 Lipase Proteins 0.000 description 2
- 102000004882 Lipase Human genes 0.000 description 2
- 239000004367 Lipase Substances 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 108090000157 Metallothionein Proteins 0.000 description 2
- 241000226677 Myceliophthora Species 0.000 description 2
- 241000588653 Neisseria Species 0.000 description 2
- 241001072230 Oceanobacillus Species 0.000 description 2
- 241000233654 Oomycetes Species 0.000 description 2
- 102100031152 PH domain leucine-rich repeat-containing protein phosphatase 1 Human genes 0.000 description 2
- 102100026367 Pancreatic alpha-amylase Human genes 0.000 description 2
- 241000222393 Phanerochaete chrysosporium Species 0.000 description 2
- 241000222350 Pleurotus Species 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 108020004511 Recombinant DNA Proteins 0.000 description 2
- 241000235070 Saccharomyces Species 0.000 description 2
- 235000003534 Saccharomyces carlsbergensis Nutrition 0.000 description 2
- 241001123227 Saccharomyces pastorianus Species 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 241000235346 Schizosaccharomyces Species 0.000 description 2
- 101100097319 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ala1 gene Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 108091081024 Start codon Proteins 0.000 description 2
- 241000264435 Streptococcus dysgalactiae subsp. equisimilis Species 0.000 description 2
- 241000194048 Streptococcus equi Species 0.000 description 2
- 241000193996 Streptococcus pyogenes Species 0.000 description 2
- 241000194054 Streptococcus uberis Species 0.000 description 2
- 241000958303 Streptomyces achromogenes Species 0.000 description 2
- 241001468227 Streptomyces avermitilis Species 0.000 description 2
- 241000187392 Streptomyces griseus Species 0.000 description 2
- 241000187398 Streptomyces lividans Species 0.000 description 2
- 241000228341 Talaromyces Species 0.000 description 2
- 241001540751 Talaromyces ruber Species 0.000 description 2
- 241001149964 Tolypocladium Species 0.000 description 2
- 229920004890 Triton X-100 Polymers 0.000 description 2
- 101710152431 Trypsin-like protease Proteins 0.000 description 2
- 241000202898 Ureaplasma Species 0.000 description 2
- 241000235013 Yarrowia Species 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 101150078331 ama-1 gene Proteins 0.000 description 2
- 230000003625 amylolytic effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 229940054340 bacillus coagulans Drugs 0.000 description 2
- 229940005348 bacillus firmus Drugs 0.000 description 2
- 229940097012 bacillus thuringiensis Drugs 0.000 description 2
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 2
- 108010047754 beta-Glucosidase Proteins 0.000 description 2
- 102000006995 beta-Glucosidase Human genes 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 235000013544 chili con carne Nutrition 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 239000005547 deoxyribonucleotide Substances 0.000 description 2
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 2
- 108010092413 endoglucanase V Proteins 0.000 description 2
- 238000001952 enzyme assay Methods 0.000 description 2
- 239000003797 essential amino acid Substances 0.000 description 2
- 235000020776 essential amino acid Nutrition 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 108010061330 glucan 1,4-alpha-maltohydrolase Proteins 0.000 description 2
- 235000013922 glutamic acid Nutrition 0.000 description 2
- 239000004220 glutamic acid Chemical class 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 229940039696 lactobacillus Drugs 0.000 description 2
- 235000019421 lipase Nutrition 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 230000004481 post-translational protein modification Effects 0.000 description 2
- 235000019419 proteases Nutrition 0.000 description 2
- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 102200053231 rs104894354 Human genes 0.000 description 2
- 102220052102 rs35524245 Human genes 0.000 description 2
- 102220026086 rs397518426 Human genes 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 229940115922 streptococcus uberis Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000010361 transduction Methods 0.000 description 2
- 230000026683 transduction Effects 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 230000009105 vegetative growth Effects 0.000 description 2
- DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
- FQVLRGLGWNWPSS-BXBUPLCLSA-N (4r,7s,10s,13s,16r)-16-acetamido-13-(1h-imidazol-5-ylmethyl)-10-methyl-6,9,12,15-tetraoxo-7-propan-2-yl-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide Chemical compound N1C(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H]1CC1=CN=CN1 FQVLRGLGWNWPSS-BXBUPLCLSA-N 0.000 description 1
- OSJPPGNTCRNQQC-UWTATZPHSA-N 3-phospho-D-glyceric acid Chemical compound OC(=O)[C@H](O)COP(O)(O)=O OSJPPGNTCRNQQC-UWTATZPHSA-N 0.000 description 1
- 101710163881 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 description 1
- 108010011619 6-Phytase Proteins 0.000 description 1
- 101150104118 ANS1 gene Proteins 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 101100510736 Actinidia chinensis var. chinensis LDOX gene Proteins 0.000 description 1
- 241000222518 Agaricus Species 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 102100034035 Alcohol dehydrogenase 1A Human genes 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
- 102000004400 Aminopeptidases Human genes 0.000 description 1
- 108090000915 Aminopeptidases Proteins 0.000 description 1
- 241000534414 Anotopterus nikparini Species 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 101000690713 Aspergillus niger Alpha-glucosidase Proteins 0.000 description 1
- 101000756530 Aspergillus niger Endo-1,4-beta-xylanase B Proteins 0.000 description 1
- 101900318521 Aspergillus oryzae Triosephosphate isomerase Proteins 0.000 description 1
- 108090000145 Bacillolysin Proteins 0.000 description 1
- 101000695691 Bacillus licheniformis Beta-lactamase Proteins 0.000 description 1
- 241000194110 Bacillus sp. (in: Bacteria) Species 0.000 description 1
- 101900040182 Bacillus subtilis Levansucrase Proteins 0.000 description 1
- 108091005658 Basic proteases Proteins 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 102100030981 Beta-alanine-activating enzyme Human genes 0.000 description 1
- 102100026189 Beta-galactosidase Human genes 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- 241000222490 Bjerkandera Species 0.000 description 1
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 108010006303 Carboxypeptidases Proteins 0.000 description 1
- 102000005367 Carboxypeptidases Human genes 0.000 description 1
- 102100035882 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 108010031396 Catechol oxidase Proteins 0.000 description 1
- 102000030523 Catechol oxidase Human genes 0.000 description 1
- 108010084185 Cellulases Proteins 0.000 description 1
- 102000005575 Cellulases Human genes 0.000 description 1
- 102100037633 Centrin-3 Human genes 0.000 description 1
- 241001277875 Ceriporiopsis rivulosa Species 0.000 description 1
- 241000524302 Ceriporiopsis subrufa Species 0.000 description 1
- 241000259840 Chaetomidium Species 0.000 description 1
- 241001057137 Chaetomium fimeti Species 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 108010022172 Chitinases Proteins 0.000 description 1
- 102000012286 Chitinases Human genes 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 241000985909 Chrysosporium keratinophilum Species 0.000 description 1
- 241001674013 Chrysosporium lucknowense Species 0.000 description 1
- 241001674001 Chrysosporium tropicum Species 0.000 description 1
- 241000355696 Chrysosporium zonatum Species 0.000 description 1
- 241000233652 Chytridiomycota Species 0.000 description 1
- 108020004638 Circular DNA Proteins 0.000 description 1
- 241000222290 Cladosporium Species 0.000 description 1
- 241000221760 Claviceps Species 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 241001085790 Coprinopsis Species 0.000 description 1
- 241000222511 Coprinus Species 0.000 description 1
- 241000222356 Coriolus Species 0.000 description 1
- 108010025880 Cyclomaltodextrin glucanotransferase Proteins 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- 230000004544 DNA amplification Effects 0.000 description 1
- 239000003155 DNA primer Substances 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 108010053770 Deoxyribonucleases Proteins 0.000 description 1
- 102000016911 Deoxyribonucleases Human genes 0.000 description 1
- 101100342470 Dictyostelium discoideum pkbA gene Proteins 0.000 description 1
- 241000935926 Diplodia Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 description 1
- 101710132690 Endo-1,4-beta-xylanase A Proteins 0.000 description 1
- 101100385973 Escherichia coli (strain K12) cycA gene Proteins 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 241000221433 Exidia Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241001465753 Fusarium torulosum Species 0.000 description 1
- 101150108358 GLAA gene Proteins 0.000 description 1
- 241000146398 Gelatoporia subvermispora Species 0.000 description 1
- 206010064571 Gene mutation Diseases 0.000 description 1
- 101100001650 Geobacillus stearothermophilus amyM gene Proteins 0.000 description 1
- 101000892220 Geobacillus thermodenitrificans (strain NG80-2) Long-chain-alcohol dehydrogenase 1 Proteins 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 102100022624 Glucoamylase Human genes 0.000 description 1
- 102100025591 Glycerate kinase Human genes 0.000 description 1
- 101150009006 HIS3 gene Proteins 0.000 description 1
- 101100295959 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) arcB gene Proteins 0.000 description 1
- 101100246753 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) pyrF gene Proteins 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001497663 Holomastigotoides Species 0.000 description 1
- 101000780443 Homo sapiens Alcohol dehydrogenase 1A Proteins 0.000 description 1
- 101000773364 Homo sapiens Beta-alanine-activating enzyme Proteins 0.000 description 1
- 101000880522 Homo sapiens Centrin-3 Proteins 0.000 description 1
- 241000223199 Humicola grisea Species 0.000 description 1
- 102220468791 Inositol 1,4,5-trisphosphate receptor type 2_Y167A_mutation Human genes 0.000 description 1
- 241000222342 Irpex Species 0.000 description 1
- 241000222344 Irpex lacteus Species 0.000 description 1
- 241001138401 Kluyveromyces lactis Species 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- STECJAGHUSJQJN-USLFZFAMSA-N LSM-4015 Chemical compound C1([C@@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-USLFZFAMSA-N 0.000 description 1
- 241000235087 Lachancea kluyveri Species 0.000 description 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
- 241000222435 Lentinula Species 0.000 description 1
- 101150068888 MET3 gene Proteins 0.000 description 1
- 239000007993 MOPS buffer Substances 0.000 description 1
- 241001344133 Magnaporthe Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229920000057 Mannan Polymers 0.000 description 1
- 108010054377 Mannosidases Proteins 0.000 description 1
- 102000001696 Mannosidases Human genes 0.000 description 1
- 241000183011 Melanocarpus Species 0.000 description 1
- 241001184659 Melanocarpus albomyces Species 0.000 description 1
- 241000123315 Meripilus Species 0.000 description 1
- 102000003792 Metallothionein Human genes 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 241000233892 Neocallimastix Species 0.000 description 1
- 241000221960 Neurospora Species 0.000 description 1
- 241000221961 Neurospora crassa Species 0.000 description 1
- 101100022915 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cys-11 gene Proteins 0.000 description 1
- 108091005507 Neutral proteases Proteins 0.000 description 1
- 102000035092 Neutral proteases Human genes 0.000 description 1
- 108090000913 Nitrate Reductases Proteins 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 102000007981 Ornithine carbamoyltransferase Human genes 0.000 description 1
- 101710113020 Ornithine transcarbamylase, mitochondrial Proteins 0.000 description 1
- 108010055012 Orotidine-5'-phosphate decarboxylase Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000194109 Paenibacillus lautus Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 241000222385 Phanerochaete Species 0.000 description 1
- 241000222395 Phlebia Species 0.000 description 1
- 241000222397 Phlebia radiata Species 0.000 description 1
- 241000425347 Phyla <beetle> Species 0.000 description 1
- 241000235379 Piromyces Species 0.000 description 1
- 241000276498 Pollachius virens Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 238000012356 Product development Methods 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 241000235402 Rhizomucor Species 0.000 description 1
- 101000968489 Rhizomucor miehei Lipase Proteins 0.000 description 1
- 101100394989 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) hisI gene Proteins 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 101900354623 Saccharomyces cerevisiae Galactokinase Proteins 0.000 description 1
- 101900084120 Saccharomyces cerevisiae Triosephosphate isomerase Proteins 0.000 description 1
- 235000001006 Saccharomyces cerevisiae var diastaticus Nutrition 0.000 description 1
- 244000206963 Saccharomyces cerevisiae var. diastaticus Species 0.000 description 1
- 241000204893 Saccharomyces douglasii Species 0.000 description 1
- 241001407717 Saccharomyces norbensis Species 0.000 description 1
- 241000235343 Saccharomycetales Species 0.000 description 1
- 241000222480 Schizophyllum Species 0.000 description 1
- 101100022918 Schizosaccharomyces pombe (strain 972 / ATCC 24843) sua1 gene Proteins 0.000 description 1
- 241000223255 Scytalidium Species 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 101100309436 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) ftf gene Proteins 0.000 description 1
- 101100370749 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) trpC1 gene Proteins 0.000 description 1
- 241000187391 Streptomyces hygroscopicus Species 0.000 description 1
- 108090000787 Subtilisin Proteins 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 241001215623 Talaromyces cellulolyticus Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 101100157012 Thermoanaerobacterium saccharolyticum (strain DSM 8691 / JW/SL-YS485) xynB gene Proteins 0.000 description 1
- 241000228178 Thermoascus Species 0.000 description 1
- 241001313536 Thermothelomyces thermophila Species 0.000 description 1
- 241000183057 Thielavia microspora Species 0.000 description 1
- 241000182980 Thielavia ovispora Species 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 108010022394 Threonine synthase Proteins 0.000 description 1
- 241000222354 Trametes Species 0.000 description 1
- 108060008539 Transglutaminase Proteins 0.000 description 1
- 241000223260 Trichoderma harzianum Species 0.000 description 1
- 241000378866 Trichoderma koningii Species 0.000 description 1
- 241000215642 Trichophaea Species 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 101150050575 URA3 gene Proteins 0.000 description 1
- 239000004904 UV filter Substances 0.000 description 1
- 108091023045 Untranslated Region Proteins 0.000 description 1
- 241000082085 Verticillium <Phyllachorales> Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 241001507667 Volvariella Species 0.000 description 1
- 241000409279 Xerochrysium dermatitidis Species 0.000 description 1
- 241001523965 Xylaria Species 0.000 description 1
- 241000235015 Yarrowia lipolytica Species 0.000 description 1
- 241000758405 Zoopagomycotina Species 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 108010045649 agarase Proteins 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000012867 alanine scanning Methods 0.000 description 1
- 101150087698 alpha gene Proteins 0.000 description 1
- 108010030291 alpha-Galactosidase Proteins 0.000 description 1
- 102000005840 alpha-Galactosidase Human genes 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000012870 ammonium sulfate precipitation Methods 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 101150009206 aprE gene Proteins 0.000 description 1
- 101150008194 argB gene Proteins 0.000 description 1
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 210000004507 artificial chromosome Anatomy 0.000 description 1
- 238000013528 artificial neural network Methods 0.000 description 1
- 235000008452 baby food Nutrition 0.000 description 1
- 101150103518 bar gene Proteins 0.000 description 1
- 235000021168 barbecue Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 102000006635 beta-lactamase Human genes 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 230000009141 biological interaction Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 108010089934 carbohydrase Proteins 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000012219 cassette mutagenesis Methods 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000034303 cell budding Effects 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229940106157 cellulase Drugs 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 235000011967 chocolate pudding Nutrition 0.000 description 1
- 238000011098 chromatofocusing Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000002361 compost Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 108010005400 cutinase Proteins 0.000 description 1
- 101150005799 dagA gene Proteins 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000009990 desizing Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002050 diffraction method Methods 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002003 electron diffraction Methods 0.000 description 1
- 238000004453 electron probe microanalysis Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 108010091371 endoglucanase 1 Proteins 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- UFZOPKFMKMAWLU-UHFFFAOYSA-N ethoxy(methyl)phosphinic acid Chemical compound CCOP(C)(O)=O UFZOPKFMKMAWLU-UHFFFAOYSA-N 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000021433 fructose syrup Nutrition 0.000 description 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 1
- 108010086476 glycerate kinase Proteins 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 108010002685 hygromycin-B kinase Proteins 0.000 description 1
- 230000028644 hyphal growth Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000017730 intein-mediated protein splicing Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000001573 invertase Substances 0.000 description 1
- 235000011073 invertase Nutrition 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000001155 isoelectric focusing Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 238000004900 laundering Methods 0.000 description 1
- 238000010412 laundry washing Methods 0.000 description 1
- 101150039489 lysZ gene Proteins 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 101150095344 niaD gene Proteins 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 101150105920 npr gene Proteins 0.000 description 1
- 101150017837 nprM gene Proteins 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000002351 pectolytic effect Effects 0.000 description 1
- 101150019841 penP gene Proteins 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 235000020030 perry Nutrition 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 108010082527 phosphinothricin N-acetyltransferase Proteins 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 238000005222 photoaffinity labeling Methods 0.000 description 1
- 229940085127 phytase Drugs 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 230000001124 posttranscriptional effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000013615 primer Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 101150108007 prs gene Proteins 0.000 description 1
- 101150086435 prs1 gene Proteins 0.000 description 1
- 101150070305 prsA gene Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 101150054232 pyrG gene Proteins 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 102200002592 rs76857106 Human genes 0.000 description 1
- 101150025220 sacB gene Proteins 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 238000012807 shake-flask culturing Methods 0.000 description 1
- 238000011172 small scale experimental method Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 238000010563 solid-state fermentation Methods 0.000 description 1
- 238000007614 solvation Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 108010075550 termamyl Proteins 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 125000000341 threoninyl group Chemical class [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 102000003601 transglutaminase Human genes 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 101150016309 trpC gene Proteins 0.000 description 1
- 125000001493 tyrosinyl group Chemical class [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 101150011516 xlnD gene Proteins 0.000 description 1
- 101150052264 xylA gene Proteins 0.000 description 1
- 101150110790 xylB gene Proteins 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2414—Alpha-amylase (3.2.1.1.)
- C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2414—Alpha-amylase (3.2.1.1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01001—Alpha-amylase (3.2.1.1)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Detergent Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11172251 | 2011-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2834102T3 true ES2834102T3 (es) | 2021-06-16 |
Family
ID=46397293
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18183123T Active ES2834102T3 (es) | 2011-06-30 | 2012-06-29 | Variantes de alfa-amilasa |
| ES12730567.0T Active ES2692544T3 (es) | 2011-06-30 | 2012-06-29 | Variantes de alfa-amilasa |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12730567.0T Active ES2692544T3 (es) | 2011-06-30 | 2012-06-29 | Variantes de alfa-amilasa |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US9434932B2 (en:Method) |
| EP (3) | EP3421595B1 (en:Method) |
| JP (1) | JP6204352B2 (en:Method) |
| KR (1) | KR20140056237A (en:Method) |
| CN (2) | CN103649307B (en:Method) |
| AU (1) | AU2012277721B2 (en:Method) |
| BR (1) | BR112013033782B1 (en:Method) |
| DK (2) | DK2726607T3 (en:Method) |
| ES (2) | ES2834102T3 (en:Method) |
| IN (1) | IN2014CN00650A (en:Method) |
| MX (1) | MX353621B (en:Method) |
| WO (1) | WO2013001078A1 (en:Method) |
| ZA (1) | ZA201400678B (en:Method) |
Families Citing this family (283)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2540824A1 (en) | 2011-06-30 | 2013-01-02 | The Procter & Gamble Company | Cleaning compositions comprising amylase variants reference to a sequence listing |
| ES2834102T3 (es) | 2011-06-30 | 2021-06-16 | Novozymes As | Variantes de alfa-amilasa |
| KR20140041801A (ko) | 2011-06-30 | 2014-04-04 | 노보자임스 에이/에스 | 알파-아밀라제 스크리닝 방법 |
| JP2015525248A (ja) | 2012-05-16 | 2015-09-03 | ノボザイムス アクティーゼルスカブ | リパーゼを含む組成物およびその使用方法 |
| HUE057894T2 (hu) | 2012-06-08 | 2022-06-28 | Danisco Us Inc | Alfa-amiláz változatok javított aktivitással keményítõpolimereken |
| EP2863759A2 (en) | 2012-06-20 | 2015-04-29 | Novozymes Biopolymer A/S | Use of polypeptides having protease activity in animal feed and detergents |
| MX357022B (es) | 2012-08-22 | 2018-06-25 | Novozymes As | Metaloproteasas de alicyclobacillus sp. |
| CN104619838A (zh) | 2012-08-22 | 2015-05-13 | 诺维信公司 | 来自微小杆菌属的金属蛋白酶 |
| JP6514107B2 (ja) | 2012-12-07 | 2019-05-15 | ノボザイムス アクティーゼルスカブ | 細菌の付着防止 |
| CN104869841A (zh) | 2012-12-21 | 2015-08-26 | 诺维信公司 | 具有蛋白酶活性的多肽和编码它的多核苷酸 |
| US9902946B2 (en) | 2013-01-03 | 2018-02-27 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| EP2970929A1 (en) * | 2013-03-11 | 2016-01-20 | Danisco US Inc. | Alpha-amylase combinatorial variants |
| US10308899B2 (en) | 2013-04-23 | 2019-06-04 | Novozymes A/S | Liquid automatic dish washing detergent compositions |
| EP2992076B1 (en) | 2013-05-03 | 2018-10-24 | Novozymes A/S | Microencapsulation of detergent enzymes |
| CN105209612A (zh) | 2013-05-14 | 2015-12-30 | 诺维信公司 | 洗涤剂组合物 |
| US20160083703A1 (en) | 2013-05-17 | 2016-03-24 | Novozymes A/S | Polypeptides having alpha amylase activity |
| WO2014195356A2 (en) | 2013-06-06 | 2014-12-11 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| US10378001B2 (en) | 2013-06-27 | 2019-08-13 | Novozymes A/S | Subtilase variants and compositions comprising same |
| WO2014207224A1 (en) | 2013-06-27 | 2014-12-31 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
| WO2015001017A2 (en) | 2013-07-04 | 2015-01-08 | Novozymes A/S | Polypeptides having anti-redeposition effect and polynucleotides encoding same |
| EP3027748B1 (en) | 2013-07-29 | 2019-09-18 | Novozymes A/S | Protease variants and polynucleotides encoding same |
| EP3613853A1 (en) | 2013-07-29 | 2020-02-26 | Novozymes A/S | Protease variants and polynucleotides encoding same |
| WO2015049370A1 (en) | 2013-10-03 | 2015-04-09 | Novozymes A/S | Detergent composition and use of detergent composition |
| WO2015091989A1 (en) | 2013-12-20 | 2015-06-25 | Novozymes A/S | Polypeptides having protease activity and polynucleotides encoding same |
| WO2015134737A1 (en) | 2014-03-05 | 2015-09-11 | Novozymes A/S | Compositions and methods for improving properties of cellulosic textile materials with xyloglucan endotransglycosylase |
| EP3114219A1 (en) | 2014-03-05 | 2017-01-11 | Novozymes A/S | Compositions and methods for improving properties of non-cellulosic textile materials with xyloglucan endotransglycosylase |
| EP3126479A1 (en) | 2014-04-01 | 2017-02-08 | Novozymes A/S | Polypeptides having alpha amylase activity |
| BR112016023188A2 (pt) | 2014-04-11 | 2018-01-16 | Novozymes As | uso de um polipeptídeo, composição detergente, métodos de lavagem para a lavagem de um item e de produção do polipeptídeo, polipeptídeo isolado, construção de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, e, formulação de caldo inteiro ou composição de cultura de células |
| WO2015181119A2 (en) | 2014-05-27 | 2015-12-03 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| EP3149160B1 (en) | 2014-05-27 | 2021-02-17 | Novozymes A/S | Methods for producing lipases |
| CN106414729A (zh) | 2014-06-12 | 2017-02-15 | 诺维信公司 | α‑淀粉酶变体以及对其进行编码的多核苷酸 |
| US20170121646A1 (en) | 2014-07-03 | 2017-05-04 | Novozymes A/S | Improved Stabilization of Non-Protease Enzyme |
| EP3140399B1 (en) | 2014-07-04 | 2018-03-28 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
| WO2016001450A2 (en) | 2014-07-04 | 2016-01-07 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
| WO2016079110A2 (en) | 2014-11-19 | 2016-05-26 | Novozymes A/S | Use of enzyme for cleaning |
| WO2016079305A1 (en) * | 2014-11-20 | 2016-05-26 | Novozymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
| CA2963331A1 (en) | 2014-12-04 | 2016-06-09 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
| WO2016087401A1 (en) | 2014-12-05 | 2016-06-09 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| WO2016096714A1 (en) | 2014-12-15 | 2016-06-23 | Henkel Ag & Co. Kgaa | Detergent composition comprising subtilase variants |
| WO2016096996A1 (en) | 2014-12-16 | 2016-06-23 | Novozymes A/S | Polypeptides having n-acetyl glucosamine oxidase activity |
| EP3034591A1 (en) | 2014-12-17 | 2016-06-22 | The Procter and Gamble Company | Method of automatic dishwashing |
| EP3034592A1 (en) | 2014-12-17 | 2016-06-22 | The Procter and Gamble Company | Method of automatic dishwashing |
| PL3034588T3 (pl) | 2014-12-17 | 2019-09-30 | The Procter And Gamble Company | Kompozycja detergentu |
| EP3034589A1 (en) | 2014-12-17 | 2016-06-22 | The Procter and Gamble Company | Detergent composition |
| EP3034596B2 (en) | 2014-12-17 | 2021-11-10 | The Procter & Gamble Company | Detergent composition |
| EP3034590A1 (en) | 2014-12-17 | 2016-06-22 | The Procter and Gamble Company | Method of automatic dishwashing |
| EP3034597A1 (en) | 2014-12-17 | 2016-06-22 | The Procter and Gamble Company | Detergent composition |
| CN107002061A (zh) | 2014-12-19 | 2017-08-01 | 诺维信公司 | 蛋白酶变体以及对其进行编码的多核苷酸 |
| WO2016097352A1 (en) | 2014-12-19 | 2016-06-23 | Novozymes A/S | Protease variants and polynucleotides encoding same |
| US20180105772A1 (en) | 2015-04-10 | 2018-04-19 | Novozymes A/S | Detergent composition |
| US20180112156A1 (en) | 2015-04-10 | 2018-04-26 | Novozymes A/S | Laundry method, use of polypeptide and detergent composition |
| WO2016180749A1 (en) | 2015-05-08 | 2016-11-17 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| CA2981409A1 (en) | 2015-05-08 | 2016-11-17 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| CN107835853B (zh) | 2015-05-19 | 2021-04-20 | 诺维信公司 | 气味减少 |
| EP3284811B1 (en) | 2015-06-04 | 2018-12-12 | The Procter & Gamble Company | Hand dishwashing liquid detergent composition |
| EP3287513A1 (en) | 2015-06-04 | 2018-02-28 | The Procter & Gamble Company | Hand dishwashing liquid detergent composition |
| WO2016202739A1 (en) | 2015-06-16 | 2016-12-22 | Novozymes A/S | Polypeptides with lipase activity and polynucleotides encoding same |
| US10717576B2 (en) | 2015-06-17 | 2020-07-21 | Novozymes A/S | Container for polypeptide |
| EP3106508B1 (en) | 2015-06-18 | 2019-11-20 | Henkel AG & Co. KGaA | Detergent composition comprising subtilase variants |
| CN108012544A (zh) | 2015-06-18 | 2018-05-08 | 诺维信公司 | 枯草杆菌酶变体以及编码它们的多核苷酸 |
| CN107922896A (zh) | 2015-06-30 | 2018-04-17 | 诺维信公司 | 衣物洗涤剂组合物、用于洗涤的方法和组合物的用途 |
| CA3175255A1 (en) | 2015-07-01 | 2017-01-05 | Novozymes A/S | Methods of reducing odor |
| CN114292829A (zh) | 2015-07-06 | 2022-04-08 | 诺维信公司 | 脂肪酶变体以及编码它们的多核苷酸 |
| AU2016323412B2 (en) | 2015-09-17 | 2021-04-01 | Henkel Ag & Co. Kgaa | Detergent compositions comprising polypeptides having xanthan degrading activity |
| EP3350323B1 (en) | 2015-09-17 | 2021-04-14 | Novozymes A/S | Polypeptides having xanthan degrading activity and polynucleotides encoding same |
| BR112018007017B1 (pt) | 2015-10-07 | 2023-11-28 | Novozymes A/S | Composição detergente, construto de ácido nucleico ou vetor de expressão, uso de um polipeptídeo, célula hospedeira recombinante e método para produzir o polipeptídeo |
| WO2017064269A1 (en) | 2015-10-14 | 2017-04-20 | Novozymes A/S | Polypeptide variants |
| EP3362558A1 (en) | 2015-10-14 | 2018-08-22 | Novozymes A/S | Polypeptides having protease activity and polynucleotides encoding same |
| BR112018007474A2 (pt) | 2015-10-14 | 2018-10-30 | Novozymes A/S | ?limpeza de membranas de filtração de água? |
| BR112018008454B1 (pt) | 2015-10-28 | 2023-09-26 | Novozymes A/S | Composição detergente que compreende variantes de amilase e protease, seu uso e métodos para lavar |
| WO2017089366A1 (en) | 2015-11-24 | 2017-06-01 | Novozymes A/S | Polypeptides having protease activity and polynucleotides encoding same |
| WO2017093318A1 (en) | 2015-12-01 | 2017-06-08 | Novozymes A/S | Methods for producing lipases |
| ES2932192T3 (es) | 2015-12-07 | 2023-01-16 | Henkel Ag & Co Kgaa | Composiciones para el lavado de vajilla que comprenden polipéptidos que tienen actividad beta-glucanasa y sus usos |
| WO2017117089A1 (en) | 2015-12-28 | 2017-07-06 | Novozymes Bioag A/S | Heat priming of bacterial spores |
| US20210171927A1 (en) | 2016-01-29 | 2021-06-10 | Novozymes A/S | Beta-glucanase variants and polynucleotides encoding same |
| WO2017162836A1 (en) | 2016-03-23 | 2017-09-28 | Novozymes A/S | Use of polypeptide having dnase activity for treating fabrics |
| WO2017174769A2 (en) | 2016-04-08 | 2017-10-12 | Novozymes A/S | Detergent compositions and uses of the same |
| BR112018072282A2 (pt) | 2016-04-29 | 2019-02-12 | Novozymes A/S | composições detergentes e usos das mesmas |
| WO2017210188A1 (en) | 2016-05-31 | 2017-12-07 | Novozymes A/S | Stabilized liquid peroxide compositions |
| CA3024276A1 (en) | 2016-06-03 | 2017-12-07 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
| EP3257931A1 (en) | 2016-06-17 | 2017-12-20 | The Procter and Gamble Company | Detergent composition |
| CN109563449B (zh) | 2016-06-23 | 2022-01-25 | 诺维信公司 | 酶的用途、组合物以及用于去除污垢的方法 |
| CN109563495A (zh) | 2016-06-30 | 2019-04-02 | 诺维信公司 | 脂肪酶变体及包含表面活性剂和脂肪酶变体的组合物 |
| WO2018002261A1 (en) | 2016-07-01 | 2018-01-04 | Novozymes A/S | Detergent compositions |
| WO2018007573A1 (en) | 2016-07-08 | 2018-01-11 | Novozymes A/S | Detergent compositions with galactanase |
| CN109415708A (zh) | 2016-07-13 | 2019-03-01 | 宝洁公司 | 食物芽孢杆菌脱氧核糖核酸酶变体及其用途 |
| EP4357453A3 (en) | 2016-07-18 | 2025-01-22 | Novozymes A/S | Lipase variants, polynucleotides encoding same and the use thereof |
| PL3284805T3 (pl) | 2016-08-17 | 2020-07-13 | The Procter & Gamble Company | Kompozycja czyszcząca zawierająca enzymy |
| WO2018060216A1 (en) | 2016-09-29 | 2018-04-05 | Novozymes A/S | Use of enzyme for washing, method for washing and warewashing composition |
| EP3519547B1 (en) | 2016-09-29 | 2025-04-09 | Novozymes A/S | Spore containing granule |
| EP3532592A1 (en) | 2016-10-25 | 2019-09-04 | Novozymes A/S | Detergent compositions |
| EP3535377B1 (en) | 2016-11-01 | 2022-02-09 | Novozymes A/S | Multi-core granules |
| WO2018102348A1 (en) * | 2016-11-29 | 2018-06-07 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| KR20190086540A (ko) | 2016-12-01 | 2019-07-22 | 바스프 에스이 | 조성물 중 효소의 안정화 |
| EP3551740B1 (en) | 2016-12-12 | 2021-08-11 | Novozymes A/S | Use of polypeptides |
| PL3357994T3 (pl) * | 2017-02-01 | 2024-03-25 | The Procter & Gamble Company | Kompozycje czyszczące zawierające warianty amylazy |
| DK3577219T5 (da) * | 2017-02-01 | 2024-09-02 | Novozymes As | Alfa-amylase-varianter |
| US11208639B2 (en) | 2017-03-31 | 2021-12-28 | Novozymes A/S | Polypeptides having DNase activity |
| US11149233B2 (en) | 2017-03-31 | 2021-10-19 | Novozymes A/S | Polypeptides having RNase activity |
| WO2018177936A1 (en) | 2017-03-31 | 2018-10-04 | Novozymes A/S | Polypeptides having dnase activity |
| EP3606936B1 (en) | 2017-04-03 | 2021-10-20 | Novozymes A/S | Recovery process |
| EP3607039A1 (en) | 2017-04-04 | 2020-02-12 | Novozymes A/S | Polypeptides |
| US20200109352A1 (en) | 2017-04-04 | 2020-04-09 | Novozymes A/S | Polypeptide compositions and uses thereof |
| US11339355B2 (en) | 2017-04-04 | 2022-05-24 | Novozymes A/S | Glycosyl hydrolases |
| DK3385361T3 (da) | 2017-04-05 | 2019-06-03 | Ab Enzymes Gmbh | Detergentsammensætninger omfattende bakterielle mannanaser |
| EP3385362A1 (en) | 2017-04-05 | 2018-10-10 | Henkel AG & Co. KGaA | Detergent compositions comprising fungal mannanases |
| EP3607042A1 (en) | 2017-04-06 | 2020-02-12 | Novozymes A/S | Cleaning compositions and uses thereof |
| JP7032430B2 (ja) | 2017-04-06 | 2022-03-08 | ノボザイムス アクティーゼルスカブ | クリーニング組成物及びその使用 |
| ES2763561T3 (es) | 2017-04-06 | 2020-05-29 | Novozymes As | Composiciones de limpieza y sus usos |
| WO2018184873A1 (en) | 2017-04-06 | 2018-10-11 | Novozymes A/S | Detergent compositions and uses thereof |
| EP3607044B1 (en) | 2017-04-06 | 2024-11-13 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2018184816A1 (en) | 2017-04-06 | 2018-10-11 | Novozymes A/S | Cleaning compositions and uses thereof |
| EP3607043A1 (en) | 2017-04-06 | 2020-02-12 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2018184818A1 (en) | 2017-04-06 | 2018-10-11 | Novozymes A/S | Cleaning compositions and uses thereof |
| EP3619304A1 (en) | 2017-05-05 | 2020-03-11 | Novozymes A/S | Compositions comprising lipase and sulfite |
| WO2018224544A1 (en) | 2017-06-08 | 2018-12-13 | Novozymes A/S | Compositions comprising polypeptides having cellulase activity and amylase activity, and uses thereof in cleaning and detergent compositions |
| US20200181542A1 (en) | 2017-06-30 | 2020-06-11 | Novozymes A/S | Enzyme Slurry Composition |
| US20200277553A1 (en) | 2017-09-20 | 2020-09-03 | Novozymes A/S | Use of Enzymes for Improving Water Absorption And/Or Whiteness |
| EP3684899A1 (en) | 2017-09-22 | 2020-07-29 | Novozymes A/S | Novel polypeptides |
| WO2019067390A1 (en) | 2017-09-27 | 2019-04-04 | The Procter & Gamble Company | DETERGENT COMPOSITIONS CONTAINING LIPASES |
| CA3073362A1 (en) | 2017-09-27 | 2019-04-04 | Novozymes A/S | Lipase variants and microcapsule compositions comprising such lipase variants |
| US11732221B2 (en) | 2017-10-02 | 2023-08-22 | Novozymes A/S | Polypeptides having mannanase activity and polynucleotides encoding same |
| EP3692147A1 (en) | 2017-10-02 | 2020-08-12 | Novozymes A/S | Polypeptides having mannanase activity and polynucleotides encoding same |
| WO2019076800A1 (en) | 2017-10-16 | 2019-04-25 | Novozymes A/S | CLEANING COMPOSITIONS AND USES THEREOF |
| US20200318037A1 (en) | 2017-10-16 | 2020-10-08 | Novozymes A/S | Low dusting granules |
| FI3697881T3 (fi) | 2017-10-16 | 2025-03-06 | Novozymes As | Niukasti pölyäviä rakeita |
| WO2019081515A1 (en) | 2017-10-24 | 2019-05-02 | Novozymes A/S | COMPOSITIONS COMPRISING POLYPEPTIDES HAVING MANNANASE ACTIVITY |
| MX2020004145A (es) | 2017-10-27 | 2020-08-03 | Novozymes As | Variantes de desoxirribonucleasa (dnasa). |
| CN117683748A (zh) | 2017-10-27 | 2024-03-12 | 宝洁公司 | 包含多肽变体的洗涤剂组合物 |
| DE102017125558A1 (de) | 2017-11-01 | 2019-05-02 | Henkel Ag & Co. Kgaa | Reinigungszusammensetzungen, die dispersine i enthalten |
| BR112020008711A2 (pt) | 2017-11-01 | 2020-11-10 | Novozymes A/S | polipeptídeos e composições que compreendem tais polipeptídeos |
| US11505767B2 (en) | 2017-11-01 | 2022-11-22 | Novozymes A/S | Methods for cleansing medical devices |
| DE102017125560A1 (de) | 2017-11-01 | 2019-05-02 | Henkel Ag & Co. Kgaa | Reinigungszusammensetzungen, die dispersine iii enthalten |
| DE102017125559A1 (de) | 2017-11-01 | 2019-05-02 | Henkel Ag & Co. Kgaa | Reinigungszusammensetzungen, die dispersine ii enthalten |
| EP3704219B1 (en) | 2017-11-01 | 2024-01-10 | Novozymes A/S | Polypeptides and compositions comprising such polypeptides |
| CN111465680A (zh) | 2017-11-29 | 2020-07-28 | 巴斯夫欧洲公司 | 组合物、其制备和用途 |
| WO2019110462A1 (en) | 2017-12-04 | 2019-06-13 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| WO2019154955A1 (en) | 2018-02-08 | 2019-08-15 | Novozymes A/S | Lipase variants and compositions thereof |
| US20210123033A1 (en) | 2018-02-08 | 2021-04-29 | Novozymes A/S | Lipases, Lipase Variants and Compositions Thereof |
| US20210002588A1 (en) | 2018-03-13 | 2021-01-07 | Novozymes A/S | Microencapsulation Using Amino Sugar Oligomers |
| WO2019180111A1 (en) | 2018-03-23 | 2019-09-26 | Novozymes A/S | Subtilase variants and compositions comprising same |
| US20210009927A1 (en) | 2018-04-17 | 2021-01-14 | Novozymes A/S | Polypeptides Comprising Carbohydrate Binding Activity in Detergent Compositions And Their use in Reducing Wrinkles in Textile or Fabrics |
| WO2019201783A1 (en) | 2018-04-19 | 2019-10-24 | Novozymes A/S | Stabilized cellulase variants |
| US11566239B2 (en) | 2018-04-19 | 2023-01-31 | Novozymes A/S | Stabilized cellulase variants |
| US11732250B2 (en) | 2018-04-26 | 2023-08-22 | Basf Se | Lipase enzymes |
| US20210115422A1 (en) | 2018-05-03 | 2021-04-22 | Basf Se | Amylase enzymes |
| WO2019238761A1 (en) | 2018-06-15 | 2019-12-19 | Basf Se | Water soluble multilayer films containing wash active chemicals and enzymes |
| EP3814472A1 (en) | 2018-06-28 | 2021-05-05 | Novozymes A/S | Detergent compositions and uses thereof |
| EP3814489A1 (en) | 2018-06-29 | 2021-05-05 | Novozymes A/S | Subtilase variants and compositions comprising same |
| EP3814473A1 (en) | 2018-06-29 | 2021-05-05 | Novozymes A/S | Detergent compositions and uses thereof |
| EP3818139A1 (en) | 2018-07-02 | 2021-05-12 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2020007875A1 (en) | 2018-07-03 | 2020-01-09 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2020008024A1 (en) | 2018-07-06 | 2020-01-09 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2020008043A1 (en) | 2018-07-06 | 2020-01-09 | Novozymes A/S | Cleaning compositions and uses thereof |
| US20210340466A1 (en) | 2018-10-01 | 2021-11-04 | Novozymes A/S | Detergent compositions and uses thereof |
| WO2020070209A1 (en) | 2018-10-02 | 2020-04-09 | Novozymes A/S | Cleaning composition |
| WO2020070014A1 (en) | 2018-10-02 | 2020-04-09 | Novozymes A/S | Cleaning composition comprising anionic surfactant and a polypeptide having rnase activity |
| US20230287306A1 (en) | 2018-10-02 | 2023-09-14 | Novozymes A/S | Cleaning Composition |
| US12146123B2 (en) | 2018-10-02 | 2024-11-19 | Novozymes A/S | Endonuclease 1 ribonucleases for cleaning |
| WO2020070249A1 (en) | 2018-10-03 | 2020-04-09 | Novozymes A/S | Cleaning compositions |
| CN113056476A (zh) | 2018-10-03 | 2021-06-29 | 诺维信公司 | 具有α-甘露聚糖降解活性的多肽以及编码它们的多核苷酸 |
| EP3677676A1 (en) | 2019-01-03 | 2020-07-08 | Basf Se | Compounds stabilizing amylases in liquids |
| MX2021003932A (es) | 2018-10-05 | 2021-06-04 | Basf Se | Compuestos estabilizadores de hidrolasas en liquidos. |
| CN112805377A (zh) | 2018-10-05 | 2021-05-14 | 巴斯夫欧洲公司 | 在液体中稳定淀粉酶的化合物 |
| EP3861115A1 (en) | 2018-10-05 | 2021-08-11 | Basf Se | Compounds stabilizing hydrolases in liquids |
| US20220033739A1 (en) | 2018-10-11 | 2022-02-03 | Novozymes A/S | Cleaning compositions and uses thereof |
| ES2981999T3 (es) | 2018-10-31 | 2024-10-14 | Henkel Ag & Co Kgaa | Composiciones limpiadoras que contienen dispersinas V |
| EP3647397A1 (en) | 2018-10-31 | 2020-05-06 | Henkel AG & Co. KGaA | Cleaning compositions containing dispersins iv |
| US20220017844A1 (en) | 2018-12-03 | 2022-01-20 | Novozymes A/S | Low pH Powder Detergent Composition |
| WO2020114968A1 (en) | 2018-12-03 | 2020-06-11 | Novozymes A/S | Powder detergent compositions |
| CN113366103A (zh) | 2018-12-21 | 2021-09-07 | 诺维信公司 | 具有肽聚糖降解活性的多肽以及编码其的多核苷酸 |
| EP3898919A1 (en) | 2018-12-21 | 2021-10-27 | Novozymes A/S | Detergent pouch comprising metalloproteases |
| EP3927837A1 (en) | 2019-02-20 | 2021-12-29 | Basf Se | Industrial fermentation process for bacillus using defined medium and magnesium feed |
| CN114127256A (zh) | 2019-02-20 | 2022-03-01 | 巴斯夫欧洲公司 | 用确定成分培养基和微量元素补料的芽孢杆菌工业发酵工艺 |
| EP3702452A1 (en) | 2019-03-01 | 2020-09-02 | Novozymes A/S | Detergent compositions comprising two proteases |
| CN113454214A (zh) | 2019-03-21 | 2021-09-28 | 诺维信公司 | α-淀粉酶变体以及对其进行编码的多核苷酸 |
| WO2020193532A1 (en) | 2019-03-25 | 2020-10-01 | Basf Se | Cleaning composition having amylase enzymes |
| EP3947665A2 (en) | 2019-03-25 | 2022-02-09 | Basf Se | Amylase enzymes |
| EP3947664A2 (en) | 2019-03-25 | 2022-02-09 | Basf Se | Amylase enzymes |
| MX2021011981A (es) | 2019-04-03 | 2021-11-03 | Novozymes As | Polipeptidos que tienen actividad de beta-glucanasa, polinucleotidos que los codifican y usos de los mismos en composiciones de limpieza y de detergente. |
| CN119842665A (zh) | 2019-04-10 | 2025-04-18 | 诺维信公司 | 多肽变体 |
| MX2021012289A (es) | 2019-04-12 | 2021-11-12 | Novozymes As | Variantes de glucosido hidrolasa estabilizadas. |
| WO2020229480A1 (en) | 2019-05-14 | 2020-11-19 | Basf Se | Compounds stabilizing hydrolases in liquids |
| MX2021015364A (es) | 2019-06-13 | 2022-01-24 | Basf Se | Metodo de recuperacion de una proteina de un caldo de fermentacion mediante el uso de un cation divalente. |
| EP3987022A1 (en) * | 2019-06-24 | 2022-04-27 | Novozymes A/S | Alpha-amylase variants |
| EP3994255A1 (en) | 2019-07-02 | 2022-05-11 | Novozymes A/S | Lipase variants and compositions thereof |
| ES2955800T3 (es) | 2019-07-05 | 2023-12-07 | Basf Se | Procedimiento de fermentación industrial de células microbianas mediante precultivo alimentado por lotes |
| WO2021009067A1 (en) | 2019-07-12 | 2021-01-21 | Novozymes A/S | Enzymatic emulsions for detergents |
| WO2021032881A1 (en) | 2019-08-22 | 2021-02-25 | Basf Se | Amylase variants |
| WO2021037878A1 (en) | 2019-08-27 | 2021-03-04 | Novozymes A/S | Composition comprising a lipase |
| US20220325204A1 (en) | 2019-08-27 | 2022-10-13 | Novozymes A/S | Detergent composition |
| EP4031644A1 (en) | 2019-09-19 | 2022-07-27 | Novozymes A/S | Detergent composition |
| US20220340843A1 (en) | 2019-10-03 | 2022-10-27 | Novozymes A/S | Polypeptides comprising at least two carbohydrate binding domains |
| US20240132808A1 (en) | 2019-10-18 | 2024-04-25 | Basf Se | Storage-Stable Hydrolase Containing Liquids |
| US12410385B2 (en) * | 2019-10-24 | 2025-09-09 | The Procter & Gamble Company | Automatic dishwashing detergent composition comprising an amylase |
| WO2021105336A1 (en) | 2019-11-29 | 2021-06-03 | Basf Se | Compositions comprising polymer and enzyme |
| WO2021115912A1 (en) | 2019-12-09 | 2021-06-17 | Basf Se | Formulations comprising a hydrophobically modified polyethyleneimine and one or more enzymes |
| JP2023506927A (ja) * | 2019-12-19 | 2023-02-20 | ノボザイムス アクティーゼルスカブ | α－アミラーゼ変異体 |
| CN114929848A (zh) | 2019-12-20 | 2022-08-19 | 诺维信公司 | 稳定的液体无硼酶组合物 |
| US20220411773A1 (en) | 2019-12-20 | 2022-12-29 | Novozymes A/S | Polypeptides having proteolytic activity and use thereof |
| CN114829564A (zh) | 2019-12-20 | 2022-07-29 | 汉高股份有限及两合公司 | 包含分散蛋白和糖酶的清洁组合物 |
| AU2020404593A1 (en) | 2019-12-20 | 2022-08-18 | Henkel Ag & Co. Kgaa | Cleaning compositions comprising dispersins VI |
| WO2021122120A2 (en) | 2019-12-20 | 2021-06-24 | Henkel Ag & Co. Kgaa | Cleaning compositions comprising dispersins viii |
| EP4097206B1 (en) | 2020-01-29 | 2023-08-09 | Unilever IP Holdings B.V. | Laundry detergent product |
| EP4097226A1 (en) | 2020-01-31 | 2022-12-07 | Novozymes A/S | Mannanase variants and polynucleotides encoding same |
| MX2022008955A (es) | 2020-01-31 | 2022-08-15 | Novozymes As | Variantes de mananasas y polinucleotidos que las codifican. |
| EP3892708A1 (en) | 2020-04-06 | 2021-10-13 | Henkel AG & Co. KGaA | Cleaning compositions comprising dispersin variants |
| CN115210371A (zh) | 2020-04-08 | 2022-10-18 | 诺维信公司 | 碳水化合物结合模块变体 |
| US20230167384A1 (en) | 2020-04-21 | 2023-06-01 | Novozymes A/S | Cleaning compositions comprising polypeptides having fructan degrading activity |
| EP3907271A1 (en) | 2020-05-07 | 2021-11-10 | Novozymes A/S | Cleaning composition, use and method of cleaning |
| US20230212548A1 (en) | 2020-05-26 | 2023-07-06 | Novozymes A/S | Subtilase variants and compositions comprising same |
| CN115836125A (zh) | 2020-06-24 | 2023-03-21 | 诺维信公司 | 纤维素酶用于从纺织品去除尘螨的用途 |
| EP3936593A1 (en) | 2020-07-08 | 2022-01-12 | Henkel AG & Co. KGaA | Cleaning compositions and uses thereof |
| WO2022008732A1 (en) | 2020-07-10 | 2022-01-13 | Basf Se | Enhancing the activity of antimicrobial preservatives |
| WO2022023250A1 (en) | 2020-07-27 | 2022-02-03 | Unilever Ip Holdings B.V. | Use of an enzyme and surfactant for inhibiting microorganisms |
| WO2022043321A2 (en) | 2020-08-25 | 2022-03-03 | Novozymes A/S | Variants of a family 44 xyloglucanase |
| CA3186910A1 (en) | 2020-08-28 | 2022-03-03 | Rolf Thomas Lenhard | Protease variants with improved solubility |
| US20230354850A1 (en) | 2020-09-15 | 2023-11-09 | Novozymes A/S | Animal feed comprising insects or insect meal |
| CN116096731A (zh) | 2020-09-22 | 2023-05-09 | 巴斯夫欧洲公司 | 蛋白酶和蛋白酶抑制剂与第二酶的改进的组合 |
| WO2022063698A1 (en) | 2020-09-22 | 2022-03-31 | Basf Se | Liquid composition comprising peptide aldehyde |
| WO2022074037A2 (en) * | 2020-10-07 | 2022-04-14 | Novozymes A/S | Alpha-amylase variants |
| WO2022084303A2 (en) | 2020-10-20 | 2022-04-28 | Novozymes A/S | Use of polypeptides having dnase activity |
| EP4237525A1 (en) | 2020-10-28 | 2023-09-06 | Novozymes A/S | Use of lipoxygenase |
| US20240035005A1 (en) | 2020-10-29 | 2024-02-01 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
| WO2022103725A1 (en) | 2020-11-13 | 2022-05-19 | Novozymes A/S | Detergent composition comprising a lipase |
| WO2022106400A1 (en) | 2020-11-18 | 2022-05-27 | Novozymes A/S | Combination of immunochemically different proteases |
| WO2022106404A1 (en) | 2020-11-18 | 2022-05-27 | Novozymes A/S | Combination of proteases |
| EP4015629A1 (en) | 2020-12-18 | 2022-06-22 | Basf Se | Polymer mixtures for increasing stability and performance of hydrolase-containing detergents |
| EP4032966A1 (en) | 2021-01-22 | 2022-07-27 | Novozymes A/S | Liquid enzyme composition with sulfite scavenger |
| EP4284905A1 (en) | 2021-01-28 | 2023-12-06 | Novozymes A/S | Lipase with low malodor generation |
| US20250263682A1 (en) | 2021-02-12 | 2025-08-21 | Novozymes A/S | Alpha-amylase variants |
| EP4291625A1 (en) | 2021-02-12 | 2023-12-20 | Novozymes A/S | Stabilized biological detergents |
| KR20230147071A (ko) | 2021-02-22 | 2023-10-20 | 헨켈 아게 운트 코. 카게아아 | 아밀라제 변이체 |
| EP4047088A1 (en) | 2021-02-22 | 2022-08-24 | Basf Se | Amylase variants |
| WO2022189521A1 (en) | 2021-03-12 | 2022-09-15 | Novozymes A/S | Polypeptide variants |
| EP4060036A1 (en) | 2021-03-15 | 2022-09-21 | Novozymes A/S | Polypeptide variants |
| US20240060061A1 (en) | 2021-03-15 | 2024-02-22 | Novozymes A/S | Dnase variants |
| CN117083370A (zh) | 2021-03-26 | 2023-11-17 | 诺维信公司 | 聚合物含量降低的洗涤剂组合物 |
| WO2022268885A1 (en) | 2021-06-23 | 2022-12-29 | Novozymes A/S | Alpha-amylase polypeptides |
| CA3238839A1 (en) * | 2021-12-16 | 2023-06-22 | The Procter & Gamble Company | Home care composition |
| CA3238546A1 (en) * | 2021-12-16 | 2023-06-22 | Katarzyna Dorota BELL-RUSIEWICZ | Home care composition comprising an amylase |
| WO2023117920A1 (en) | 2021-12-21 | 2023-06-29 | Basf Se | Chemical product passport for recyclate content data and/or bio-based content data |
| US20250129310A1 (en) | 2021-12-21 | 2025-04-24 | Novozymes A/S | Composition comprising a lipase and a booster |
| EP4206309A1 (en) | 2021-12-30 | 2023-07-05 | Novozymes A/S | Protein particles with improved whiteness |
| EP4234664A1 (en) | 2022-02-24 | 2023-08-30 | Evonik Operations GmbH | Composition comprising glucolipids and enzymes |
| EP4486859A1 (en) | 2022-03-02 | 2025-01-08 | Novozymes A/S | Use of xyloglucanase for improvement of sustainability of detergents |
| EP4486876A1 (en) | 2022-03-04 | 2025-01-08 | Novozymes A/S | Dnase variants and compositions |
| JP2025511813A (ja) | 2022-04-08 | 2025-04-16 | ノボザイムス アクティーゼルスカブ | ヘキソサミニダーゼバリアント及び組成物 |
| CN119630280A (zh) | 2022-05-14 | 2025-03-14 | 诺维信公司 | 用于预防、处理、抑制和/或消除植物病原性侵染和感染的组合物和方法 |
| WO2023233026A1 (en) | 2022-06-03 | 2023-12-07 | Unilever Ip Holdings B.V. | Laundry detergent product |
| EP4544036A1 (en) | 2022-06-21 | 2025-04-30 | Novozymes A/S | Mannanase variants and polynucleotides encoding same |
| EP4544015A2 (en) | 2022-06-24 | 2025-04-30 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
| CN119585409A (zh) | 2022-07-15 | 2025-03-07 | 巴斯夫欧洲公司 | 用于液体配制品中酶稳定的烷醇胺甲酸盐 |
| WO2024033136A1 (en) | 2022-08-11 | 2024-02-15 | Basf Se | Amylase variants |
| CN119677846A (zh) | 2022-08-11 | 2025-03-21 | 巴斯夫欧洲公司 | 淀粉酶变体 |
| EP4612286A1 (en) | 2022-11-04 | 2025-09-10 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| EP4612287A1 (en) | 2022-11-04 | 2025-09-10 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| CN120153069A (zh) | 2022-11-04 | 2025-06-13 | 巴斯夫欧洲公司 | 用于在洗涤剂组合物中使用的具有蛋白酶活性的多肽 |
| WO2024121058A1 (en) | 2022-12-05 | 2024-06-13 | Novozymes A/S | A composition comprising a lipase and a peptide |
| CN120265742A (zh) | 2022-12-05 | 2025-07-04 | 诺维信公司 | 蛋白酶变体以及编码其的多核苷酸 |
| WO2024126483A1 (en) | 2022-12-14 | 2024-06-20 | Novozymes A/S | Improved lipase (gcl1) variants |
| EP4389864A1 (en) | 2022-12-20 | 2024-06-26 | Basf Se | Cutinases |
| KR20250130619A (ko) | 2022-12-23 | 2025-09-02 | 노보자임스 에이/에스 | 카탈라제 및 아밀라제를 포함하는 세제 조성물 |
| WO2024146919A1 (en) | 2023-01-05 | 2024-07-11 | Basf Se | Use of foldases to improve heterologous expression of secreted molecules |
| WO2024156628A1 (en) | 2023-01-23 | 2024-08-02 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2024194245A1 (en) | 2023-03-21 | 2024-09-26 | Novozymes A/S | Detergent compositions based on biosurfactants |
| WO2024213513A1 (en) | 2023-04-12 | 2024-10-17 | Novozymes A/S | Compositions comprising polypeptides having alkaline phosphatase activity |
| WO2024213755A1 (en) | 2023-04-14 | 2024-10-17 | Basf Se | Porous starch |
| AU2024263329A1 (en) | 2023-04-26 | 2025-09-25 | Novozymes A/S | Cleaning composition and cleaning method |
| EP4461796A1 (en) | 2023-05-10 | 2024-11-13 | Novozymes A/S | Detergent composition comprising laccase |
| EP4461795A1 (en) | 2023-05-10 | 2024-11-13 | Novozymes A/S | Detergent composition comprising laccase |
| WO2024231483A1 (en) | 2023-05-11 | 2024-11-14 | Novozymes A/S | Automatic dishwashing detergent compositions comprising a lipase |
| WO2024256175A1 (en) | 2023-06-13 | 2024-12-19 | Basf Se | Stabilized cleaning compositions comprising edds and enzymes and their use |
| WO2025002934A1 (en) | 2023-06-28 | 2025-01-02 | Novozymes A/S | Detergent composition comprising lipases |
| WO2025011933A1 (en) | 2023-07-07 | 2025-01-16 | Novozymes A/S | Washing method for removing proteinaceous stains |
| WO2025036643A1 (en) | 2023-08-15 | 2025-02-20 | Evonik Operations Gmbh | Biosurfactant for washing wool |
| WO2025088003A1 (en) | 2023-10-24 | 2025-05-01 | Novozymes A/S | Use of xyloglucanase for replacement of optical brightener |
| WO2025093368A1 (en) | 2023-11-02 | 2025-05-08 | Basf Se | Enzyme stabilization in compositions containing a protease inhibitor |
| WO2025103765A1 (en) | 2023-11-17 | 2025-05-22 | Novozymes A/S | Lytic polysaccharide monooxygenases and their use in detergent |
| WO2025114053A1 (en) | 2023-11-30 | 2025-06-05 | Novozymes A/S | Biopolymers for use in detergent |
| WO2025132258A1 (en) | 2023-12-20 | 2025-06-26 | Basf Se | Stabilized enzyme composition comprising a protease |
| WO2025153046A1 (en) | 2024-01-19 | 2025-07-24 | Novozymes A/S | Detergent compositions and uses thereof |
| EP4624572A1 (en) | 2024-03-27 | 2025-10-01 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
Family Cites Families (198)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1296839A (en:Method) | 1969-05-29 | 1972-11-22 | ||
| GB1372034A (en) | 1970-12-31 | 1974-10-30 | Unilever Ltd | Detergent compositions |
| US3912590A (en) | 1973-01-03 | 1975-10-14 | Novo Industri As | Procedure for liquefying starch |
| US4105827A (en) | 1973-04-20 | 1978-08-08 | Interox | Particulate peroxygen compounds coated with sodium sesquicarbonate or Na2 SO4 mNa2 CO3 |
| FR2226460B1 (en:Method) | 1973-04-20 | 1976-12-17 | Interox | |
| GB1590432A (en) | 1976-07-07 | 1981-06-03 | Novo Industri As | Process for the production of an enzyme granulate and the enzyme granuate thus produced |
| US4316956A (en) | 1980-02-06 | 1982-02-23 | Novo Industri A/S | Fermentation process |
| US4335208A (en) | 1980-03-11 | 1982-06-15 | Novo Industri A/S | Saccharification of starch hydrolysates |
| DK187280A (da) | 1980-04-30 | 1981-10-31 | Novo Industri As | Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode |
| FR2498783B1 (fr) | 1981-01-23 | 1988-03-04 | Decis Mario | Dispositif de controle automatique de presence |
| JPS57174089A (en) | 1981-04-20 | 1982-10-26 | Novo Industri As | Chain dividing enzyme product |
| FR2543181B1 (fr) | 1983-03-22 | 1985-07-26 | Ugine Kuhlmann | Procede ameliore de desencollage-blanchiment simultane des tissus |
| US4519934A (en) | 1983-04-19 | 1985-05-28 | Novo Industri A/S | Liquid enzyme concentrates containing alpha-amylase |
| DK263584D0 (da) | 1984-05-29 | 1984-05-29 | Novo Industri As | Enzymholdige granulater anvendt som detergentadditiver |
| US4689297A (en) | 1985-03-05 | 1987-08-25 | Miles Laboratories, Inc. | Dust free particulate enzyme formulation |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| JPH0697997B2 (ja) | 1985-08-09 | 1994-12-07 | ギスト ブロカデス ナ−ムロ−ゼ フエンノ−トチヤツプ | 新規の酵素的洗浄剤添加物 |
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| DK311186D0 (da) | 1986-06-30 | 1986-06-30 | Novo Industri As | Enzymer |
| CA1283376C (en) | 1986-07-09 | 1991-04-23 | John O. Carroll | .alpha.-AMYLASE MIXTURES FOR STARCH LIQUEFACTION |
| US4810414A (en) | 1986-08-29 | 1989-03-07 | Novo Industri A/S | Enzymatic detergent additive |
| NZ221627A (en) | 1986-09-09 | 1993-04-28 | Genencor Inc | Preparation of enzymes, modifications, catalytic triads to alter ratios or transesterification/hydrolysis ratios |
| DE3854249T2 (de) | 1987-08-28 | 1996-02-29 | Novonordisk As | Rekombinante Humicola-Lipase und Verfahren zur Herstellung von rekombinanten Humicola-Lipasen. |
| JPS6474992A (en) | 1987-09-16 | 1989-03-20 | Fuji Oil Co Ltd | Dna sequence, plasmid and production of lipase |
| JP2624859B2 (ja) | 1988-01-07 | 1997-06-25 | ノボ‐ノルディスク アクティーゼルスカブ | 酵素洗剤 |
| DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| CN1056187C (zh) | 1988-02-11 | 2000-09-06 | 金克克国际有限公司 | 新的蛋白水解酶及其在洗涤剂中的应用 |
| US6287841B1 (en) | 1988-02-11 | 2001-09-11 | Genencor International, Inc. | High alkaline serine protease |
| EP0406314B1 (en) | 1988-03-24 | 1993-12-01 | Novo Nordisk A/S | A cellulase preparation |
| US5776757A (en) | 1988-03-24 | 1998-07-07 | Novo Nordisk A/S | Fungal cellulase composition containing alkaline CMC-endoglucanase and essentially no cellobiohydrolase and method of making thereof |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DE3909096A1 (de) | 1989-03-20 | 1990-09-27 | Garabed Antranikian | Alpha-amylase |
| DK198089D0 (da) | 1989-04-24 | 1989-04-24 | Danske Spritfabrikker | Dna-materialer og anvendelse deraf |
| ATE166922T1 (de) | 1989-06-29 | 1998-06-15 | Genencor Int | Mutierte mikrobielle alpha-amylasen mit erhöhter thermischer, saurer und/oder alkylischer stabilität |
| GB8915658D0 (en) | 1989-07-07 | 1989-08-23 | Unilever Plc | Enzymes,their production and use |
| WO1991016422A1 (de) | 1990-04-14 | 1991-10-31 | Kali-Chemie Aktiengesellschaft | Alkalische bacillus-lipasen, hierfür codierende dna-sequenzen sowie bacilli, die diese lipasen produzieren |
| DK0531372T4 (da) | 1990-05-09 | 2004-08-09 | Novozymes As | Cellulasepræparat omfattende et endoglucanaseenzym |
| US5814501A (en) | 1990-06-04 | 1998-09-29 | Genencor International, Inc. | Process for making dust-free enzyme-containing particles from an enzyme-containing fermentation broth |
| KR930702514A (ko) | 1990-09-13 | 1993-09-09 | 안네 제케르 | 리파제 변체 |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| WO1992006221A1 (en) | 1990-10-05 | 1992-04-16 | Genencor International, Inc. | Methods for treating cotton-containing fabrics with cellulase |
| US5180669A (en) | 1991-03-27 | 1993-01-19 | Genencor International, Inc. | Liquefaction of granular-starch slurries using alpha-amylase in the presence of carbonate ion |
| GB9108136D0 (en) | 1991-04-17 | 1991-06-05 | Unilever Plc | Concentrated detergent powder compositions |
| JP3219765B2 (ja) | 1991-04-30 | 2001-10-15 | ザ、プロクター、エンド、ギャンブル、カンパニー | タンパク分解酵素を阻害するためのホウ酸系物質−ポリオール複合体を有するビルダー入り液体洗剤 |
| EP0511456A1 (en) | 1991-04-30 | 1992-11-04 | The Procter & Gamble Company | Liquid detergents with aromatic borate ester to inhibit proteolytic enzyme |
| EP0583339B1 (en) | 1991-05-01 | 1998-07-08 | Novo Nordisk A/S | Stabilized enzymes and detergent compositions |
| US5231017A (en) | 1991-05-17 | 1993-07-27 | Solvay Enzymes, Inc. | Process for producing ethanol |
| EP0551408B2 (en) | 1991-06-11 | 2012-08-15 | Genencor International, Inc. | Detergent compositions containing cellulase compositions deficient in cbh i type components |
| US5324649A (en) | 1991-10-07 | 1994-06-28 | Genencor International, Inc. | Enzyme-containing granules coated with hydrolyzed polyvinyl alcohol or copolymer thereof |
| WO1993009244A1 (en) | 1991-10-31 | 1993-05-13 | Genencor International, Inc. | Liquefaction of dry milled starch grain slurries |
| DK72992D0 (da) | 1992-06-01 | 1992-06-01 | Novo Nordisk As | Enzym |
| DK88892D0 (da) | 1992-07-06 | 1992-07-06 | Novo Nordisk As | Forbindelse |
| JP3678309B2 (ja) | 1992-07-23 | 2005-08-03 | ノボザイムス アクティーゼルスカブ | 突然変異α−アミラーゼ、洗剤、皿洗い剤及び液化剤 |
| PL310326A1 (en) | 1993-02-11 | 1995-12-11 | Genencor Int | Novel oxidation-stable mutants of alpha-amylase as well as detergent and starch liquefaction compositions containing them |
| DK39093D0 (da) | 1993-04-01 | 1993-04-01 | Novo Nordisk As | Enzym |
| US5576281A (en) | 1993-04-05 | 1996-11-19 | Olin Corporation | Biogradable low foaming surfactants as a rinse aid for autodish applications |
| CN1108457A (zh) | 1993-04-27 | 1995-09-13 | 吉斯特·布罗卡迪斯股份有限公司 | 用于洗涤剂领域的新的脂酶变异体 |
| DK52393D0 (en:Method) | 1993-05-05 | 1993-05-05 | Novo Nordisk As | |
| DK0697036T3 (da) | 1993-05-08 | 2000-01-31 | Henkel Kgaa | Sølvkorrosionsbeskyttelsesmiddel II |
| ATE163191T1 (de) | 1993-05-08 | 1998-02-15 | Henkel Kgaa | Silberkorrosionsschutzmittel i |
| US5888954A (en) | 1993-05-08 | 1999-03-30 | Henkel Kommanditgesellschaft Auf Aktien | Corrosion inhibitors for silver |
| US5698504A (en) | 1993-07-01 | 1997-12-16 | The Procter & Gamble Company | Machine dishwashing composition containing oxygen bleach and paraffin oil and benzotriazole compound silver tarnishing inhibitors |
| JP2859520B2 (ja) | 1993-08-30 | 1999-02-17 | ノボ ノルディスク アクティーゼルスカブ | リパーゼ及びそれを生産する微生物及びリパーゼ製造方法及びリパーゼ含有洗剤組成物 |
| CN1189558C (zh) | 1993-10-08 | 2005-02-16 | 诺沃奇梅兹有限公司 | 淀粉酶变体 |
| EP1707624A3 (en) | 1993-10-08 | 2007-01-03 | Novozymes A/S | Amylase variants |
| EP0724631A1 (en) | 1993-10-13 | 1996-08-07 | Novo Nordisk A/S | H 2?o 2?-stable peroxidase variants |
| US5679630A (en) | 1993-10-14 | 1997-10-21 | The Procter & Gamble Company | Protease-containing cleaning compositions |
| DK131193D0 (en:Method) | 1993-11-23 | 1993-11-23 | Novo Nordisk As | |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| TW268980B (en:Method) | 1994-02-02 | 1996-01-21 | Novo Nordisk As | |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| CN1077598C (zh) | 1994-02-22 | 2002-01-09 | 诺沃奇梅兹有限公司 | 制备脂解酶变异体的方法 |
| ES2250969T3 (es) | 1994-03-29 | 2006-04-16 | Novozymes A/S | Amilasa alcalina de bacilo. |
| US5453216A (en) | 1994-04-28 | 1995-09-26 | Creative Products Resource, Inc. | Delayed-release encapsulated warewashing composition and process of use |
| CA2189441C (en) | 1994-05-04 | 2009-06-30 | Wolfgang Aehle | Lipases with improved surfactant resistance |
| FI964808L (fi) | 1994-06-03 | 1996-12-02 | Novo Nordisk Biotech Inc | Puhdistetut Myceliophthora lakkaasit ja niitä koodaavat nukleiinihapot |
| DE69534369T2 (de) | 1994-06-17 | 2006-03-09 | Genencor International, Inc., Palo Alto | Von der alpha-amylase aus b. licheniformis abgeleitete amylolytische enzyme mit verbesserten eigenschaften |
| AU2884595A (en) | 1994-06-20 | 1996-01-15 | Unilever Plc | Modified pseudomonas lipases and their use |
| AU2884695A (en) | 1994-06-23 | 1996-01-19 | Unilever Plc | Modified pseudomonas lipases and their use |
| DE69534185T2 (de) | 1994-06-30 | 2006-02-23 | Novozymes Biotech, Inc., Davis | Nicht-toxisches, nicht-toxigenes, nicht-pathogenes fusarium expressionssystem und darin zu verwendende promotoren und terminatoren |
| GB9413419D0 (en) | 1994-07-04 | 1994-08-24 | Danisco | Amylase enzyme |
| GB2291058B (en) | 1994-07-14 | 1998-12-23 | Solvay | Acid-stable and thermo-stable alpha-amylases derived from sufolobus species |
| JPH10504197A (ja) | 1994-08-11 | 1998-04-28 | ジェネンコア インターナショナル インコーポレーテッド | 改善洗浄用組成物 |
| BE1008998A3 (fr) | 1994-10-14 | 1996-10-01 | Solvay | Lipase, microorganisme la produisant, procede de preparation de cette lipase et utilisations de celle-ci. |
| CN1167503A (zh) | 1994-10-26 | 1997-12-10 | 诺沃挪第克公司 | 一种具有脂解活性的酶 |
| US6440716B1 (en) | 1995-02-03 | 2002-08-27 | Novozymes A/S | α-amylase mutants |
| US7115409B1 (en) | 1995-02-03 | 2006-10-03 | Novozymes A/S | α-amylase mutants |
| JP4047379B2 (ja) | 1995-02-03 | 2008-02-13 | ノボザイムス アクティーゼルスカブ | 予め決められた性質を有するα−アミラーゼ変異体のデザイン方法 |
| US6093562A (en) | 1996-02-05 | 2000-07-25 | Novo Nordisk A/S | Amylase variants |
| CN101363017A (zh) * | 1995-02-03 | 2009-02-11 | 诺维信公司 | 淀粉酶变体 |
| AR000862A1 (es) * | 1995-02-03 | 1997-08-06 | Novozymes As | Variantes de una ó-amilasa madre, un metodo para producir la misma, una estructura de adn y un vector de expresion, una celula transformada por dichaestructura de adn y vector, un aditivo para detergente, composicion detergente, una composicion para lavado de ropa y una composicion para la eliminacion del |
| JPH08228778A (ja) | 1995-02-27 | 1996-09-10 | Showa Denko Kk | 新規なリパーゼ遺伝子及びそれを用いたリパーゼの製造方法 |
| KR19980702782A (ko) | 1995-03-09 | 1998-08-05 | 혼 마가렛 에이. | 녹말 액화 방법 |
| EP0815193A1 (en) | 1995-03-24 | 1998-01-07 | Genencor International Inc. | An improved laundry detergent composition comprising amylase |
| US5652127A (en) | 1995-06-02 | 1997-07-29 | Genencor International, Inc. | Method for liquefying starch |
| US5736499A (en) | 1995-06-06 | 1998-04-07 | Genencor International, Inc. | Mutant A-amylase |
| JP3025627B2 (ja) | 1995-06-14 | 2000-03-27 | 花王株式会社 | 液化型アルカリα−アミラーゼ遺伝子 |
| EP0839186B1 (en) | 1995-07-14 | 2004-11-10 | Novozymes A/S | A modified enzyme with lipolytic activity |
| AU6655196A (en) | 1995-08-11 | 1997-03-12 | Novo Nordisk A/S | Novel lipolytic enzymes |
| WO1997041213A1 (en) | 1996-04-30 | 1997-11-06 | Novo Nordisk A/S | α-AMYLASE MUTANTS |
| US5763385A (en) | 1996-05-14 | 1998-06-09 | Genencor International, Inc. | Modified α-amylases having altered calcium binding properties |
| US6211134B1 (en) | 1996-05-14 | 2001-04-03 | Genecor International, Inc. | Mutant α-amylase |
| IL128316A0 (en) | 1996-08-01 | 2000-01-31 | Procter & Gamble | Detergent compositions comprising improved amylase for dingy fabric clean-up |
| EP0963192B1 (en) | 1996-10-08 | 2003-01-08 | Novozymes A/S | Diaminobenzoic acid derivatives as dye precursors |
| JP2001503269A (ja) | 1996-11-04 | 2001-03-13 | ノボ ノルディスク アクティーゼルスカブ | ズブチラーゼ変異体及び、組成物 |
| KR100561826B1 (ko) | 1996-11-04 | 2006-03-16 | 노보자임스 에이/에스 | 섭틸라제 변종과 조성물 |
| AU733082B2 (en) | 1996-11-26 | 2001-05-03 | Genencor International, Inc. | Chemically modified enzymes |
| WO1998034946A1 (en) | 1997-02-12 | 1998-08-13 | Massachusetts Institute Of Technology | Daxx, a novel fas-binding protein that activates jnk and apoptosis |
| WO1999006270A1 (en) | 1997-08-01 | 1999-02-11 | Marine Shuttle Operations As | Method and transporter for installation or removal of an offshore platform topsides |
| US6599871B2 (en) | 1997-08-02 | 2003-07-29 | The Procter & Gamble Company | Detergent tablet |
| GB2327947A (en) | 1997-08-02 | 1999-02-10 | Procter & Gamble | Detergent tablet |
| US6080568A (en) | 1997-08-19 | 2000-06-27 | Genencor International, Inc. | Mutant α-amylase comprising modification at residues corresponding to A210, H405 and/or T412 in Bacillus licheniformis |
| US6361989B1 (en) | 1997-10-13 | 2002-03-26 | Novozymes A/S | α-amylase and α-amylase variants |
| ES2322825T3 (es) | 1997-10-13 | 2009-06-29 | Novozymes A/S | Mutantes de alfa-amilasa. |
| AR016969A1 (es) | 1997-10-23 | 2001-08-01 | Procter & Gamble | VARIANTE DE PROTEASA, ADN, VECTOR DE EXPRESIoN, MICROORGANISMO HUESPED, COMPOSICIoN DE LIMPIEZA, ALIMENTO PARA ANIMALES Y COMPOSICIoN PARA TRATAR UN TEXTIL |
| CN1163597C (zh) * | 1997-10-30 | 2004-08-25 | 诺维信公司 | α-淀粉酶突变体 |
| US6562612B2 (en) | 1997-11-19 | 2003-05-13 | Genencor International, Inc. | Cellulase producing actinomycetes, cellulase produced therefrom and method of producing same |
| US6773907B2 (en) | 1997-11-21 | 2004-08-10 | Peter Kamp Hansen | Subtilase enzymes |
| KR100808499B1 (ko) | 1997-11-26 | 2008-02-29 | 노보자임스 에이/에스 | 열안정성 글루코아밀라제 |
| JP2002504323A (ja) | 1998-02-18 | 2002-02-12 | ノボザイムス アクティーゼルスカブ | アルカリ性バチルスアミラーゼ |
| JP2002509704A (ja) | 1998-04-01 | 2002-04-02 | デーエスエム・ナムローゼ・フェンノートシャップ | フィテートの含量が少ない飼料におけるフィターゼの使用 |
| JP2002520047A (ja) | 1998-07-15 | 2002-07-09 | ノボザイムス アクティーゼルスカブ | グルコアミラーゼ変異体 |
| DK1124949T3 (da) | 1998-10-26 | 2006-11-06 | Novozymes As | Konstruktion og screening af et DNA-bibliotek af interesse i trådformede svampeceller |
| US6197565B1 (en) | 1998-11-16 | 2001-03-06 | Novo-Nordisk A/S | α-Amylase variants |
| US6403355B1 (en) | 1998-12-21 | 2002-06-11 | Kao Corporation | Amylases |
| DK2278016T3 (da) | 1999-03-22 | 2012-11-26 | Novozymes Inc | Promotorsekvenser fra Fusarium Venenatum og anvendelse deraf |
| US6410295B1 (en) | 1999-03-30 | 2002-06-25 | Novozymes A/S | Alpha-amylase variants |
| DK1165762T3 (da) | 1999-03-30 | 2007-09-03 | Novozymes As | Alpha-amylase varianter |
| US6623948B1 (en) | 1999-03-31 | 2003-09-23 | Novozymes A/S | Nucleic acid sequences encoding alkaline alpha-amylases |
| EP2011864B1 (en) | 1999-03-31 | 2014-12-31 | Novozymes A/S | Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same |
| CN100523181C (zh) | 1999-03-31 | 2009-08-05 | 诺维信公司 | 具有碱性α-淀粉酶活性的多肽及其编码核酸 |
| EP2009098A1 (en) | 1999-07-09 | 2008-12-31 | Novozymes A/S | Glucoamylase variant |
| CA2382084C (en) | 1999-08-13 | 2013-03-05 | The Victoria University Of Manchester | Phytase enzymes, nucleic acids encoding phytase enzymes and vectors and host cells incorporating same |
| ATE356868T1 (de) | 1999-08-20 | 2007-04-15 | Novozymes As | Alkalische amylase aus bacillus |
| US6995125B2 (en) | 2000-02-17 | 2006-02-07 | The Procter & Gamble Company | Detergent product |
| WO2001064852A1 (en) | 2000-03-03 | 2001-09-07 | Novozymes A/S | Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same |
| EP2221365A1 (en) * | 2000-03-08 | 2010-08-25 | Novozymes A/S | Variants with altered properties |
| CA2415304A1 (en) | 2000-07-19 | 2002-01-24 | The Procter & Gamble Company | Gel form automatic dishwashing compositions, methods of preparation and use thereof |
| GB2365018A (en) | 2000-07-24 | 2002-02-13 | Procter & Gamble | Water soluble pouches |
| JP2004504837A (ja) | 2000-07-28 | 2004-02-19 | ヘンケル・コマンディットゲゼルシャフト・アウフ・アクチエン | バシラス種ａ７−７（ｄｓｍ１２３６８）から抽出した新規デンプン分解酵素ならびに該新規デンプン分解酵素を含有する洗浄および清浄剤 |
| US20020155574A1 (en) * | 2000-08-01 | 2002-10-24 | Novozymes A/S | Alpha-amylase mutants with altered properties |
| CA2778199A1 (en) * | 2000-08-01 | 2002-02-07 | Novozymes A/S | Alpha-amylase mutants with altered properties |
| ATE400648T1 (de) | 2000-08-11 | 2008-07-15 | Genencor Int | Transformation von bacillus, transformanten und mutanten-bibliotheken |
| JP4426716B2 (ja) | 2000-10-11 | 2010-03-03 | 花王株式会社 | 高生産性α−アミラーゼ |
| EP1326965A2 (en) | 2000-10-13 | 2003-07-16 | Novozymes A/S | Alpha-amylase variant with altered properties |
| US7125828B2 (en) | 2000-11-27 | 2006-10-24 | The Procter & Gamble Company | Detergent products, methods and manufacture |
| ES2249749T3 (es) | 2000-11-27 | 2006-04-01 | THE PROCTER & GAMBLE COMPANY | Metodo para lavar la vajilla. |
| EP1340063B1 (en) | 2000-11-27 | 2012-10-17 | Novozymes A/S | Automated mechanical stress assay for screening cleaning ingredients |
| DE60123463T2 (de) | 2000-11-27 | 2007-08-02 | The Procter & Gamble Company, Cincinnati | Geschirrspülverfahren |
| US20020169091A1 (en) | 2001-02-14 | 2002-11-14 | Clare Jonathan Richard | Automatic dishwashing compositions comprising blooming perfume and base masking ingredients |
| US20020183226A1 (en) | 2001-02-28 | 2002-12-05 | Chandrika Kasturi | Liquid detergent composition exhibiting enhanced alpha-amylase enzyme stability |
| EP2264160A3 (en) | 2001-05-15 | 2011-08-31 | Novozymes A/S | Alpha-amylase variant with altered properties |
| GB0114847D0 (en) | 2001-06-18 | 2001-08-08 | Unilever Plc | Water soluble package and liquid contents thereof |
| JP2005500841A (ja) | 2001-07-27 | 2005-01-13 | アメリカ合衆国 | オリゴヌクレオチドを用いるインビボ部位指定変異誘発のためのシステム |
| MXPA04004523A (es) | 2001-11-14 | 2004-08-11 | Procter & Gamble | Composicion para el lavado automatico de platos y utensilios de cocina en forma de dosis unitaria que contiene un polimero antiescamas. |
| US7888093B2 (en) | 2002-11-06 | 2011-02-15 | Novozymes A/S | Subtilase variants |
| EP1923455A3 (en) | 2003-02-18 | 2009-01-21 | Novozymes A/S | Detergent compositions |
| DE60319347T2 (de) | 2003-05-23 | 2009-02-19 | The Procter & Gamble Company, Cincinnati | Waschmittelzusammensetzung zum Gebrauch in einer Textilwasch- oder Geschirrspülmaschine |
| US7985569B2 (en) | 2003-11-19 | 2011-07-26 | Danisco Us Inc. | Cellulomonas 69B4 serine protease variants |
| EP1694847B1 (en) | 2003-11-19 | 2012-06-13 | Danisco US Inc. | Serine proteases, nucleic acids encoding serine enzymes and vectors and host cells incorporating same |
| DE102004020082A1 (de) | 2004-04-24 | 2005-05-19 | Henkel Kgaa | Verfahren zur Herstellung von Wasch- und/oder Reinigungsmitteln |
| GB2414958A (en) | 2004-06-11 | 2005-12-14 | Reckitt Benckiser Nv | A process for preparing a water soluble article. |
| CA2571864C (en) | 2004-07-05 | 2014-09-23 | Novozymes A/S | Alpha-amylase variants with altered properties |
| DE102004047776B4 (de) | 2004-10-01 | 2018-05-09 | Basf Se | Gegen Di- und/oder Multimerisierung stabilisierte Alpha-Amylase-Varianten, Verfahren zu deren Herstellung sowie deren Verwendung |
| DE102004047777B4 (de) * | 2004-10-01 | 2018-05-09 | Basf Se | Alpha-Amylase-Varianten mit erhöhter Lösungsmittelstabilität, Verfahren zu deren Herstellung sowie deren Verwendung |
| GB0423139D0 (en) | 2004-10-18 | 2004-11-17 | Danisco | Enzymes |
| PL1824970T3 (pl) | 2004-11-30 | 2012-01-31 | Genencor Int | Glukoamylaza z Trichoderma reesei oraz jej homologi |
| DE602006016938D1 (de) | 2005-05-13 | 2010-10-28 | Procter & Gamble | Funktionalisierte folien |
| US7562841B2 (en) | 2005-07-15 | 2009-07-21 | Sonoco Development, Inc. | Textile carrier having identification feature and method for manufacturing the same |
| AR055444A1 (es) | 2005-10-12 | 2007-08-22 | Procter & Gamble | Uso y produccion de metalopretasa neutra estable al almacenamiento |
| US20070191248A1 (en) | 2006-01-23 | 2007-08-16 | Souter Philip F | Detergent compositions |
| JP2009523425A (ja) | 2006-01-23 | 2009-06-25 | ザ プロクター アンド ギャンブル カンパニー | 洗剤組成物 |
| CA2633668A1 (en) | 2006-01-23 | 2007-08-02 | The Procter & Gamble Company | Detergent compositions |
| US20070184855A1 (en) | 2006-02-03 | 2007-08-09 | Research In Motion Limited | Visual representation of contact location |
| US8071345B2 (en) | 2006-03-31 | 2011-12-06 | Novozymes A/S | Stabilized subtilisin composition |
| DE102006022224A1 (de) | 2006-05-11 | 2007-11-15 | Henkel Kgaa | Subtilisin aus Bacillus pumilus und Wasch- und Reinigungsmittel enthaltend dieses neue Subtilisin |
| DE102006022216A1 (de) | 2006-05-11 | 2007-11-15 | Henkel Kgaa | Neue Alkalische Protease aus Bacillus gibsonii und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease |
| BRPI0712374A2 (pt) | 2006-06-05 | 2012-06-12 | Procter & Gamble | estabilizante de enzimas |
| WO2008002472A2 (en) | 2006-06-23 | 2008-01-03 | Danisco Us Inc., Genencor Division | Systematic evaluation of sequence and activity relationships using site evaluation libraries for engineering multiple properties |
| EP2059591B1 (en) | 2006-07-18 | 2012-09-05 | Danisco US Inc. | Dishwashing composition that contains a protease variant |
| US20080220498A1 (en) | 2007-03-06 | 2008-09-11 | Cervin Marguerite A | Variant Buttiauxella sp. phytases having altered properties |
| RU2553550C2 (ru) | 2007-06-06 | 2015-06-20 | ДАНИСКО ЮЭс, ИНК., ДЖЕНЕНКОР ДИВИЖН | Способы улучшения множественных свойств белка |
| GB0718944D0 (en) | 2007-09-28 | 2007-11-07 | Reckitt Benckiser Nv | Detergent composition |
| CN101883841A (zh) | 2007-11-05 | 2010-11-10 | 丹尼斯科美国公司 | 具有增强的热稳定性和/或减少的钙依赖性的地衣芽孢杆菌α-淀粉酶的变体 |
| NZ584328A (en) | 2007-11-05 | 2012-08-31 | Danisco Us Inc | Alpha-amylase variants with altered properties |
| EP2085070A1 (en) * | 2008-01-11 | 2009-08-05 | Procter & Gamble International Operations SA. | Cleaning and/or treatment compositions |
| US20090209447A1 (en) | 2008-02-15 | 2009-08-20 | Michelle Meek | Cleaning compositions |
| EP2100947A1 (en) | 2008-03-14 | 2009-09-16 | The Procter and Gamble Company | Automatic dishwashing detergent composition |
| EP2100948A1 (en) | 2008-03-14 | 2009-09-16 | The Procter and Gamble Company | Automatic dishwashing detergent composition |
| US20090233830A1 (en) | 2008-03-14 | 2009-09-17 | Penny Sue Dirr | Automatic detergent dishwashing composition |
| ES2527645T3 (es) | 2008-06-06 | 2015-01-27 | Danisco Us Inc. | Variantes de alfa-amilasa de Geobacillus stearothermophilus (AMYS) con propiedades mejoradas |
| DK2414514T3 (en) * | 2009-04-01 | 2015-08-24 | Danisco Us Inc | FORMATIONS AND PROCEDURES COMPREHENSIVE Alpha- amylase variants WITH CHANGED PROPERTIES |
| MX342388B (es) | 2010-02-10 | 2016-09-28 | Novozymes As | Variantes y composiciones que comprenden variantes con alta estabilidad en presencia de un agente quelante. |
| EP2357220A1 (en) * | 2010-02-10 | 2011-08-17 | The Procter & Gamble Company | Cleaning composition comprising amylase variants with high stability in the presence of a chelating agent |
| KR20140041801A (ko) | 2011-06-30 | 2014-04-04 | 노보자임스 에이/에스 | 알파-아밀라제 스크리닝 방법 |
| EP2540824A1 (en) | 2011-06-30 | 2013-01-02 | The Procter & Gamble Company | Cleaning compositions comprising amylase variants reference to a sequence listing |
| ES2834102T3 (es) | 2011-06-30 | 2021-06-16 | Novozymes As | Variantes de alfa-amilasa |
| EP3301145A1 (en) * | 2016-10-03 | 2018-04-04 | The Procter & Gamble Company | Low ph laundry detergent composition |
-
2012
- 2012-06-29 ES ES18183123T patent/ES2834102T3/es active Active
- 2012-06-29 KR KR1020147002238A patent/KR20140056237A/ko not_active Withdrawn
- 2012-06-29 IN IN650CHN2014 patent/IN2014CN00650A/en unknown
- 2012-06-29 MX MX2014000065A patent/MX353621B/es active IP Right Grant
- 2012-06-29 ES ES12730567.0T patent/ES2692544T3/es active Active
- 2012-06-29 CN CN201280032708.4A patent/CN103649307B/zh active Active
- 2012-06-29 WO PCT/EP2012/062748 patent/WO2013001078A1/en active Application Filing
- 2012-06-29 US US14/129,565 patent/US9434932B2/en active Active
- 2012-06-29 EP EP18183123.1A patent/EP3421595B1/en active Active
- 2012-06-29 EP EP20199999.2A patent/EP3798303A1/en active Pending
- 2012-06-29 DK DK12730567.0T patent/DK2726607T3/en active
- 2012-06-29 JP JP2014517743A patent/JP6204352B2/ja active Active
- 2012-06-29 CN CN201810763433.0A patent/CN109097347A/zh active Pending
- 2012-06-29 AU AU2012277721A patent/AU2012277721B2/en active Active
- 2012-06-29 EP EP12730567.0A patent/EP2726607B1/en active Active
- 2012-06-29 DK DK18183123.1T patent/DK3421595T3/da active
- 2012-06-29 BR BR112013033782-6A patent/BR112013033782B1/pt active IP Right Grant
-
2014
- 2014-01-28 ZA ZA2014/00678A patent/ZA201400678B/en unknown
-
2016
- 2016-07-25 US US15/218,599 patent/US10167458B2/en active Active
-
2018
- 2018-11-14 US US16/190,580 patent/US10752889B2/en active Active
-
2020
- 2020-07-14 US US16/928,207 patent/US11091748B2/en active Active
-
2021
- 2021-07-16 US US17/378,288 patent/US12012623B2/en active Active
-
2024
- 2024-03-11 US US18/601,534 patent/US20240247244A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12012623B2 (en) | Alpha-amylase variants | |
| US11718840B2 (en) | Method for screening alpha-amylases | |
| ES2963486T3 (es) | Variantes de alfa-amilasa | |
| JP7626576B2 (ja) | 酵素変異体およびこれをコードするポリヌクレオチド | |
| CN109415421B (zh) | α-淀粉酶变体以及编码它们的多核苷酸 | |
| WO2020260223A1 (en) | Alpha-amylase variants | |
| BR122024014524A2 (pt) | Variantes de alfa-amilase, polinucleotídeo, construção de ácido nucleico, vetor de expressão, célula hospedeira e método de produção da referida variante de alfa-amilase |