ES2403107T3 - Método de tratamiento de insuficiencia y deficiencia de vitamina D - Google Patents
Método de tratamiento de insuficiencia y deficiencia de vitamina D Download PDFInfo
- Publication number
- ES2403107T3 ES2403107T3 ES08837933T ES08837933T ES2403107T3 ES 2403107 T3 ES2403107 T3 ES 2403107T3 ES 08837933 T ES08837933 T ES 08837933T ES 08837933 T ES08837933 T ES 08837933T ES 2403107 T3 ES2403107 T3 ES 2403107T3
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- vitamin
- supplement
- hydroxyvitamin
- administration
- serum
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- A—HUMAN NECESSITIES
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- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Nutrition Science (AREA)
- Diabetes (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US8404667B2 (en) * | 2006-12-29 | 2013-03-26 | Wisconsin Alumni Research Foundation | Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog |
| ATE469883T1 (de) * | 2004-11-22 | 2010-06-15 | Wisconsin Alumni Res Found | 2-methylen-19-nor-1alpha-hydroxy-17- enhormopregnacalziferol und anwendungen davon |
| SI1993559T1 (sl) | 2006-02-03 | 2017-01-31 | Opko Renal, Llc | Zdravljenje nezadostnosti in pomanjkanja vitamina D s 25-hidroksivitaminon D2 in 25-hidroksivitaminom D3 |
| PT3357496T (pt) | 2006-06-21 | 2020-05-12 | Opko Ireland Global Holdings Ltd | Terapia utilizando um agente de repleção de vitamina d e um agente de substituição hormonal de vitamina d |
| CN101668532B (zh) | 2007-04-25 | 2014-08-20 | 赛特克罗公司 | 治疗维生素d不足和缺乏、继发性甲状旁腺功能亢进症和维生素d-响应疾病的组合物及其相应的制药用途 |
| KR20190141269A (ko) | 2007-04-25 | 2019-12-23 | 사이토크로마 인코포레이티드 | 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물 |
| PL3225243T3 (pl) | 2007-04-25 | 2025-12-22 | Opko Renal, Llc | Sposób bezpiecznego i skutecznego leczenia i zapobiegania wtórnej nadczynności przytarczyc w przewlekłej chorobie nerek |
| CN101951916A (zh) | 2008-02-13 | 2011-01-19 | 帝斯曼知识产权资产管理有限公司 | 25-羟基-维生素d3用于影响人肌肉生理学的用途 |
| KR20100126375A (ko) * | 2008-02-13 | 2010-12-01 | 디에스엠 아이피 어셋츠 비.브이. | 비타민 ｄ와 25-하이드록시비타민 ｄ3의 조합물 |
| CN102046812A (zh) | 2008-04-02 | 2011-05-04 | 赛特克罗公司 | 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒 |
| HRP20150093T1 (hr) * | 2008-07-24 | 2015-03-27 | Wisconsin Alumni Research Foundation | Tjedna administracija 25-hidroksi vitamina d3 za održavanje povišene koncentracije u krvi pri stacionarnoj farmakokinetici |
| US20100331412A1 (en) * | 2009-03-30 | 2010-12-30 | Patricia Lawler Kenet | Two container skin care product |
| US8518917B2 (en) * | 2009-10-02 | 2013-08-27 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-vitamin D analogs and their uses |
| CA2797537C (en) | 2010-03-29 | 2021-11-23 | Cytochroma Inc. | Use of 25-hydroxyvitamin d compound for reducing parathyroid levels |
| ES2712740T3 (es) * | 2010-12-06 | 2019-05-14 | Dsm Ip Assets Bv | Tratamiento de afecciones asociadas con eotaxina incrementada con 25-hidroxivitamina D3 |
| CN103141433A (zh) * | 2013-03-07 | 2013-06-12 | 青岛农业大学 | 维生素a临界缺乏家禽动物模型的构建方法 |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| CR20170085A (es) * | 2014-08-07 | 2017-04-25 | Opko Ireland Global Holdings Ltd | Terapia adjuntiva con 25-hidroxi vitamina d |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| US20160131574A1 (en) * | 2014-11-06 | 2016-05-12 | The Chinese University Of Hong Kong | Method for screening vitamin d insufficiency using skin colourimetry |
| EP3053598A1 (en) | 2015-02-06 | 2016-08-10 | Faes Farma, S.A. | Calcifediol soft capsules |
| EP3851114B1 (en) | 2015-11-20 | 2024-10-09 | Société des Produits Nestlé S.A. | Composition comprising micellar whey protein, vitamin d and calcium for use in decreasing fat deposition in skeletal muscle in an elderly individual |
| EP4596045A3 (en) | 2016-03-28 | 2025-10-15 | EirGen Pharma Ltd. | Methods of vitamin d treatment |
| CA3094915A1 (en) | 2018-04-03 | 2019-10-10 | Opko Ireland Global Holdings, Ltd. | Use of calcifediol in bariatric surgery patients |
| CA3128153A1 (en) | 2019-02-06 | 2020-08-13 | Eirgen Pharma Ltd. | Method of controlling progression of hyperparathyroidism with calcifediol, and compositions for use therein |
| EP3708171A1 (en) * | 2019-03-11 | 2020-09-16 | Roger Bouillon | Treatment of vitamin d deficiency with 25(oh) vitamin d in critically ill patients |
| WO2021204812A2 (en) | 2020-04-07 | 2021-10-14 | Carbogen Amcis B.V. | Novel use of 25-hydroxyvitamin d |
| CN114748486A (zh) * | 2022-03-25 | 2022-07-15 | 南京盛德生物科技研究院有限公司 | 一种含有维生素k2改善心血管钙化的药物组合物及其制备方法与应用 |
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Family Cites Families (250)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998008517A2 (en) * | 1996-08-26 | 1998-03-05 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition containing osteogenesis-promoting substance and a polyethylene glycol |
| US3565924A (en) * | 1968-07-01 | 1971-02-23 | Wisconsin Alumni Res Found | 25-hydroxycholfcalciferol |
| US3833622A (en) | 1969-03-17 | 1974-09-03 | Upjohn Co | Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds |
| US3974272A (en) | 1972-09-01 | 1976-08-10 | Merck & Co., Inc. | Palatable cholestyramine coacervate compositions |
| US3880894A (en) * | 1974-05-24 | 1975-04-29 | Wisconsin Alumni Res Found | 1,25-Dihydroxyergocalciferol |
| US4004003A (en) * | 1974-08-28 | 1977-01-18 | The Upjohn Company | 25-Hydroxycalciferol compounds for treatment of steroid-induced osteoporosis |
| US4230701A (en) * | 1979-03-21 | 1980-10-28 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
| US4335120A (en) * | 1979-03-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
| JPS55139320A (en) | 1979-04-16 | 1980-10-31 | Teijin Ltd | Bone metabolism regulator |
| US4338312A (en) * | 1981-05-11 | 1982-07-06 | Wisconsin Alumni Research Foundation | Method for preventing parturient paresis in dairy cattle |
| JPS57188520A (en) | 1981-05-15 | 1982-11-19 | Kureha Chem Ind Co Ltd | Antihyperkalemia |
| US4442093A (en) | 1981-05-15 | 1984-04-10 | Kureha Kagaku Kogyo Kabushiki Kaisha | Method for administering 24,25-dihydroxycholecalciferol to persons suffering from hypercalcemia |
| JPS5832823A (ja) * | 1981-08-20 | 1983-02-25 | Chugai Pharmaceut Co Ltd | 脱癌剤 |
| JPS58206524A (ja) | 1982-05-26 | 1983-12-01 | Kureha Chem Ind Co Ltd | 抗腫瘍剤 |
| US4448721A (en) | 1982-09-20 | 1984-05-15 | Wisconsin Alumni Research Foundation | Hydroxyvitamin D2 compounds and process for preparing same |
| US4721613A (en) * | 1982-12-13 | 1988-01-26 | Alza Corporation | Delivery system comprising means for shielding a multiplicity of reservoirs in selected environment of use |
| JPS59155309A (ja) * | 1983-02-22 | 1984-09-04 | Teijin Ltd | 活性型ビタミンｄ↓３類組成物 |
| US4684524A (en) * | 1984-03-19 | 1987-08-04 | Alza Corporation | Rate controlled dispenser for administering beneficial agent |
| US4555364A (en) * | 1984-11-01 | 1985-11-26 | Wisconsin Alumni Research Foundation | Method for preparing 1-hydroxyvitamin D compounds |
| US4695591A (en) * | 1985-03-29 | 1987-09-22 | Schering Corporation | Controlled release dosage forms comprising hydroxypropylmethylcellulose |
| US4668517A (en) * | 1985-04-04 | 1987-05-26 | Norwich Eaton Pharmaceuticals, Inc. | Furazolidone dosage form |
| EP0207638B1 (en) * | 1985-06-04 | 1990-12-19 | Teijin Limited | Sustained-release pharmaceutical preparation |
| JPS61293911A (ja) | 1985-06-24 | 1986-12-24 | Teisan Seiyaku Kk | 徐放化製剤 |
| US5167965A (en) | 1987-02-09 | 1992-12-01 | The Dow Chemical Company | Palatable cholestyramine granules, tablets and methods for preparation thereof |
| US4892821A (en) | 1987-07-08 | 1990-01-09 | Taisho Pharmaceutical Co., Ltd. | Method for preparing vitamin D compounds |
| US4997824A (en) | 1987-07-22 | 1991-03-05 | Teva Pharmaceutical Industries Ltd. | Combination of cholecalciferol derivatives for the treatment of renal bone disease |
| CA1341408C (en) * | 1988-08-02 | 2002-12-10 | Charles W. Bishop | Method for treating and preventing loss of bone mass |
| US5602116A (en) | 1988-08-02 | 1997-02-11 | Bone Care International, Inc. | Method for treating and preventing secondary hyperparathyroidism |
| US5104864A (en) * | 1988-08-02 | 1992-04-14 | Bone Care International, Inc. | Method for treating and preventing loss of bone mass |
| US5869473A (en) * | 1988-08-02 | 1999-02-09 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| JP2893191B2 (ja) * | 1988-11-08 | 1999-05-17 | 武田薬品工業株式会社 | 放出制御性マトリックス剤 |
| JP2525478B2 (ja) | 1989-03-01 | 1996-08-21 | 帝人株式会社 | 安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤 |
| JPH02240024A (ja) | 1989-03-13 | 1990-09-25 | Ss Pharmaceut Co Ltd | 活性型ビタミンｄ↓３類製剤用組成物 |
| US5026559A (en) * | 1989-04-03 | 1991-06-25 | Kinaform Technology, Inc. | Sustained-release pharmaceutical preparation |
| GB9004544D0 (en) | 1990-03-01 | 1990-04-25 | Leo Pharm Prod Ltd | Novel treatment ii |
| JP2845342B2 (ja) | 1990-04-28 | 1999-01-13 | 大正製薬株式会社 | ビタミンｄ▲下３▼誘導体含有固形製剤組成物 |
| JPH04198129A (ja) | 1990-11-28 | 1992-07-17 | Sumitomo Pharmaceut Co Ltd | 活性型ビタミンｄ↓３類含有組成物 |
| JP2893140B2 (ja) | 1990-11-30 | 1999-05-17 | エスエス製薬株式会社 | 安定なビタミンｄ製剤 |
| JPH04288016A (ja) | 1991-03-14 | 1992-10-13 | Tokai Capsule Kk | 活性型ビタミンｄ３類軟カプセル剤の製造方法 |
| ATE144424T1 (de) | 1991-04-09 | 1996-11-15 | Takeda Chemical Industries Ltd | Stabilisiertes vitamin d arzneimittel |
| US5693615A (en) * | 1991-06-05 | 1997-12-02 | The Procter & Gamble Company | Therapeutic compositions for osteoinduction |
| BR9206110A (pt) * | 1991-06-05 | 1995-07-11 | Procter & Gamble | Composições terapêuticas para osteoindução |
| US6313146B1 (en) | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6031003A (en) | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6001884A (en) | 1991-08-23 | 1999-12-14 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6011068A (en) | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US5266331A (en) | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
| US5472712A (en) | 1991-12-24 | 1995-12-05 | Euroceltique, S.A. | Controlled-release formulations coated with aqueous dispersions of ethylcellulose |
| US5160742A (en) * | 1991-12-31 | 1992-11-03 | Abbott Laboratories | System for delivering an active substance for sustained release |
| ATE141914T1 (de) * | 1992-05-20 | 1996-09-15 | Hoffmann La Roche | Fluorierte analoge vitamins d3 |
| US5795882A (en) | 1992-06-22 | 1998-08-18 | Bone Care International, Inc. | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
| AU4645893A (en) * | 1992-06-22 | 1994-01-24 | Lunar Corporation | Oral 1alpha-hydroxyprevitamin D |
| US5354743A (en) | 1992-09-15 | 1994-10-11 | Thys Jacobs Susan | Method for the treatment of premenstrual syndrome with vitamin D |
| US5431917A (en) | 1992-10-08 | 1995-07-11 | Japan Elanco Company, Ltd. | Hard capsule for pharmaceutical drugs and method for producing the same |
| US5342626A (en) | 1993-04-27 | 1994-08-30 | Merck & Co., Inc. | Composition and process for gelatin-free soft capsules |
| JP2684587B2 (ja) | 1993-06-21 | 1997-12-03 | 呉羽化学工業株式会社 | 腎性骨異栄養症における骨量減少抑制剤 |
| US6121469A (en) | 1993-12-23 | 2000-09-19 | The Regents Of The University Of California | Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs |
| JPH07242550A (ja) | 1994-03-02 | 1995-09-19 | Teijin Ltd | 二次性副甲状腺機能亢進症治療剤 |
| IL110117A0 (en) | 1994-06-24 | 1994-10-07 | Univ Ben Gurion | Pharmaceutical compositions comprising vitamin-d analogs |
| SE9402422D0 (sv) | 1994-07-08 | 1994-07-08 | Astra Ab | New beads for controlled release and a pharmaceutical preparation containing the same |
| CA2195623A1 (en) | 1994-07-22 | 1996-02-08 | Rajeev D. Gokhale | Self-emulsifying drug delivery system |
| JPH0892098A (ja) | 1994-09-27 | 1996-04-09 | Teijin Ltd | 肺結核治療剤 |
| CN1147459C (zh) | 1994-10-21 | 2004-04-28 | Nps药物有限公司 | 钙受体活性化合物 |
| US5756123A (en) | 1994-12-01 | 1998-05-26 | Japan Elanco Co., Ltd. | Capsule shell |
| US6376479B1 (en) * | 1995-04-03 | 2002-04-23 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US6242434B1 (en) | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| CA2229316C (en) | 1995-09-21 | 2005-04-12 | Wisconsin Alumni Research Foundation | Calcitriol derivatives and their uses |
| DE19549243A1 (de) | 1995-12-21 | 1997-06-26 | Schering Ag | Pharmazeutische Präparate enthaltend Clathrate von Cyclodextrinen und nichtnatürliche Vitamin D-Analoga |
| NO971934L (no) | 1996-05-23 | 1997-11-24 | Hoffmann La Roche | Flourinerte vitamin D3 -analoger |
| US5939408A (en) | 1996-05-23 | 1999-08-17 | Hoffman-La Roche Inc. | Vitamin D3 analogs |
| US5958451A (en) | 1996-09-03 | 1999-09-28 | Yung Shin Pharm Ind. Co., Ltd. | Process for producing porous, controlled-release capsules and encapsulated composition |
| US5976784A (en) * | 1996-09-20 | 1999-11-02 | Wisconsin Alumni Research Foundation | Calcitriol derivatives and their uses |
| US8828432B2 (en) | 1996-10-28 | 2014-09-09 | General Mills, Inc. | Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles |
| DE69730982T2 (de) * | 1996-10-28 | 2005-09-01 | General Mills, Inc., Minneapolis | Einbettung und einkapselung von teilchen zur kontrollierten abgabe |
| JPH10158171A (ja) | 1996-12-02 | 1998-06-16 | Kita:Kk | ビタミンｄ化合物を配合した眼内投与剤 |
| US20020128240A1 (en) | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
| US6503893B2 (en) | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
| US20030129194A1 (en) | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
| US6034075A (en) | 1997-03-20 | 2000-03-07 | The Trustees Of Columbia University In The City Of New York | Method of treating polycystic ovarian syndrome |
| US5872113A (en) | 1997-05-16 | 1999-02-16 | Syntex (U.S.A.) Inc. | Fluorinated vitamin D3 analogs |
| AU8293498A (en) | 1997-07-02 | 1999-01-25 | Euro-Celtique S.A. | Stabilized sustained release tramadol formulations |
| JPH1175863A (ja) | 1997-07-10 | 1999-03-23 | Kyowa Hakko Kogyo Co Ltd | ２５−ヒドロキシビタミンＤ３−１α−水酸化酵素および該酵素をコードするＤＮＡ |
| US6096876A (en) | 1997-08-06 | 2000-08-01 | Shriners Hospitals For Children | 1-α-hydroxylase materials and methods |
| AU9376998A (en) | 1997-09-02 | 1999-03-22 | Johns Hopkins University School Of Medicine, The | Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders |
| US5919986A (en) | 1997-10-17 | 1999-07-06 | Hoffmann-La Roche Inc. | D-homo vitamin D3 derivatives |
| JPH11158074A (ja) | 1997-12-03 | 1999-06-15 | Hayashi Tomie | 高アミノ酸付加活性型ビタミンｄ強化組成物 |
| US20030059471A1 (en) | 1997-12-15 | 2003-03-27 | Compton Bruce Jon | Oral delivery formulation |
| CN1301298A (zh) | 1998-03-25 | 2001-06-27 | 卡坦诺根公司 | 用于预防和治疗癌症的方法 |
| EP1064000B1 (en) | 1998-03-27 | 2011-07-06 | Oregon Health & Science University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
| US6197340B1 (en) | 1998-05-28 | 2001-03-06 | Medical Research Institute | Controlled release lipoic acid |
| US8133694B2 (en) | 1998-06-25 | 2012-03-13 | Immundiagnostik Ag | Functional vitamin D derivatives and method of determining 25-hydroxy- and 1α, 25-dihydroxy vitamin D |
| US6214376B1 (en) | 1998-08-25 | 2001-04-10 | Banner Pharmacaps, Inc. | Non-gelatin substitutes for oral delivery capsules, their composition and process of manufacture |
| SE9803871D0 (sv) | 1998-11-11 | 1998-11-11 | Pharmacia & Upjohn Ab | Therapeutic method and formulation |
| CA2311755C (en) | 1998-08-27 | 2010-03-23 | Pharmacia & Upjohn Ab | Therapeutic formulation for administering tolterodine with controlled release |
| US6139875A (en) * | 1998-09-29 | 2000-10-31 | Eastman Chemical Company | Aqueous enteric coating composition and low gastric permeability enteric coating |
| EP2266542A3 (en) | 1998-10-01 | 2013-07-31 | Elan Pharma International Limited | Controlled release nanoparticulate compositions |
| AU777977B2 (en) | 1998-10-09 | 2004-11-04 | General Mills Inc. | Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles |
| JP3449253B2 (ja) | 1998-10-29 | 2003-09-22 | シオノギクオリカプス株式会社 | 硬質カプセルの製造方法 |
| JP2000206312A (ja) | 1998-11-12 | 2000-07-28 | Olympus Optical Co Ltd | 光学素子 |
| MXPA01006108A (es) | 1998-12-17 | 2002-09-18 | Alza Corp | Conversion de capsulas de gelatina rellenas de liquido en sistemas de liberacion controlada mediante multiples recubrimientos. |
| US6342249B1 (en) * | 1998-12-23 | 2002-01-29 | Alza Corporation | Controlled release liquid active agent formulation dosage forms |
| US6432936B1 (en) * | 1999-01-20 | 2002-08-13 | Wisconsin Alumni Research Foundation | Crystalline 1α-hydroxyvitamin D2 and method of purification thereof |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| ATE344039T1 (de) * | 1999-04-01 | 2006-11-15 | Univ Johns Hopkins | Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung |
| US7648826B1 (en) | 1999-04-02 | 2010-01-19 | The Regents Of The University Of California | Detecting CYP24 expression level as a marker for predisposition to cancer |
| DE19916419B4 (de) | 1999-04-08 | 2005-06-16 | Schering Ag | Kombinationspräparat aus Vitamin-D-Metaboliten oder Vitamin-D-Analoga und einem Östrogenpartialagonisten zur Behandlung von Osteoporose |
| WO2000072831A1 (en) * | 1999-05-27 | 2000-12-07 | Drugtech Corporation | Nutritional formulations |
| US6340473B1 (en) | 1999-07-07 | 2002-01-22 | R.P. Scherer Technologies, Inc. | Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same |
| US6274169B1 (en) * | 1999-08-02 | 2001-08-14 | Abbott Laboratories | Low oxygen content compostions of 1α, 25-dihydroxycholecalciferol |
| US6051567A (en) * | 1999-08-02 | 2000-04-18 | Abbott Laboratories | Low oxygen content compositions of 1α, 25-dihydroxycholecalciferol |
| KR100587245B1 (ko) | 1999-08-31 | 2006-06-07 | 쥬가이 세이야쿠 가부시키가이샤 | 연질 캡슐제 |
| US20060034937A1 (en) | 1999-11-23 | 2006-02-16 | Mahesh Patel | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| GB0007419D0 (en) * | 2000-03-27 | 2000-05-17 | Smithkline Beecham Gmbh | Composition |
| US6375981B1 (en) | 2000-06-01 | 2002-04-23 | A. E. Staley Manufacturing Co. | Modified starch as a replacement for gelatin in soft gel films and capsules |
| WO2002006218A2 (en) * | 2000-07-18 | 2002-01-24 | Bone Care International, Inc. | STABILIZED 1α-HYDROXY VITAMIN D |
| US6491950B1 (en) | 2000-08-07 | 2002-12-10 | Kos Pharmaceuticals, Inc. | Controlled release pharmaceutical composition |
| KR100829474B1 (ko) | 2000-08-29 | 2008-05-16 | 닛신 가세이 가부시키가이샤 | 경질 캡슐 |
| US6887493B2 (en) | 2000-10-25 | 2005-05-03 | Adi Shefer | Multi component controlled release system for oral care, food products, nutraceutical, and beverages |
| CN101653411A (zh) | 2000-10-30 | 2010-02-24 | 欧罗赛铁克股份有限公司 | 控释氢可酮制剂 |
| US6479649B1 (en) | 2000-12-13 | 2002-11-12 | Fmc Corporation | Production of carrageenan and carrageenan products |
| JP2002302447A (ja) | 2001-04-03 | 2002-10-18 | Shimizu Pharmaceutical Co Ltd | 局所投与用癌治療剤 |
| CZ20033116A3 (cs) | 2001-05-15 | 2004-09-15 | Warner-Lambert Company Llc | Způsob výroby lékové formy fenytoinu sodného užívající kompaktor |
| CN100366239C (zh) | 2001-07-05 | 2008-02-06 | 涌永制药株式会社 | 软胶囊剂 |
| US6870833B2 (en) | 2001-07-20 | 2005-03-22 | Net2Phone, Inc. | Active voice messaging |
| US7166585B2 (en) | 2001-08-22 | 2007-01-23 | Cytochroma Inc. | 24-Sulfur-substituted analogs of 1α,25-dihydroxy vitamin D3 |
| US7033996B2 (en) | 2001-08-31 | 2006-04-25 | University Of Medicine & Dentistry Of New Jersey | Method for the treatment of vitamin D related disease |
| DE10149674A1 (de) | 2001-10-09 | 2003-04-24 | Apogepha Arzneimittel Gmbh | Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung |
| CA2463505C (en) * | 2001-10-12 | 2011-07-12 | Johns Hopkins University | Low-calcemic oxime analogs of 1.alpha.,25-dihydroxy vitamin d3 |
| US6524788B1 (en) | 2001-11-02 | 2003-02-25 | Thomas L. Cantor | Methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism |
| US7056655B2 (en) | 2001-11-02 | 2006-06-06 | Scantibodies Laboratory, Inc. | Methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism |
| ITMI20012366A1 (it) | 2001-11-09 | 2003-05-09 | Farmatron Ltd | Sistemi terapeutici stabilizzati a rilascio immediato e/o modificato per la somministrazione orale di principi attivi e/o eccipienti e/o ali |
| CA2466996C (en) | 2001-11-22 | 2010-09-14 | Morishita Jintan Co., Ltd. | Non-gelatinous capsule shell compositions and capsules using the same |
| GB0128415D0 (en) | 2001-11-27 | 2002-01-16 | Univ Sheffield | Medicaments |
| MXPA04005260A (es) | 2001-12-03 | 2005-03-23 | Novacea Inc | Composiciones farmaceuticas que comprenden compuestos activos de vitamina d. |
| US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| FR2829142B1 (fr) | 2001-12-27 | 2004-02-13 | Ulice | Composition filmogene d'heteroxylanes pour la fabrication de capsules ainsi obtenues |
| US7632518B2 (en) * | 2002-01-15 | 2009-12-15 | Dsm Ip Assets B.V. | 25-hydroxy vitamin D3 compositions |
| US6949256B2 (en) | 2002-01-18 | 2005-09-27 | Banner Pharmacaps, Inc. | Non-gelatin capsule shell formulation |
| NO20021592D0 (no) | 2002-04-04 | 2002-04-04 | Fmc Biopolymer As | Polysakkaridkapsler og fremgangsmåte ved fremstilling derav |
| US20050176685A1 (en) | 2002-04-05 | 2005-08-11 | Daifotis Anastasia G. | Method for inhibiting bone resorption with an alendronate and vitamin d formulation |
| EP1499303A4 (en) | 2002-04-10 | 2007-07-25 | Fred H Miller | MULTIPHASE MULTI-COMPONENT CAPSULE SYSTEM |
| US7288407B2 (en) | 2002-05-02 | 2007-10-30 | Cytochroma, Inc. | Stable cytochrome P450 24 (CYP24) expressing cell line and methods and uses thereof |
| CA2488334C (en) | 2002-06-13 | 2010-12-07 | Johns Hopkins University | 24-sulfoximine vitamin d3 compounds |
| DK1519717T3 (da) | 2002-07-05 | 2011-01-10 | Temrel Ltd | Sammensætning til kontrolleret frisætning |
| TWI336260B (en) | 2002-07-25 | 2011-01-21 | Glaxo Group Ltd | Dosage form suitable for retaining drug substance |
| JP4500679B2 (ja) | 2002-07-29 | 2010-07-14 | アルザ・コーポレーシヨン | パリペリドンを制御送達する方法および投薬形態物 |
| US8268352B2 (en) | 2002-08-05 | 2012-09-18 | Torrent Pharmaceuticals Limited | Modified release composition for highly soluble drugs |
| WO2004028515A1 (en) | 2002-09-26 | 2004-04-08 | Young-Kweon Choi | Matrix type patch for transdermal administration of vitamin d analog and the use thereof |
| US20050101576A1 (en) | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| US8999372B2 (en) | 2002-11-14 | 2015-04-07 | Cure Pharmaceutical Corporation | Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use |
| JP2004175750A (ja) * | 2002-11-28 | 2004-06-24 | Kose Corp | 皮膚障害抑制剤、皮膚障害改善剤、及びそれらを含有する皮膚外用剤 |
| US20050026877A1 (en) | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| JP2006514695A (ja) | 2002-12-16 | 2006-05-11 | テバ ファーマシューティカル インダストリーズ リミティド | ビタミンｄ誘導体の前用量投与によってアレンドロネート又は他のビスフォスフォネートの全体利用効率を高める方法 |
| DE20321698U1 (de) | 2002-12-16 | 2008-12-24 | Teva Pharmaceutical Industries Ltd. | Medikament zur Erhöhung der Bioverfügbarkeit von Alendronat oder einem anderen Bisphosphonat durch Verabreichen einer Vordosis eines Vitamin-D-Derivats |
| AU2003292920A1 (en) | 2002-12-18 | 2004-07-09 | Cytochroma Inc. | 25-so2-substituted analogs of 1alpha, 25-dihydroxyvitamin d3 (calcitriol) |
| KR20050123097A (ko) | 2003-02-11 | 2005-12-29 | 알자 코포레이션 | 변형된 층 형상을 갖는 방법 및 제형 |
| US7816341B2 (en) | 2003-04-14 | 2010-10-19 | Fmc Corporation | Homogeneous, thermoreversible gel containing reduced viscosity carrageenan and products made therefrom |
| JP2007525451A (ja) | 2003-04-14 | 2007-09-06 | エフ エム シー コーポレーション | 均一かつ熱可逆性アルギネートフィルムの伝達システム |
| US20070032461A1 (en) | 2003-04-30 | 2007-02-08 | Bioxell S.P.A. | 1,3 Aclyated 24-keto-vitamin d3 compounds and methods of use thereof |
| CA2529495C (en) | 2003-06-16 | 2013-02-05 | Solx, Inc. | Shunt for the treatment of glaucoma |
| ES2379466T3 (es) | 2003-06-26 | 2012-04-26 | Psivida Us, Inc. | Sistema de suministro de fármacos de liberación sostenida bioerosionables |
| AU2003903382A0 (en) | 2003-07-03 | 2003-07-17 | Medvet Science Pty Ltd | Inhibition of calcitriol mediated cyp24 induction screening for compounds therefor and uses thereof |
| EP1643978A1 (en) | 2003-07-04 | 2006-04-12 | Nycomed Danmark A/S | Parathyroid hormone (pth) containing pharmaceutical compositions for oral use |
| US20050148557A1 (en) | 2003-07-29 | 2005-07-07 | Jin Tian | Use of Vitamin Ds to treat kidney disease |
| US20050124591A1 (en) * | 2003-07-29 | 2005-06-09 | Jin Tian | Use of vitamin Ds to treat kidney disease |
| EP1663182B2 (en) | 2003-09-12 | 2019-11-20 | Amgen Inc. | RAPID DISSOLUTION FORMULATION OF CINACALCET HCl |
| US7053075B2 (en) | 2003-11-25 | 2006-05-30 | Deluca Hector F | Methods for reducing body fat using vitamin D compounds |
| CA2494572A1 (en) | 2003-12-19 | 2005-06-19 | Cytochroma Inc. | Cytochrome p450 24 (cyp24) monoclonal antibody and methods and uses thereof |
| US20060009425A1 (en) | 2004-05-28 | 2006-01-12 | Leticia Delgado-Herrera | Oral formulations of paricalcitol |
| US9750797B2 (en) | 2004-06-16 | 2017-09-05 | Virbac Corporation | Sustained release vaccine composition |
| US20050287213A1 (en) | 2004-06-28 | 2005-12-29 | Wong Patrick S | Dosage forms for low solubility and or low dissolution rate free acid pharmaceutical agents |
| US20060019933A1 (en) | 2004-07-22 | 2006-01-26 | David Boardman | Process for preparing stabilized vitamin D |
| MX2007001138A (es) | 2004-07-29 | 2007-04-19 | Sanofi Aventis | Comprimido farmaceutico multicapa para la liberacion controlada de ingredientes activos con solubilidad muy dependiente del ph. |
| US8231896B2 (en) | 2004-11-08 | 2012-07-31 | R.P. Scherer Technologies, Llc | Non-gelatin soft capsule system |
| AU2004325362B2 (en) | 2004-12-03 | 2012-09-06 | Council Of Scientific And Industrial Research | Process of preparation of biodegradable films from semi refined kappa carrageenan |
| US8318210B2 (en) * | 2005-02-28 | 2012-11-27 | Neos Therapeutics, Lp | Compositions and methods of making sustained release liquid formulations |
| US7745226B2 (en) | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
| EP1871384A4 (en) | 2005-04-15 | 2012-01-25 | Clarus Therapeutics Inc | SYSTEMS FOR THE PHARMACEUTICAL ADMINISTRATION OF HYDROPHOUS ACTIVE SUBSTANCES AND COMPOSITIONS THEREWITH |
| US20060257481A1 (en) | 2005-04-21 | 2006-11-16 | Decode Genetics Ehf. | Sustained release formulation and dosing schedule of leukotriene synthesis inhibitor for human therapy |
| US9205047B2 (en) | 2005-04-25 | 2015-12-08 | The Governing Council Of The University Of Toronto | Tunable sustained release of a sparingly soluble hydrophobic therapeutic agent from a hydrogel matrix |
| US20080134937A1 (en) | 2005-05-25 | 2008-06-12 | Joo Hwan Yang | Cellulose hard capsule enhancing mechanical film strength |
| AR055099A1 (es) | 2005-07-28 | 2007-08-08 | Alza Corp | Formulaciones liquidas para la administracion controlada de derivados de bencisoxazol |
| ATE427965T1 (de) | 2005-09-29 | 2009-04-15 | Hoffmann La Roche | Antikírper gegen 25-hydroxyvitamin d |
| ITFI20050206A1 (it) | 2005-09-30 | 2007-04-01 | Valpharma Sa | Composizione farmaceutica a rilascio controllato di venlafaxina cloridrato, e processo per la sua preparazione |
| CA2924200C (en) * | 2005-10-12 | 2017-09-05 | Proventiv Therapeutics, Llc | Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency |
| CN101351196B (zh) | 2005-10-26 | 2013-07-03 | 班纳制药公司 | 作为胶囊填充物的基于亲脂性载体的双重控释基质系统 |
| EP1959935A2 (en) | 2005-10-26 | 2008-08-27 | Banner Pharmacaps Inc. | Hydrophilic vehicle-based dual controlled release matrix system as capsule fill |
| CA2628207A1 (en) | 2005-11-01 | 2007-05-10 | Andries Hanzen | Films and capsules made from modified carboxymethycellulose materials and methods of making same |
| WO2007068287A1 (en) | 2005-12-15 | 2007-06-21 | Laboratoria Qualiphar | Sustained release vitamin preparation |
| MXPA05014091A (es) | 2005-12-20 | 2007-06-20 | Leopoldo De Jesus Espinosa Abdala | Composiciones farmaceuticas que comprenden derivados de esteroides sinteticos, minerales y el metabolito activo de la vitamina d, 1,25(oh)2d3 (calcitriol) para la prevencion y tratamiento de la osteoporosis y el control de los sintomas de la menopaus |
| WO2007092221A2 (en) | 2006-01-31 | 2007-08-16 | Health Research Inc. | Method for identifying altered vitamin d metabolism |
| US7528122B2 (en) * | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| SI1993559T1 (sl) | 2006-02-03 | 2017-01-31 | Opko Renal, Llc | Zdravljenje nezadostnosti in pomanjkanja vitamina D s 25-hidroksivitaminon D2 in 25-hidroksivitaminom D3 |
| GB0606426D0 (en) | 2006-03-30 | 2006-05-10 | Novartis Ag | Benzimidazole derivatives |
| EP2024436A1 (en) | 2006-06-06 | 2009-02-18 | Fmc Corporation | Kappa-2 carrageenan composition and products made therefrom |
| US20080109983A1 (en) | 2006-11-10 | 2008-05-15 | Kegel, Llc | Zero Turning Radius Lane Maintenance Machine |
| PT3357496T (pt) | 2006-06-21 | 2020-05-12 | Opko Ireland Global Holdings Ltd | Terapia utilizando um agente de repleção de vitamina d e um agente de substituição hormonal de vitamina d |
| EP1912400A1 (en) | 2006-10-10 | 2008-04-16 | Matsushita Electric Industrial Co., Ltd. | Method and apparatus for mobile IP route optimization |
| US20100168410A1 (en) | 2006-10-27 | 2010-07-01 | Pfizer Products Inc. | Hydroxypropyl Methyl Cellulose Hard Capsules and Process of Manufacture |
| WO2008097646A1 (en) | 2007-02-09 | 2008-08-14 | Schering Corporation | Methods to treat and/or prevent mucositis |
| US8491937B2 (en) | 2007-02-15 | 2013-07-23 | Wyeth Llc | Stability in vitamin and mineral supplements |
| CN101682239A (zh) | 2007-03-20 | 2010-03-24 | 电锁公司 | 具有导电毡的罗贝尔绕组 |
| EP2136814A4 (en) | 2007-03-21 | 2012-05-30 | Univ Duke | MEDICAL KITS AND FORMULATIONS FOR PREVENTING, TREATING OR REDUCING SECONDARY FRACTURES FROM A PREVIOUS FRACTURE |
| CN101668532B (zh) | 2007-04-25 | 2014-08-20 | 赛特克罗公司 | 治疗维生素d不足和缺乏、继发性甲状旁腺功能亢进症和维生素d-响应疾病的组合物及其相应的制药用途 |
| KR20190141269A (ko) | 2007-04-25 | 2019-12-23 | 사이토크로마 인코포레이티드 | 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물 |
| PL3225243T3 (pl) | 2007-04-25 | 2025-12-22 | Opko Renal, Llc | Sposób bezpiecznego i skutecznego leczenia i zapobiegania wtórnej nadczynności przytarczyc w przewlekłej chorobie nerek |
| US8592401B2 (en) | 2007-04-25 | 2013-11-26 | Proventiv Therapeutics, Llc | Methods and compounds for vitamin D therapy |
| US20090004284A1 (en) | 2007-06-26 | 2009-01-01 | Watson Pharmaceuticals, Inc. | Controlled release tamsulosin hydrochloride formulation |
| KR100836960B1 (ko) | 2007-09-07 | 2008-06-10 | 주식회사 서울제약 | 새로운 나이아신 제어방출형 제제 |
| EP2042165A1 (de) | 2007-09-28 | 2009-04-01 | Swiss Caps Rechte und Lizenzen AG | Hot-Melt-Befüllte Weichkapseln |
| US20090155355A1 (en) | 2007-12-12 | 2009-06-18 | Multi Formulations Ltd. | Particles in a capsule |
| KR20100126375A (ko) | 2008-02-13 | 2010-12-01 | 디에스엠 아이피 어셋츠 비.브이. | 비타민 ｄ와 25-하이드록시비타민 ｄ3의 조합물 |
| CN101951916A (zh) | 2008-02-13 | 2011-01-19 | 帝斯曼知识产权资产管理有限公司 | 25-羟基-维生素d3用于影响人肌肉生理学的用途 |
| JP5509504B2 (ja) | 2008-02-13 | 2014-06-04 | ディーエスエム アイピー アセッツ ビー．ブイ． | 骨塩密度を改善し、骨粗鬆症を治療するための２５−ヒドロキシ−ビタミンｄ３とビタミンｄ３の併用 |
| EA201001288A1 (ru) * | 2008-02-13 | 2011-02-28 | ДСМ АйПи АССЕТС Б. В. | Лечение гипертонии 25-гидроксивитамином d3 |
| ES2588241T3 (es) | 2008-02-13 | 2016-10-31 | Dsm Ip Assets B.V. | Tratamiento de la hiperglucemia con 25-hidroxivitamina D3 y vitamina D |
| CN102046812A (zh) | 2008-04-02 | 2011-05-04 | 赛特克罗公司 | 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒 |
| HRP20150093T1 (hr) | 2008-07-24 | 2015-03-27 | Wisconsin Alumni Research Foundation | Tjedna administracija 25-hidroksi vitamina d3 za održavanje povišene koncentracije u krvi pri stacionarnoj farmakokinetici |
| CA2738078C (en) | 2008-09-24 | 2015-12-29 | Evonik Operations Gmbh | Ph-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol |
| EP2179727B1 (en) | 2008-10-27 | 2013-05-29 | Roquette Freres | Water insoluble polymer: modified starch derivative-based film coatings for colon targeting |
| BRPI1006902A2 (pt) | 2009-01-23 | 2016-02-16 | Aziende Chimiche Riunte Angelini Francesco A C R A F S P A | formulação farmacêutica ou alimentícia de liberação controlada, processo para a produção de uma forma farmacêutica ou alimentícia, sistema de liberação controlada, e, uso de um sistema de liberação controlada |
| CH700543A2 (de) | 2009-03-03 | 2010-09-15 | Innogel Ag | Film auf Basis von Stärke. |
| CN102596251B (zh) | 2009-09-10 | 2014-06-11 | Fmc有限公司 | 高强度无缝海藻酸盐胶囊 |
| IT1396937B1 (it) | 2009-11-26 | 2012-12-20 | Bruzzese | Formulazioni di bisfosfonati e vitamina d idonee alla somministrazione intermittente per via intramuscolare e sottocutanea |
| FR2953139B1 (fr) | 2009-11-27 | 2012-04-13 | Servier Lab | Composition pharmaceutique comprenant un sel de strontium, de la vitamine d et une cyclodextrine |
| US8101203B2 (en) | 2010-01-14 | 2012-01-24 | Karl Wei Cao | Hard capsule composition and method of use |
| US8101204B2 (en) | 2010-01-14 | 2012-01-24 | Karl Wei Cao | Hard capsule composition and method of use |
| WO2011095388A1 (en) | 2010-02-04 | 2011-08-11 | Synthon Bv | Tolterodine bead |
| CA2797537C (en) | 2010-03-29 | 2021-11-23 | Cytochroma Inc. | Use of 25-hydroxyvitamin d compound for reducing parathyroid levels |
| WO2012006475A1 (en) | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| KR20120005228A (ko) | 2010-07-08 | 2012-01-16 | 주식회사 네비팜 | 골다공증 치료용 비스포스폰산 함유 장용 약학조성물 및 그의 제조방법 |
| BR112013002721B8 (pt) | 2010-08-04 | 2021-05-25 | Scherer Technologies Llc R P | composição formadora de filme para cápsulas moles, cápsulas moles e seu invólucro |
| US20120135103A1 (en) | 2010-11-30 | 2012-05-31 | Mead Johnson Nutrition Company | Staged Infant Feeding Regimen To Promote Healthy Development And Growth |
| ES2712740T3 (es) | 2010-12-06 | 2019-05-14 | Dsm Ip Assets Bv | Tratamiento de afecciones asociadas con eotaxina incrementada con 25-hidroxivitamina D3 |
| JP6138053B2 (ja) | 2010-12-28 | 2017-05-31 | フューチャー・ダイアグノスティックス・ベーフェー | ビタミンｄのための放出試薬 |
| ES2641091T3 (es) | 2011-03-02 | 2017-11-07 | D3 Pharma Limited | Composición de vitamina D |
| WO2012145491A2 (en) | 2011-04-20 | 2012-10-26 | Jason Fisher | Composition and method for enhancing an immune response |
| WO2012144789A2 (ko) | 2011-04-20 | 2012-10-26 | 주식회사 서흥캅셀 | 붕해도 및 피막 경도를 개선한 비동물성 연질 캡슐 피막 조성물 |
| CN102771688A (zh) | 2011-05-13 | 2012-11-14 | 富曼实（上海）商贸有限公司 | 可食用液体填充的多糖胶囊 |
| US20130085121A1 (en) | 2011-09-30 | 2013-04-04 | Jianguo Wang | Pharmaceutical compositions comprising phosphate binder, calcium receptor-active compound and/or active vitamin d |
| WO2014029953A1 (en) | 2012-08-21 | 2014-02-27 | Cipla Limited | Hot melt extruded (hme) pharmaceutical composition of cinacalcet |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| PT106978A (pt) | 2013-05-31 | 2014-12-02 | Tecnimede Sociedade Tecnico Medicinal S A | Composição sólida oral contendo ácido ibandrónico e vitamina d |
| EP2815745A1 (en) | 2013-06-21 | 2014-12-24 | Swiss Caps Rechte und Lizenzen AG | Soft shell capsule and process for its manufacture |
| CN103495176B (zh) | 2013-10-26 | 2015-01-28 | 中山市凯博思淀粉材料科技有限公司 | 一种共混挤出法制备淀粉基软胶囊的方法 |
| CN103520133B (zh) | 2013-10-26 | 2015-02-04 | 中山市凯博思淀粉材料科技有限公司 | 一种淀粉基软胶囊的制备方法 |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| CR20170085A (es) | 2014-08-07 | 2017-04-25 | Opko Ireland Global Holdings Ltd | Terapia adjuntiva con 25-hidroxi vitamina d |
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- 2008-04-25 CN CN201410348022.7A patent/CN104257667B/zh active Active
- 2008-04-25 WO PCT/IB2008/003480 patent/WO2009047644A2/en not_active Ceased
- 2008-04-25 DK DK08837933.4T patent/DK2148684T3/da active
- 2008-04-25 ES ES08837933T patent/ES2403107T3/es active Active
- 2008-04-25 JP JP2010504912A patent/JP5444212B2/ja active Active
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- 2008-04-25 EP EP08837933A patent/EP2148684B1/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| HK1205936A1 (en) | 2015-12-31 |
| WO2009047644A3 (en) | 2009-05-28 |
| JP2014055184A (ja) | 2014-03-27 |
| KR101495578B1 (ko) | 2015-02-25 |
| CA2683628A1 (en) | 2009-04-16 |
| JP5855633B2 (ja) | 2016-02-09 |
| DK2148684T3 (da) | 2013-04-22 |
| EP2148684B1 (en) | 2013-01-16 |
| CN104257667A (zh) | 2015-01-07 |
| JP5444212B2 (ja) | 2014-03-19 |
| WO2009047644A2 (en) | 2009-04-16 |
| KR20100017238A (ko) | 2010-02-16 |
| PT2148684E (pt) | 2013-04-19 |
| PL2148684T3 (pl) | 2013-06-28 |
| CN104257667B (zh) | 2019-06-04 |
| CN101668532B (zh) | 2014-08-20 |
| CA2683628C (en) | 2018-03-06 |
| US11752158B2 (en) | 2023-09-12 |
| EP2148684A2 (en) | 2010-02-03 |
| JP2010525050A (ja) | 2010-07-22 |
| CN101668532A (zh) | 2010-03-10 |
| US20100120728A1 (en) | 2010-05-13 |
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