ES2403107T3 - Método de tratamiento de insuficiencia y deficiencia de vitamina D - Google Patents
Método de tratamiento de insuficiencia y deficiencia de vitamina D Download PDFInfo
- Publication number
- ES2403107T3 ES2403107T3 ES08837933T ES08837933T ES2403107T3 ES 2403107 T3 ES2403107 T3 ES 2403107T3 ES 08837933 T ES08837933 T ES 08837933T ES 08837933 T ES08837933 T ES 08837933T ES 2403107 T3 ES2403107 T3 ES 2403107T3
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- vitamin
- supplement
- hydroxyvitamin
- administration
- serum
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- A—HUMAN NECESSITIES
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- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Chemical & Material Sciences (AREA)
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- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US8404667B2 (en) * | 2006-12-29 | 2013-03-26 | Wisconsin Alumni Research Foundation | Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog |
| EP1828114B1 (en) * | 2004-11-22 | 2010-04-21 | Wisconsin Alumni Research Foundation | 17,20(e)-dehydro vitamin d analogs and their uses |
| HUE056937T2 (hu) | 2006-02-03 | 2022-04-28 | Opko Renal Llc | A D-vitamin elégtelenség és hiány kezelése 25-hidroxivitamin D2-vel és 25-hidroxivitamin D3-mal |
| LT2679228T (lt) | 2006-06-21 | 2018-05-10 | Opko Ireland Global Holdings, Ltd. | Terapija naudojant vitamino d atstatymo agentą ir vitamino d hormoninį pakaitinį agentą |
| CA2683628C (en) | 2007-04-25 | 2018-03-06 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
| ES2401205T3 (es) | 2007-04-25 | 2013-04-17 | Cytochroma Inc. | Composiciones de orales de liberación controlada que comprende un compuesto de vitamina D y un soporte céreo |
| EP2148683A4 (en) | 2007-04-25 | 2012-09-12 | Proventiv Therapeutics Llc | SAFE AND EFFECTIVE METHOD OF TREATING AND PREVENTING SECONDARY HYPERPARATHYROIDIA IN CHRONIC RENAL DISEASES |
| CN101951920A (zh) * | 2008-02-13 | 2011-01-19 | 帝斯曼知识产权资产管理有限公司 | 维生素d和25-羟基维生素d3的组合 |
| EP2249842B2 (en) | 2008-02-13 | 2025-03-05 | DSM IP Assets B.V. | Use of 25-hydroxy-vitamin d3 and vitamin d to affect human muscle physiology |
| US8962239B2 (en) | 2008-04-02 | 2015-02-24 | Opko Renal, Llc | Methods useful for vitamin D deficiency and related disorders |
| US8759328B2 (en) * | 2008-07-24 | 2014-06-24 | Wisconsin Alumni Research Foundation | Once-a-week administration of 25-hydroxy vitamin D3 to sustain elevated steady-state pharmacokinetic blood concentration |
| US20100331412A1 (en) * | 2009-03-30 | 2010-12-30 | Patricia Lawler Kenet | Two container skin care product |
| US8518917B2 (en) * | 2009-10-02 | 2013-08-27 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-vitamin D analogs and their uses |
| EP3636280B1 (en) | 2010-03-29 | 2025-05-14 | EirGen Pharma Ltd. | Methods and compositions for reducing parathyroid levels |
| WO2012076429A1 (en) * | 2010-12-06 | 2012-06-14 | Dsm Ip Assets B.V. | Treating conditions associated with increased eotaxin with 25-hydroxyvitamin d3 |
| CN103141433A (zh) * | 2013-03-07 | 2013-06-12 | 青岛农业大学 | 维生素a临界缺乏家禽动物模型的构建方法 |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| KR20170047265A (ko) * | 2014-08-07 | 2017-05-04 | 옵코 아일랜드 글로벌 홀딩스 리미티드 | 25-하이드록시비타민 d를 이용한 보조요법 |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| US20160131574A1 (en) * | 2014-11-06 | 2016-05-12 | The Chinese University Of Hong Kong | Method for screening vitamin d insufficiency using skin colourimetry |
| EP3053598A1 (en) | 2015-02-06 | 2016-08-10 | Faes Farma, S.A. | Calcifediol soft capsules |
| BR112018008186B1 (pt) * | 2015-11-20 | 2021-11-23 | Société des Produits Nestlé S.A. | Composição que compreende micelas de proteína de soro de leite, e seus usos |
| SG10201913863TA (en) | 2016-03-28 | 2020-03-30 | Opko Ireland Global Holdings Limited | Methods of vitamin d treatment |
| KR20200140284A (ko) | 2018-04-03 | 2020-12-15 | 옵코 아일랜드 글로벌 홀딩스 리미티드 | 비만대사 수술 환자에서의 칼시페디올의 용도 |
| JP2022519789A (ja) * | 2019-02-06 | 2022-03-24 | エアジェン ファーマ リミテッド | カルシフェジオールを用いた副甲状腺機能亢進症の進行を制御する方法、およびそれに使用するための組成物 |
| EP3708171A1 (en) * | 2019-03-11 | 2020-09-16 | Roger Bouillon | Treatment of vitamin d deficiency with 25(oh) vitamin d in critically ill patients |
| WO2021204812A2 (en) | 2020-04-07 | 2021-10-14 | Carbogen Amcis B.V. | Novel use of 25-hydroxyvitamin d |
| CN114748486A (zh) * | 2022-03-25 | 2022-07-15 | 南京盛德生物科技研究院有限公司 | 一种含有维生素k2改善心血管钙化的药物组合物及其制备方法与应用 |
| WO2025094144A1 (en) | 2023-11-02 | 2025-05-08 | Eirgen Pharma Ltd. | Controlling loss of kidney function |
Family Cites Families (250)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3565924A (en) | 1968-07-01 | 1971-02-23 | Wisconsin Alumni Res Found | 25-hydroxycholfcalciferol |
| US3833622A (en) | 1969-03-17 | 1974-09-03 | Upjohn Co | Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds |
| US3974272A (en) | 1972-09-01 | 1976-08-10 | Merck & Co., Inc. | Palatable cholestyramine coacervate compositions |
| US3880894A (en) | 1974-05-24 | 1975-04-29 | Wisconsin Alumni Res Found | 1,25-Dihydroxyergocalciferol |
| US4004003A (en) | 1974-08-28 | 1977-01-18 | The Upjohn Company | 25-Hydroxycalciferol compounds for treatment of steroid-induced osteoporosis |
| US4230701A (en) | 1979-03-21 | 1980-10-28 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
| US4335120A (en) | 1979-03-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
| JPS55139320A (en) | 1979-04-16 | 1980-10-31 | Teijin Ltd | Bone metabolism regulator |
| US4338312A (en) * | 1981-05-11 | 1982-07-06 | Wisconsin Alumni Research Foundation | Method for preventing parturient paresis in dairy cattle |
| US4442093A (en) | 1981-05-15 | 1984-04-10 | Kureha Kagaku Kogyo Kabushiki Kaisha | Method for administering 24,25-dihydroxycholecalciferol to persons suffering from hypercalcemia |
| JPS57188520A (en) | 1981-05-15 | 1982-11-19 | Kureha Chem Ind Co Ltd | Antihyperkalemia |
| JPS5832823A (ja) * | 1981-08-20 | 1983-02-25 | Chugai Pharmaceut Co Ltd | 脱癌剤 |
| JPS58206524A (ja) | 1982-05-26 | 1983-12-01 | Kureha Chem Ind Co Ltd | 抗腫瘍剤 |
| US4448721A (en) | 1982-09-20 | 1984-05-15 | Wisconsin Alumni Research Foundation | Hydroxyvitamin D2 compounds and process for preparing same |
| US4721613A (en) | 1982-12-13 | 1988-01-26 | Alza Corporation | Delivery system comprising means for shielding a multiplicity of reservoirs in selected environment of use |
| JPS59155309A (ja) | 1983-02-22 | 1984-09-04 | Teijin Ltd | 活性型ビタミンｄ↓３類組成物 |
| US4684524A (en) | 1984-03-19 | 1987-08-04 | Alza Corporation | Rate controlled dispenser for administering beneficial agent |
| US4555364A (en) | 1984-11-01 | 1985-11-26 | Wisconsin Alumni Research Foundation | Method for preparing 1-hydroxyvitamin D compounds |
| US4695591A (en) | 1985-03-29 | 1987-09-22 | Schering Corporation | Controlled release dosage forms comprising hydroxypropylmethylcellulose |
| US4668517A (en) | 1985-04-04 | 1987-05-26 | Norwich Eaton Pharmaceuticals, Inc. | Furazolidone dosage form |
| DE3676235D1 (de) | 1985-06-04 | 1991-01-31 | Teijin Ltd | Arzneizubereitung mit verzoegerter wirkstoffabgabe. |
| JPS61293911A (ja) | 1985-06-24 | 1986-12-24 | Teisan Seiyaku Kk | 徐放化製剤 |
| US5167965A (en) | 1987-02-09 | 1992-12-01 | The Dow Chemical Company | Palatable cholestyramine granules, tablets and methods for preparation thereof |
| US4892821A (en) | 1987-07-08 | 1990-01-09 | Taisho Pharmaceutical Co., Ltd. | Method for preparing vitamin D compounds |
| US4997824A (en) | 1987-07-22 | 1991-03-05 | Teva Pharmaceutical Industries Ltd. | Combination of cholecalciferol derivatives for the treatment of renal bone disease |
| US5104864A (en) * | 1988-08-02 | 1992-04-14 | Bone Care International, Inc. | Method for treating and preventing loss of bone mass |
| US5602116A (en) | 1988-08-02 | 1997-02-11 | Bone Care International, Inc. | Method for treating and preventing secondary hyperparathyroidism |
| CA1341408C (en) * | 1988-08-02 | 2002-12-10 | Charles W. Bishop | Method for treating and preventing loss of bone mass |
| US5869473A (en) | 1988-08-02 | 1999-02-09 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| JP2893191B2 (ja) | 1988-11-08 | 1999-05-17 | 武田薬品工業株式会社 | 放出制御性マトリックス剤 |
| JP2525478B2 (ja) | 1989-03-01 | 1996-08-21 | 帝人株式会社 | 安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤 |
| JPH02240024A (ja) | 1989-03-13 | 1990-09-25 | Ss Pharmaceut Co Ltd | 活性型ビタミンｄ↓３類製剤用組成物 |
| US5026559A (en) | 1989-04-03 | 1991-06-25 | Kinaform Technology, Inc. | Sustained-release pharmaceutical preparation |
| GB9004544D0 (en) | 1990-03-01 | 1990-04-25 | Leo Pharm Prod Ltd | Novel treatment ii |
| JP2845342B2 (ja) | 1990-04-28 | 1999-01-13 | 大正製薬株式会社 | ビタミンｄ▲下３▼誘導体含有固形製剤組成物 |
| JPH04198129A (ja) | 1990-11-28 | 1992-07-17 | Sumitomo Pharmaceut Co Ltd | 活性型ビタミンｄ↓３類含有組成物 |
| JP2893140B2 (ja) | 1990-11-30 | 1999-05-17 | エスエス製薬株式会社 | 安定なビタミンｄ製剤 |
| JPH04288016A (ja) | 1991-03-14 | 1992-10-13 | Tokai Capsule Kk | 活性型ビタミンｄ３類軟カプセル剤の製造方法 |
| ATE144424T1 (de) | 1991-04-09 | 1996-11-15 | Takeda Chemical Industries Ltd | Stabilisiertes vitamin d arzneimittel |
| US5693615A (en) | 1991-06-05 | 1997-12-02 | The Procter & Gamble Company | Therapeutic compositions for osteoinduction |
| AU667815B2 (en) * | 1991-06-05 | 1996-04-18 | Procter & Gamble Company, The | Therapeutic compositions for osteoinduction |
| US6011068A (en) | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6001884A (en) | 1991-08-23 | 1999-12-14 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6031003A (en) | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6313146B1 (en) | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US5266331A (en) | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
| US5472712A (en) | 1991-12-24 | 1995-12-05 | Euroceltique, S.A. | Controlled-release formulations coated with aqueous dispersions of ethylcellulose |
| US5160742A (en) | 1991-12-31 | 1992-11-03 | Abbott Laboratories | System for delivering an active substance for sustained release |
| DK0580968T3 (da) * | 1992-05-20 | 1996-10-14 | Hoffmann La Roche | Fluorerede analoger af vitamin D3 |
| US5795882A (en) | 1992-06-22 | 1998-08-18 | Bone Care International, Inc. | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
| ES2170069T3 (es) | 1992-06-22 | 2002-08-01 | Bone Care Int Inc | 1-alfa-hidroxiprevitamina d para administracion oral. |
| US5354743A (en) | 1992-09-15 | 1994-10-11 | Thys Jacobs Susan | Method for the treatment of premenstrual syndrome with vitamin D |
| US5431917A (en) | 1992-10-08 | 1995-07-11 | Japan Elanco Company, Ltd. | Hard capsule for pharmaceutical drugs and method for producing the same |
| US5342626A (en) | 1993-04-27 | 1994-08-30 | Merck & Co., Inc. | Composition and process for gelatin-free soft capsules |
| JP2684587B2 (ja) | 1993-06-21 | 1997-12-03 | 呉羽化学工業株式会社 | 腎性骨異栄養症における骨量減少抑制剤 |
| US6121469A (en) | 1993-12-23 | 2000-09-19 | The Regents Of The University Of California | Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs |
| JPH07242550A (ja) | 1994-03-02 | 1995-09-19 | Teijin Ltd | 二次性副甲状腺機能亢進症治療剤 |
| IL110117A0 (en) | 1994-06-24 | 1994-10-07 | Univ Ben Gurion | Pharmaceutical compositions comprising vitamin-d analogs |
| SE9402422D0 (sv) | 1994-07-08 | 1994-07-08 | Astra Ab | New beads for controlled release and a pharmaceutical preparation containing the same |
| WO1996003113A1 (en) | 1994-07-22 | 1996-02-08 | G.D. Searle & Co. | Self-emulsifying drug delivery system |
| JPH0892098A (ja) | 1994-09-27 | 1996-04-09 | Teijin Ltd | 肺結核治療剤 |
| ES2234768T3 (es) | 1994-10-21 | 2005-07-01 | Nps Pharmaceuticals, Inc. | Compuestos capaces de modular la actividad del receptor de calcio. |
| US5756123A (en) | 1994-12-01 | 1998-05-26 | Japan Elanco Co., Ltd. | Capsule shell |
| US20020183288A1 (en) | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US6242434B1 (en) | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US20040043971A1 (en) | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US6376479B1 (en) | 1995-04-03 | 2002-04-23 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| NZ319819A (en) | 1995-09-21 | 2000-02-28 | Wisconsin Alumni Res Found | Calcitriol derivatives and their uses |
| DE19549243A1 (de) | 1995-12-21 | 1997-06-26 | Schering Ag | Pharmazeutische Präparate enthaltend Clathrate von Cyclodextrinen und nichtnatürliche Vitamin D-Analoga |
| NO971934L (no) | 1996-05-23 | 1997-11-24 | Hoffmann La Roche | Flourinerte vitamin D3 -analoger |
| US5939408A (en) | 1996-05-23 | 1999-08-17 | Hoffman-La Roche Inc. | Vitamin D3 analogs |
| ATE226078T1 (de) | 1996-08-26 | 2002-11-15 | Takeda Chemical Industries Ltd | Pharmazeutische zusammensetzung enthaltend ein osteogenese foerderndes mittel und ein polyethylen-glycol |
| US5958451A (en) | 1996-09-03 | 1999-09-28 | Yung Shin Pharm Ind. Co., Ltd. | Process for producing porous, controlled-release capsules and encapsulated composition |
| US5976784A (en) * | 1996-09-20 | 1999-11-02 | Wisconsin Alumni Research Foundation | Calcitriol derivatives and their uses |
| DE69730982T2 (de) | 1996-10-28 | 2005-09-01 | General Mills, Inc., Minneapolis | Einbettung und einkapselung von teilchen zur kontrollierten abgabe |
| US8828432B2 (en) | 1996-10-28 | 2014-09-09 | General Mills, Inc. | Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles |
| JPH10158171A (ja) | 1996-12-02 | 1998-06-16 | Kita:Kk | ビタミンｄ化合物を配合した眼内投与剤 |
| US6503893B2 (en) | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
| US20020128240A1 (en) | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
| US20030129194A1 (en) | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
| US6034075A (en) | 1997-03-20 | 2000-03-07 | The Trustees Of Columbia University In The City Of New York | Method of treating polycystic ovarian syndrome |
| US5872113A (en) | 1997-05-16 | 1999-02-16 | Syntex (U.S.A.) Inc. | Fluorinated vitamin D3 analogs |
| AU8293498A (en) | 1997-07-02 | 1999-01-25 | Euro-Celtique S.A. | Stabilized sustained release tramadol formulations |
| JPH1175863A (ja) | 1997-07-10 | 1999-03-23 | Kyowa Hakko Kogyo Co Ltd | ２５−ヒドロキシビタミンＤ３−１α−水酸化酵素および該酵素をコードするＤＮＡ |
| US6096876A (en) | 1997-08-06 | 2000-08-01 | Shriners Hospitals For Children | 1-α-hydroxylase materials and methods |
| AU9376998A (en) | 1997-09-02 | 1999-03-22 | Johns Hopkins University School Of Medicine, The | Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders |
| US5919986A (en) | 1997-10-17 | 1999-07-06 | Hoffmann-La Roche Inc. | D-homo vitamin D3 derivatives |
| JPH11158074A (ja) | 1997-12-03 | 1999-06-15 | Hayashi Tomie | 高アミノ酸付加活性型ビタミンｄ強化組成物 |
| US20030059471A1 (en) | 1997-12-15 | 2003-03-27 | Compton Bruce Jon | Oral delivery formulation |
| JP2002507415A (ja) | 1998-03-25 | 2002-03-12 | キュタノジェン， インコーポレイテッド | 癌の予防および処置のための方法 |
| US6521608B1 (en) | 1998-03-27 | 2003-02-18 | Oregon Health & Science University | Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders |
| US6197340B1 (en) | 1998-05-28 | 2001-03-06 | Medical Research Institute | Controlled release lipoic acid |
| US8133694B2 (en) | 1998-06-25 | 2012-03-13 | Immundiagnostik Ag | Functional vitamin D derivatives and method of determining 25-hydroxy- and 1α, 25-dihydroxy vitamin D |
| US6214376B1 (en) | 1998-08-25 | 2001-04-10 | Banner Pharmacaps, Inc. | Non-gelatin substitutes for oral delivery capsules, their composition and process of manufacture |
| SI1039882T1 (sl) | 1998-08-27 | 2011-01-31 | Pfizer Health Ab | Terapevtska formulacija za dajanje tolterodina s kontroliranim sproščanjem |
| SE9803871D0 (sv) | 1998-11-11 | 1998-11-11 | Pharmacia & Upjohn Ab | Therapeutic method and formulation |
| US6139875A (en) | 1998-09-29 | 2000-10-31 | Eastman Chemical Company | Aqueous enteric coating composition and low gastric permeability enteric coating |
| JP2002525311A (ja) | 1998-10-01 | 2002-08-13 | エラン ファーマ インターナショナル，リミティド | 徐放性ナノ粒子組成物 |
| AR020729A1 (es) | 1998-10-09 | 2002-05-29 | Gen Mills Marketing Inc | Un metodo para el encapsulado de componentes sensibles en una matriz para obtener particulas discretas y estables durante su almacenamiento |
| JP3449253B2 (ja) | 1998-10-29 | 2003-09-22 | シオノギクオリカプス株式会社 | 硬質カプセルの製造方法 |
| JP2000206312A (ja) | 1998-11-12 | 2000-07-28 | Olympus Optical Co Ltd | 光学素子 |
| JP2002532406A (ja) | 1998-12-17 | 2002-10-02 | アルザ・コーポレーション | 複合コーティングによる液体充填ゼラチンカプセルの放出制御システムへの変換 |
| US6342249B1 (en) | 1998-12-23 | 2002-01-29 | Alza Corporation | Controlled release liquid active agent formulation dosage forms |
| US6432936B1 (en) | 1999-01-20 | 2002-08-13 | Wisconsin Alumni Research Foundation | Crystalline 1α-hydroxyvitamin D2 and method of purification thereof |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| EP1180035B1 (en) | 1999-04-01 | 2006-11-02 | Johns Hopkins University | NON-CALCEMIC, ANTIPROLIFERATIVE, TRANSCRIPTIONALLY ACTIVE SULFUR-CONTAINING ANALOGS OF 1-alpha, 25-DIHYDROXY VITAMIN D3 |
| US7648826B1 (en) | 1999-04-02 | 2010-01-19 | The Regents Of The University Of California | Detecting CYP24 expression level as a marker for predisposition to cancer |
| DE19916419B4 (de) | 1999-04-08 | 2005-06-16 | Schering Ag | Kombinationspräparat aus Vitamin-D-Metaboliten oder Vitamin-D-Analoga und einem Östrogenpartialagonisten zur Behandlung von Osteoporose |
| WO2000072831A1 (en) | 1999-05-27 | 2000-12-07 | Drugtech Corporation | Nutritional formulations |
| US6340473B1 (en) | 1999-07-07 | 2002-01-22 | R.P. Scherer Technologies, Inc. | Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same |
| US6274169B1 (en) | 1999-08-02 | 2001-08-14 | Abbott Laboratories | Low oxygen content compostions of 1α, 25-dihydroxycholecalciferol |
| US6051567A (en) | 1999-08-02 | 2000-04-18 | Abbott Laboratories | Low oxygen content compositions of 1α, 25-dihydroxycholecalciferol |
| CN1179725C (zh) | 1999-08-31 | 2004-12-15 | 中外制药株式会社 | 软胶囊剂 |
| US20060034937A1 (en) | 1999-11-23 | 2006-02-16 | Mahesh Patel | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| GB0007419D0 (en) * | 2000-03-27 | 2000-05-17 | Smithkline Beecham Gmbh | Composition |
| US6375981B1 (en) | 2000-06-01 | 2002-04-23 | A. E. Staley Manufacturing Co. | Modified starch as a replacement for gelatin in soft gel films and capsules |
| WO2002006218A2 (en) | 2000-07-18 | 2002-01-24 | Bone Care International, Inc. | STABILIZED 1α-HYDROXY VITAMIN D |
| US6491950B1 (en) | 2000-08-07 | 2002-12-10 | Kos Pharmaceuticals, Inc. | Controlled release pharmaceutical composition |
| CA2419825C (en) | 2000-08-29 | 2010-05-25 | Nisshin Kasei Co., Ltd. | Hard capsule made from a polymer or copolymer formed by polymerizing at least one polymerizable vinyl monomer in the presence of polyvinylalcohol or a derivative thereof |
| US6887493B2 (en) | 2000-10-25 | 2005-05-03 | Adi Shefer | Multi component controlled release system for oral care, food products, nutraceutical, and beverages |
| US6733783B2 (en) | 2000-10-30 | 2004-05-11 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
| US6479649B1 (en) | 2000-12-13 | 2002-11-12 | Fmc Corporation | Production of carrageenan and carrageenan products |
| JP2002302447A (ja) | 2001-04-03 | 2002-10-18 | Shimizu Pharmaceutical Co Ltd | 局所投与用癌治療剤 |
| KR20030096392A (ko) | 2001-05-15 | 2003-12-24 | 워너-램버트 캄파니 엘엘씨 | 나트륨 페니토인 제형 제조를 위한 압축 방법 |
| WO2003004003A1 (fr) | 2001-07-05 | 2003-01-16 | Wakunaga Pharmaceutical Co., Ltd. | Capsules molles |
| US6870833B2 (en) | 2001-07-20 | 2005-03-22 | Net2Phone, Inc. | Active voice messaging |
| US7166585B2 (en) | 2001-08-22 | 2007-01-23 | Cytochroma Inc. | 24-Sulfur-substituted analogs of 1α,25-dihydroxy vitamin D3 |
| US7033996B2 (en) | 2001-08-31 | 2006-04-25 | University Of Medicine & Dentistry Of New Jersey | Method for the treatment of vitamin D related disease |
| DE10149674A1 (de) | 2001-10-09 | 2003-04-24 | Apogepha Arzneimittel Gmbh | Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung |
| ES2283593T3 (es) | 2001-10-12 | 2007-11-01 | Johns Hopkins University | Analogos de oxima poco calcemicos de 1alfa,25-dihidroxi vitamina d3. |
| US6524788B1 (en) | 2001-11-02 | 2003-02-25 | Thomas L. Cantor | Methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism |
| US7056655B2 (en) | 2001-11-02 | 2006-06-06 | Scantibodies Laboratory, Inc. | Methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism |
| ITMI20012366A1 (it) | 2001-11-09 | 2003-05-09 | Farmatron Ltd | Sistemi terapeutici stabilizzati a rilascio immediato e/o modificato per la somministrazione orale di principi attivi e/o eccipienti e/o ali |
| US7255921B2 (en) | 2001-11-22 | 2007-08-14 | Morishita Jintan Co., Ltd. | Non-gelatinous capsule shell composition and a capsule formed from the same |
| GB0128415D0 (en) | 2001-11-27 | 2002-01-16 | Univ Sheffield | Medicaments |
| CN100391464C (zh) | 2001-12-03 | 2008-06-04 | 诺瓦西股份有限公司 | 含活性维生素d化合物的药物组合物 |
| US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| FR2829142B1 (fr) | 2001-12-27 | 2004-02-13 | Ulice | Composition filmogene d'heteroxylanes pour la fabrication de capsules ainsi obtenues |
| US7632518B2 (en) * | 2002-01-15 | 2009-12-15 | Dsm Ip Assets B.V. | 25-hydroxy vitamin D3 compositions |
| US6949256B2 (en) | 2002-01-18 | 2005-09-27 | Banner Pharmacaps, Inc. | Non-gelatin capsule shell formulation |
| NO20021592D0 (no) | 2002-04-04 | 2002-04-04 | Fmc Biopolymer As | Polysakkaridkapsler og fremgangsmåte ved fremstilling derav |
| US20050176685A1 (en) * | 2002-04-05 | 2005-08-11 | Daifotis Anastasia G. | Method for inhibiting bone resorption with an alendronate and vitamin d formulation |
| CA2481486C (en) | 2002-04-10 | 2012-06-12 | Fred H. Miller | Multi-phase, multi-compartment capsular system |
| CA2484244A1 (en) | 2002-05-02 | 2003-11-13 | Cytochroma Inc. | Stable cytochrome p450 24 (cyp24) expressing cell line and methods and uses thereof |
| ATE543796T1 (de) | 2002-06-13 | 2012-02-15 | Univ Johns Hopkins | 24-sulfoximine vitamin d3 derivate |
| PL374922A1 (en) | 2002-07-05 | 2005-11-14 | Temrel Limited | Controlled release composition |
| AR040672A1 (es) | 2002-07-25 | 2005-04-13 | Glaxo Group Ltd | Forma de dosificacion farmaceutica multicomponenete, cuerpo apropiado para ser utilizado en la misma y procedimiento para prepararla |
| WO2004010981A1 (en) | 2002-07-29 | 2004-02-05 | Alza Corporation | Methods and dosage forms for controlled delivery of paliperidone |
| US8268352B2 (en) | 2002-08-05 | 2012-09-18 | Torrent Pharmaceuticals Limited | Modified release composition for highly soluble drugs |
| AU2002368245A1 (en) | 2002-09-26 | 2004-04-19 | Young-Kweon Choi | Matrix type patch for transdermal administration of vitamin d analog and the use thereof |
| US20050101576A1 (en) | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| US8999372B2 (en) | 2002-11-14 | 2015-04-07 | Cure Pharmaceutical Corporation | Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use |
| JP2004175750A (ja) * | 2002-11-28 | 2004-06-24 | Kose Corp | 皮膚障害抑制剤、皮膚障害改善剤、及びそれらを含有する皮膚外用剤 |
| US20050026877A1 (en) | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| JP2006514695A (ja) | 2002-12-16 | 2006-05-11 | テバ ファーマシューティカル インダストリーズ リミティド | ビタミンｄ誘導体の前用量投与によってアレンドロネート又は他のビスフォスフォネートの全体利用効率を高める方法 |
| DE20321698U1 (de) | 2002-12-16 | 2008-12-24 | Teva Pharmaceutical Industries Ltd. | Medikament zur Erhöhung der Bioverfügbarkeit von Alendronat oder einem anderen Bisphosphonat durch Verabreichen einer Vordosis eines Vitamin-D-Derivats |
| WO2004054968A2 (en) | 2002-12-18 | 2004-07-01 | Johns Hopkins University | 25-so2-substituted analogs of 1alpha, 25-dihydroxyvitamin d3 (calcitriol) |
| DE602004015246D1 (de) | 2003-02-11 | 2008-09-04 | Alza Corp | Verfahren und dosierformen mit modifizierter schichtgeometrie |
| US7816341B2 (en) | 2003-04-14 | 2010-10-19 | Fmc Corporation | Homogeneous, thermoreversible gel containing reduced viscosity carrageenan and products made therefrom |
| BRPI0409329A (pt) | 2003-04-14 | 2006-04-25 | Fmc Corp | processo para fabricar pelìculas de gel termorreversìveis, homogêneas, pelìcula homogênea, termorreversìvel, de sólidos altos, umidade baixa, processo para fabricar cápsulas moles, cápsulas moles, processo para fabricar uma forma de dosagem sólida, forma sólida, processo para preparar uma sistema de liberação de pelìcula de gel homogênea, e, sistema de liberação |
| EP1677802A2 (en) | 2003-04-30 | 2006-07-12 | Bioxell S.p.a. | 1,3 aclyated 24-keto-vitamin d3 compounds and methods of use thereof |
| ES2523454T3 (es) | 2003-06-16 | 2014-11-26 | Solx, Inc. | Derivación para el tratamiento del glaucoma |
| DK1635787T3 (da) | 2003-06-26 | 2012-03-26 | Control Delivery Sys Inc | Bioeroderbare lægemiddelafgivelsessystemer med forhalet frigivelse |
| AU2003903382A0 (en) | 2003-07-03 | 2003-07-17 | Medvet Science Pty Ltd | Inhibition of calcitriol mediated cyp24 induction screening for compounds therefor and uses thereof |
| KR20060105735A (ko) | 2003-07-04 | 2006-10-11 | 니코메드 덴마크 에이피에스 | 경구용 부갑상선 호르몬 함유 약학 조성물 |
| US20050148557A1 (en) | 2003-07-29 | 2005-07-07 | Jin Tian | Use of Vitamin Ds to treat kidney disease |
| US20050124591A1 (en) | 2003-07-29 | 2005-06-09 | Jin Tian | Use of vitamin Ds to treat kidney disease |
| ES2737348T3 (es) | 2003-09-12 | 2020-01-13 | Amgen Inc | Formulación de disolución rápida que comprende cinacalcet HCl |
| EP1694333A2 (en) | 2003-11-25 | 2006-08-30 | Deltanoid Pharmaceuticals, Inc. | Methods for reducing body fat using vitamin d compounds |
| US7427670B2 (en) | 2003-12-19 | 2008-09-23 | Cytochroma Inc. | Cytochrome P450 24 (CYP24) monoclonal antibody and methods and uses thereof |
| US20060009425A1 (en) | 2004-05-28 | 2006-01-12 | Leticia Delgado-Herrera | Oral formulations of paricalcitol |
| WO2005123120A1 (en) | 2004-06-16 | 2005-12-29 | Smart Drug Systems Inc. | Sustained release vaccine composition |
| US20050287213A1 (en) | 2004-06-28 | 2005-12-29 | Wong Patrick S | Dosage forms for low solubility and or low dissolution rate free acid pharmaceutical agents |
| US20060019933A1 (en) | 2004-07-22 | 2006-01-26 | David Boardman | Process for preparing stabilized vitamin D |
| CN1993112A (zh) | 2004-07-29 | 2007-07-04 | 赛诺菲-安万特 | 用于具有高度pH依赖性溶解度的活性成分的控释的药物多层片剂 |
| US8231896B2 (en) | 2004-11-08 | 2012-07-31 | R.P. Scherer Technologies, Llc | Non-gelatin soft capsule system |
| CN101316865B (zh) | 2004-12-03 | 2012-01-25 | 科学与工业研究委员会 | 由半精制κ角叉菜聚糖制备生物可降解膜的方法 |
| US8318210B2 (en) | 2005-02-28 | 2012-11-27 | Neos Therapeutics, Lp | Compositions and methods of making sustained release liquid formulations |
| US7745226B2 (en) | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
| RU2623206C2 (ru) | 2005-04-15 | 2017-06-22 | Кларус Терапьютикс, Инк. | Фармацевтические системы доставки для гидрофобных лекарственных средств и композиций, их содержащих |
| US20060257481A1 (en) | 2005-04-21 | 2006-11-16 | Decode Genetics Ehf. | Sustained release formulation and dosing schedule of leukotriene synthesis inhibitor for human therapy |
| US9205047B2 (en) | 2005-04-25 | 2015-12-08 | The Governing Council Of The University Of Toronto | Tunable sustained release of a sparingly soluble hydrophobic therapeutic agent from a hydrogel matrix |
| US20080134937A1 (en) | 2005-05-25 | 2008-06-12 | Joo Hwan Yang | Cellulose hard capsule enhancing mechanical film strength |
| AR055099A1 (es) | 2005-07-28 | 2007-08-08 | Alza Corp | Formulaciones liquidas para la administracion controlada de derivados de bencisoxazol |
| JP2009509992A (ja) | 2005-09-29 | 2009-03-12 | エフ．ホフマン−ラ ロシュ アーゲー | ２５−ヒドロキシビタミンｄに対する抗体 |
| ITFI20050206A1 (it) | 2005-09-30 | 2007-04-01 | Valpharma Sa | Composizione farmaceutica a rilascio controllato di venlafaxina cloridrato, e processo per la sua preparazione |
| WO2007047327A2 (en) * | 2005-10-12 | 2007-04-26 | Proventiv Therapeutics, Llc | Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency |
| EP1951208A2 (en) | 2005-10-26 | 2008-08-06 | Banner Pharmacaps Inc. | Lipophilic vehicle-based dual controlled release matrix system as capsule fill |
| WO2007050975A2 (en) | 2005-10-26 | 2007-05-03 | Banner Pharmacaps, Inc. | Hydrophilic vehicle-based dual controlled release matrix system as capsule fill |
| KR101372110B1 (ko) | 2005-11-01 | 2014-03-14 | 씨피 켈코 유에스, 인코포레이티드 | 고점도 디우탄 검 및 제조 방법 |
| WO2007068287A1 (en) | 2005-12-15 | 2007-06-21 | Laboratoria Qualiphar | Sustained release vitamin preparation |
| MXPA05014091A (es) | 2005-12-20 | 2007-06-20 | Leopoldo De Jesus Espinosa Abdala | Composiciones farmaceuticas que comprenden derivados de esteroides sinteticos, minerales y el metabolito activo de la vitamina d, 1,25(oh)2d3 (calcitriol) para la prevencion y tratamiento de la osteoporosis y el control de los sintomas de la menopaus |
| EP1987164A2 (en) | 2006-01-31 | 2008-11-05 | Health Research, Inc. | Method for identifying altered vitamin d metabolism |
| US7528122B2 (en) * | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| HUE056937T2 (hu) | 2006-02-03 | 2022-04-28 | Opko Renal Llc | A D-vitamin elégtelenség és hiány kezelése 25-hidroxivitamin D2-vel és 25-hidroxivitamin D3-mal |
| GB0606426D0 (en) | 2006-03-30 | 2006-05-10 | Novartis Ag | Benzimidazole derivatives |
| WO2007146004A1 (en) | 2006-06-06 | 2007-12-21 | Fmc Corporation | Kappa-2 carrageenan composition and products made therefrom |
| US20080109983A1 (en) | 2006-11-10 | 2008-05-15 | Kegel, Llc | Zero Turning Radius Lane Maintenance Machine |
| LT2679228T (lt) | 2006-06-21 | 2018-05-10 | Opko Ireland Global Holdings, Ltd. | Terapija naudojant vitamino d atstatymo agentą ir vitamino d hormoninį pakaitinį agentą |
| EP1912400A1 (en) | 2006-10-10 | 2008-04-16 | Matsushita Electric Industrial Co., Ltd. | Method and apparatus for mobile IP route optimization |
| EP3594248B1 (en) | 2006-10-27 | 2021-08-04 | Capsugel Belgium NV | Hydroxypropyl methyl cellulose hard capsules and process of manufacture |
| US8501717B2 (en) | 2007-02-09 | 2013-08-06 | Merck, Sharp & Dohme Corp. | Methods to treat and/or prevent mucositis |
| US8491937B2 (en) | 2007-02-15 | 2013-07-23 | Wyeth Llc | Stability in vitamin and mineral supplements |
| EP2135345A4 (en) | 2007-03-20 | 2016-12-14 | Electrolock Inc | ROEBEL WINDING WITH CONDUCTIVE FELT |
| WO2008116133A1 (en) | 2007-03-21 | 2008-09-25 | Duke University | Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture |
| US8592401B2 (en) | 2007-04-25 | 2013-11-26 | Proventiv Therapeutics, Llc | Methods and compounds for vitamin D therapy |
| CA2683628C (en) | 2007-04-25 | 2018-03-06 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
| EP2148683A4 (en) | 2007-04-25 | 2012-09-12 | Proventiv Therapeutics Llc | SAFE AND EFFECTIVE METHOD OF TREATING AND PREVENTING SECONDARY HYPERPARATHYROIDIA IN CHRONIC RENAL DISEASES |
| ES2401205T3 (es) | 2007-04-25 | 2013-04-17 | Cytochroma Inc. | Composiciones de orales de liberación controlada que comprende un compuesto de vitamina D y un soporte céreo |
| US20090004284A1 (en) | 2007-06-26 | 2009-01-01 | Watson Pharmaceuticals, Inc. | Controlled release tamsulosin hydrochloride formulation |
| KR100836960B1 (ko) | 2007-09-07 | 2008-06-10 | 주식회사 서울제약 | 새로운 나이아신 제어방출형 제제 |
| EP2042165A1 (de) | 2007-09-28 | 2009-04-01 | Swiss Caps Rechte und Lizenzen AG | Hot-Melt-Befüllte Weichkapseln |
| US20090155355A1 (en) | 2007-12-12 | 2009-06-18 | Multi Formulations Ltd. | Particles in a capsule |
| US20110039811A1 (en) | 2008-02-12 | 2011-02-17 | Neil Robert Buck | Treating hyperglycemia with 25-hydroxyvitamin d3 |
| AU2009214048A1 (en) * | 2008-02-13 | 2009-08-20 | Dsm Ip Assets B.V. | Treating hypertension with 25-hydroxyvitamin D3 |
| EP2249842B2 (en) | 2008-02-13 | 2025-03-05 | DSM IP Assets B.V. | Use of 25-hydroxy-vitamin d3 and vitamin d to affect human muscle physiology |
| CN101951920A (zh) | 2008-02-13 | 2011-01-19 | 帝斯曼知识产权资产管理有限公司 | 维生素d和25-羟基维生素d3的组合 |
| KR20150103336A (ko) | 2008-02-13 | 2015-09-09 | 디에스엠 아이피 어셋츠 비.브이. | 골 무기질 밀도를 개선시키고 골다공증을 치료하기 위한 25-하이드록시-비타민 ｄ3과 비타민 ｄ3의 조합된 용도 |
| US8962239B2 (en) | 2008-04-02 | 2015-02-24 | Opko Renal, Llc | Methods useful for vitamin D deficiency and related disorders |
| US8759328B2 (en) | 2008-07-24 | 2014-06-24 | Wisconsin Alumni Research Foundation | Once-a-week administration of 25-hydroxy vitamin D3 to sustain elevated steady-state pharmacokinetic blood concentration |
| SI2341899T1 (sl) | 2008-09-24 | 2015-04-30 | Evonik Roehm Gmbh | Od pH odvisen opioidni farmacevtski sestavek z nadzorovanim sproščanjem z odpornostjo na vpliv etanola |
| ES2425762T3 (es) | 2008-10-27 | 2013-10-17 | Roquette Freres | Polímero insoluble en agua: revestimientos de película a base de derivados de almidón modificado para la liberación dirigida al colon |
| SG171444A1 (en) | 2009-01-23 | 2011-07-28 | Acraf | Controlled release pharmaceutical or food formulation and process for its preparation |
| CH700543A2 (de) | 2009-03-03 | 2010-09-15 | Innogel Ag | Film auf Basis von Stärke. |
| BR112012005453B1 (pt) | 2009-09-10 | 2019-09-24 | DuPont Nutrition USA, Inc. | Cápsula sem costura, e, método para preparar uma cápsula de alginato sem costura |
| IT1396937B1 (it) | 2009-11-26 | 2012-12-20 | Bruzzese | Formulazioni di bisfosfonati e vitamina d idonee alla somministrazione intermittente per via intramuscolare e sottocutanea |
| FR2953139B1 (fr) | 2009-11-27 | 2012-04-13 | Servier Lab | Composition pharmaceutique comprenant un sel de strontium, de la vitamine d et une cyclodextrine |
| US8101203B2 (en) | 2010-01-14 | 2012-01-24 | Karl Wei Cao | Hard capsule composition and method of use |
| US8101204B2 (en) | 2010-01-14 | 2012-01-24 | Karl Wei Cao | Hard capsule composition and method of use |
| WO2011095388A1 (en) | 2010-02-04 | 2011-08-11 | Synthon Bv | Tolterodine bead |
| EP3636280B1 (en) | 2010-03-29 | 2025-05-14 | EirGen Pharma Ltd. | Methods and compositions for reducing parathyroid levels |
| EP2591354B1 (en) | 2010-07-07 | 2016-09-07 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| KR20120005228A (ko) | 2010-07-08 | 2012-01-16 | 주식회사 네비팜 | 골다공증 치료용 비스포스폰산 함유 장용 약학조성물 및 그의 제조방법 |
| BR112013002721B8 (pt) | 2010-08-04 | 2021-05-25 | Scherer Technologies Llc R P | composição formadora de filme para cápsulas moles, cápsulas moles e seu invólucro |
| US20120135103A1 (en) | 2010-11-30 | 2012-05-31 | Mead Johnson Nutrition Company | Staged Infant Feeding Regimen To Promote Healthy Development And Growth |
| WO2012076429A1 (en) | 2010-12-06 | 2012-06-14 | Dsm Ip Assets B.V. | Treating conditions associated with increased eotaxin with 25-hydroxyvitamin d3 |
| CA2821415C (en) | 2010-12-28 | 2017-08-01 | Future Diagnostics B.V. | Release reagent for vitamin d |
| DK2680826T3 (en) | 2011-03-02 | 2017-10-09 | D3 Pharma Ltd | VITAMIN D COMPOSITION |
| WO2012144789A2 (ko) | 2011-04-20 | 2012-10-26 | 주식회사 서흥캅셀 | 붕해도 및 피막 경도를 개선한 비동물성 연질 캡슐 피막 조성물 |
| MX2013012165A (es) | 2011-04-20 | 2014-06-11 | Mico Bio Inc | Composicion y metodo para mejorar una respuesta inmune. |
| CN102771688A (zh) | 2011-05-13 | 2012-11-14 | 富曼实（上海）商贸有限公司 | 可食用液体填充的多糖胶囊 |
| US20130085121A1 (en) | 2011-09-30 | 2013-04-04 | Jianguo Wang | Pharmaceutical compositions comprising phosphate binder, calcium receptor-active compound and/or active vitamin d |
| WO2014029953A1 (en) | 2012-08-21 | 2014-02-27 | Cipla Limited | Hot melt extruded (hme) pharmaceutical composition of cinacalcet |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| PT106978A (pt) | 2013-05-31 | 2014-12-02 | Tecnimede Sociedade Tecnico Medicinal S A | Composição sólida oral contendo ácido ibandrónico e vitamina d |
| EP2815745A1 (en) | 2013-06-21 | 2014-12-24 | Swiss Caps Rechte und Lizenzen AG | Soft shell capsule and process for its manufacture |
| CN103495176B (zh) | 2013-10-26 | 2015-01-28 | 中山市凯博思淀粉材料科技有限公司 | 一种共混挤出法制备淀粉基软胶囊的方法 |
| CN103520133B (zh) | 2013-10-26 | 2015-02-04 | 中山市凯博思淀粉材料科技有限公司 | 一种淀粉基软胶囊的制备方法 |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| KR20170047265A (ko) | 2014-08-07 | 2017-05-04 | 옵코 아일랜드 글로벌 홀딩스 리미티드 | 25-하이드록시비타민 d를 이용한 보조요법 |
-
2008
- 2008-04-25 CA CA2683628A patent/CA2683628C/en active Active
- 2008-04-25 DK DK08837933.4T patent/DK2148684T3/da active
- 2008-04-25 PL PL08837933T patent/PL2148684T3/pl unknown
- 2008-04-25 US US12/597,230 patent/US11752158B2/en active Active
- 2008-04-25 ES ES08837933T patent/ES2403107T3/es active Active
- 2008-04-25 KR KR1020097024309A patent/KR101495578B1/ko active Active
- 2008-04-25 EP EP08837933A patent/EP2148684B1/en active Active
- 2008-04-25 JP JP2010504912A patent/JP5444212B2/ja active Active
- 2008-04-25 WO PCT/IB2008/003480 patent/WO2009047644A2/en not_active Ceased
- 2008-04-25 CN CN200880013367.XA patent/CN101668532B/zh active Active
- 2008-04-25 PT PT88379334T patent/PT2148684E/pt unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101668532B (zh) | 2014-08-20 |
| PT2148684E (pt) | 2013-04-19 |
| CA2683628A1 (en) | 2009-04-16 |
| EP2148684A2 (en) | 2010-02-03 |
| CN101668532A (zh) | 2010-03-10 |
| US20100120728A1 (en) | 2010-05-13 |
| CN104257667A (zh) | 2015-01-07 |
| EP2148684B1 (en) | 2013-01-16 |
| CA2683628C (en) | 2018-03-06 |
| HK1205936A1 (en) | 2015-12-31 |
| WO2009047644A2 (en) | 2009-04-16 |
| WO2009047644A3 (en) | 2009-05-28 |
| CN104257667B (zh) | 2019-06-04 |
| JP2010525050A (ja) | 2010-07-22 |
| PL2148684T3 (pl) | 2013-06-28 |
| KR101495578B1 (ko) | 2015-02-25 |
| JP2014055184A (ja) | 2014-03-27 |
| KR20100017238A (ko) | 2010-02-16 |
| JP5444212B2 (ja) | 2014-03-19 |
| DK2148684T3 (da) | 2013-04-22 |
| JP5855633B2 (ja) | 2016-02-09 |
| US11752158B2 (en) | 2023-09-12 |
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