DK0600079T3 - Oral 1alpha-hydroxyprævitamin D - Google Patents
Oral 1alpha-hydroxyprævitamin DInfo
- Publication number
- DK0600079T3 DK0600079T3 DK93916684T DK93916684T DK0600079T3 DK 0600079 T3 DK0600079 T3 DK 0600079T3 DK 93916684 T DK93916684 T DK 93916684T DK 93916684 T DK93916684 T DK 93916684T DK 0600079 T3 DK0600079 T3 DK 0600079T3
- Authority
- DK
- Denmark
- Prior art keywords
- vitamin
- oral
- hydroxypravitamin
- 1alpha
- hydroxyprevitamin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90188692A | 1992-06-22 | 1992-06-22 | |
PCT/US1993/005961 WO1994000128A1 (en) | 1992-06-22 | 1993-06-22 | ORAL 1α-HYDROXYPREVITAMIN D |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0600079T3 true DK0600079T3 (da) | 2002-04-15 |
Family
ID=25414989
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93916684T DK0600079T3 (da) | 1992-06-22 | 1993-06-22 | Oral 1alpha-hydroxyprævitamin D |
Country Status (11)
Country | Link |
---|---|
US (6) | US5622941A (da) |
EP (1) | EP0600079B1 (da) |
JP (1) | JP3722832B2 (da) |
AT (1) | ATE211387T1 (da) |
AU (2) | AU4645893A (da) |
CA (1) | CA2116238C (da) |
DE (1) | DE69331409T2 (da) |
DK (1) | DK0600079T3 (da) |
ES (1) | ES2170069T3 (da) |
NZ (1) | NZ254424A (da) |
WO (1) | WO1994000128A1 (da) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
US5493027A (en) * | 1993-01-22 | 1996-02-20 | Board Of Regents, The University Of Texas System | Anticonvulsive agents and uses thereof |
US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
US5696103A (en) * | 1995-11-17 | 1997-12-09 | Syntex (U.S.A.) Inc. | Method for treating osteoporosis |
US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
BR9815442A (pt) * | 1997-02-13 | 2001-08-21 | Bone Care Int Inc | Liberação terapêutica dirigida de compostos de vitamina d |
US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
ES2368824T3 (es) | 1998-03-27 | 2011-11-22 | Oregon Health & Science University | Vitamina d y sus análogos en el tratamiento de tumores y otros desórdenes hiperproliferativos. |
DE19916419B4 (de) * | 1999-04-08 | 2005-06-16 | Schering Ag | Kombinationspräparat aus Vitamin-D-Metaboliten oder Vitamin-D-Analoga und einem Östrogenpartialagonisten zur Behandlung von Osteoporose |
US6274169B1 (en) | 1999-08-02 | 2001-08-14 | Abbott Laboratories | Low oxygen content compostions of 1α, 25-dihydroxycholecalciferol |
US6051567A (en) | 1999-08-02 | 2000-04-18 | Abbott Laboratories | Low oxygen content compositions of 1α, 25-dihydroxycholecalciferol |
IL153378A0 (en) * | 2000-07-18 | 2003-07-06 | Bone Care Internat Inc | STABILIZED 1alpha-HYDROXY VITAMIN D |
US7858602B2 (en) | 2000-10-16 | 2010-12-28 | Rodriguez Victorio C | Therapeutic and prophylactic uses of cell specific carbonic anhydrase enzymes in treating aging disorders due to oxidative stress and as growth factors of stem cells |
BR0214679A (pt) * | 2001-12-03 | 2004-12-14 | Novacea Inc | Composições farmacêuticas compreendendo compostos a base de vitamina d ativa |
US20050026871A1 (en) * | 2002-07-17 | 2005-02-03 | Moshe Flashner-Barak | Method of increasing bioavailability of alendronate or other bis-phosphonate by predose administration of vitamin D derivative |
US7566696B2 (en) * | 2002-09-05 | 2009-07-28 | Wisconsin Alumni Research Foundation | Use of calcitonin and calcitonin-like peptides to treat and prevent multiple sclerosis |
US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
US20040162292A1 (en) * | 2002-12-03 | 2004-08-19 | Evenstad Kenneth L. | Multivitamin formulations for promoting healthy collagen, and methods of their use |
US20050020546A1 (en) * | 2003-06-11 | 2005-01-27 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
US20060189586A1 (en) * | 2003-06-11 | 2006-08-24 | Cleland Jeffrey L | Pharmaceutical compositions comprising active vitamin D compounds |
US20050148557A1 (en) * | 2003-07-29 | 2005-07-07 | Jin Tian | Use of Vitamin Ds to treat kidney disease |
US20050244490A1 (en) * | 2003-12-09 | 2005-11-03 | Michael Otto | Dosing methods for beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine antiviral therapy |
US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
US7094775B2 (en) * | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
US20060024376A1 (en) * | 2004-07-30 | 2006-02-02 | The University Of Chicago | Methods and compositions for reducing toxicity associated with leflunomide treatment |
JP2008530121A (ja) * | 2005-02-14 | 2008-08-07 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | 多発性硬化症を治療および予防するためのカルシトニンおよびカルシトニン様ペプチド類の使用 |
JP5303276B2 (ja) * | 2005-10-12 | 2013-10-02 | プロヴェンティヴ セラピュティックス リミテッド ライアビリティ カンパニー | 25−ヒドロキシビタミンd不足および欠乏を治療するための方法および製品 |
CA2882048C (en) * | 2006-02-03 | 2020-03-24 | Proventiv Therapeutics, Llc | Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3 |
DK3357496T3 (da) | 2006-06-21 | 2020-05-11 | Opko Ireland Global Holdings Ltd | Terapi ved brug af vitamin d-repletteringsmiddel og vitamin d-hormonsubstitutionsmiddel |
EP2148683A4 (en) | 2007-04-25 | 2012-09-12 | Proventiv Therapeutics Llc | METHOD FOR THE SAFE AND EFFECTIVE TREATMENT AND PREVENTION OF SECONDARY HYPERPARATHYREOSIS IN CHRONIC KIDNEY DISEASE |
KR101495578B1 (ko) | 2007-04-25 | 2015-02-25 | 사이토크로마 인코포레이티드 | 비타민 d 부족 및 결핍의 치료 방법 |
US8592401B2 (en) | 2007-04-25 | 2013-11-26 | Proventiv Therapeutics, Llc | Methods and compounds for vitamin D therapy |
ES2956794T3 (es) * | 2007-04-25 | 2023-12-28 | Eirgen Pharma Ltd | Liberación controlada de 25-hidroxivitamina D |
EP2281058B1 (en) | 2008-04-02 | 2016-06-29 | Opko Ireland Global Holdings, Ltd. | Methods, compositions, uses, and kits useful for vitamin d deficiency and related disorders |
EP3636280A1 (en) | 2010-03-29 | 2020-04-15 | Opko Ireland Global Holdings, Ltd. | Methods and compositions for reducing parathyroid levels |
US9416102B2 (en) * | 2013-01-23 | 2016-08-16 | Wisconsin Alumni Research Foundation | (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs |
KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 d 방출 제형 |
US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
KR20180123100A (ko) | 2016-03-28 | 2018-11-14 | 옵코 아일랜드 글로벌 홀딩스 리미티드 | 비타민 d 치료 방법 |
CR20210158A (es) | 2018-08-31 | 2021-05-21 | Opko Ireland Global Holdings Ltd | Formas de dosificación pediátricas de vitamina d, métodos de elaboración y uso |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2216719A (en) * | 1935-07-06 | 1940-10-08 | Hartford Nat Bank & Trust Co | Vitamin |
US2434015A (en) * | 1942-11-21 | 1948-01-06 | Du Pont | Stable provitamin d composition |
US4230701A (en) * | 1979-03-21 | 1980-10-28 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
US4335120A (en) * | 1979-03-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
DE3270978D1 (en) * | 1981-07-17 | 1986-06-12 | Duphar Int Res | Method of preparing 1-alpha-hydroxyvitamin d and 1-alpha-hydroxy-previtamin d compounds, and adduct of a previtamin d or tachysterol compound with a suitable dienophile |
JPS5910562A (ja) * | 1982-07-07 | 1984-01-20 | Teijin Ltd | プレ−1α−ヒドロキシコレカルシフエロ−ル類の製造法 |
CH665834A5 (de) * | 1983-05-09 | 1988-06-15 | Wisconsin Alumni Res Found | Verfahren zur herstellung von 1alpha,25-dihydroxyliertem vitamin d(2) und verwandten verbindungen. |
US4505906A (en) * | 1984-01-30 | 1985-03-19 | Wisconsin Alumni Research Foundation | Hydroxyvitamin D2 isomers |
US4684524A (en) * | 1984-03-19 | 1987-08-04 | Alza Corporation | Rate controlled dispenser for administering beneficial agent |
US4728643A (en) * | 1984-11-02 | 1988-03-01 | The General Hospital Corporation | Method of treating psoriasis |
EP0215956A4 (en) * | 1985-03-14 | 1988-09-07 | Chugai Pharmaceutical Co Ltd | AGENTS FOR TREATING SKIN DISEASES. |
JPS649932A (en) * | 1987-07-01 | 1989-01-13 | Toyo Capsel Kk | Soft capsule preparation using newly combined component as the base |
ZA886284B (en) * | 1987-08-31 | 1990-04-25 | Advanced Polymer Systems Inc | Controlled release formulations |
AU5185790A (en) * | 1989-02-16 | 1990-09-05 | University Of Georgia Research Foundation, Inc., The | Treatment of tibial dyschondroplasia |
US5013728A (en) * | 1990-05-04 | 1991-05-07 | Colgate - Palmolive Company | Composition for treating osteoporosis and hormonal imbalance |
DE69132862T2 (de) * | 1990-09-21 | 2002-08-29 | Bone Care International Inc., Madison | Neues 1alpha-hydroxy vitamin-d4 und neue zwischenprodukte und analoge |
JPH04198129A (ja) * | 1990-11-28 | 1992-07-17 | Sumitomo Pharmaceut Co Ltd | 活性型ビタミンd↓3類含有組成物 |
-
1993
- 1993-06-22 NZ NZ254424A patent/NZ254424A/en unknown
- 1993-06-22 DE DE69331409T patent/DE69331409T2/de not_active Expired - Lifetime
- 1993-06-22 AU AU46458/93A patent/AU4645893A/en not_active Abandoned
- 1993-06-22 CA CA002116238A patent/CA2116238C/en not_active Expired - Fee Related
- 1993-06-22 WO PCT/US1993/005961 patent/WO1994000128A1/en active IP Right Grant
- 1993-06-22 EP EP93916684A patent/EP0600079B1/en not_active Expired - Lifetime
- 1993-06-22 ES ES93916684T patent/ES2170069T3/es not_active Expired - Lifetime
- 1993-06-22 JP JP50253194A patent/JP3722832B2/ja not_active Expired - Lifetime
- 1993-06-22 DK DK93916684T patent/DK0600079T3/da active
- 1993-06-22 AT AT93916684T patent/ATE211387T1/de not_active IP Right Cessation
-
1994
- 1994-01-26 US US08/188,942 patent/US5622941A/en not_active Expired - Lifetime
- 1994-02-22 US US08/196,116 patent/US5529991A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/485,354 patent/US5614513A/en not_active Expired - Lifetime
- 1995-06-07 US US08/476,420 patent/US6147064A/en not_active Expired - Lifetime
- 1995-06-07 US US08/474,757 patent/US6150346A/en not_active Expired - Lifetime
-
1996
- 1996-07-22 AU AU60608/96A patent/AU696402B2/en not_active Ceased
- 1996-08-21 US US08/700,798 patent/US6133250A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NZ254424A (en) | 1997-09-22 |
CA2116238C (en) | 2007-09-04 |
ES2170069T3 (es) | 2002-08-01 |
DE69331409D1 (de) | 2002-02-07 |
US6133250A (en) | 2000-10-17 |
CA2116238A1 (en) | 1994-01-06 |
AU6060896A (en) | 1996-10-03 |
AU696402B2 (en) | 1998-09-10 |
ATE211387T1 (de) | 2002-01-15 |
US5622941A (en) | 1997-04-22 |
JPH07501343A (ja) | 1995-02-09 |
EP0600079A1 (en) | 1994-06-08 |
EP0600079B1 (en) | 2002-01-02 |
DE69331409T2 (de) | 2002-08-29 |
WO1994000128A1 (en) | 1994-01-06 |
US5614513A (en) | 1997-03-25 |
US5529991A (en) | 1996-06-25 |
AU4645893A (en) | 1994-01-24 |
US6150346A (en) | 2000-11-21 |
US6147064A (en) | 2000-11-14 |
JP3722832B2 (ja) | 2005-11-30 |
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