EP3131630B1 - Bandwandlerultraschalltherapie - Google Patents

Bandwandlerultraschalltherapie Download PDF

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Publication number
EP3131630B1
EP3131630B1 EP15780378.4A EP15780378A EP3131630B1 EP 3131630 B1 EP3131630 B1 EP 3131630B1 EP 15780378 A EP15780378 A EP 15780378A EP 3131630 B1 EP3131630 B1 EP 3131630B1
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EP
European Patent Office
Prior art keywords
treatment
transducer
ultrasound
tissue
cylindrical
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EP15780378.4A
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English (en)
French (fr)
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EP3131630A1 (de
EP3131630A4 (de
Inventor
Charles D. Emery
Joshua D. Hope
Michael T. Peterson
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Ulthera Inc
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Ulthera Inc
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Publication of EP3131630A4 publication Critical patent/EP3131630A4/de
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • G—PHYSICS
    • G10—MUSICAL INSTRUMENTS; ACOUSTICS
    • G10K—SOUND-PRODUCING DEVICES; METHODS OR DEVICES FOR PROTECTING AGAINST, OR FOR DAMPING, NOISE OR OTHER ACOUSTIC WAVES IN GENERAL; ACOUSTICS NOT OTHERWISE PROVIDED FOR
    • G10K11/00—Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
    • G10K11/18—Methods or devices for transmitting, conducting or directing sound
    • G10K11/26—Sound-focusing or directing, e.g. scanning
    • G10K11/30—Sound-focusing or directing, e.g. scanning using refraction, e.g. acoustic lenses
    • G—PHYSICS
    • G10—MUSICAL INSTRUMENTS; ACOUSTICS
    • G10K—SOUND-PRODUCING DEVICES; METHODS OR DEVICES FOR PROTECTING AGAINST, OR FOR DAMPING, NOISE OR OTHER ACOUSTIC WAVES IN GENERAL; ACOUSTICS NOT OTHERWISE PROVIDED FOR
    • G10K11/00—Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
    • G10K11/18—Methods or devices for transmitting, conducting or directing sound
    • G10K11/26—Sound-focusing or directing, e.g. scanning
    • G10K11/35—Sound-focusing or directing, e.g. scanning using mechanical steering of transducers or their beams
    • G10K11/352—Sound-focusing or directing, e.g. scanning using mechanical steering of transducers or their beams by moving the transducer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00084—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00106—Sensing or detecting at the treatment site ultrasonic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0034—Skin treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0056—Beam shaping elements
    • A61N2007/0065—Concave transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0082—Scanning transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0091—Beam steering with moving parts, e.g. transducers, lenses, reflectors

Definitions

  • Several embodiments of the present disclosure generally relate to noninvasive, semi-invasive, and/or invasive energy-based treatments to achieve cosmetic and/or medical effects.
  • some embodiments generally relate to devices, systems and methods with linear, curved, planar, and/or three-dimensional ultrasound treatment focus zones for performing various treatment procedures safely and effectively.
  • Various embodiments of a treatment system can improve cosmetic results and patient outcomes through reduced treatment time and/or reduced treatment energy, which can increase comfort and cosmetic outcomes.
  • ultrasound transducers have treatment focus zones in the form of one or more lines, belts, bands, and/or planes.
  • band treatment provides targeted heating and treatment at a specific, prescribed depth range below the skin surface without heating the skin surface and/or intermediary tissue between the skin surface and the target tissue.
  • This offset band treatment reduces damage and associated pain at the skin surface, and treats tissue only at the prescribed, targeted tissue depth.
  • embodiments of the present invention can be used to treat tissue in a specific range of depths below the skin surface without heating the skin surface.
  • band treatment can also be used to prepare tissue at target depths for a second, ultrasound treatment by pre-heating the target tissue to an elevated temperature so the secondary treatment can be performed with reduced time and/or energy and increased comfort.
  • a cosmetic ultrasound treatment system and/or method can non-invasively produce single or multiple cosmetic treatment zones and/or thermal treatment points, lines, bands, belts, planes, areas, volumes, and/or shapes, where ultrasound is focused in one or more locations in a region of treatment in tissue at one or more depths under a skin surface.
  • Some systems and methods provide cosmetic treatment at different locations in tissue, with treatment areas at various depths, heights, widths, and/or positions.
  • a method and system comprise a transducer system configured for providing ultrasound treatment to more than one region of interest, such as between at least two treatment positions and/or regions of interest.
  • a method and system comprise a transducer system configured for providing ultrasound treatment to more than one region of interest, such as between at least two lines in various locations (e.g. at a fixed or variable depth, height, width, orientation, etc.) in a region of interest in tissue.
  • lines can be straight, curved, continuous, and/or non-continuous.
  • the energy beam is split to focus at two, three, four, or more focal zones (e.g., multiple focal lines, multi-focal lines) for cosmetic treatment zones and/or for imaging in a region of interest in tissue.
  • Position of the focal zones can be positioned axially, laterally, or otherwise within the tissue.
  • Some embodiments can be configured for spatial control, such as by the location of a focus line, changing the distance or angle between a transducer and an optional motion mechanism, and/or changing the angles of energy focused or unfocused to the region of interest, and/or configured for temporal control, such as by controlling changes in the frequency, drive amplitude and timing of the transducer.
  • the position of multiple treatment zones can be enabled through poling, phasic poling, biphasic poling, and/or multi-phasic poling.
  • changes in the location of the treatment region, the number, shape, size and/or volume of treatment zones, heating zones, and/or lesions in a region of interest, as well as the thermal conditions can be dynamically controlled over time. Additional details regarding poling and modulation are disclosed in U.S. Application No. 14/193,234 filed on February 28, 2014 and published as U.S. Publication No. 2014-0257145 , which is incorporated in its entirety by reference herein.
  • an aesthetic imaging and treatment system includes a hand held probe with a housing that encloses an ultrasound transducer configured to apply ultrasound therapy to tissue at a focal zone.
  • the focal zone is a line.
  • the focal zone is a two dimensional region or plane.
  • the focal zone is a volume.
  • the focal zone treats a treatment area that is linear, curved, rectangular, and/or planar.
  • the size of the treatment area depends on the size of the transducer. The treatment can be performed in lines and/or planes.
  • the width of the treatment focal zone is 5 - 50 mm, 5 - 30 mm, 5-25 mm, 10 - 25 mm, 10 mm - 15 mm, 15 mm - 20 mm, 10 mm, 15 mm, 20 mm, 25 mm, or any range therein (including but not limited to 12 mm - 22 mm).
  • a focal zone can be moved to sweep a volume between a first position and a second position.
  • one or more a focal zone locations are positioned in a substantially linear sequence within a cosmetic treatment zone.
  • one or more a focal zone locations are positioned with one, two, or more motion mechanisms to form any shape for a treatment area within a cosmetic treatment zone.
  • a first set of locations is positioned within a first cosmetic treatment zone and a second set of locations is positioned within a second cosmetic treatment zone, the first zone being different from the second zone.
  • the first cosmetic treatment zone includes a substantially linear sequence of the first set of locations and the second cosmetic treatment zone includes a substantially linear sequence of the second set of locations.
  • transducers can be configured for a treatment zone at a tissue depth below a skin surface of 1.5 mm, 3 mm, 4.5 mm, 6 mm, less than 3 mm, between 1.5 mm and 3 mm, between 1.5 mm and 4.5 mm, more than more than 4.5 mm, more than 6 mm, and anywhere in the ranges of 0.1 mm - 3 mm, 0.1 mm - 4.5 mm, 3 mm - 7 mm, 3 mm - 9 mm, 0.1 mm - 25 mm, 0.1 mm - 100 mm, and any depths therein (including, for example, 4.5 mm - 6 mm, 1 mm - 20 mm, 1 mm - 15 mm, 1 mm - 10 mm, 5 mm - 25 mm, and any depths therein).
  • cosmetic treatment zones are continuous. In one embodiment, cosmetic treatment zones have no spacing. In one embodiment, a sequence of individual cosmetic treatment zones with a treatment spacing in a range from about 0.05 mm to about 25 mm (e.g., 0.05 - 0.1 mm, 0.05 - 1 mm, 0.2 - 0.5 mm, 0.5 - 2 mm, 1 - 10 mm, 0.5 - 3 mm, 5 - 12 mm). In various embodiments, the treatment spacing has a constant pitch, a variable pitch, an overlapping pitch, and/or a non-overlapping pitch.
  • the ultrasonic transducer is configured to provide therapeutic intensity on the transducer surface in a range of between about 1 W/cm 2 to 100 W/cm 2 (e.g., 1 - 50, 10 - 90, 25 - 75, 10 - 40, 50 - 80 W/cm 2 and any ranges and values therein).
  • the ultrasonic transducer is configured to provide an acoustic power of the ultrasonic therapy in a range of between about 1W to about 100W and a frequency of about 1 MHz to about 10 MHz to thermally heat the tissue.
  • the transducer module is configured to provide an acoustic power of the ultrasonic therapy in a range of between about 1W to about 100W (e.g., 5 - 40 W, 10 - 50 W, 25 - 35 W, 35 - 60 W, 35 W, 40 W, 50 W, 60 W) and a frequency of about 1 MHz to about 10 MHz to thermally heat the tissue.
  • the acoustic power can be from a range of 1 W to about 100 W in a frequency range from about 1 MHz to about 12 MHz (e.g., 3.5 MHz, 4MHz, 4.5MHz, 7 MHz, 10MHz, 3 - 5MHz), or from about 10 W to about 50 W at a frequency range from about 3 MHz to about 8 MHz.
  • the acoustic power and frequencies are about 40 W at about 4.3 MHz and about 30 W at about 7.5 MHz.
  • the transducer module is configured to deliver energy with no pitch or a pitch of 0.1 - 2 mm (e.g., 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.5 mm).
  • the pitch is constant or variable.
  • the transducer module is configured to deliver energy with an on-time of 10 - 500 ms (e.g., 30 - 100, 90 - 200, 30, 32, 35, 40, 50, 60, 64, 75, 90, 100, 112, 200, 300, 400 ms and any range therein).
  • the transducer module is configured to deliver energy with an off-time of 1- 200 ms (e.g., 4, 10, 22, 45, 60, 90, 100, 150 ms and any range therein).
  • an acoustic energy produced by this acoustic power can be between about 0.01 joule ("J") to about 10 J or about 2 J to about 5 J. In one embodiment, the acoustic energy is in a range less than about 3 J.
  • an acoustic energy produced by this acoustic power in a single dose pass can be between about 1 - 500 J (e.g., 20 - 310, 70, 100, 120, 140, 150, 160, 200, 250, 300, 350, 400, 450 J and any range therein).
  • a treatment can involve 1, 2, 3, 4, 5, 10 or more dose passes.
  • non-invasive ultrasound is used to achieve one or more of the following effects: tissue heating, tissue pre-heating, a face lift, a brow lift, a chin lift, an eye treatment, a wrinkle reduction, a scar reduction, a burn treatment, a tattoo removal, a vein removal, a vein reduction, a treatment on a sweat gland, a fat or adipose and/or cellulite reduction, a sun spot removal, an acne treatment, a pimple reduction.
  • Treatment of the Vietnameselletage is provided in several embodiments.
  • the system, device and/or method may be applied in the genital area (e.g., vaginal rejuvenation and/or vaginal tightening, such as for tightening the supportive tissue of the vagina).
  • the procedure is entirely cosmetic and not a medical act.
  • the methods described herein need not be performed by a doctor, but at a spa or other aesthetic institute.
  • a system can be used for the non-invasive cosmetic treatment of skin.
  • a method of reducing variance in focal gain of a cylindrical ultrasound transducer includes providing a cylindrical transduction element comprising a convex surface and a concave surface, wherein one of the surfaces (e.g., the concave surface) comprises a plurality of electrodes (or e.g., electrical conductor or electrical material), and subsequently applying a current to the electrode, thereby directing ultrasound energy to a linear focal zone at a focal depth.
  • the ultrasound energy produces a reduced variance in focal gain at the linear focal zone.
  • the concave surface can be plated with silver.
  • the convex surface can include an uncoated region and a plurality of coated regions.
  • the plurality of coated regions can include fired silver to form the plurality of electrodes.
  • the features on the convex surface can instead be on the concave surface.
  • the reduction of edge noise facilitates the efficient and consistent treatment of tissue, wherein the cylindrical transduction element is configured to apply ultrasonic therapy to a linear tissue thermal treatment zone at a focal depth.
  • the reduction of edge noise facilitates the efficient and consistent heating of a material, wherein the material is any one of the group consisting of a compound, an adhesive, and food.
  • an ultrasound transduction system for reducing edge noise at a focal line includes a cylindrical transduction element and a power source configured to drive the cylindrical transduction element.
  • the cylindrical transduction element is configured to apply ultrasonic energy to a linear focal zone at a focal depth.
  • the cylindrical transduction element includes a convex surface and a concave surface.
  • the concave surface is plated with an electrical conductor, such as silver.
  • the convex surface includes an uncoated region and one or more coated regions, wherein the one or more coated regions includes silver to form an electrode.
  • the power source is in electric communication with the electrode. The coated regions are configured to reduce variance in focal gain at the linear focal zone at the focal depth.
  • an ultrasound transduction system for reducing edge noise at a focal line includes a cylindrical transduction element and a power source configured to drive the cylindrical transduction element.
  • the cylindrical transduction element is configured to apply ultrasonic energy to a linear focal zone at a focal depth.
  • the cylindrical transduction element includes a convex surface and a concave surface.
  • the convex surface plated with silver.
  • the concave surface includes an uncoated region and one or more coated regions, wherein the one or more coated regions includes silver to form an electrode.
  • the power source is in electric communication with the electrode.
  • the coated regions are configured to reduce variance in focal gain at the linear focal zone at the focal depth.
  • a coated transducer for reducing variance in focal gain at a focal zone includes a cylindrical transduction element comprising a convex surface and a concave surface.
  • the concave surface is plated with silver.
  • the convex surface includes an uncoated region and a plurality of coated regions.
  • the plurality of coated regions includes silver to form a plurality of electrodes.
  • the cylindrical transduction element is configured to apply ultrasonic therapy to a linear focal zone at a focal depth.
  • the coated regions are configured to reduce variance in focal gain at the linear focal zone.
  • a coated transducer for reducing variance in focal gain at a focal zone includes a cylindrical transduction element comprising a convex surface and a concave surface.
  • the convex surface is plated.
  • the concave surface is plated.
  • the concave surface includes an uncoated region and a plurality of coated regions.
  • the convex surface includes an uncoated region and a plurality of coated regions.
  • the plurality of coated regions includes a conductor to form a plurality of electrodes.
  • the cylindrical transduction element is configured to apply ultrasonic therapy to a linear focal zone at a focal depth.
  • the coated regions are configured to reduce variance in focal gain at the linear focal zone.
  • an aesthetic treatment system includes a cylindrical transduction element comprising a convex surface and a concave surface.
  • the concave surface is plated with silver to form an electrode.
  • the convex surface is plated with silver to form an electrode.
  • the convex surface includes an uncoated region and one or more coated regions, wherein the one or more coated regions includes silver to form an electrode.
  • the concave surface includes an uncoated region and one or more coated regions, wherein the one or more coated regions includes silver to form an electrode.
  • the cylindrical transduction element is configured to apply ultrasonic therapy to a linear tissue thermal treatment zone at a focal depth.
  • the coated regions are configured to reduce variance in focal gain at the thermal treatment zone.
  • the cylindrical transduction element is housed within an ultrasonic hand-held probe.
  • the ultrasonic probe includes a housing, the cylindrical transduction element, and a motion mechanism.
  • the ultrasound transducer is movable within the housing.
  • the motion mechanism is attached to the ultrasound transducer and configured to move the ultrasound transducer along a linear path within the housing.
  • an aesthetic imaging and treatment system includes an ultrasonic probe that includes a housing, a coated ultrasound transducer, and a motion mechanism.
  • the ultrasound transducer is movable within the housing, the ultrasound transducer including a cylindrical transduction element and an imaging element.
  • the cylindrical transduction element is configured to apply ultrasonic therapy to a linear tissue thermal treatment zone at a focal depth.
  • the cylindrical transduction element has an opening configured for placement of the imaging element.
  • the cylindrical transduction element includes a convex surface and a concave surface. In one embodiment, the entire concave surface is plated with silver. In one embodiment, the entire convex surface is plated with silver. In one embodiment, the convex surface includes an uncoated portion and one or more coated regions.
  • the concave surface includes an uncoated portion and one or more coated regions.
  • the coated region includes silver to form an electrode.
  • the coated regions are configured to reduce variance in focal gain at the thermal treatment zone.
  • the motion mechanism is attached to the ultrasound transducer and configured to move the ultrasound transducer along a linear path within the housing.
  • one of the surfaces of the transduction element is fully coated (or at least 90% coated) with an electrically conductive material (including but not limited to silver or another metal or alloy) and the other surface (either the convex or the concave surface) has regions (or a pattern or patchwork) of coated and uncoated portions that are coated with an electrically conductive material (including but not limited to silver or another metal or alloy).
  • an electrically conductive material including but not limited to silver or another metal or alloy
  • regions (or a pattern or patchwork) of coated and uncoated portions that are coated with an electrically conductive material (including but not limited to silver or another metal or alloy).
  • both surfaces (convex and concave surfaces) contain regions (or a pattern or patchwork) of coated and uncoated portions.
  • convex and concave surfaces are described herein, one or both of these surfaces may be planar in some embodiments. Additionally, convex or concave surfaces as described herein may be multi-faceted (e.g., with multiple convexities and/or concavities) and also include surfaces with a curvature (e.g., one or more angles less than 180 degrees).
  • the pattern of coated and uncoated regions can include one, two or more coated regions and one, two or more uncoated regions, wherein the coated regions cover at least 60%, 70%, 80%, or 90% of the surfaces. Further, the uncoated region may be considered uncoated to the extent it does not have an electrically conductive coating - the uncoated region may have other types of surface coatings in certain embodiments.
  • an ultrasound system includes a transducer with a transduction element (e.g., a flat, round, circular, cylindrical, annular, have rings, concave, convex, contoured or other shaped transduction element).
  • a transduction element e.g., a flat, round, circular, cylindrical, annular, have rings, concave, convex, contoured or other shaped transduction element.
  • an ultrasound transduction system includes a transduction element (e.g., a cylindrical transduction element), and a power source configured to drive the transduction element, wherein the transduction element is configured to apply ultrasonic energy to a linear focal zone at a focal depth, wherein the transduction element comprises a first surface and a second surface, wherein the first surface comprises an electrically conductive coating, wherein the second surface comprises at least one electrically conductive coated region and at least one uncoated region that is not coated with an electrically conductive coating, wherein the at least one coated region on the second surface comprises a conductive material that forms an electrode when the power source is in electric communication with the at least one coated region, wherein the at least one coated region on the second surface is configured to reduce edge noise at the linear focal zone at the focal depth.
  • a transduction element e.g., a cylindrical transduction element
  • the transduction element comprises a first surface and a second surface, wherein the first surface comprises an electrically conductive coating, wherein the second surface comprises at least one electrically
  • an ultrasound transduction system includes a cylindrical transduction element and a power source configured to drive the cylindrical transduction element, wherein the cylindrical transduction element is configured to apply ultrasonic energy to a linear focal zone at a focal depth.
  • the cylindrical transduction element comprises a first surface and a second surface, wherein the first surface comprises a coating, wherein the second surface comprises at least one coated region and at least one uncoated region, wherein the at least one coated region on the second surface comprises a conductive material that forms an electrode when the power source is in electric communication with the at least one coated region, wherein the at least one coated region on the second surface is configured to reduce edge noise at the linear focal zone at the focal depth.
  • the uncoated region does not comprise a conductive material.
  • the conductive material is a metal (e.g., silver, gold, platinum, mercury, and/or copper, or an alloy).
  • the first surface is a concave surface and the second surface is a convex surface. In an embodiment, the first surface is a convex surface and the second surface is a concave surface.
  • the cylindrical transduction element is housed within an ultrasonic hand-held probe, wherein the ultrasonic probe includes a housing, the cylindrical transduction element, and a motion mechanism, wherein the ultrasound transducer is movable within the housing, wherein the motion mechanism is attached to the ultrasound transducer and configured to move the ultrasound transducer along a linear path within the housing.
  • the motion mechanism automatically moves the cylindrical transduction element to heat a treatment area at the focal depth.
  • the reduction of edge noise facilitates the production of a uniform (e.g., completely uniform, substantially uniform, about uniform) temperature in a treatment area.
  • the reduction of edge noise facilitates the efficient and consistent treatment of a tissue, wherein the cylindrical transduction element is configured to apply ultrasonic therapy to a treatment zone at the focal depth in the tissue.
  • the reduction of edge noise reduces a peak such that a variance around the focal depth is reduced by 75 - 200% (e.g., 75 - 100, 80 - 150, 100 - 150, 95 - 175%, and any values therein).
  • the reduction of edge noise reduces a peak such that a variance of an intensity around the focal depth is 5 mm or less (e.g., 4.5, 4, 3.5, 3, 2.5, 2, 1.5, 1, 0.5 or less).
  • the reduction of edge noise reduces a variance in focal gain in a range of 0.01 - 10 (e.g., 1 - 5, 2 - 8, 0.5 - 3, and any any values therein).
  • the power source is configured to drive the cylindrical transduction element to produce a temperature in a range of 42 - 55 degrees Celsius (e.g., 43 - 48, 45 - 53, 45 - 50 degrees Celsius, and any values therein) in a tissue at the focal depth.
  • a temperature sensor is located on the housing proximate an acoustic window in the housing configured to measure a temperature at a skin surface.
  • a system includes one or more imaging elements, wherein the cylindrical transduction element has an opening configured for placement of the one or more imaging elements.
  • the imaging element is configured to confirm a level of acoustic coupling between the system and a skin surface.
  • the imaging element is configured to confirm a level of acoustic coupling between the system and a skin surface via any one of the group consisting of: defocused imaging and Voltage Standing Wave Ratio (VSWR).
  • VSWR Voltage Standing Wave Ratio
  • the imaging element is configured to measure a temperature at a target tissue at the focal depth below a skin surface.
  • the imaging element is configured to measure a temperature at a target tissue at the focal depth below a skin surface with any one of the group of Acoustic Radiation Force Impulse (ARFI), Shear Wave Elasticity Imaging (SWEI), and measurement of attenuation.
  • ARFI Acoustic Radiation Force Impulse
  • SWEI Shear Wave Elasticity Imaging
  • a method of heating tissue with a cylindrical ultrasound transducer includes providing a cylindrical transduction element comprising a first surface, a second surface, a coated region, and an uncoated region.
  • the coated region comprises an electrical conductor.
  • the uncoated region does not comprise an electrical conductor.
  • the first surface comprises at least one coated region, wherein the second surface comprises the uncoated region and a plurality of coated regions, applying a current to the coated region, thereby directing ultrasound energy to a linear focal zone at a focal depth, wherein the ultrasound energy produces a reduction in focal gain at the linear focal zone.
  • a cosmetic method of non-invasively and non-ablatively heating tissue with a heating source e.g., a cylindrical ultrasound transducer
  • a heating source e.g., a cylindrical ultrasound transducer
  • the heating occurs in increments over a period of 5-120 minutes with a graded or gradual increase in temperature.
  • the heating can be performed by the cylindrical ultrasound transducer systems described herein.
  • an ablative or coagulative energy can subsequently be applied by increasing the temperature by another 5-25 degrees Celsius.
  • the initial pre-heating step or bulk heating is advantageous because it allows less energy to be applied to achieve the coagulative/ablative state.
  • the initial pre-heating step is performed with a heating source other than an ultrasound transducer.
  • a heating source other than an ultrasound transducer.
  • radiofrequency, microwave, light, convective, conversion, and/or conductive heat sources can be used instead of or in addition to ultrasound.
  • a non-invasive, cosmetic method of heating tissue includes applying a cosmetic heating system to a skin surface, wherein the cosmetic heating system comprises a hand-held probe.
  • the hand-held probe comprises a housing that encloses an ultrasound transducer configured to heat tissue below the skin surface to a tissue temperature in the range of 40 - 50 degrees Celsius (e.g., 44 - 47, 41 - 49, 45 - 50 degrees Celsius, and any values therein).
  • the ultrasound transducer comprises a cylindrical transduction element comprising a first surface, a second surface, a coated region, and an uncoated region, wherein the coated region comprises an electrical conductor, wherein the first surface comprises at least one coated region, wherein the second surface comprises the uncoated region and a plurality of coated regions.
  • the method includes applying a current to the plurality of coated regions, thereby directing ultrasound energy to a linear focal zone at a focal depth, wherein the ultrasound energy produces a reduction in focal gain at the linear focal zone, thereby heating the tissue at the focal depth in the linear focal zone to the tissue temperature in the range of 40 - 50 degrees Celsius for a cosmetic treatment duration of less than 1 hour (e.g., 1 - 55, 10 - 30, 5 - 45, 15 - 35, 20 - 40 minutes and any values therein), thereby reducing a volume of an adipose tissue in the tissue.
  • a cosmetic treatment duration of less than 1 hour (e.g., 1 - 55, 10 - 30, 5 - 45, 15 - 35, 20 - 40 minutes and any values therein), thereby reducing a volume of an adipose tissue in the tissue.
  • the reduction of focal gain facilitates the efficient and consistent treatment of tissue, wherein the cylindrical transduction element is configured to apply ultrasonic therapy to a thermal treatment zone at a focal depth.
  • the reduction of focal gain reduces a peak such that a variance around the focal depth is reduced by 25 - 100% (e.g., 30 - 50, 45 - 75, 50 - 90%, and any values therein).
  • the reduction of focal gain reduces a peak such that a variance of an intensity around the focal depth is 5 mm or less (e.g., 1, 2, 3, 4 mm or less).
  • the reduction of focal gain reduces a variance in focal gain in a range of 0.01 - 10 (e.g., 0.06, 3, 4.5, 8, or any values therein).
  • the electrical conductor is a metal.
  • the first surface is a concave surface and the second surface is a convex surface.
  • the first surface is a convex surface and the second surface is a concave surface.
  • the cylindrical transduction element is housed within an ultrasonic hand-held probe, wherein the ultrasonic probe includes a housing, the cylindrical transduction element, and a motion mechanism, wherein the ultrasound transducer is movable within the housing, wherein the motion mechanism is attached to the ultrasound transducer and configured to move the ultrasound transducer along a linear path within the housing.
  • the motion mechanism automatically moves the cylindrical transduction element to heat a treatment area at the focal depth to a temperature in a range between 40 - 65 degrees Celsius.
  • the cylindrical transduction element produces a temperature in a range of 42 - 55 degrees Celsius in a tissue at the focal depth.
  • the method also includes imaging tissue with one or more imaging elements, wherein the cylindrical transduction element has an opening configured for placement of the one or more imaging elements.
  • the method also includes confirming a level of acoustic coupling between the system and a skin surface with an image from the imaging element.
  • the method also includes confirming a level of acoustic coupling between the system and a skin surface with the imaging element using any one of the group consisting of: defocused imaging and Voltage Standing Wave Ratio (VSWR).
  • VSWR Voltage Standing Wave Ratio
  • the method also includes measuring a temperature at a target tissue at the focal depth below a skin surface with the imaging element.
  • the method also includes measuring a temperature with the imaging element at a target tissue at the focal depth below a skin surface with any one of the group of Acoustic Radiation Force Impulse (ARFI), Shear Wave Elasticity Imaging (SWEI), and measurement of attenuation.
  • ARFI Acoustic Radiation Force Impulse
  • SWEI Shear Wave Elasticity Imaging
  • actions taken by a practitioner; however, it should be understood that they can also include the instruction of those actions by another party.
  • actions such as “applying an ultrasound energy” include “instructing the application of ultrasound energy.”
  • systems and methods for ultrasound treatment of tissue are configured to provide cosmetic treatment.
  • Various embodiments of the present disclosure address potential challenges posed by administration of ultrasound therapy.
  • the amount of time and/or energy to create a thermal treatment zone (also referred to herein "TTZ") for a desired cosmetic and/or therapeutic treatment for a desired clinical approach at a target tissue is reduced.
  • tissue below or at a skin surface such as epidermis, dermis, platysma, lymph node, nerve, fascia, muscle, fat, and/or superficial muscular aponeurotic system (“SMAS”), are treated non-invasively with ultrasound energy.
  • SMAS superficial muscular aponeurotic system
  • tissue below or at a skin surface such as epidermis, dermis, platysma, lymph node, nerve, fascia, muscle, fat, and/or SMAS are not treated.
  • the ultrasound energy can be focused at one or more treatment zones, can be unfocused and/or defocused, and can be applied to a region of interest to achieve a cosmetic and/or therapeutic effect.
  • systems and/or methods provide non-invasive dermatological treatment to tissue through heating, thermal treatment, coagulation, ablation, and/or tissue tightening (including, for example, hyperthermia, thermal dosimetry, apoptosis, and lysis).
  • dermal tissue volume is increased.
  • fat tissue volume is reduced, or decreased.
  • target tissue is, but is not limited to, any of skin, eyelids, eye lash, eye brow, caruncula lacrimalis, crow's feet, wrinkles, eye, nose, mouth, tongue, teeth, gums, ears, brain, chest, back, buttocks, legs, arms, hands, arm pits, heart, lungs, ribs, abdomen, stomach, liver, kidneys, uterus, breast, vagina, penis, prostate, testicles, glands, thyroid glands, internal organs, hair, muscle, bone, ligaments, cartilage, fat, fat lobuli, adipose tissue, cellulite, subcutaneous tissue, implanted tissue, an implanted organ, lymphoid, a tumor, a cyst, an abscess, or a portion of a nerve, or any combination thereof.
  • non-invasive ultrasound is used to achieve one or more of the following effects: a face lift, a brow lift, a chin lift, an eye treatment, a wrinkle reduction, a scar reduction, a fat reduction, a reduction in the appearance of cellulite, a Vietnameselletage treatment, a burn treatment, a tattoo removal, a vein reduction, a treatment on a sweat gland, a treatment of hyperhidrosis, sun spot removal, an acne treatment, and a pimple removal.
  • two, three or more beneficial effects are achieved during the same treatment session, and may be achieved simultaneously.
  • various embodiments of the present disclosure relate to devices or methods of controlling the delivery of energy to tissue.
  • various forms of energy can include acoustic, ultrasound, light, laser, radio-frequency (RF), microwave, electromagnetic, radiation, thermal, cryogenic, electron beam, photon-based, magnetic, magnetic resonance, and/or other energy forms.
  • RF radio-frequency
  • Various embodiments of the present disclosure relate to devices or methods of splitting an ultrasonic energy beam into multiple beams.
  • devices or methods can be used to alter the delivery of ultrasound acoustic energy in any procedures such as, but not limited to, therapeutic ultrasound, diagnostic ultrasound, non-destructive testing (NDT) using ultrasound, ultrasonic welding, any application that involves coupling mechanical waves to an object, and other procedures.
  • NDT non-destructive testing
  • a tissue effect is achieved by concentrating the acoustic energy using focusing techniques from the aperture.
  • high intensity focused ultrasound HIFU
  • a tissue effect created by application of therapeutic ultrasound at a particular location e.g., depth, width
  • creation of a thermal treatment zone It is through creation of thermal treatment zones at particular positions that thermal and/or mechanical heating, coagulation, and/or ablation of tissue can occur non-invasively or remotely offset from the skin surface.
  • an embodiment of an ultrasound system 20 includes a hand wand 100, module 200, and a controller 300.
  • the hand wand 100 can be coupled to the controller 300 by an interface 130, which may be a wired or wireless interface.
  • the interface 130 can be coupled to the hand wand 100 by a connector 145.
  • the distal end of the interface 130 can be connected to a controller connector on a circuit 345.
  • the interface 130 can transmit controllable power from the controller 300 to the hand wand 100.
  • the controller 300 can be configured for operation with the hand wand 100 and the module 200, as well as the overall ultrasound system 20 functionality.
  • a controller 300 is configured for operation with a hand wand 100 with one or more removable modules 200, 200', 200", etc.
  • the controller 300 can include an interactive graphical display 310, which can include a touchscreen monitor and Graphic User Interface (GUI) that allows the user to interact with the ultrasound system 20.
  • GUI Graphic User Interface
  • the graphical display 315 includes a touchscreen interface 315.
  • the display 310 sets and displays the operating conditions, including equipment activation status, treatment parameters, system messages and prompts, and ultrasound images.
  • the controller 300 can be configured to include, for example, a microprocessor with software and input/output devices, systems and devices for controlling electronic and/or mechanical scanning and/or multiplexing of transducers and/or multiplexing of transducer modules, a system for power delivery, systems for monitoring, systems for sensing the spatial position of the probe and/or transducers and/or multiplexing of transducer modules, and/or systems for handling user input and recording treatment results, among others.
  • a microprocessor with software and input/output devices systems and devices for controlling electronic and/or mechanical scanning and/or multiplexing of transducers and/or multiplexing of transducer modules
  • a system for power delivery systems for monitoring, systems for sensing the spatial position of the probe and/or transducers and/or multiplexing of transducer modules
  • systems for handling user input and recording treatment results among others.
  • the controller 300 can include a system processor and various analog and/or digital control logic, such as one or more of microcontrollers, microprocessors, field-programmable gate arrays, computer boards, and associated components, including firmware and control software, which may be capable of interfacing with user controls and interfacing circuits as well as input/output circuits and systems for communications, displays, interfacing, storage, documentation, and other useful functions.
  • System software running on the system process may be configured to control all initialization, timing, level setting, monitoring, safety monitoring, and all other ultrasound system functions for accomplishing user-defined treatment objectives.
  • the controller 300 can include various input/output modules, such as switches, buttons, etc., that may also be suitably configured to control operation of the ultrasound system 20.
  • the controller 300 can include one or more data ports 390.
  • the data ports 390 can be a USB port, Bluetooth port, IrDA port, parallel port, serial port, and the like.
  • the data ports 390 can be located on the front, side, and/or back of the controller 300, and can be used for accessing storage devices, printing devices, computing devices, etc.
  • the ultrasound system 20 can include a lock 395.
  • the lock 395 in order to operate the ultrasound system 20, the lock 395 should be unlocked so that a power switch 393 may be activated.
  • the lock 395 can be connectable to the controller 300 via a data port 390 (e.g., a USB port).
  • the lock 395 could be unlocked by inserting into the data port 390 an access key (e.g., USB access key), a hardware dongle, or the like.
  • the controller 300 can include an emergency stop button 392, which can be readily accessible for emergency deactivation.
  • the hand wand 100 includes one or more finger activated controllers or switches, such as 150 and 160.
  • the hand wand 100 can include a removable module 200.
  • the module 200 may be non-removable.
  • the module 200 can be mechanically coupled to the hand wand 100 using a latch or coupler 140.
  • An interface guide 235 can be used for assisting the coupling of the module 200 to the hand wand 100.
  • the module 200 can include one or more ultrasound transducers 280.
  • an ultrasound transducer 280 includes one or more ultrasound elements 281.
  • the module 200 can include one or more ultrasound elements 281.
  • the elements 281 can be therapy elements, and/or imaging elements.
  • the hand wand 100 can include imaging-only modules 200, treatment-only modules 200, imaging-and-treatment modules 200, and the like. In one embodiment, the imaging is provided through the hand wand 100.
  • the control module 300 can be coupled to the hand wand 100 via the interface 130, and the graphic user interface 310 can be configured for controlling the module 200. In one embodiment, the control module 300 can provide power to the hand wand 100. In one embodiment, the hand wand 100 can include a power source.
  • the switch 150 can be configured for controlling a tissue imaging function and the switch 160 can be configured for controlling a tissue treatment function
  • the module 200 can be coupled to the hand wand 100.
  • the module 200 can emit and receive energy, such as ultrasonic energy.
  • the module 200 can be electronically coupled to the hand wand 100 and such coupling may include an interface which is in communication with the controller 300.
  • the interface guide 235 can be configured to provide electronic communication between the module 200 and the hand wand 100.
  • the module 200 can comprise various probe and/or transducer configurations.
  • the module 200 can be configured for a combined dual-mode imaging/therapy transducer, coupled or co-housed imaging/therapy transducers, separate therapy and imaging probes, and the like.
  • the controller 300 automatically detects it and updates the interactive graphical display 310.
  • tissue below or even at a skin surface such as epidermis, dermis, hypodermis, fascia, and SMAS, and/or muscle are treated non-invasively with ultrasound energy.
  • Tissue may also include blood vessels and/or nerves.
  • the ultrasound energy can be focused, unfocused or defocused and applied to a region of interest containing at least one of epidermis, dermis, hypodermis, fascia, and SMAS to achieve a therapeutic effect.
  • FIG. 2 is a schematic illustration of the ultrasound system 20 coupled to a region of interest 10, such as with an acoustic gel.
  • an embodiment of the ultrasound system 20 includes the hand wand 100, the module 200, and the controller 300.
  • tissue layers of the region of interest 10 can be at any part of the body of a subject.
  • the tissue layers are in the head, face, neck and/or body region of the subject.
  • the cross-sectional portion of the tissue of the region of interest 10 includes a skin surface 501, an epidermal layer 502, a dermal layer 503, a fat layer 505, a SMAS 507, and a muscle layer 509.
  • the tissue can also include the hypodermis 504, which can include any tissue below the dermal layer 503.
  • the combination of these layers in total may be known as subcutaneous tissue 510.
  • a treatment zone 525 which is the active treatment area below the surface 501.
  • the surface 501 can be a surface of the skin of a subject 500.
  • the system can be applied to any tissue in the body.
  • the system and/or methods may be used on muscles (or other tissue) of the face, neck, head, arms, legs, or any other location in the body.
  • the therapy can be applied to a face, head, neck, submental region, shoulder, arm, back, chest, buttock, abdomen, stomach, waist, flank, leg, thigh, or any other location in or on the body.
  • a transducer 280 can comprise one or more therapy elements 281 that can have various shapes that correspond to various focal zone geometries.
  • the transducer 280 comprises a single therapy element 281.
  • the transducer 280 does not have a plurality of elements.
  • the transducer 280 does not have an array of elements.
  • the transducers 280 and/or therapy elements 281 described herein can be flat, round, circular, cylindrical, annular, have rings, concave, convex, contoured, and/or have any shape.
  • the transducers 280 and/or therapy elements 281 described herein are not flat, round, circular, cylindrical, annular, have rings, concave, convex, and/or contoured.
  • the transducers 280 and/or therapy elements 281 have a mechanical focus.
  • the transducers 280 and/or therapy elements 281 do not have a mechanical focus.
  • the transducers 280 and/or therapy elements 281 have an electrical focus.
  • the transducers 280 and/or therapy elements 281 do not have an electrical focus.
  • a cylinder transducer and/or a cylindrical element is discussed here, the transducer and/or element need not be cylindrical.
  • the transducer and/or element has one or more shapes or configurations that cause edge effects, such as variance, spikes or other inconsistencies in the delivery of ultrasound.
  • the transducer and/or element may have one or more non-linear (e.g., curved) portions.
  • a transducer may be comprised of one or more individual transducers and/or elements in any combination of focused, planar, or unfocused single-element, multi-element, or array transducers, including 1-D, 2-D, and annular arrays; linear, curvilinear, sector, or spherical arrays; spherically, cylindrically, and/or electronically focused, defocused, and/or lensed sources.
  • a transducer 280 can include a spherically shaped bowl with a diameter and one or more concave surfaces (with respective radii or diameters) geometrically focused to a single point TTZ 550 at a focal depth 278 below a tissue surface, such as skin surface 501.
  • a transducer 280 may be radially symmetrical in three dimensions.
  • transducer 280 may be a radially symmetrical bowl that is configured to produce a focus point in a single point in space.
  • the transducer is not spherically shaped.
  • the element is not spherically shaped.
  • increasing the size (e.g. width, depth, area) and/or number of focus zone locations for an ultrasonic procedure can be advantageous because it permits treatment of a patient at varied tissue widths, heights and/or depths even if the focal depth 278 of a transducer 280 is fixed.
  • This can provide synergistic results and maximizing the clinical results of a single treatment session.
  • treatment at larger treatment areas under a single surface region permits a larger overall volume of tissue treatment, which can heat larger tissue volumes, and which can result in enhanced collagen formation and tightening.
  • larger treatment areas, such as at different depths affects different types of tissue, thereby producing different clinical effects that together provide an enhanced overall cosmetic result.
  • a larger treatment area can be accomplished using a transducer with a larger focus zones (e.g., such as a linear focus zone compared to a point focus zone).
  • a transducer 280 comprises a cylindrical transduction element 281.
  • the cylindrical transduction element 281 extends linearly along its longitudinal axis (X-axis, azimuth) with a curved cross section along a Y-axis (elevation).
  • the cylindrical surface has a radius at a focal depth (z-axis) at the center of the curvature of the cylindrical surface, such that the TTZ 550 is focused at the center of the radius.
  • cylindrical transduction element 281 has a concave surface that extends like a cylinder that produces a focus zone that extends along a line, such as a therapy line, such as TTZ 550.
  • the focus zone TTZ 550 extends along the width (along the X-axis, azimuth) of the cylindrical transduction element 281, in a line parallel to the longitudinal axis of the cylindrical transduction element 281.
  • the TTZ 550 is a line extending in and/or out of the page.
  • a concave surface directs ultrasound energy to a linear TTZ 550.
  • Cylindrical transduction element 281 need not be cylindrical; in some embodiments, element 281 is a transduction element having one or more curved or non-linear portions.
  • transducers 280 can comprise one or more transduction elements 281.
  • the transduction elements 281 can comprise a piezoelectrically active material, such as lead zirconante titanate (PZT), or any other piezoelectrically active material, such as a piezoelectric ceramic, crystal, plastic, and/or composite materials, as well as lithium niobate, lead titanate, barium titanate, and/or lead metaniobate.
  • PZT lead zirconante titanate
  • transducers in addition to, or instead of, a piezoelectrically active material, can comprise any other materials configured for generating radiation and/or acoustical energy.
  • cylindrical transduction element 281 when cylindrical transduction element 281 comprises a piezoelectric ceramic material that is excited by an electrical stimulus, the material may expand or contract. The amount of expansion or contraction is related to boundary conditions in the ceramic as well as the magnitude of the electric field created in the ceramic.
  • the front surface e.g. subject side
  • the back surface of a transducer 280 is coupled to a low impedance medium which is typically air.
  • the ceramic is free to expand at the back interface, essentially no mechanical energy is coupled from the ceramic to the air because of the significant acoustic impedance disparity. This results in this energy at the back of the ceramic reflecting and exiting the front (or subject side) surface.
  • the focus is created by forming, casting, and/or machining the ceramic to the correct radius-of-curvature.
  • a flat transducer material is bent to form a cylindrical transducer.
  • transducers 280 and/or therapy elements 281 can be configured to operate at different frequencies and treatment depths.
  • Transducer properties can be defined by a focal length (F L ), sometimes referred to as a focal depth 278.
  • the focal depth 278 is the distance from the concave cylindrical surface to the focal zone TTZ 550.
  • the focal depth 278 is the sum of a standoff distance 270 and a treatment depth 279 when the housing of a probe is placed against a skin surface.
  • the standoff distance 270 is the distance between the transducer 280 and a surface of an acoustically transparent member 230 on the housing of a probe.
  • the treatment depth 279 is a tissue depth 279 below a skin surface 501, to a target tissue.
  • the height of the aperture in the curved dimension is increased or maximized to have a direct effect on overall focal gain, which correlates to the ability to heat tissue. For example, in one embodiment, the height of the aperture in the curved dimension is maximized for a treatment depth of 6 mm or less. In one embodiment, as the aperture is increased (e.g. decreasing the f#), the actual heating zone gets closer to the surface.
  • a transducer can be configured to have a focal depth 278 of 6 mm, 2-12 mm, 3 - 10 mm, 4 - 8 mm, 5 - 7 mm. In other embodiments, other suitable values of focal depth 278 can be used, such as focal depth 278 of less than about 15 mm, greater than about 15 mm, 5-25 mm, 10 - 20 mm, etc.
  • Transducer modules can be configured to apply ultrasonic energy at different target tissue depths. In one embodiment, a therapy of 20 mm or less (e.g., 0.1 mm - 20 mm, 5 - 17 mm, 10 - 15 mm).
  • a devices that goes to 6 mm or less has a radius of curvature (ROC) of 13.6 mm, with a ratio of treatment depth to ROC at approximately 44%.
  • the height of the element is 22 mm.
  • the aperture height would be 74.5 mm with a ROC of 45 mm.
  • a system may comprise a movement mechanism 285 configured to move a transducer 280 comprising a cylindrical transduction element 281 in one, two, three or more directions.
  • a motion mechanism 285 can move in a linear direction, one or both ways, denoted by the arrow marked 290 in order move a TTZ 550 through tissue.
  • the motion mechanism 285 can move the transducer in one, two, and/or three linear dimensions and/or one, two, and/or three rotational dimensions.
  • a motion mechanism 285 can move in up to six degrees of freedom.
  • Movement of the TTZ 550 can be with the transducer continuously delivering energy to create a treatment area 552.
  • a movement mechanism 285 can automatically move the cylindrical transduction element 281 across the surface of a treatment area so that the TTZ 550 can form a treatment area 552.
  • a cylindrical transduction element 281 can be connected to a motion mechanism 285 and placed inside a module 200 or a probe.
  • a movement mechanism 285, or a motion mechanism 285 moves the transducer 280 and/or treatment element 281 such that the corresponding TTZ 550 moves to treat a larger treatment area 552.
  • a movement mechanism 285 is configured to move a transducer within a module or a probe.
  • a transducer is held by a transducer holder.
  • the transducer holder includes a sleeve which is moved along motion constraining bearings, such as linear bearings, namely, a bar (or shaft) to ensure a repeatable linear movement of the transducer.
  • sleeve is a spline bushing which prevents rotation about a spline shaft, but any guide to maintain the path of motion is appropriate.
  • the transducer holder is driven by a motion mechanism 285, which may be located in a hand wand or in a module, or in a probe.
  • a motion mechanism 285 includes any one or more of a scotch yoke, a movement member, and a magnetic coupling.
  • the magnetic coupling helps move the transducer.
  • a motion mechanism 285 provides for a more efficient, accurate and precise use of an ultrasound transducer, for imaging and/or therapy purposes.
  • This type of motion mechanism has over conventional fixed arrays of multiple transducers fixed in space in a housing is that the fixed arrays are a fixed distance apart.
  • a track e.g., such as a linear track
  • embodiments of the system and device provide for adaptability and flexibility in addition to efficiency, accuracy and precision. Real time and near real time adjustments can be made to imaging and treatment positioning along the controlled motion by the motion mechanism 285.
  • one or more sensors may be included in the module. In one embodiment, one or more sensors may be included in the module to ensure that a mechanical coupling between the movement member and the transducer holder is indeed coupled. In one embodiment, an encoder may be positioned on top of the transducer holder and a sensor may be located in a portion of the module, or vice versa (swapped).
  • the senor is a magnetic sensor, such as a giant magnetoresistive effect (GMR) or Hall Effect sensor, and the encoder a magnet, collection of magnets, or multi-pole magnetic strip.
  • the sensor may be positioned as a transducer module home position.
  • the sensor is a contact pressure sensor.
  • the sensor is a contact pressure sensor on a surface of the device to sense the position of the device or the transducer on the patient.
  • the sensor can be used to map the position of the device or a component in the device in one, two, or three dimensions.
  • the sensor is configured to sense the position, angle, tilt, orientation, placement, elevation, or other relationship between the device (or a component therein) and the patient.
  • the senor comprises an optical sensor. In one embodiment, the sensor comprises a roller ball sensor. In one embodiment, the sensor is configured to map a position in one, two and/or three dimensions to compute a distance between areas or lines of treatment on the skin or tissue on a patient.
  • a motion mechanism 285 can be any mechanism that may be found to be useful for movement of the transducer.
  • the motion mechanism 285 comprises a stepper motor.
  • the motion mechanism 285 comprises a worm gear.
  • the motion mechanism 285 is located in a module 200.
  • the motion mechanism 285 is located in the hand wand 100.
  • the motion mechanism 285 can provide for linear, rotational, multi-dimensional motion or actuation, and the motion can include any collection of points, lines and/or orientations in space.
  • Various embodiments for motion can be used in accordance with several embodiments, including but not limited to rectilinear, circular, elliptical, arc-like, spiral, a collection of one or more points in space, or any other 1-D, 2-D, or 3-D positional and attitudinal motional embodiments.
  • the speed of the motion mechanism 285 may be fixed or may be adjustably controlled by a user.
  • a speed of the motion mechanism 285 for an image sequence may be different than that for a treatment sequence.
  • the speed of the motion mechanism 285 is controllable by a controller.
  • the energy transmitted from the transducer is turned on and off, forming a non-continuous treatment area 552 such that the TTZ 550 moves with a treatment spacing between individual TTZ 550 positions.
  • treatment spacing can be about 1 mm, 1.5 mm, 2 mm, 5mm, 10 mm, etc.
  • a probe can further comprise a movement mechanism configured to direct ultrasonic treatment in a sequence so that TTZs 550 are formed in linear or substantially linear sequences.
  • a transducer module can be configured to form TTZs 550 along a first linear sequence and a second linear sequence separated by treatment spacing between about 2 mm and 3 mm from the first linear sequence.
  • a user can manually move the transducer modules across the surface of a treatment area so that adjacent linear sequences of TTZs are created.
  • a TTZ can be swept from a first position to a second position. In one embodiment, a TTZ can be swept from the first position to the second position repeatedly. In one embodiment, a TTZ can be swept from the first position, to the second position, and back to the first position. In one embodiment, a TTZ can be swept from the first position, to the second position, and back to the first position, and repeated. In one embodiment, multiple sequences of TTZs can be created in a treatment region. For example, TTZs can be formed along a first linear sequence and a second linear sequence separated by a treatment distance from the first linear sequence.
  • TTZs can be created in a linear or substantially linear zone or sequence, with each individual TTZ separated from neighboring TTZs by a treatment spacing, such as shown in FIG. 9.
  • FIG. 9 illustrates an embodiment of an ultrasound system 20 with a transducer 280 configured to treat tissue at a focal depth 278.
  • the focal depth 278 is a distance between the transducer 280 and the target tissue for treatment.
  • a focal depth 278 is fixed for a given transducer 280.
  • a focal depth 278 is variable for a given transducer 280. As illustrated in FIG.
  • FIG. 9 illustrates one embodiment of a depth that corresponds to a depth for treating muscle.
  • the depth can correspond to any tissue, tissue layer, skin, epidermis, dermis, hypodermis, fat, SMAS, muscle, blood vessel, nerve, or other tissue.
  • the module 200 and/or the transducer 280 can also be mechanically and/or electronically scanned along the surface 501 to treat an extended area.
  • monitoring of the treatment area and surrounding structures can be provided to plan and assess the results and/or provide feedback to the controller 300 and the user via a graphical interface 310.
  • an ultrasound system 20 generates ultrasound energy which is directed to and focused below the surface 501. This controlled and focused ultrasound energy 50 creates the thermal treatment zone (TTZ) 550.
  • the TTZ 550 is a line.
  • the TTZ 550 is a point. In one embodiment, the TTZ 550 is a two dimensional region or plane. In one embodiment, the TTZ 550 is a volume. In one embodiment, the ultrasound energy 50 heat treats the subcutaneous tissue 510. In various embodiments, the emitted energy 50 targets the tissue below the surface 501 at a specified focal depth 278. In one embodiment, during the treatment sequence, the transducer 280 moves in a direction denoted by the arrow marked 290 to move the TTZ 550.
  • an active TTZ can be moved (continuously, or non-continuously) through tissue to form a treatment area 552, such as shown in FIG. 10 .
  • the module 200 can include a transducer 280 which can emit energy through an acoustically transparent member 230.
  • a depth may refer to the focal depth 278.
  • the transducer 280 can have an offset distance 270, which is the distance between the transducer 280 and a surface of the acoustically transparent member 230.
  • the focal depth 278 of a transducer 280 is a fixed distance from the transducer.
  • a transducer 280 may have a fixed offset distance 270 from the transducer to the acoustically transparent member 230.
  • an acoustically transparent member 230 is configured at a position on the module 200 or the ultrasound system 20 for contacting the skin surface 501.
  • the focal depth 278 exceeds the offset distance 270 by an amount to correspond to treatment at a target area located at a tissue depth 279 below a skin surface 501.
  • the tissue depth 279 is a distance between the acoustically transparent member 230 and the target area, measured as the distance from the portion of the hand wand 100 or module 200 surface that contacts skin (with or without an acoustic coupling gel, medium, etc.) and the depth in tissue from that skin surface contact point to the target area.
  • the focal depth 278 can correspond to the sum of an offset distance 270 (as measured to the surface of the acoustically transparent member 230 in contact with a coupling medium and/or skin 501) in addition to a tissue depth 279 under the skin surface 501 to the target region.
  • the acoustically transparent member 230 is not used.
  • therapeutic treatment advantageously can be delivered at a faster rate and with improved accuracy by using a transducer configured to deliver energy to an expanded TTZ. This in turn can reduce treatment time and decrease pain experienced by a subject.
  • treatment time is reduced by creating a TTZ and sweeping the TTZ through an area or volume for treatment from a single transducer. In some embodiments, it is desirable to reduce treatment time and corresponding risk of pain and/or discomfort experienced by a patient. Therapy time can be reduced by treating larger areas in a given time by forming larger a TTZ 550, multiple TTZs simultaneously, nearly simultaneously, or sequentially, and/or moving the TTZ 550 to form larger treatment areas 552.
  • a reduction in treatment time is reduced by treating a given area or volume with multiple TTZs reduces the overall amount of movement for a device.
  • overall treatment time can be reduced 10%, 20%, 25%, 30%, 35%, 40%, 4%, 50%, 55%, 60%, 65%, 70%, 75%, 80% or more by through creation of continuous treatment areas 552 or discrete, segmented treatment areas 552 from a sequence of individual TTZs.
  • therapy time can be reduced by 10-25%, 30-50%, 40-80%, 50-90%, or approximately 40%, 50%, 60%, 70%, and/or 80%.
  • a subject may be treated under the same surface region at one depth in time one, a second depth in time two, etc.
  • the time can be on the order of nanoseconds, microseconds, milliseconds, seconds, minutes, hours, days, weeks, months, or other time periods.
  • the transducer module is configured to deliver energy with an on-time of 10 ms - 100 minutes (e.g., 100 ms, 1 second, 1 - 60 seconds, 1 minute - 10 minutes, 1 minute - 60 minutes, and any range therein).
  • the new collagen produced by the first treatment may be more sensitive to subsequent treatments, which may be desired for some indications.
  • multiple depth treatment under the same surface region in a single session may be advantageous because treatment at one depth may synergistically enhance or supplement treatment at another depth (due to, for example, enhanced blood flow, stimulation of growth factors, hormonal stimulation, etc.).
  • different transducer modules provide treatment at different depths.
  • a single transducer module can be adjusted or controlled for varied depths.
  • an aesthetic treatment system includes an ultrasonic probe with a removable module that includes an ultrasound transducer configured to apply ultrasonic therapy to tissue at in a focal zone.
  • the focal zone is a point.
  • the focal zone is a line.
  • the focal zone is a two dimensional region or plane.
  • the focal zone is a volume.
  • a focal zone can be moved to sweep a volume between a first position and a second position.
  • one or more a focal zone locations are positioned in a substantially linear sequence within a cosmetic treatment zone.
  • a first set of locations is positioned within a first cosmetic treatment zone and a second set of locations is positioned within a second cosmetic treatment zone, the first zone being different from the second zone.
  • the first cosmetic treatment zone includes a substantially linear sequence of the first set of locations and the second cosmetic treatment zone includes a substantially linear sequence of the second set of locations.
  • the transducer module 280 can provide an acoustic power in a range of about 1 W or less, between about 1 W to about 100 W, and more than about 100 W. In one embodiment, the transducer module 280 can provide an acoustic power at a frequency of about 1 MHz or less, between about 1 MHz to about 10 MHz, and more than about 10 MHz. In one embodiment, the module 200 has a focal depth 278 for a treatment at a tissue depth 279 of about 4.5 mm below the skin surface 501.
  • transducers 280 or modules 200 can be configured for delivering ultrasonic energy at a tissue depth of 3 mm, 4.5 mm, 6 mm, less than 3 mm, between 3 mm and 4.5 mm, between 4.5 mm and 6 mm, more than more than 4.5 mm, more than 6 mm, etc., and anywhere in the ranges of 0.1 - 3 mm, 0.1 - 4.5 mm, 0.1 - 6 mm, 0.1 - 25 mm, 0.1 - 100 mm, etc. and any depths therein.
  • the ultrasound system 20 is provided with two or more removable transducer modules 280.
  • a transducer 280 can apply treatment at a tissue depth (e.g., about 6 mm).
  • a first transducer module can apply treatment at a first tissue depth (e.g., about 4.5 mm) and a second transducer module can apply treatment at a second tissue depth (e.g., of about 3 mm), and a third transducer module can apply treatment at a third tissue depth (e.g., of about 1.5 - 2 mm).
  • at least some or all transducer modules can be configured to apply treatment at substantially same depths.
  • the tissue depth can be 1.5 mm, 2 mm, 3 mm, 4.5 mm, 7 mm, 10 mm, 12 mm, 14 mm, 15 mm, 17 mm, 18 mm, and/or 20 mm, or any range therein (including but not limited to 12-20 mm, or higher).
  • a transducer module permits a treatment sequence at a fixed depth at or below the skin surface. In one embodiment, a transducer module permits a treatment sequence at a range of depths below the skin surface. In several embodiments, the transducer module comprises a movement mechanism configured to move the ultrasonic treatment at the TTZ. In one embodiment, the linear sequence of individual TTZs has a treatment spacing in a range from about 0.01 mm to about 25 mm. For example, the spacing can be 1.1 mm or less, 1.5 mm or more, between about 1.1 mm and about 1.5 mm, etc. In one embodiment, the individual TTZs are discrete. In one embodiment, the individual TTZs are overlapping.
  • a transducer module comprises a movement mechanism configured to direct ultrasonic treatment in a sequence so that TTZs are formed in linear or substantially linear sequences separated by a treatment distance.
  • a transducer module can be configured to form TTZs along a first linear sequence and a second linear sequence separated by a treatment distance from the first linear sequence.
  • treatment distance between adjacent linear sequences of individual TTZs is in a range from about 0.01 mm to about 25 mm.
  • the treatment distance can be 2 mm or less, 3 mm or more, between about 2 mm and about 3 mm, etc.
  • a transducer module can comprise one or more movement mechanisms configured to direct ultrasonic treatment in a sequence so that TTZs are formed in linear or substantially linear sequences of individual thermal lesions separated by a treatment distance from other linear sequences.
  • the treatment distance separating linear or substantially linear TTZs sequences is the same or substantially the same. In one embodiment, the treatment distance separating linear or substantially linear TTZs sequences is different or substantially different for various adjacent pairs of linear TTZs sequences.
  • an imaging transducer or imaging element with a cylindrical transduction element 281 can be used to improve safety and/or efficacy of a treatment.
  • an imaging element can be used to confirm acceptable coupling between the ultrasound therapy transducer and/or identify target tissue below the skin surface.
  • a transducer 280 comprises a cylindrical transduction element 281 and one or more imaging elements 284.
  • the imaging element 284 is configured to image a region of interest at any suitable tissue depths 279.
  • an imaging element is centered on a therapy element.
  • an imaging element is axis symmetric with a therapy element.
  • an imaging element is not axis symmetric with a therapy element.
  • the imaging axis may be pointed in a completely different direction and translated from the therapy beam axis.
  • the number of imaging elements in the aperture may be greater than one.
  • the imaging elements may be located on each corner of a cylinder pointed straight ahead and/or in the middle.
  • a combined imaging and cylindrical therapy transducer 280 comprises a cylindrical transduction element 281 and one or more imaging elements 284.
  • a combined imaging and cylindrical therapy transducer 280 comprises a cylindrical transduction element 281 with an opening 285 through which one imaging element 284 is configured to operate.
  • the opening 284 is a circular hole through the wall thickness of the cylindrical transduction element 281 at the center of the X-axis (azimuth) and Y-axis (elevation) of the cylindrical transduction element 281.
  • the imaging element 284 is circular in cross-section and fits in the opening 284.
  • first and second removable transducer modules are provided.
  • each of the first and second transducer modules are configured for both ultrasonic imaging and ultrasonic treatment.
  • a transducer module is configured for treatment only.
  • an imaging transducer may be attached to a handle of a probe or a hand wand.
  • the first and second transducer modules are configured for interchangeable coupling to a hand wand.
  • the first transducer module is configured to apply ultrasonic therapy to a first treatment area
  • the second transducer module is configured to apply ultrasonic therapy to a second treatment area.
  • the second treatment area can be at a different depth, width, height, position, and/or orientation than the first treatment area.
  • treatment advantageously can be delivered with improved accuracy. Further, efficiency, comfort and safety can be increased if variance is reduced in a treatment area. This in turn can reduce treatment time and decrease pain experienced by a subject.
  • non-uniform heating at a focal zone can result from geometric aspects of a transducer. Inconsistencies in pressure or temperature profiles can be attributed to edge effects, which can cause spikes in pressure or temperature around the focal zone of a transducer. Thus, with edge effects, instead of achieving a uniform line segment of heating, the segment is broken into many isolated hot spots which may fail to meet an objective a more uniform heat distribution at the focal zone. This phenomenon is further exacerbated at high heating rates which relate to elevated acoustic pressures.
  • FIG. 23 shows the normalized harmonic pressure at the focal depth across an azimuth of one embodiment of a cylindrical element with an imaging element.
  • FIG. 23 shows the rapid swings in harmonic pressure at this depth which causes hot spots and non-uniform heating.
  • a way to combat these hot and cold spots that are the result from edge effects is to reduce the average intensity at the focal depth and/or increase the heating time.
  • These two processes can reduce the amount on nonlinear heating as well as allow for the conduction of the heat away from the hot spot into the cold areas.
  • the thermal conduction of tissue effectively acts as a low pass filter to the acoustic intensity distribution as the heating time increases.
  • these methods may reduce the non-uniform heating issues, they can also reduce the localization of the heating zone and can also increase the treatment time. Therefore, three performance areas of ultrasound therapy, e.g. efficacy, comfort, and treatment time, are adversely affected.
  • a more normalized pressure profile results in more consistent therapy, such that temperature increase through heating, coagulation, and/or ablation is more predictable and can better ensure the desired or targeted temperature profiles are obtained in the TTZ 550.
  • apodization of edge effects is accomplished with transducers coated in specific regions.
  • FIG. 24 shows a harmonic pressure distribution from an embodiment of a shaded aperture, or a coated element, that has an imaging transducer.
  • the coated element is a coated cylindrical element with an imaging element.
  • the variation in harmonic pressure across the treatment line varies by less the 1.5 dB with the highest intensity near the center and sharp edges at -10 mm and +10 mm.
  • the coated element design does not require the conduction of heat away from hot spots since the tissue along the focused line has a uniform temperature increase during the absorption. Therefore, the amount of intensity at the focus can be increased to localize the heating zone and reduce treatment time.
  • the coated element is a shaded therapeutic cylinder.
  • a coated element also has benefits outside the intended heating zone.
  • the boundary between the heated and unheated junction is vastly improved when compared to an uncoated element.
  • FIG. 25 shows a comparison of harmonic pressure across an azimuth of an embodiment of a cylindrical element 280 compared to an embodiment of a coated cylindrical element 600 at this boundary.
  • FIG. 25 shows that, in one embodiment, the possible harmonic pressures are approximately 20 dB lower for the shaded aperture with a coated cylindrical element 600, which helps confine the heating zone and maximize comfort.
  • areas of plating or non-plating are initially used to define regions where the piezoelectric material will be poled or not poled.
  • Regions where there is plating define regions that will be poled or actually mechanically vibrating.
  • a cylindrical element 280 can be uncoated. Further, an uncoated region may be considered uncoated to the extent it does not have an electrically conductive coating - the uncoated region may have other types of surface coatings in certain embodiments.
  • a cylindrical element is completely coated.
  • a first transducer 280 includes a first coated region 287 that fully plates the concave surface 282 of the cylindrical transduction element and a second coated region 287 that fully plates the convex surface 283 of the cylindrical transduction element.
  • a second coated transducer 600 includes a first coated region 287 that fully plates the concave surface 282 of the cylindrical transduction element and at least a second coated region 287 that partially plates the convex surface 283 of the cylindrical transduction element. As shown in FIG. 27 , the fully coated first transducer 281 demonstrates the spikes in focal gain due to edge effects.
  • transducer treatment profiles were plotted based on theoretical and experimental performance with a cylindrical transduction element 281 that was coated on the entire concave surface 282 and the entire convex surface 283 with a coating.
  • the coating is a metal.
  • the coating is a conductive metal.
  • the coating is an electrical conductor.
  • the coating is plated with any one or more of silver, gold, platinum, mercury, copper or other materials.
  • a coating comprises fired silver.
  • a surface is fully coated.
  • a surface is fully non-coated.
  • a surface is partially coated and partially non-coated.
  • the normalized pressure is proportional to a thermal heating measure at the specified depth.
  • the discontinuous spikes (pointed regions at the top of the plots) plots indicate pressure and/or temperature peaks that occur as a result of the geometric edge effects of the geometry of the cylindrical transduction element 281.
  • the spikes, or peaks can be reduced with a coated transducer 600 comprising one or more coated regions 287.
  • the coated region 287 only partially coats a transducer surface. In one embodiment, the coated region 287 does not completely coat a transducer surface.
  • a coated transducer 600 comprises a cylindrical transduction element 281 with one or more coated regions 287.
  • the coated region 287 coats part, a portion, and/or all of a surface of the transducer 600.
  • the coated region 287 coats part or all of a surface of the cylindrical transduction element 281.
  • a coated transducer 600 comprises one or more imaging elements 284.
  • one, two, three or more imaging element(s) are placed in 'unused regions' of coatings/shading for the purpose of imaging.
  • FIG. 27 is a plot illustrating focal gain across the azimuth of two embodiments of combined imaging and cylindrical therapy transducers with different coatings.
  • a first transducer 280 includes a first coated region 287 that fully plates the concave surface 282 of the cylindrical transduction element and a second coated region 287 that fully plates the convex surface 283 of the cylindrical transduction element. Both the first and the second coated regions 287 of the first transducer 280 are plated with silver.
  • a second coated transducer 600 includes a first coated region 287 that fully plates the concave surface 282 of the cylindrical transduction element and at least a second coated region 287 that partially plates the convex surface 283 of the cylindrical transduction element. Both the first and the second coated regions 287 of the second transducer 600 are plated with silver. As shown in FIG. 27 , the fully coated first transducer 281 demonstrates the spikes in focal gain due to edge effects. The partially coated second transducer 600 has a more consistent, normalized performance output with the spikes substantially reduced and/or removed.
  • a coated transducer 600 reduces the peaks such that variance around the focal depth is reduced by 1 - 50%, 25 - 100%, 75 - 200%, and/or 10 - 20%, 20 - 40% and 60 - 80%. In various embodiments, a coated transducer 600 reduces the peaks such that variance of the intensity in a location around the focal depth is +/- 0.01 - 5 mm, 5 mm or less, 4 mm or less, 3 mm or less, 2 mm or less, 1 mm or less, 0.5 mm or less, 0.25 mm or less, 0.1 mm or less, 0.05 mm or less, or any range therein.
  • a coated transducer 600 reduces the peaks in focal gain such that variance in focal gain is 0.01 - 0.1, 0.01 - 1.0, 0.01 - 5, 0.01 - 10, 1 - 10, 1 - 5, 10, 9, 8, 7, 6, 5, 4, 3, 2, 1 or less, or any range therein.
  • FIGS. 28, 29 , and 30 illustrate the embodiment of the performance of the partially coated second transducer 600 in FIG. 27 at different depths.
  • the partially coated second transducer 600 has a focal depth of 15 mm.
  • the focal depth can be at any depth.
  • the focal depth is at 7, 8, 9, 10, 12, 13, 13.6, 14, 15, 16, 17, 18, or any depth therein.
  • the coated region 287 is plating. In one embodiment, the coated region 287 is a conductive material. In one embodiment, the coated region 287 is a semi-conductive material. In one embodiment, the coated region 287 is an insulator material. In various embodiments, the coated region 287 is silver, copper, gold, platinum, nickel, chrome, and/or any conductive material that will adhere with the surface of a piezoelectric material, or any combinations thereof. In one embodiment, the coated region 287 is silver plating.
  • a cylindrical transduction element 281 has an azimuth (x-axis) dimension in the range of 1 - 50 mm, 5 - 40 mm, 10 - 20 mm, 15 - 25 mm, and/or 15 mm, 16 mm, 17 mm, 18 mm, 19 mm, 20 mm, 21 mm, 22 mm, 23 mm, 24 mm, and 25 mm.
  • a cylindrical transduction element 281 has an elevation (y-axis) dimension in the range of 1 - 50 mm, 5 - 40 mm, 10 - 20 mm, 15 - 25 mm, and/or 15 mm, 16 mm, 17 mm, 18 mm, 19 mm, 20 mm, 21 mm, 22 mm, 23 mm, 24 mm, and 25 mm.
  • a cylindrical transduction element 281 has focal depth (z-axis) dimension in the range of 1 - 50 mm, 5 - 40 mm, 10 - 20 mm, 15 - 25 mm, 12 - 17 mm, 13 - 15 mm, and/or 10mm, 11mm, 12mm, 13mm, 13.6mm, 14mm, 15 mm, 16 mm, 17 mm, 18 mm, 19 mm, 20 mm, 21 mm, 22 mm, 23 mm, 24 mm, and 25 mm.
  • transducers can be configured for a treatment zone at a tissue depth below a skin surface of 1.5 mm, 3 mm, 4.5 mm, 6 mm, less than 3 mm, between 1.5 mm and 3 mm, between 1.5 mm and 4.5 mm, more than more than 4.5 mm, more than 6 mm, and anywhere in the ranges of 0.1 mm - 3 mm, 0.1 mm -4.5 mm, 3 mm - 7 mm, 3 mm - 9mm, 0.1 mm - 25 mm, 0.1 mm - 100 mm, and any depths therein.
  • a coated transducer 600 comprising a cylindrical transduction element 281 has one, two, three, four, or more coated regions 287.
  • a coated region 287 covers an entire surface of the element.
  • a coated region 287 covers a portion of a surface of the element.
  • the coated region 287 includes a conductive plating.
  • a coated region 287 includes a silver plating to form an electrode. When an electrical signal is applied to an electrode at a coated region 287, the coated region 287 expands and/or contracts the corresponding portion of the cylindrical transduction element 281.
  • the coated region 287 has a shape or border that is a complete or a partial point, edge, line, curve, radius, circle, oval, ellipse, parabola, star, triangle, square, rectangle, pentagon, polygon, a combination of shapes, or other shape.
  • a coated transducer 600 can also comprise an opening 285.
  • a partially coated transducer 600 comprising a cylindrical transduction element 281 has one, two, three, four, or more coated regions 287 of one or more shapes on a convex 283 surface.
  • a partially coated transducer 600 comprising a cylindrical transduction element 281 has one, two, three, four, or more coated regions 287 of one or more shapes on a concave 282 surface.
  • the coated region 287 has a lateral edge 293, a side edge 290, and a medial edge 291.
  • the various edges can be straight, curved, and/or have a radius, and the sizes can be modified to result in various performance profiles.
  • a partially coated transducer 600 comprising a cylindrical transduction element 281 has one, two, three, four, or more circular, round, curved and/or elliptical coated regions 287.
  • the coated region 287 has a lateral edge 293, a side edge 290, and a medial edge 291.
  • the various edges can be straight, curved, and/or have a radius, and the sizes can be modified to result in various performance profiles.
  • a partially coated transducer 600 comprising a cylindrical transduction element 281 has one, two, three, four, or more triangular coated regions 287.
  • the coated region 287 has a lateral edge 293, a side edge 290, and a medial edge 291.
  • the various edges can be straight, curved, and/or have a radius, and the sizes can be modified to result in various performance profiles.
  • a partially coated transducer 600 comprising a cylindrical transduction element 281 has one, two or more square, rectangular, and/or polygon coated regions 287.
  • the coated region 287 has a lateral edge 293, a side edge 290, and a medial edge 291.
  • the various edges and/or sizes can be modified to result in various performance profiles.
  • a partially coated transducer 600 comprising a cylindrical transduction element 281 has one, two or more combined and/or mixed shape coated regions 287.
  • a partially coated transducer 600 is a combined imaging and cylindrical therapy transducer comprising a cylindrical transduction element 281 with an opening 285 for an imaging element 284.
  • the coated transducer 600 includes a concave surface 282 that is fully plated with fired silver, and has a convex surface 283 with two coated regions 287 that are plated with fired silver to form electrodes. When an electrical signal is applied to an electrode at a coated region 287, the coated region 287 expands and/or contracts the corresponding portion of the cylindrical transduction element 281.
  • the shape may be applied before or after the poling process, as vibration will occur where the electrode is located.
  • an electrode could be defined before or after poling.
  • a coating pattern may be on the concave or convex surface.
  • the coated region 287 has a lateral edge 293, a first and second side edge 290, and a medial edge 291 with a central edge 297.
  • the various edges can be straight, curved, and/or have a radius.
  • Various dimensions 294, 295, 296, and the various edges can be modified to result in various performance profiles.
  • the medial edge 291 along the curved dimension (elevation) is a portion of an ellipse.
  • the medial edge 291 along the curved dimension (elevation) is a portion of a parabola.
  • the first and second side edge 290 along the uncurved dimension (azimuth) is a portion of a parabola.
  • the first and second side edge 290 along the uncurved dimension (azimuth) is a portion of an ellipse.
  • a partially coated transducer 600 comprising a cylindrical transduction element 281 has one, two, three, four, or more diamond, rhombus, and/or other polygon coated regions 287.
  • the coated region 287 has a lateral edge 293, a side edge 290, and a medial edge 291. The various edges and/or sizes can be modified to result in various performance profiles.
  • a partially coated transducer 600 comprising a cylindrical transduction element 281 has one, two, three, four or more coated regions 287.
  • the coated region 287 has a lateral edge 293, a side edge 290, and a medial edge 291.
  • the coated region 287 is configured to position one, two, three, four, or more (e.g., multiple) thermal treatment zones through poling, phasic poling, biphasic poling, and/or multi-phasic poling.
  • a coated cylindrical transducer 600 comprising one or more coated regions 287 is configured for non-therapeutic use.
  • a coated cylindrical transducer 600 comprising one or more coated regions 287 is configured for materials processing. In one embodiment, a coated cylindrical transducer 600 comprising one or more coated regions 287 is configured for ultrasonic impact treatment for the enhancement of properties of a material, such as a metal, compound, polymer, adhesive, liquid, slurry, industrial material.
  • a material such as a metal, compound, polymer, adhesive, liquid, slurry, industrial material.
  • a coated cylindrical transducer 600 comprising one or more coated regions 287 is configured for material heating.
  • the cylindrical transducer 600 is configured for cooking, heating, and/or warming materials, food, adhesives or other products.
  • systems and/or methods provide non-invasive dermatological treatment to tissue through heating, hyperthermia, thermal dosimetry, thermal treatment, coagulation, ablation, apoptosis, lysis, increasing tissue volume, decreasing or reducing tissue volume, and/or tissue tightening.
  • dermal tissue volume is increased.
  • fat tissue volume is reduced, or decreased.
  • band treatment involves metrics that quantify the magnitude of adipocyte death with heat.
  • a band treatment is configured under a relationship that that for every 1 degree Celsius increase in tissue temperature above in a range above body temperature, the rate of cell death doubles. A theoretical survival fraction can then be determined by comparing the thermal dose to empirical data from the literature.
  • band treatment provides improved thermal heating and treatment of tissue compared to diathermy or general bulk heating techniques.
  • normal body temperatures tend to range between about 33 - 37 degrees Celsius.
  • physiological hyperthermia can take place, and exposure to this temperature range on order of, for example, a few hours, can result in increased normal tissue metabolism and/or increased normal tissue blood flow, and in some embodiments, accelerated normal tissue repair.
  • tissue As temperature in the tissues reaches the higher ⁇ 43 degrees Celsius range and/or the tissue is subject to the temperature for longer periods of time (e.g., 2 hours, 3, hours or more) the tissue can experience acute tissue metabolism and/or acute tissue blood flow, and in some embodiments, accelerated normal tissue repair.
  • heating e.g., bulk heating
  • tissue to a range of about 42 - 55 degrees Celsius is performed.
  • heating of tissue to about 43 - 50 degrees Celsius can be considered adjuvant synergistic hyperthermia, and exposure to this temperature range on order of, for example, a few minutes, can result in immediate or delayed cell death, apoptosis, decreased tumor metabolism, increased tissue oxygen levels, increased tissue damage, increased sensitivity to therapy, vascular status, DNA damage, cell reproductive failure, and/or cell destruction.
  • heating of tissue to about 50 - 100 degrees Celsius can be considered surgical hyperthermia, and exposure to this temperature range on order of, for example, a few seconds or fractions of a second, can result in coagulation, ablation, vaporization, and immediate cell destruction.
  • the temperature of the tissue treatment site is elevated to 38 - 43 degrees Celsius, and according to one embodiment, thereby increasing tissue metabolism and perfusion and accelerating tissue repair mechanisms.
  • the temperature of the tissue treatment site e.g., the adipocytes
  • the temperature of the tissue treatment site is elevated to 43 - 50 degrees Celsius, which in one embodiment can increase cell damage starts and result in immediate cell death, particularly when the temperature remains elevated on the order of several minutes to an hour (or longer).
  • the temperature of the tissue treatment site e.g., the adipocytes
  • the temperature of the tissue treatment site is elevated to above 50 degrees Celsius, which in one embodiment results in protein coagulation on the order of seconds and less and can lead to immediate cell death and ablation.
  • the temperature of the tissue treatment site is heated to 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 70, 75, 80, 90, or 100 degrees Celsius, and/or any range therein.
  • a treatment area has uniform temperature, a variance of 1%, 2%, 3%, 4%, 5%, 6%, 7 %, 8%, 9%, 10%, 12%, 15%, 20%, 25%, 30%, 40%, 50% or more.
  • a treatment area has a variance of +/- 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 15, 20, 25 degrees Celsius or more.
  • temperature of the tissue treatment site e.g., the adipocytes
  • 38 - 50 degrees Celsius for a time period between 1 - 120 minutes, and then optionally increasing the temperature in one, two, three, four five or more increments by 10-50%.
  • the target temperatures may be increased as follows: (i) elevate temperature to about 40-42 degrees Celsius for 10-30 minutes, (ii) then optionally increase temperature by about 20% to elevate temperature to about 48-51 degrees Celsius for 1-10 minutes, and (iii) then optionally increase by about 10-50% for a shorter time frame.
  • the target temperature may be increased as follows: (i) elevate temperature to about 50 degrees Celsius for 30 seconds to 5 minutes (e.g., about 1 minute) to destroy over 90%, 95% or 99% of target (e.g., adipose) cells, with an optional pre-heating step of raising the temperature to 38 - 49 degrees Celsius for a period of 10-120 minutes prior to the elevation to 50 degrees Celsius.
  • target e.g., adipose
  • a non-invasive, cosmetic method of heating tissue comprises applying a cosmetic heating system to a skin surface, wherein the cosmetic heating system comprises a hand-held probe, wherein the hand-held probe comprises a housing that encloses an ultrasound transducer configured to heat tissue below the skin surface to a tissue temperature in the range of 40 - 50 degrees Celsius, wherein the ultrasound transducer comprises a cylindrical transduction element comprising a first surface, a second surface, a coated region, and an uncoated region, wherein the coated region comprises an electrical conductor, wherein the first surface comprises at least one coated region, wherein the second surface comprises the uncoated region and a plurality of coated regions, applying a current to the plurality of coated regions, thereby directing ultrasound energy to a linear focal zone at a focal depth, wherein the ultrasound energy produces a reduction in focal gain at the linear focal zone, thereby heating the tissue at the focal depth in the linear focal zone to the tissue temperature in the range of 40 - 50 degrees Celsius for a cosmetic
  • a band therapy system uses a relationship between cell death and time-temperature dosages as quantified using the Arrhenius equation.
  • the Arrhenius equation shows an exponential relationship exists between cell death and exposure time and temperature. Above a certain break temperature, the increase in the rate of cell killing with temperature is relatively constant. Time-temperature relationships to achieve isoeffective dose in several types of tissue appears to be conserved both in vitro and in-vivo across multiple cell types.
  • clinical situations involve ramp-up of temperatures, cooling, and fluctuations when approaching and maintaining a steady state temperature.
  • different thermal profiles can produce the same thermal dose.
  • a temperature curve is discretized into small time steps, and the average temperature during each time step is calculated.
  • the thermal dosage is then calculated as an equivalent exposure time at the break temperature (43 degrees Celsius) by integrating these temperatures according to equation (2):
  • Equation (2) suggests that the increase in the rate of killing with temperature is relatively constant. In some embodiments, a 1 degree Celsius increase above a break point results in the rate of cell death doubles.
  • FIGs. 39 and 40 illustrate theoretical cell death fractions over time depending on tissue temperature, with higher theoretical cell killing fractions at higher temperatures and/or higher periods of time. The higher a kill fraction (such as shown with kill fractions of 99%, 80%, 50%, 40%, and 20%) the higher a temperature and/or a time is used in an embodiment of a treatment.
  • a dose survival response can be estimated from empirical data.
  • an isoeffective dose of 43 degrees Celsius for 100 minutes theoretically yields a cell survival fraction of 1%.
  • a similar surviving fraction can be obtained with an isoeffective dose of 44 degrees Celsius for 50 minutes, or 25 minutes at 45 degrees Celsius, etc. as tabulated in the table listing isoeffective dosages to theoretically achieve 1% survival fraction at FIG. 41 ,
  • simulations of various embodiments of band therapy using a cylindrical transducer source conditions linked to the relationship between tissue and heat equation showed that successive treatment pulses obey linear superposition, which allows for simplification of the heat transfer physics so that the heating rate may be described as a temperature rise per time (degrees Celsius/sec), and as a temperature rise per pass (degrees Celsius/button push).
  • a band therapy system is configured for treating the tissue.
  • a band treatment is configured for treatment of supraplatysmal submental fat.
  • a treatment of fat includes selectively causing thermal heat shock followed by apoptosis to a fat layer, at a depth of about 2.5 - 6.0 mm, without causing any major skin surface effects.
  • the treatment involves exposing fat to a bulk heating treatment with a temperature of 42-55 degrees Celsius for 1-5 minutes without exceeding 41 degrees Celsius on the skin surface, with physiologic/biologic effect (e.g. one or more of coagulation, apoptosis, fat cell lysis, etc.).
  • treatment with a band transducer treats tissue with isoeffective doses, as shown in a graph representing various levels of theoretical cell kill fractions in FIG. 42 .
  • FIG. 43 shows the results of a KZK simulation of cylindrical transducer output showing linear superposition of multiple pulses; approximately the same temperatures are reached when treating with 3 pulses of 0.45 J or 1 pulse of 1.35 J (3 * 0.45 J).
  • a therapy system with a hand wand 100 includes a module 200 with one or more ultrasound transducers 280.
  • an ultrasound transducer 280 includes one or more cylindrical ultrasound elements 281, as shown in FIGs. 5A - 8 .
  • the cylindrical transducer element 281 is configured for bulk heating treatments with its linear focus along an axis, resulting in a continuous line that can be moved with an automated motion mechanism to treat a rectangular plane.
  • lines of treatment are deposited perpendicular to the direction of motor movement in a single direction. A single "pass" of treatment creates a number of therapy lines equal to ⁇ Length ⁇ / ⁇ Spacing ⁇ .
  • various cylindrical geometries were tested from the first build (4.5 MHz - 12 mm width at 4.5 mm and 6.0 mm depths); however, acoustic tank testing showed higher acoustic pressures (and therefore heating rates) at the each edge of the therapy line.
  • a ceramic transducer was apodized to produce a flat thermal profile, as shown in FIGs. 44 and 45 .
  • a tissue temperature measurement system included one or more of including IR thermography, temperature strips, and resistance temperature detectors (RTDs), and thermocouples.
  • IR thermography can be used to read skin surface temperatures. Temperature strips are able to provide peak temperature reached. RTD sheaths have a large thermal mass and may have a slow response time.
  • thermocouples have a response time less than a second, which is helpful for measuring the heating and cooling phase of a single treatment pass. Thermocouples also have the advantage of being small enough that they can be positioned through a large bore needle to the desired tissue depth.
  • a particular isoeffective dose is attached via the heating phase followed by a maintenance phase in which the system or an operator pulses treatment at an interval to sustain a steady state temperature.
  • a parameter of interest during this phase is the average pulse period needed to maintain the steady state temperature.
  • a band therapy system is configured for body contouring.
  • body contouring treatment involves thermal heat shock concurrent with, and/or followed by apoptosis.
  • body contouring treatment involves exposing fat to 42-55 degrees Celsius for 1-5 minutes to induce delayed apoptosis.
  • body contouring treatment involves exposing fat at a focus depth of at least 13 mm below the skin surface.
  • one or more sensors may be included in the module 200 or system 20 to measure a temperature.
  • methods of temperature and/or dose control are provided.
  • temperature is measured to control dosage of energy provided for a tissue treatment.
  • a temperature sensor is used to measure a tissue temperature to increase, decrease, and/or maintain the application of energy to the tissue in order to reach a target temperature or target temperature range.
  • a temperature sensor is used for safety, for example, to reduce or cease energy application if a threshold or maximum target temperature is reached.
  • a cooling device or system can be employed to cool a tissue temperature if a certain temperature is reached.
  • a temperature sensor is used to modulate an energy dose, for example, via modulation, termination of amplitude, power, frequency, pulse, speed, or other factors.
  • a temperature sensor is used to measure a skin surface temperature.
  • a temperature sensor may be positioned on top of the transducer holder and a sensor may be located in a portion of the module, or vice versa (swapped).
  • a temperature sensor is positioned on a system or module housing, such as in one embodiment, near or on an acoustic window, such as an acoustically transparent member 230.
  • one or more temperature sensors are positioned around or proximate an acoustically transparent member 230.
  • one or more temperature sensors are positioned in or on an acoustically transparent member 230.
  • a temperature sensor measure from a skin surface can be used to calculate a temperature in a tissue at the focus depth of the energy application.
  • a target tissue temperature can be calculated and/or correlated to the depth in tissue, type of tissue (e.g. epidermis, dermis, fat, etc.) and relative thickness of tissue between the skin surface and the focus depth.
  • a temperature sensor provides a temperature measurement for a signal to a control system.
  • a temperature sensor provides a temperature measurement for visual and/or auditory feedback to a system operator, such as a text, color, flash, sound, beep, alert, alarm, or other sensory indicator of a temperature state.
  • imaging can be used to control energy dose.
  • a thermal lens effect can be used to account for speckle shift and/or feature shift to indicate a temperature of a tissue at a target location, such as at a focus depth in tissue below the skin surface.
  • Acoustic Radiation Force Impulse (ARFI) imaging is used to calculate a tissue temperature.
  • Shear Wave Elasticity Imaging (SWEI) is used to calculate a tissue temperature.
  • attenuation is used to calculate a tissue temperature.
  • a variable dose delivery technique is used to attain a target temperature in a tissue and maintain that target temperature.
  • the body temperature at a depth in tissue surrounds a thermal treatment zone (TTZ).
  • TTZ thermal treatment zone
  • a treatment focuses energy at the TTZ at a first rate to bring the tissue temperature in the TTZ to a target temperature. Once that target temperature is attained, the second rate can be reduced or stopped to maintain the tissue at the target temperature.
  • energy is focused at a depth or position in tissue at the TTZ, such that the temperature in the focal zone is increased.
  • a boundary condition at body temperature can result in temperature fluctuations at the boundaries of the treatment area 552.
  • movement of the TTZ 550 can be with the transducer delivering energy to create a treatment area 552.
  • a movement mechanism 285 can automatically move the cylindrical transduction element 281 across the surface of a treatment area so that the TTZ 550 can form a treatment area 552.
  • the treatment area 552 is surrounded at the edges by body temperature, or approximately body temperature.
  • the temperature in the treatment area 552 along the edges/boundary are lower than the desired, target temperature.
  • mechanical velocity modulation is used to attain a specific thermal distribution in the treatment area 552.
  • the applied temperature at the edges/boundaries is increased to counteract the surrounding body temperature difference.
  • FIG. 54 illustrates an embodiment of mechanical velocity modulation in which the velocity, or speed of the automatic motion of the motion mechanism moving the transducer along direction 290 (along the elevation direction), is varied to provide a more uniform temperature in the treatment area 552 by slowing near the boundaries, resulting in increased temperature at the boundaries (start and stop position, such as along a 25 mm travel distance, in one embodiment).
  • the increased velocity near the middle delivers a lower temperature than the decreased velocity.
  • amplitude modulation is used to attain a specific thermal distribution in the treatment area 552.
  • the applied temperature at the edges/boundaries is increased to counteract the surrounding body temperature difference.
  • FIG. 55 illustrates an embodiment of amplitude modulation in which the amplitude (correlates to power) of the energy delivered by the transducer as the automatic motion of the motion mechanism moves along direction 290 (along the elevation direction), is varied to provide a more uniform temperature in the treatment area 552 by increasing amplitude near the boundaries, resulting in increased temperature at the boundaries (start and stop position, such as along a 25 mm travel distance, in one embodiment).
  • the lower amplitude near the middle delivers a lower temperature than the higher amplitude near the boundaries.
  • aperture apodization is used to attain a specific thermal distribution in the treatment area 552.
  • aperture apodization along the non-focused dimension (such as along TTZ 550 and/or the azimuth direction) is used in order to attain a more uniform temperature in the treatment area 552.
  • the applied temperature at the end points, along the edges/boundaries is increased to counteract the surrounding body temperature difference.
  • a temperature profile can be generated along the TTZ with embodiments of a coated transduction element 600, such as illustrated in FIGs. 31-38 .
  • pulsing and/or duty cycles are controlled to attain a specific thermal distribution in the treatment area 552.
  • treatment patterns can have a consistent or a constant pulsing or duty cycle.
  • treatment patterns can have variable pulsing or a variable duty cycle, with variations in any of peak amplitude, spacing of application, duration of application. As shown in FIG. 58 , the application of energy is longer and covers more area near the boundary of the treatment area 552, while the internal region has less power application for a corresponding lower temperature application in the internal region.
  • treatment patterns are used to attain a specific thermal distribution in the treatment area 552.
  • the TTZ 550 has a dimension (e.g., width, height, thickness, etc.).
  • the pulsed application of TTZ 550 is non-overlapping, as shown in FIG. 59 .
  • the pulsed application of TTZ 550 is overlapping, as is shown near a boundary in FIG. 60 , where the amount of overlapping can be constant or vary. As shown in the embodiment in FIG. 60 , the amount of overlap varies and includes a non-overlapping portion.
  • a cross hatching pattern is used, wherein the system hand piece is rotated about 90 degrees, or orthogonally, and the motion mechanism is operated in one or more additional passes over a target tissue region in an orthogonal direction to a prior treatment pass.
  • a specific thermal distribution in the treatment area 552 comprises treatment with a tissue temperature of 37 - 50 degrees Celsius for a duration of minutes to hours to cause a targeted percentage of cell death (such as fat cell death) which a relationship can be determined via Arrhenius equation, such as is shown on the left side of FIG. 61 .
  • a specific thermal distribution in the treatment area 552 comprises treatment with a tissue temperature of over 60 degrees Celsius for a duration of seconds to fractions of a second (or near instantaneous) coagulation, ablation, and/or cell death (such as fat cell death) at the elevated temperature, such as shown on the right side of FIG. 62 .
  • a treatment can be either one, or both in sequence and/or simultaneous treatments.
  • one, two, three, four, or more of mechanical velocity modulation, amplitude modulation, aperture apodization, pulsing duty cycles, and/or treatments at different temperatures can be used to achieve a desired temperature profile across the treatment area 552.
  • one or more of mechanical velocity modulation, amplitude modulation, aperture apodization, pulsing duty cycles, and/or treatments at different temperatures is used to create a temperature profile, wherein the temperature profile can include areas for increased, decreased, and/or uniform temperatures.
  • one, two, or more types of treatment are applied in one, two, or three dimensions (along any of the azimuth, elevation, and/or depth directions) and is configured for treatment in any of one, two, or three dimensions to create a one, two, or three dimensional temperature profile.
  • a compound lens system produces various peak intensities and different depths.
  • a mechanical and/or electronic focus lens can be used in any one or more of the azimuth, elevation, and/or depth directions. As illustrated in FIG. 62 and FIG. 63 , a compound lens system can create two or more focal lines 550 and 550a.
  • an ultrasound system 20 comprises a motion mechanism 285 configured for moving a plurality of ultrasound transducers 280 and/or a plurality of ultrasound elements 281.
  • the motion mechanism 285 is configured to minimize heat fluctuation in treated tissue and reduce treatment time by presenting the plurality of elements 281 on a conveyor system, such as with a belt and/or pulley system that can move the plurality of elements 281 at a velocity v.
  • velocity can be constant, variable, zero (e.g., stopped), reversible (e.g., forward and backward, left and right, first direction and second direction, etc.) and/or have values in the range 0 - 100 RPM, 1 RPM - 50 RPM, or other velocities.
  • the velocity is any value 1 - 1,000 cm/second (e.g., 10, 20, 50, 100, 200, 500, 1000 cm/sec, and any other values therein).
  • the motion mechanism 285 moves one, two, three, four, five, six, seven, eight, or more ultrasound elements 281.
  • ultrasound elements 281 are connected, or spaced at a distance of 0.01 - 10 cm apart, (e.g., 0.1, 0.5, 1, 2, 5 cm and any values therein), such that one, two, or more ultrasound elements 281 are configured to treat a treatment area.
  • imaging is used to confirm the quality of the acoustic coupling between a treatment device and the skin.
  • clarity of an ultrasound image along a treatment area, line, or point is used to determine the extent to which a device is acoustically coupled to a skin surface.
  • defocused imaging and/or Voltage Standing Wave Ratio (VSWR) from backscatter is used to check acoustic coupling for a treatment.
  • VSWR Voltage Standing Wave Ratio
  • a treatment is automated.
  • a treatment is set up by acoustically coupling a system to a skin surface, and the movement mechanism and treatment is automated to function.
  • the system is coupled to a skin surface via suction.
  • a system operator couples the system to a skin surface, activates the system, and can leave the system to automatically perform a treatment, or a portion of a treatment.
  • a system uses suction and/or vacuum pressure to hold a probe or portion of the system to a skin surface, allowing the system user to initiate treatment and leave the system to automatically perform a treatment or a portion of a treatment for a period of time.
  • a treatment system includes a TENS stimulation device to reduce pain at a skin treatment site.
  • a transducer 280 comprising a cylindrical transduction element 281, which was applied to a simulated target tissue, an artificial tissue, and to porcine tissue sample, formed localized, linear thermal treatment zone (TTZ 550) in a targeted focal area 552.
  • the single cylindrical transduction element 281 was constructed with a radius and focal depth of 15 mm.
  • the size of the cylindrical transduction element 281 was 20 mm (azimuth) by 17 mm (elevation). Additional focal gain could be achieved with a larger aperture. Depth is limited by frequency and focal gain, and was set to 6 mm below a simulated tissue surface.
  • FIGS. 11A-13B treatment profiles were plotted based on theoretical and experimental performance with a cylindrical transduction element 281.
  • the normalized pressure is proportional to a thermal heating measure at the specified depth.
  • the spikes (pointed regions at the top of the plots) plots indicate pressure peaks that occur as a result of the geometric edge effects of the geometry of the cylindrical transduction element 281.
  • the spikes are visible in both the theoretical and the experimental performance results.
  • the software simulated experiments reflect the theoretical performance of the 15 mm cylindrical transduction element 281 in FIGS. 11A , 12A , 13A , 14A , 15A , and 16A .
  • the physical experiments in simulated tissue were performed and measured, with results in FIGS. 11B , 12B , 13B , 14B , 15B and 16B .
  • the depth is 20 mm, where the normalized pressure peaks at a value of roughly 0.15. As shown in FIG. 14A-14B , the normalized pressure is not visible. In FIGS. 12A - 12B and 15A-15B , the depth is the designed, optimal 15 mm, where the normalized pressure peaks at a value of roughly 0.8. As shown in FIG. 15A-15B , the normalized pressure is clearly visible, with peak normalized pressures at approximately 0.9 - 1.0.
  • the size of the cylindrical transduction element 281 was 20 mm (azimuth) by 17 mm (elevation).
  • the size of the TTZ 550 at a depth of 15 mm was about 0.5 mm thick (along azimuth) by 17 mm width (along elevation).
  • the depth is 13 mm, where the normalized pressure peaks at a value of roughly 0.25.
  • the normalized pressure is barely visible.
  • the normalized pressure corresponding to the TTZ 550 for a 15 mm focal depth cylindrical transduction element 281 is at the 15 mm depth, with a linear TTZ 550.
  • a transducer 280 comprising a cylindrical transduction element 281, which was applied to a porcine tissue sample (muscle tissue), formed localized, linear thermal treatment zone (TTZ 550) in a targeted focal area 552.
  • an embodiment of a transducer 280 comprising a cylindrical transduction element 281 was passed over the porcine muscle tissue with three passes in 20 seconds, operating at 4.5 MHz and a tissue depth of 6 mm. As shown in FIG. 17 , the three passes (shown with the three spikes in temperature) increased the temperature of the porcine muscle. Two power levels are shown.
  • the 40 W porcine muscle started at 30 degrees Celsius, and over the course of 20 seconds (between the 20 and 40 second marks) of heating through three passes of the cylindrical transduction element 281 over the target tissue region, the temperature spiked to a maximum of about 55 degrees Celsius, then gradually cooled to about 32 degrees Celsius 100 seconds after the start of the treatment.
  • the 60 W porcine muscle started at about 24 degrees Celsius, and over the course of 20 seconds (between the 40 and 60 second marks) of heating through three passes of the cylindrical transduction element 281 over the target tissue region, the temperature spiked to a maximum of about 59 degrees Celsius, then gradually cooled to about 40 degrees Celsius about 80 seconds after the start of the treatment.
  • FIG. 18 is a photograph of the porcine muscle after treatment confirming line and plane heating. In one embodiment, the coagulation was dependent on time-off between lines, time-off between passes, and number of passes. Slower temperature rise than thermal coagulation points.
  • FIG. 19 is a cross-section cut through the porcine muscle in FIG. 18 showing a linear thermal treatment zone.
  • FIG. 20 is an orthogonal cross-section cut through the porcine muscle in FIG. 19 showing a planar thermal treatment zone.
  • a partially coated transducer 600 comprising a cylindrical transduction element 281, which was applied to a simulated target tissue, formed a localized, linear thermal treatment zone (TTZ 550) in a targeted focal area 552.
  • the partially coated transducer 600 includes a first coated region 287 that fully plates the concave surface 282 of the cylindrical transduction element and at least a second coated region 287 that partially plates the convex surface 283 of the cylindrical transduction element. Both the first and the second coated regions 287 of the partially coated transducer 600 are plated with silver.
  • the single cylindrical transduction element 281 was constructed with a radius and focal depth of 15 mm.
  • the size of the cylindrical transduction element 281 was 20 mm (azimuth) by 17 mm (elevation).
  • the cylindrical transduction element 281 had an opening 285 in the center of 4mm in diameter.
  • FIGS. 28, 29 and 30 treatment profiles were plotted based on theoretical performance with a cylindrical transduction element 281.
  • the theoretical performance is proportional the thermal heating at the specified depth.
  • the software simulated experiment reflects the theoretical performance of the 15 mm partially coated transducer 600, showing a consistent linear thermal treatment zone 550 at the 15 mm depth.
  • in-vivo porcine studies and multiple cadaver studies were conducted to evaluate various embodiments of hardware to perform bulk heating treatments. Early studies focused on specifying and improving the instrumentation necessary to measure subdermal temperatures.
  • insulated wire thermocouples were placed at focal and subfocal depths by snaking the thermocouple through a needle-bored hole in the skin and verifying the depth with a Siemens s2000 ultrasound device. Temperature profiles were collected using a high sampling DAQ card. Once the measurement setup was defined, a replicated 3-factor 3-level design of experiments was performed in the in-vivo porcine model to determine energy settings that could safely reach isoeffective dosages without causing skin surface damage. In one embodiment, a mean temperature differential of 10 degrees Celsius was observed, with a mean focal heating rate of ⁇ 1.2 degrees Celsius/pass. Safe heating rates appear to be similar across transducer.
  • a thermal dosage study was performed in the in-vivo porcine model after safe heating rates were determined.
  • use of higher temperature, shorter exposure time treatments may have the potential to overshoot the target temperature and could overheat the skin surface.
  • the longer it takes to perform an isoeffective dose the more heat diffuses to the surrounding tissue and less selective the treatment becomes with depth. Additionally, the longer the isoeffective exposure time, the more impractical the treatment becomes from an operator and ergonomics point of view. For these reasons, in some embodiments, use of higher isoeffective temperatures and shorter exposure times were preferred.
  • In-vivo porcine tests were conducted to determine if the candidate treatment settings for submental could cause adverse surface skin effects.
  • the animals procured for these studies were light skinned, 120-140 pound castrated male Yucatan miniature pigs, selected due to its skin characteristics being similar to that of human tissue. Skin surface data was evaluated by monitoring the animal for evidence of erythema, edema, and contusion on the skin surface after treatment. Photographs of each treatment area were taken prior to and following treatment (Cannon G9 and Cannon VIXIA HF 510).
  • a thermal dosage study using a cylindrical element transducer was performed on in-vivo porcine models.
  • test sites were able to achieve a significant temperature differential between the focus tissue site and the skin surface without causing damage to the skin surface.
  • FIG. 46 shows the temperature profiles from an embodiment of an in-vivo porcine model treatment in which the temperature profile reached 50 degrees Celsius for several seconds without the skin surface exceeding 41 degrees Celsius, and shows a temperature differential of as much as 15 degrees Celsius between the focus tissue site and the skin surface.
  • the temperature change accrued from a single pass of treatment is sufficiently small (approximately 0.9 degrees Celsius/pass or 0.13 degrees Celsius/sec) to perform corrective action and maintain a target temperature within +/-1 degrees Celsius.
  • FIG. 47 The Design of Experiments (DOE) tests an acoustic power range of 10-20 W, exposure times of 20-40 ms, and spacings in the range of 0.1 - 0.3 mm.
  • FIG. 48 shows an embodiment of a treatment setting that was able to achieve a relatively high thermal dosage at the focus with little to no dose or temperature increase at the skin surface.
  • similar temperature rises and heating rates were achieved at the focus and surface across various embodiments of transducers for treatments that did not cause significant skin surface damage.
  • a mean temperature differential of 10 degrees Celsius was observed, with a mean focal heating rate of ⁇ 1.2 degrees Celsius/pass.
  • the largest temperature differential between the focus and the skin was achieved by the 3.5MHz, 22mm width, 6.0 depth design which had an average difference of 12 degrees Celsius across treatments. Since the heating rates that produce little to no surface effects are similar across transducer, the 3.5MHz, 22mm width, 6.0mm depth transducer was selected to be assessed in a thermal dosage study.
  • thermal dosage studies were performed on in-vivo porcine and cadaver models to determine safe isoeffective dosages, and the geometry of adipocyte death through histological evaluation.
  • the Table at FIG. 49 tabulates the target time-temperature exposures to achieve different levels of adipocyte death. According to the empirical data in FIG. 42 , Site 2 and 5 should achieve little to no adipocyte death. Sites 3, 6 and 7 should achieve a high degree of adipocyte death. Sites 1 and 4 are within the transition region and should achieve a moderate amount of adipocyte death.
  • the table at FIG. 50 lists the energy settings used to approach each isoeffective dose using a 3.5 MHz, 22 mm width, 6.0 mm depth transducer.
  • FIG. 51 shows one site that was treated aggressively for the purpose of coagulating tissue for histological control through overdosing.
  • the dimension of the lesion represents a an example of the spread of thermal energy, measuring 12.6 x 19.9 mm on the skin surface with a depth of edema that can be detected up to 12 mm from the skin surface.
  • FIG. 52 A visual representation of the time-temperature goals listed in the table at FIG. 49 is shown in FIG. 52 (triangle marks), with six isoeffective dosages achieved in the lab are overlayed in FIG. 52 (square marks). Two of these isoeffective dosages fall in the coagulative region, two fall in the transition region, and two in the hyperthermia region.
  • actions such as “coupling an ultrasound probe to a skin surface” include “instructing the coupling of an ultrasound probe to a skin surface.”
  • the ranges disclosed herein also encompass any and all overlap, sub-ranges, and combinations thereof.
  • Language such as “up to,” “at least,” “greater than,” “less than,” “between,” and the like includes the number recited. Numbers preceded by a term such as “about” or “approximately” include the recited numbers. For example, “about 25 mm” includes “25 mm.”
  • the terms “approximately”, “about”, and “substantially” as used herein represent an amount or characteristic close to the stated amount or characteristic that still performs a desired function or achieves a desired result.
  • the terms “approximately”, “about”, and “substantially” may refer to an amount that is within less than 10% of, within less than 5% of, within less than 1% of, within less than 0.1% of, and within less than 0.01% of the stated amount or characteristic.

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Claims (14)

  1. Ein Ultraschallübertragungssystem (20), das Folgendes umfasst:
    eine handgehaltene Ultraschallsonde (100), wobei die Ultraschallsonde umfasst:
    ein Gehäuse,
    ein zylindrisches Wandlerelement (281), das sich entlang der Längsachse erstreckt und dessen Querschnitt entlang der y-Achse gekrümmt ist,
    einen Bewegungsmechanismus (400), wobei der Ultraschallwandler (280; 600) innerhalb des Gehäuses beweglich ist, wobei der Bewegungsmechanismus an dem Ultraschallwandler angebracht und so konfiguriert ist, dass er den Ultraschallwandler entlang einer linearen Bahn (290) innerhalb des Gehäuses bewegt; und
    eine Energiequelle, die so konfiguriert ist, dass sie das zylindrische Wandlerelement (281) antreibt,
    wobei das zylindrische Wandlerelement (281) so konfiguriert ist, dass es Ultraschallenergie auf eine lineare Fokuszone in einer Fokustiefe aufbringt,
    wobei das zylindrische Wandlerelement (281) eine erste Oberfläche (282) und eine zweite Oberfläche (283) aufweist, wobei die erste Oberfläche (282) eine konkave Oberfläche und die zweite Oberfläche (283) eine konvexe Oberfläche ist oder die erste Oberfläche (282) eine konvexe Oberfläche und die zweite Oberfläche (283) eine konkave Oberfläche ist,
    wobei die erste Oberfläche (282) eine elektrisch leitfähige Beschichtung aufweist,
    wobei die zweite Oberfläche (283) zwei, drei oder vier elektrisch leitfähig beschichtete Bereiche (287) und mindestens einen Bereich aufweist, der nicht mit einer elektrisch leitfähigen Beschichtung versehen ist,
    wobei die zwei, drei oder vier beschichteten Bereiche (287) auf der zweiten Oberfläche (283) ein leitfähiges Material umfassen, das eine Elektrode bildet, und die Energiequelle in elektrischer Verbindung mit den zwei, drei oder vier beschichteten Bereichen (287) steht, die die Elektrode bilden,
    wobei die Untergruppe der zwei, drei oder vier elektrisch leitfähigen beschichteten Bereiche (287) auf der zweiten Oberfläche (283) mindestens 60 % der zweiten Oberfläche bedecken,
    wobei die zwei, drei oder vier elektrisch leitfähigen beschichteten Bereiche (287) auf der zweiten Oberfläche (283) eine Seitenkante (293), eine Mittelkante (291), einen ersten Seitenrand (290) und einen zweiten Seitenrand (290) umfassen, wobei die erste Seitenkante (290) und die zweite Seitenkante (290) jeweils entlang einer Längsachse des zylindrischen Wandlerelements (281) verlaufen, die Seitenkante (293) und die Mittelkante (291) entlang der Y-Achse verlaufen und die Mittelkante der Mitte der zweiten Oberfläche (283) zugewandt ist, und
    wobei ein Teil des zylindrischen Wandlerelements (281) die zwei, drei oder vier elektrisch leitfähigen beschichteten Bereiche (287) umfasst,
    wobei die zwei, drei oder vier elektrisch leitfähigen beschichteten Bereiche (287) auf der zweiten Oberfläche (283) so konfiguriert sind, dass sie das Kantenrauschen in der linearen Fokuszone in der Fokustiefe reduzieren.
  2. Das Ultraschallübertragungssystem nach Anspruch 1 mit einem oder mehreren Abbildungselementen (284), wobei das zylindrische Wandlerelement (281) eine Öffnung (285) aufweist, die zur Platzierung des einen oder der mehreren Abbildungselemente (284) konfiguriert ist,
    wobei das leitfähige Material Silber ist, wobei die erste Oberfläche (282) eine konkave Oberfläche ist und die zweite Oberfläche (283) eine konvexe Oberfläche ist.
  3. Das Ultraschallübertragungssystem nach Anspruch 1, wobei der Bewegungsmechanismus (400) das zylindrische Wandlerelement (281) automatisch bewegt, um einen Behandlungsbereich in der Fokustiefe auf eine Temperatur in einem Bereich zwischen 40 und 65 Grad Celsius zu erwärmen.
  4. Das Ultraschallübertragungssystem nach einem der Ansprüche 1 - 3, wobei das zylindrische Wandlerelement (281) so konfiguriert ist, dass es eine Ultraschalltherapie auf eine Behandlungszone in der Fokustiefe in einem Gewebe anwendet.
  5. Das Ultraschallübertragungssystem nach einem der Ansprüche 1 - 3, wobei die Verringerung des Kantenrauschens eine Spitze so reduziert, dass eine Varianz um die Fokustiefe um 75 - 200% verringert wird.
  6. Das Ultraschallübertragungssystem nach einem der Ansprüche 1 - 3, wobei die Verringerung des Kantenrauschens eine Spitze so reduziert, dass eine Varianz einer Intensität um die Fokustiefe 5 mm oder weniger beträgt.
  7. Das Ultraschallübertragungssystem nach einem der Ansprüche 1 - 3, wobei die Reduzierung des Kantenrauschens eine Varianz der fokalen Verstärkung in einem Bereich von 0,01 bis 10 reduziert.
  8. Das Ultraschallübertragungssystem nach einem der Ansprüche 1 - 3, wobei die Energiequelle so konfiguriert ist, dass sie das zylindrische Wandlerelement (281) antreibt, um in einem Gewebe in der Fokustiefe eine Temperatur in einem Bereich von 42 bis 55 Grad Celsius zu erzeugen.
  9. Das Ultraschallübertragungssystem nach einem der Ansprüche 2 - 3, das ferner einen Temperatursensor umfasst, der sich am Gehäuse in der Nähe eines akustischen Fensters (230) im Gehäuse befindet und so konfiguriert ist, dass er eine Temperatur an einer Hautoberfläche misst.
  10. Das Ultraschallübertragungssystem nach einem der Ansprüche 1 und 3, das ferner ein oder mehrere Abbildungselemente (284) umfasst, wobei das zylindrische Wandlerelement (281) eine Öffnung (285) aufweist, die zur Platzierung des einen oder der mehreren Abbildungselemente (284) konfiguriert ist,
    wobei das Abbildungselement (284) so konfiguriert ist, dass es ein Niveau der akustischen Kopplung zwischen dem System und einer Hautoberfläche bestätigt.
  11. Das Ultraschallübertragungssystem nach einem der Ansprüche 1 und 3, das ferner ein oder mehrere Abbildungselemente (284) umfasst, wobei das zylindrische Wandlerelement (281) eine Öffnung (285) aufweist, die für die Platzierung des einen oder der mehreren Abbildungselemente (284) konfiguriert ist, wobei das Abbildungselement (284) so konfiguriert ist, dass es einen Pegel der akustischen Kopplung zwischen dem System und einer Hautoberfläche über eines der folgenden Elemente bestätigt: defokussierte Abbildung und Spannungs-Stehwellen-Verhältnis (VSWR).
  12. Das Ultraschallübertragungssystem nach einem der Ansprüche 1 und 3, das ferner ein oder mehrere Abbildungselemente (284) umfasst, wobei das zylindrische Wandlerelement (281) eine Öffnung (285) aufweist, die für die Platzierung des einen oder der mehreren Abbildungselemente (284) konfiguriert ist, wobei das Abbildungselement (2849) so konfiguriert ist, dass es eine Temperatur an einem Zielgewebe in der Fokustiefe unter einer Hautoberfläche misst.
  13. Das Ultraschallübertragungssystem nach einem der Ansprüche 1 und 3, wobei das Abbildungselement (284) so konfiguriert ist, dass es eine Temperatur in einem Zielgewebe in der Fokustiefe unter einer Hautoberfläche mit einem der folgenden Verfahren misst: Acoustic Radiation Force Impulse (ARFI), Shear Wave Elasticity Imaging (SWEI) und Messung der Dämpfung.
  14. Ein nicht-invasives, nicht-therapeutisches, kosmetisches ltraschallbehandlungsverfahren, das nicht von einem Arzt durchgeführt wird, zur Erwärmung von Gewebe mit einem zylindrischen Ultraschallwandler (280; 600), umfassend:
    Bereitstellen eines zylindrischen Wandlerelements (281) mit einer ersten Oberfläche (282), einer zweiten Oberfläche (283), einem beschichteten Bereich und einem unbeschichteten Bereich, wobei die erste Oberfläche (282) eine konkave Oberfläche und die zweite Oberfläche (283) eine konvexe Oberfläche ist oder die erste Oberfläche (282) eine konvexe Oberfläche und die zweite Oberfläche (283) eine konkave Oberfläche ist,
    wobei der beschichtete Bereich einen elektrischen Leiter umfasst,
    wobei die erste Oberfläche (282) mindestens einen beschichteten Bereich aufweist,
    wobei die zweite Oberfläche (283) den unbeschichteten Bereich und zwei, drei oder vier beschichtete Bereiche (287) umfasst, wobei die zwei, drei oder vier beschichteten Bereiche (287) auf der zweiten Oberfläche (283) ein leitfähiges Material umfassen, das eine Elektrode bildet, die mit einer Energiequelle in Verbindung steht,
    wobei die zwei, drei oder vier beschichteten Bereiche (287) auf der zweiten Oberfläche mindestens 60 % der zweiten Oberfläche bedecken,
    wobei die zwei, drei oder vier beschichteten Bereiche (287) auf der zweiten Oberfläche (283) eine Seitenkante (293), eine Mittelkante (291), einen ersten Seitenrand (290) und einen zweiten Seitenrand (290) umfassen, wobei die erste Seitenkante (290) und die zweite Seitenkante (290) jeweils entlang einer Längsachse des zylindrischen Wandlerelements (281) verlaufen, die Seitenkante (293) und die Mittelkante (291) entlang der X-Achse verlaufen und die Mittelkante der Mitte der zweiten Oberfläche (283) zugewandt ist,
    Anlegen eines Stroms an den beschichteten Bereich (287), wodurch Ultraschallenergie auf eine lineare Fokuszone in einer Fokustiefe gelenkt wird,
    wobei die Ultraschallenergie eine Verringerung der fokalen Verstärkung in der linearen Fokuszone bewirkt, und
    Bewegen des zylindrischen Wandlerelements (281) mit einem Bewegungsmechanismus (400) entlang einer linearen Bahn (290) senkrecht zur linearen Fokuszone, um einen ebenen Bandbehandlungsbereich zu erzeugen.
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