CN108136166A - 用于增强有益剂的局部应用的装置和方法 - Google Patents
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- CN108136166A CN108136166A CN201680054849.4A CN201680054849A CN108136166A CN 108136166 A CN108136166 A CN 108136166A CN 201680054849 A CN201680054849 A CN 201680054849A CN 108136166 A CN108136166 A CN 108136166A
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0654—Lamps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0034—Skin treatment
Abstract
Description
Claims (18)
Applications Claiming Priority (3)
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US201562221889P | 2015-09-22 | 2015-09-22 | |
US62/221,889 | 2015-09-22 | ||
PCT/US2016/052914 WO2017053448A1 (en) | 2015-09-22 | 2016-09-21 | Devices and methods for enhancing the topical application of a benefit agent |
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Publication Number | Publication Date |
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CN108136166A true CN108136166A (zh) | 2018-06-08 |
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CN201680054906.9A Pending CN108025185A (zh) | 2015-09-22 | 2016-09-21 | 用于增强有益剂的局部应用的方法 |
CN201911082171.2A Pending CN110772710A (zh) | 2015-09-22 | 2016-09-21 | 用于增强有益剂的局部应用的方法 |
CN201680054849.4A Pending CN108136166A (zh) | 2015-09-22 | 2016-09-21 | 用于增强有益剂的局部应用的装置和方法 |
CN201680054974.5A Pending CN108136167A (zh) | 2015-09-22 | 2016-09-21 | 用于增强有益剂的局部应用的方法 |
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CN201680054906.9A Pending CN108025185A (zh) | 2015-09-22 | 2016-09-21 | 用于增强有益剂的局部应用的方法 |
CN201911082171.2A Pending CN110772710A (zh) | 2015-09-22 | 2016-09-21 | 用于增强有益剂的局部应用的方法 |
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CN201680054974.5A Pending CN108136167A (zh) | 2015-09-22 | 2016-09-21 | 用于增强有益剂的局部应用的方法 |
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US (3) | US10449348B2 (zh) |
EP (3) | EP3352837B1 (zh) |
JP (7) | JP2018528839A (zh) |
KR (3) | KR20180056694A (zh) |
CN (4) | CN108025185A (zh) |
AU (6) | AU2016326439A1 (zh) |
BR (3) | BR112018005592A8 (zh) |
CA (3) | CA2999139A1 (zh) |
ES (3) | ES2929624T3 (zh) |
HK (3) | HK1258209A1 (zh) |
IL (3) | IL257910A (zh) |
MX (3) | MX2018003465A (zh) |
RU (3) | RU2018114474A (zh) |
WO (3) | WO2017053456A1 (zh) |
ZA (2) | ZA201802666B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110613892A (zh) * | 2019-07-10 | 2019-12-27 | 厦门大学 | 一种经皮给药系统 |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8535228B2 (en) | 2004-10-06 | 2013-09-17 | Guided Therapy Systems, Llc | Method and system for noninvasive face lifts and deep tissue tightening |
US10864385B2 (en) | 2004-09-24 | 2020-12-15 | Guided Therapy Systems, Llc | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
US8444562B2 (en) | 2004-10-06 | 2013-05-21 | Guided Therapy Systems, Llc | System and method for treating muscle, tendon, ligament and cartilage tissue |
US9694212B2 (en) | 2004-10-06 | 2017-07-04 | Guided Therapy Systems, Llc | Method and system for ultrasound treatment of skin |
US8133180B2 (en) | 2004-10-06 | 2012-03-13 | Guided Therapy Systems, L.L.C. | Method and system for treating cellulite |
US11235179B2 (en) | 2004-10-06 | 2022-02-01 | Guided Therapy Systems, Llc | Energy based skin gland treatment |
US11883688B2 (en) | 2004-10-06 | 2024-01-30 | Guided Therapy Systems, Llc | Energy based fat reduction |
US8690778B2 (en) | 2004-10-06 | 2014-04-08 | Guided Therapy Systems, Llc | Energy-based tissue tightening |
US9827449B2 (en) | 2004-10-06 | 2017-11-28 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
US11724133B2 (en) | 2004-10-07 | 2023-08-15 | Guided Therapy Systems, Llc | Ultrasound probe for treatment of skin |
US11207548B2 (en) | 2004-10-07 | 2021-12-28 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
EP3058875B1 (en) | 2008-06-06 | 2022-08-17 | Ulthera, Inc. | A system for cosmetic treatment and imaging |
EP2382010A4 (en) | 2008-12-24 | 2014-05-14 | Guided Therapy Systems Llc | METHOD AND SYSTEMS FOR FAT REDUCTION AND / OR TREATMENT OF CELLULITE |
CN104027893B (zh) | 2013-03-08 | 2021-08-31 | 奥赛拉公司 | 用于多焦点超声治疗的装置和方法 |
AU2015247951A1 (en) | 2014-04-18 | 2016-11-17 | Ulthera, Inc. | Band transducer ultrasound therapy |
FI3405294T3 (fi) | 2016-01-18 | 2023-03-23 | Ulthera Inc | Pienikokoinen ultraäänilaite, jossa on renkaan muotoinen ultraääniryhmä, joka on yhdistetty sähköisesti reunalle taipuisaan piirilevyyn |
BR112018072101B1 (pt) | 2016-08-16 | 2024-01-02 | Ulthera, Inc | Sistemas e métodos para tratamento cosmético da pele com ultrassom |
US11944849B2 (en) | 2018-02-20 | 2024-04-02 | Ulthera, Inc. | Systems and methods for combined cosmetic treatment of cellulite with ultrasound |
IT201800009384A1 (it) * | 2018-10-11 | 2020-04-11 | Cosmo Srl | Peptide for cosmetic application |
KR102284490B1 (ko) * | 2019-02-22 | 2021-08-02 | 엘지전자 주식회사 | 피부 관리 기기 |
DE102020200423A1 (de) * | 2020-01-15 | 2021-07-15 | Beiersdorf Aktiengesellschaft | Verfahren zur Wirkstoffeinbringung in die Haut |
JP7144813B2 (ja) * | 2020-04-14 | 2022-09-30 | ピクシーダストテクノロジーズ株式会社 | 頭髪ケア装置、および、プログラム |
KR102252668B1 (ko) * | 2020-09-29 | 2021-05-17 | 조준현 | 탄력 개선 및 미백 기능의 필링제 조성물 |
JP7170283B2 (ja) * | 2020-11-04 | 2022-11-14 | ピクシーダストテクノロジーズ株式会社 | ヘアケア装置及びヘアケア装置用筐体 |
JP2023551826A (ja) | 2020-11-26 | 2023-12-13 | ロレアル | ヒトのケラチン物質をクレンジングする方法、前記方法を実施するためのデバイス及びキット |
FR3116451B1 (fr) * | 2020-11-26 | 2023-04-14 | Oreal | Procédé de nettoyage des matières kératiniques humaines et kit pour la mise en œuvre de ce procédé |
FR3116450A1 (fr) * | 2020-11-26 | 2022-05-27 | L'oreal | Dispositif de nettoyage des matières kératiniques générant des bulles de gaz |
CN113559424A (zh) * | 2021-07-16 | 2021-10-29 | 复旦大学 | 空耦超声毛发理疗装置及方法 |
WO2023222789A1 (en) | 2022-05-18 | 2023-11-23 | L'oreal | Device for treating human keratin materials |
FR3135604A1 (fr) | 2022-05-18 | 2023-11-24 | L'oreal | Dispositif de traitement de matières kératiniques humaines |
FR3135603A1 (fr) | 2022-05-18 | 2023-11-24 | L'oreal | Dispositif de traitement des cheveux et procédé |
FR3135606A1 (fr) * | 2022-05-18 | 2023-11-24 | L'oreal | Dispositif de nettoyage de matières kératiniques humaines |
FR3135605A1 (fr) | 2022-05-18 | 2023-11-24 | L'oreal | Procédé de nettoyage de matières kératiniques humaines |
US11951082B2 (en) | 2022-08-22 | 2024-04-09 | Ford Therapeutics, Llc | Composition of chlorhexidine |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999039763A1 (en) * | 1998-02-10 | 1999-08-12 | Children's Medical Center Corporation | Ultrasound-mediated drug delivery |
WO2000015300A1 (en) * | 1998-09-16 | 2000-03-23 | Ultra Cure Ltd. | Method for peeling of epithelial tissue and apparatus and system for use therefor |
WO2003013654A1 (en) * | 2001-08-09 | 2003-02-20 | Exogen, Inc. | Method and means for controlling acoustic modes in tissue healing applications |
WO2003077833A2 (en) * | 2002-03-20 | 2003-09-25 | Yoni Iger | Method and apparatus for altering activity of tissue layers |
US20090318852A1 (en) * | 2008-06-18 | 2009-12-24 | Jenu Biosciences, Inc. | Ultrasound based cosmetic therapy method and apparatus |
WO2012081011A1 (en) * | 2010-12-14 | 2012-06-21 | Slender Medical Ltd. | Ultrasound skin treatment |
CN102671312A (zh) * | 2006-04-07 | 2012-09-19 | 史密夫和内修有限公司 | 在组织愈合应用中控制声学模式 |
CN104083829A (zh) * | 2014-07-11 | 2014-10-08 | 中国人民解放军第三军医大学第二附属医院 | 诊断超声联合微泡作为增强单侧血脑屏障通透性的方法 |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5084577A (en) | 1988-03-16 | 1992-01-28 | The Procter & Gamble Company | Volatile silicon compounds |
US5133967A (en) | 1991-06-24 | 1992-07-28 | The Dow Chemical Company | Toning composition and process of using |
US5458140A (en) * | 1993-11-15 | 1995-10-17 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers |
US5830177A (en) * | 1996-11-22 | 1998-11-03 | Anticancer, Inc. | Skin vibration method for topical targeted delivery of beneficial agents into hair follicles |
US6284234B1 (en) * | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
US20020006418A1 (en) | 1998-10-13 | 2002-01-17 | John Kung | Composition to enhance permeation of topical skin agents |
CN2393485Y (zh) | 1999-11-04 | 2000-08-30 | 金友贺 | 医用系列成角度聚声探头帽 |
TWI220386B (en) * | 2002-01-21 | 2004-08-21 | Matsushita Electric Works Ltd | Ultrasonic transdermal permeation device |
CA2525980C (en) * | 2003-06-13 | 2009-10-06 | The Procter & Gamble Company | Sonophoresis skin care device |
ES2453195T3 (es) | 2003-06-30 | 2014-04-04 | Johnson & Johnson Consumer Companies, Inc. | Composición tópica para el tratamiento del acné y de la rosácea con electricidad generada galvánicamente |
US20060008538A1 (en) * | 2004-07-07 | 2006-01-12 | Wu Jeffrey M | Methods of treating the skin |
JP2006034651A (ja) * | 2004-07-28 | 2006-02-09 | Japan Giyaruzu:Kk | 超音波美容器 |
US20080045882A1 (en) * | 2004-08-26 | 2008-02-21 | Finsterwald P M | Biological Cell Acoustic Enhancement and Stimulation |
US20060111744A1 (en) * | 2004-10-13 | 2006-05-25 | Guided Therapy Systems, L.L.C. | Method and system for treatment of sweat glands |
JP2008531587A (ja) * | 2005-02-24 | 2008-08-14 | ダーミソニックス インコーポレイテッド | 皮膚および経皮物質放出システムで有用な吸収性材料の減衰特性を高める方法 |
AU2006230187B2 (en) * | 2005-03-29 | 2012-07-26 | The Trustees Of The University Of Pennsylvania | Methods for generating new hair follicles, treating baldness, and hair removal |
US8133191B2 (en) | 2006-02-16 | 2012-03-13 | Syneron Medical Ltd. | Method and apparatus for treatment of adipose tissue |
US9492686B2 (en) | 2006-12-04 | 2016-11-15 | Koninklijke Philips N.V. | Devices and methods for treatment of skin conditions |
WO2008146206A2 (en) * | 2007-06-01 | 2008-12-04 | Koninklijke Philips Electronics, N.V. | Wireless ultrasound probe asset tracking |
US20090177122A1 (en) * | 2007-12-28 | 2009-07-09 | Celleration, Inc. | Methods for treating inflammatory skin disorders |
JP5438983B2 (ja) * | 2008-02-08 | 2014-03-12 | 株式会社東芝 | 超音波プローブ及び超音波診断装置 |
DE202009003586U1 (de) | 2009-03-16 | 2009-06-04 | Emag Ag | Ultraschallbehandlungsgerät, insbesondere für kosmetische Behandlungen |
CA2763221C (en) * | 2009-05-26 | 2019-01-08 | The General Hospital Corporation | Method and apparatus for dermal delivery of a substance |
US8460221B2 (en) | 2009-08-20 | 2013-06-11 | Krypton Systems LLC | Ultra-sonic and vibratory treatment devices and methods |
MX2012004045A (es) | 2009-10-06 | 2012-05-22 | Syneron Medical Ltd | Monitoreo de ultrasonido de tratamientos esteticos. |
WO2011107927A1 (en) * | 2010-03-01 | 2011-09-09 | Yoni Iger | Method and apparatus for the removal of non desired biological components from external surfaces of tissues |
US20110251523A1 (en) * | 2010-04-08 | 2011-10-13 | Elcos America, Inc. | Skin care apparatus and method of skin care using the same |
US20110270137A1 (en) * | 2010-04-29 | 2011-11-03 | Applisonix Ltd. | Method and system for treating skin tissue |
US9980897B2 (en) * | 2010-04-30 | 2018-05-29 | Dow Corning Toray Co., Ltd. | Organopolysiloxane and powder treatment agent, preparation for external use and cosmetic comprising the same |
US20140066837A1 (en) | 2012-07-26 | 2014-03-06 | Ronald L. Moy | Skin care compositions and methods |
WO2014127091A1 (en) * | 2013-02-14 | 2014-08-21 | Thync, Inc. | Transcranial ultrasound systems |
US20150174387A1 (en) * | 2013-12-23 | 2015-06-25 | L'oreal | Combined sonic and ultrasonic skin care device |
CN105916480B (zh) * | 2014-01-14 | 2021-08-17 | 宝洁公司 | 用于改善人体皮肤外观和感觉的多步产品 |
US20150313993A1 (en) * | 2014-05-04 | 2015-11-05 | Robert T. Bock | Ultrasonic Method and Device for Cosmetic Applications |
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2016
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- 2016-09-21 KR KR1020187010839A patent/KR20180056694A/ko unknown
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- 2016-09-21 US US15/271,299 patent/US20170080198A1/en not_active Abandoned
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- 2016-09-21 MX MX2018003466A patent/MX2018003466A/es unknown
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- 2018-03-06 IL IL257915A patent/IL257915A/en unknown
- 2018-04-20 ZA ZA2018/02666A patent/ZA201802666B/en unknown
- 2018-04-20 ZA ZA2018/02665A patent/ZA201802665B/en unknown
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2019
- 2019-01-14 HK HK19100566.3A patent/HK1258209A1/zh unknown
- 2019-01-14 HK HK19100567.2A patent/HK1258210A1/zh unknown
- 2019-01-14 HK HK19100563.6A patent/HK1258206A1/zh unknown
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2020
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- 2021-06-16 JP JP2021100067A patent/JP2021151531A/ja active Pending
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Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999039763A1 (en) * | 1998-02-10 | 1999-08-12 | Children's Medical Center Corporation | Ultrasound-mediated drug delivery |
WO2000015300A1 (en) * | 1998-09-16 | 2000-03-23 | Ultra Cure Ltd. | Method for peeling of epithelial tissue and apparatus and system for use therefor |
WO2003013654A1 (en) * | 2001-08-09 | 2003-02-20 | Exogen, Inc. | Method and means for controlling acoustic modes in tissue healing applications |
WO2003077833A2 (en) * | 2002-03-20 | 2003-09-25 | Yoni Iger | Method and apparatus for altering activity of tissue layers |
CN102671312A (zh) * | 2006-04-07 | 2012-09-19 | 史密夫和内修有限公司 | 在组织愈合应用中控制声学模式 |
US20090318852A1 (en) * | 2008-06-18 | 2009-12-24 | Jenu Biosciences, Inc. | Ultrasound based cosmetic therapy method and apparatus |
WO2012081011A1 (en) * | 2010-12-14 | 2012-06-21 | Slender Medical Ltd. | Ultrasound skin treatment |
CN104083829A (zh) * | 2014-07-11 | 2014-10-08 | 中国人民解放军第三军医大学第二附属医院 | 诊断超声联合微泡作为增强单侧血脑屏障通透性的方法 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110613892A (zh) * | 2019-07-10 | 2019-12-27 | 厦门大学 | 一种经皮给药系统 |
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