EE03606B1 - Kristalliline [R-(R*,R*)]-2-(4-fluorofenüül)-beeta, delta-dihüdroksü-5-(1-metüületüül)-3-fenüül-4-[(fenüülamino)karbonüül]-1H-pürrool-1-hept aanhappehemikaltsiumsool (atorvastatiin) - Google Patents
Kristalliline [R-(R*,R*)]-2-(4-fluorofenüül)-beeta, delta-dihüdroksü-5-(1-metüületüül)-3-fenüül-4-[(fenüülamino)karbonüül]-1H-pürrool-1-hept aanhappehemikaltsiumsool (atorvastatiin)Info
- Publication number
- EE03606B1 EE03606B1 EE9800015A EE9800015A EE03606B1 EE 03606 B1 EE03606 B1 EE 03606B1 EE 9800015 A EE9800015 A EE 9800015A EE 9800015 A EE9800015 A EE 9800015A EE 03606 B1 EE03606 B1 EE 03606B1
- Authority
- EE
- Estonia
- Prior art keywords
- calcium
- atorvastatin
- phenylamino
- methylethyl
- fluorophenyl
- Prior art date
Links
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title 2
- 229910052791 calcium Inorganic materials 0.000 title 2
- 239000011575 calcium Substances 0.000 title 2
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title 1
- 229960005370 atorvastatin Drugs 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US145295P | 1995-07-17 | 1995-07-17 | |
PCT/US1996/011368 WO1997003959A1 (en) | 1995-07-17 | 1996-07-08 | Crystalline [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin) |
Publications (2)
Publication Number | Publication Date |
---|---|
EE9800015A EE9800015A (et) | 1998-08-17 |
EE03606B1 true EE03606B1 (et) | 2002-02-15 |
Family
ID=21696090
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EE9800015A EE03606B1 (et) | 1995-07-17 | 1996-07-08 | Kristalliline [R-(R*,R*)]-2-(4-fluorofenüül)-beeta, delta-dihüdroksü-5-(1-metüületüül)-3-fenüül-4-[(fenüülamino)karbonüül]-1H-pürrool-1-hept aanhappehemikaltsiumsool (atorvastatiin) |
Country Status (38)
Country | Link |
---|---|
US (1) | US5969156A (ja) |
EP (2) | EP0848705B1 (ja) |
JP (4) | JP3296564B2 (ja) |
KR (2) | KR100431038B1 (ja) |
CN (1) | CN1087288C (ja) |
AR (2) | AR003458A1 (ja) |
AT (3) | ATE208375T1 (ja) |
AU (1) | AU725424B2 (ja) |
BG (1) | BG63630B1 (ja) |
BR (1) | BR9609872A (ja) |
CA (1) | CA2220018C (ja) |
CO (1) | CO4700443A1 (ja) |
CY (1) | CY2358B1 (ja) |
CZ (3) | CZ294740B6 (ja) |
DE (2) | DE69634054T2 (ja) |
DK (2) | DK0848705T3 (ja) |
EA (1) | EA000474B1 (ja) |
EE (1) | EE03606B1 (ja) |
ES (2) | ES2233526T3 (ja) |
GE (1) | GEP20002029B (ja) |
HK (1) | HK1018052A1 (ja) |
HR (1) | HRP960339B1 (ja) |
HU (1) | HU223599B1 (ja) |
IL (7) | IL128864A (ja) |
MX (1) | MX9709099A (ja) |
NO (1) | NO309898B1 (ja) |
NZ (1) | NZ312907A (ja) |
PE (1) | PE1898A1 (ja) |
PL (1) | PL193479B1 (ja) |
PT (2) | PT1148049E (ja) |
RO (1) | RO120070B1 (ja) |
SI (2) | SI0848705T1 (ja) |
SK (1) | SK284202B6 (ja) |
TW (1) | TW486467B (ja) |
UA (1) | UA51661C2 (ja) |
UY (2) | UY24285A1 (ja) |
WO (1) | WO1997003959A1 (ja) |
ZA (1) | ZA966044B (ja) |
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US6087511A (en) * | 1996-07-16 | 2000-07-11 | Warner-Lambert Company | Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1) |
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