EA202090956A3 - Антитела к cd73 и их применения - Google Patents

Антитела к cd73 и их применения

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Publication number
EA202090956A3
EA202090956A3 EA202090956A EA202090956A EA202090956A3 EA 202090956 A3 EA202090956 A3 EA 202090956A3 EA 202090956 A EA202090956 A EA 202090956A EA 202090956 A EA202090956 A EA 202090956A EA 202090956 A3 EA202090956 A3 EA 202090956A3
Authority
EA
Eurasian Patent Office
Prior art keywords
antibodies
present
methods
contemplated
expressing
Prior art date
Application number
EA202090956A
Other languages
English (en)
Other versions
EA202090956A2 (ru
Inventor
Нилс Лонберг
Алан Дж. Корман
Брайан С. Барнхарт
Аарон П. Ямнюк
Мохан Сринивасан
Карла А. Хеннинг
Мин Лэй
Эмануэла Сега
Анджела Гудинаф
Мариа Н. Джуре-Кункел
Годун Чэнь
Джон Сэк
Ричард Хуанг
Мартин Дж. Корбетт
Джозеф Е. Майерс
Лианг Швайцер
Сандра В. Хэтчер
Хайчун Хуан
Пинпин Чжан
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA202090956A2 publication Critical patent/EA202090956A2/ru
Publication of EA202090956A3 publication Critical patent/EA202090956A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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Abstract

Настоящим изобретением предполагаются выделенные моноклональные антитела, в частности человеческие антитела, которые связываются с человеческим кластером дифференцировки 73 (CD73) с высокой аффинностью, и ингибируют активность CD73, и необязательно опосредуют зависимую от антитела интернализацию CD73. Также предполагаются молекулы нуклеиновой кислоты, кодирующие антитела согласно настоящему изобретению, векторы экспрессии, клетки-хозяева и способы экспрессии антител согласно настоящему изобретению. Также предполагаются иммуноконъюгаты, биспецифичные молекулы и фармацевтические композиции, содержащие антитела согласно настоящему изобретению. Настоящим изобретением также предполагаются способы ингибирования роста опухолевой клетки, экспрессирующей CD73, с применением антител согласно настоящему изобретению, в том числе способы лечения различных злокачественных опухолей.
EA202090956A 2014-11-21 2015-11-19 Антитела к cd73 и их применения EA202090956A3 (ru)

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