MX2019003058A - Anticuerpos monoclonales novedosos para muerte programada 1 (pd-1). - Google Patents
Anticuerpos monoclonales novedosos para muerte programada 1 (pd-1).Info
- Publication number
- MX2019003058A MX2019003058A MX2019003058A MX2019003058A MX2019003058A MX 2019003058 A MX2019003058 A MX 2019003058A MX 2019003058 A MX2019003058 A MX 2019003058A MX 2019003058 A MX2019003058 A MX 2019003058A MX 2019003058 A MX2019003058 A MX 2019003058A
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- monoclonal antibodies
- programmed death
- novel monoclonal
- present
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención proporciona anticuerpos monoclonales PD-1, particularmente anticuerpos monoclonales humanos de PD-1, que se unen específicamente a PD-1 con alta afinidad y comprenden una cadena pesada y una cadena ligera. La presente invención proporciona además una secuencia de ácido nucleico que codifica los anticuerpos de la invención, los vectores de clonación o expresión, las células hospederas y los métodos para expresar o aislar los anticuerpos. También se proporcionan inmunoconjugados, composiciones terapéuticas que comprenden los anticuerpos de la invención. La invención también proporciona métodos para tratar diversos cánceres con anticuerpos anti-PD-1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2016/099576 WO2018053709A1 (en) | 2016-09-21 | 2016-09-21 | The novel monoclonal antibodies to programmed death 1 (pd-1) |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019003058A true MX2019003058A (es) | 2019-11-28 |
Family
ID=61690082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019003058A MX2019003058A (es) | 2016-09-21 | 2016-09-21 | Anticuerpos monoclonales novedosos para muerte programada 1 (pd-1). |
Country Status (11)
Country | Link |
---|---|
US (3) | US11414487B2 (es) |
EP (1) | EP3515938A4 (es) |
JP (2) | JP7101169B2 (es) |
KR (2) | KR102527160B1 (es) |
AU (1) | AU2016423559C1 (es) |
BR (1) | BR112019005316A2 (es) |
CA (1) | CA3037407C (es) |
IL (1) | IL265525A (es) |
MX (1) | MX2019003058A (es) |
RU (1) | RU2757316C2 (es) |
WO (1) | WO2018053709A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112018002824A2 (pt) | 2015-08-11 | 2018-11-06 | Open Monoclonal Tech Inc | anticorpo, polinucleotídeo, vetor, célula, métodos para expressar o anticorpo, para tratar uma condição associada com pd-1 e para tratar uma condição em um sujeito, kit, composição farmacêutica e uso do anticorpo |
BR112018008904A2 (pt) | 2015-11-03 | 2018-11-27 | Janssen Biotech Inc | anticorpos que se ligam especificamente a tim-3 e seus usos |
ES2898025T3 (es) | 2016-11-02 | 2022-03-03 | Jounce Therapeutics Inc | Anticuerpos contra PD-1 y sus usos |
BR112020002013B1 (pt) | 2017-08-03 | 2023-01-24 | Amgen Inc | Muteínas de il-21, método de preparação das mesmas, ácido nucleico, vetor, célula hospedeira, kit, uso dos mesmos e composição farmacêutica |
CA3087273A1 (en) | 2018-01-12 | 2019-07-18 | Amgen Inc. | Anti-pd-1 antibodies and methods of treatment |
AU2019254215A1 (en) * | 2018-04-15 | 2020-10-22 | Salubris (Chengdu) Biotech Co., Ltd | Antibodies binding PD-1 and uses thereof |
KR20230110841A (ko) * | 2018-04-15 | 2023-07-25 | 임비라 컴퍼니 리미티드 | Pd-1에 결합하는 항체 및 그 용도 |
CN109160949B (zh) * | 2018-07-23 | 2021-05-14 | 中国医学科学院血液病医院(血液学研究所) | 一种鼠抗人pd-1单克隆抗体及应用 |
CN113727731B (zh) * | 2019-04-26 | 2023-06-02 | 上海药明生物技术有限公司 | 靶向pd-1和lag-3的双特异性抗体 |
AU2020281535A1 (en) | 2019-05-24 | 2022-01-27 | Merck Patent Gmbh | Combination therapies using CDK inhibitors |
KR20220102609A (ko) | 2019-09-25 | 2022-07-20 | 우시 바이올로직스 아일랜드 리미티드 | 신규한 항-pd-l1 항체 |
BR112022009042A2 (pt) * | 2019-11-11 | 2022-10-11 | Cstone Pharmaceuticals Suzhou Co Ltd | Combinações farmacêuticas, composições farmacêuticas, kits e métodos para tratar um câncer |
WO2021110122A1 (zh) * | 2019-12-05 | 2021-06-10 | 基石药业(苏州)有限公司 | Cdk4/6抑制剂的组合疗法 |
WO2022068919A1 (zh) * | 2020-09-30 | 2022-04-07 | 正大天晴康方(上海)生物医药科技有限公司 | 结合pd-1抗体的肽及其应用 |
WO2022118197A1 (en) | 2020-12-02 | 2022-06-09 | Pfizer Inc. | Time to resolution of axitinib-related adverse events |
BR112023015652A2 (pt) | 2021-02-04 | 2023-10-17 | Genuv Inc | Anticorpo ou fragmento de ligação a antígeno do mesmo que se liga a um epítopo de uma proteína de morte celular programada 1 (pd-1); molécula de ácido nucleico; vetor de clonagem ou de expressão; célula hospedeira; método para produzir o anticorpo ou fragmento de ligação a antígeno do mesmo; animal transgênico; molécula de ligação a antígeno multiespecífico, imunoconjugado, receptor de antígeno quimérico, receptor de célula t modificado ou vírus oncolítico; composição farmacêutica para prevenir ou tratar uma afecção associada a pd-1; método para prevenir ou tratar tumores, doenças autoimunes de câncer, doenças autoimunes, doenças neurológicas, doenças neurodegenerativas ou doenças infecciosas; composição farmacêutica para aumentar uma resposta imunológica em um indivíduo que tem câncer; e hibridoma |
TW202327595A (zh) | 2021-10-05 | 2023-07-16 | 美商輝瑞大藥廠 | 用於治療癌症之氮雜內醯胺化合物的組合 |
WO2023079428A1 (en) | 2021-11-03 | 2023-05-11 | Pfizer Inc. | Combination therapies using tlr7/8 agonist |
CN116036266A (zh) * | 2022-12-28 | 2023-05-02 | 广州誉衡生物科技有限公司 | 抗-pd-1抗体及其在制备治疗结肠癌患者的药物中的用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090123413A1 (en) | 2004-08-23 | 2009-05-14 | Britta Hardy | Use of bat monoclonal antibody for immunotherapy |
PL2439273T3 (pl) * | 2005-05-09 | 2019-08-30 | Ono Pharmaceutical Co., Ltd. | Ludzkie przeciwciała monoklonalne przeciwko białku programowanej śmierci komórki 1(pd-1) oraz metody leczenia nowotworów z wykorzystaniem przeciwciał anty-pd-1 samodzielnie lub w połączeniu z innymi immunoterapeutykami |
EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
JP6285414B2 (ja) * | 2012-03-30 | 2018-02-28 | モルフォテック, インコーポレイテッド | Tem−1診断用抗体 |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
CN105330740B (zh) | 2014-07-30 | 2018-08-17 | 珠海市丽珠单抗生物技术有限公司 | 抗pd-1抗体及其应用 |
WO2016077397A2 (en) | 2014-11-11 | 2016-05-19 | Sutro Biopharma, Inc. | Anti-pd-1 antibodies, compositions comprising anti-pd-1 antibodies and methods of using anti-pd-1 antibodies |
TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗pd-1抗體類和使用彼等之方法 |
EA201791768A1 (ru) | 2015-02-06 | 2018-07-31 | КАДМОН КОРПОРЕЙШН, ЭлЭлСи | Иммуномодулирующие агенты |
BR112018002824A2 (pt) | 2015-08-11 | 2018-11-06 | Open Monoclonal Tech Inc | anticorpo, polinucleotídeo, vetor, célula, métodos para expressar o anticorpo, para tratar uma condição associada com pd-1 e para tratar uma condição em um sujeito, kit, composição farmacêutica e uso do anticorpo |
CA3000564A1 (en) | 2015-10-02 | 2017-04-06 | Symphogen A/S | Anti-pd-1 antibodies and compositions |
CN109575139A (zh) * | 2017-09-29 | 2019-04-05 | 上海药明生物技术有限公司 | 针对表皮生长因子受体和程序性死亡受体的双特异抗体 |
-
2016
- 2016-09-21 MX MX2019003058A patent/MX2019003058A/es unknown
- 2016-09-21 RU RU2019111277A patent/RU2757316C2/ru active
- 2016-09-21 JP JP2019515471A patent/JP7101169B2/ja active Active
- 2016-09-21 KR KR1020217020495A patent/KR102527160B1/ko active IP Right Grant
- 2016-09-21 EP EP16916449.8A patent/EP3515938A4/en active Pending
- 2016-09-21 WO PCT/CN2016/099576 patent/WO2018053709A1/en active Application Filing
- 2016-09-21 CA CA3037407A patent/CA3037407C/en active Active
- 2016-09-21 KR KR1020197010353A patent/KR102273634B1/ko active IP Right Grant
- 2016-09-21 BR BR112019005316A patent/BR112019005316A2/pt active Search and Examination
- 2016-09-21 US US16/333,993 patent/US11414487B2/en active Active
- 2016-09-21 AU AU2016423559A patent/AU2016423559C1/en active Active
-
2019
- 2019-03-20 IL IL265525A patent/IL265525A/en unknown
-
2021
- 2021-04-21 JP JP2021071948A patent/JP2021120378A/ja active Pending
-
2022
- 2022-06-29 US US17/853,606 patent/US20230014722A1/en not_active Abandoned
-
2023
- 2023-08-31 US US18/459,236 patent/US20240101676A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
IL265525A (en) | 2019-05-30 |
US20230014722A1 (en) | 2023-01-19 |
WO2018053709A1 (en) | 2018-03-29 |
US11414487B2 (en) | 2022-08-16 |
AU2016423559B2 (en) | 2020-07-30 |
CA3037407A1 (en) | 2018-03-29 |
JP2019536432A (ja) | 2019-12-19 |
KR102273634B1 (ko) | 2021-07-07 |
US20240101676A1 (en) | 2024-03-28 |
RU2019111277A (ru) | 2020-10-23 |
JP7101169B2 (ja) | 2022-07-14 |
AU2016423559C1 (en) | 2020-11-19 |
KR102527160B1 (ko) | 2023-04-28 |
AU2016423559A1 (en) | 2019-04-04 |
BR112019005316A2 (pt) | 2019-09-03 |
CA3037407C (en) | 2022-10-18 |
KR20190072524A (ko) | 2019-06-25 |
EP3515938A1 (en) | 2019-07-31 |
JP2021120378A (ja) | 2021-08-19 |
KR20210104749A (ko) | 2021-08-25 |
EP3515938A4 (en) | 2020-06-10 |
RU2757316C2 (ru) | 2021-10-13 |
RU2019111277A3 (es) | 2020-10-23 |
US20200002420A1 (en) | 2020-01-02 |
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