EA200401437A1 - Ненуклеозидные ингибиторы обратной транскриптазы для лечения вич инфекции, способ их получения (варианты), способ увеличения периода полупревращения ненуклеозидного соединения, обладающего активностью против ретровирусов, и способ получения фармацевтической композиции, обладающей специфичностью к лейкоцитам - Google Patents
Ненуклеозидные ингибиторы обратной транскриптазы для лечения вич инфекции, способ их получения (варианты), способ увеличения периода полупревращения ненуклеозидного соединения, обладающего активностью против ретровирусов, и способ получения фармацевтической композиции, обладающей специфичностью к лейкоцитамInfo
- Publication number
- EA200401437A1 EA200401437A1 EA200401437A EA200401437A EA200401437A1 EA 200401437 A1 EA200401437 A1 EA 200401437A1 EA 200401437 A EA200401437 A EA 200401437A EA 200401437 A EA200401437 A EA 200401437A EA 200401437 A1 EA200401437 A1 EA 200401437A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- nucleoside
- treatment
- leukocytes
- specificity
- variants
- Prior art date
Links
- 238000000034 method Methods 0.000 title 3
- 208000031886 HIV Infections Diseases 0.000 title 1
- 208000037357 HIV infectious disease Diseases 0.000 title 1
- 229940122313 Nucleoside reverse transcriptase inhibitor Drugs 0.000 title 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 title 1
- 210000000265 leukocyte Anatomy 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- -1 nucleoside compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 title 1
- 241001430294 unidentified retrovirus Species 0.000 title 1
- 108010010369 HIV Protease Proteins 0.000 abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical group [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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| EA200401436A EA008775B1 (ru) | 2002-04-26 | 2003-04-25 | Ингибиторы протеазы вич для лечения инфекции вич и фармацевтическая композиция |
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- 2003-04-25 CA CA2481261A patent/CA2481261C/en not_active Expired - Lifetime
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- 2003-04-25 EA EA200401436A patent/EA008775B1/ru not_active IP Right Cessation
- 2003-04-25 AU AU2003231765A patent/AU2003231765B9/en not_active Expired
- 2003-04-25 KR KR10-2004-7017134A patent/KR20040108756A/ko not_active Withdrawn
- 2003-04-25 MX MXPA04010528A patent/MXPA04010528A/es not_active Application Discontinuation
- 2003-04-25 BR BR0309573-8A patent/BR0309573A/pt not_active IP Right Cessation
- 2003-04-25 AU AU2003228707A patent/AU2003228707A1/en not_active Abandoned
- 2003-04-25 PL PL374968A patent/PL211979B1/pl unknown
- 2003-04-25 CA CA002481449A patent/CA2481449A1/en not_active Abandoned
- 2003-11-06 US US10/554,287 patent/US20070190523A1/en not_active Abandoned
- 2003-11-06 AU AU2003291998A patent/AU2003291998A1/en not_active Abandoned
- 2003-11-06 EP EP03767521A patent/EP1620445A2/en not_active Withdrawn
- 2003-11-06 JP JP2004571244A patent/JP2006524487A/ja active Pending
- 2003-11-06 WO PCT/EP2003/012423 patent/WO2004096818A2/en not_active Ceased
-
2004
- 2004-10-11 IL IL164490A patent/IL164490A/en active IP Right Grant
- 2004-11-22 ZA ZA2004/09376A patent/ZA200409376B/en unknown
- 2004-11-22 ZA ZA200409377A patent/ZA200409377B/en unknown
- 2004-11-25 NO NO20045150A patent/NO336469B1/no not_active IP Right Cessation
- 2004-11-25 NO NO20045152A patent/NO20045152L/no not_active Application Discontinuation
- 2004-11-25 IS IS7556A patent/IS2714B/is unknown
- 2004-11-25 IS IS7555A patent/IS7555A/is unknown
-
2007
- 2007-10-15 CY CY20071101320T patent/CY1108036T1/el unknown
-
2009
- 2009-03-05 JP JP2009052719A patent/JP2009112319A/ja active Pending
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