DK2612862T3 - Quinazolinoner som inhibitorer af human phosphatidylinositol 3-kinase delta - Google Patents
Quinazolinoner som inhibitorer af human phosphatidylinositol 3-kinase delta Download PDFInfo
- Publication number
- DK2612862T3 DK2612862T3 DK13150110.8T DK13150110T DK2612862T3 DK 2612862 T3 DK2612862 T3 DK 2612862T3 DK 13150110 T DK13150110 T DK 13150110T DK 2612862 T3 DK2612862 T3 DK 2612862T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- purin
- amino
- substituted
- ylamino
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61P11/06—Antiasthmatics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Pharmacology & Pharmacy (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Pulmonology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
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Claims (12)
1. Farmaceutisk acceptabelt salt af forbindelsen:
hvor det farmaceutisk acceptable salt er valgt fra gruppen bestående af hydrochlorid, hydrobromid, hydroiodid og phosphatsalt.
2. Det farmaceutisk acceptable salt ifølge krav 1, hvor et farmaceutisk acceptable salt er hydrochloridsaltet.
3. Det farmaceutisk acceptable salt ifølge krav 1, hvor forbindelsen er S-enantiomeren.
4. Det farmaceutisk acceptable salt ifølge krav 1, hvor forbindelsen er
og det farmaceutisk acceptable salt er hydrochloridsaltet.
5. Den farmaceutiske sammensætning omfattende et farmaceutisk acceptabelt salt ifølge krav 1 og mindst én farmaceutisk acceptabel excipiens.
6. Den farmaceutiske sammensætning ifølge krav 5, hvor det farmaceutisk acceptable salt er hydrochloridsaltet.
7. Den farmaceutiske sammensætning ifølge krav 5, hvor forbindelsen er S-enantiomeren.
8. Farmaceutisk sammensætning ifølge krav 7, hvor det farmaceutisk acceptable salt er hydrochloridsaltet.
9. Kit omfattende et farmaceutisk acceptabelt salt ifølge krav 1.
10. Kittet ifølge krav 9, hvor det farmaceutisk acceptable salt er hydrochloridsaltet.
11. Kittet ifølge krav 9, hvor forbindelsen er S-enantiomeren.
12. Kittet ifølge krav 11, hvor det farmaceutisk acceptable salt er hydrochloridsaltet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57078404P | 2004-05-13 | 2004-05-13 | |
EP05752122.1A EP1761540B1 (en) | 2004-05-13 | 2005-05-12 | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2612862T3 true DK2612862T3 (da) | 2016-12-05 |
Family
ID=34969603
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05752122.1T DK1761540T3 (da) | 2004-05-13 | 2005-05-12 | Quinazolinoner som inhibitorer af human phosphatidylinositol 3-kinase delta |
DK13150110.8T DK2612862T3 (da) | 2004-05-13 | 2005-05-12 | Quinazolinoner som inhibitorer af human phosphatidylinositol 3-kinase delta |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05752122.1T DK1761540T3 (da) | 2004-05-13 | 2005-05-12 | Quinazolinoner som inhibitorer af human phosphatidylinositol 3-kinase delta |
Country Status (21)
Country | Link |
---|---|
US (14) | USRE44638E1 (da) |
EP (4) | EP2612862B1 (da) |
JP (1) | JP2007537291A (da) |
CN (2) | CN102229609A (da) |
AU (2) | AU2005245875C1 (da) |
CA (1) | CA2566609C (da) |
CY (3) | CY2016046I1 (da) |
DK (2) | DK1761540T3 (da) |
ES (3) | ES2605792T3 (da) |
HR (2) | HRP20161657T1 (da) |
HU (3) | HUE030839T2 (da) |
IL (4) | IL179176A (da) |
LT (3) | LT2612862T (da) |
LU (1) | LUC00005I2 (da) |
ME (2) | ME02688B (da) |
NL (1) | NL300867I2 (da) |
PL (3) | PL3153514T3 (da) |
PT (3) | PT1761540T (da) |
RS (2) | RS55551B1 (da) |
SI (2) | SI3153514T1 (da) |
WO (2) | WO2005113554A2 (da) |
Families Citing this family (380)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
US20050043239A1 (en) * | 2003-08-14 | 2005-02-24 | Jason Douangpanya | Methods of inhibiting immune responses stimulated by an endogenous factor |
CA2566436C (en) * | 2004-05-13 | 2011-05-10 | Vanderbilt University | Phosphoinositide 3-kinase delta selective inhibitors for inhibiting angiogenesis |
ES2605792T3 (es) | 2004-05-13 | 2017-03-16 | Icos Corporation | Quinazolinona usada como inhibidor de la fosfatidilinositol 3-quinasa delta humana |
EP1831225A2 (en) * | 2004-11-19 | 2007-09-12 | The Regents of the University of California | Anti-inflammatory pyrazolopyrimidines |
CA2598409A1 (en) * | 2005-02-17 | 2006-08-24 | Icos Corporation | Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation |
GB2431156A (en) * | 2005-10-11 | 2007-04-18 | Piramed Ltd | 1-cyclyl-3-substituted- -benzenes and -azines as inhibitors of phosphatidylinositol 3-kinase |
EA200870409A1 (ru) | 2006-04-04 | 2009-04-28 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Антагонисты киназы pi3 |
JP5313909B2 (ja) * | 2006-11-13 | 2013-10-09 | アイコス コーポレイション | 炎症性疾患および癌の処置のためのチエノピリミジノン |
EP1953163A1 (en) * | 2007-02-01 | 2008-08-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Pteridinone derivatives as PI3-kinases inhibitors |
US20110123486A1 (en) * | 2007-06-25 | 2011-05-26 | Prolexys Pharmaceuticals, Inc. | Methods of treating multiple myeloma and resistant cancers |
FR2918668B1 (fr) * | 2007-07-09 | 2009-08-21 | Arkema France | Procede ameliore de preparation d'alcoxyamines issues de nitroxydes beta-phosphores. |
WO2009046448A1 (en) * | 2007-10-04 | 2009-04-09 | Intellikine, Inc. | Chemical entities and therapeutic uses thereof |
GEP20125635B (en) * | 2007-11-13 | 2012-09-10 | Icos Corp | Inhibitors of human phosphatidyl-inositol 3-kinase delta |
MX2010007418A (es) * | 2008-01-04 | 2010-11-12 | Intellikine Inc | Ciertas entidades quimicas, composiciones y metodos. |
US8193182B2 (en) * | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
RU2537549C2 (ru) * | 2008-01-04 | 2015-01-10 | Интелликайн ЭлЭлСи | Некоторые химические структуры, композиции и способы |
AU2014203687B2 (en) * | 2008-01-04 | 2016-04-14 | Intellikine Llc | Certain chemical entities, compositions and methods |
US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
US8637542B2 (en) | 2008-03-14 | 2014-01-28 | Intellikine, Inc. | Kinase inhibitors and methods of use |
JPWO2009128520A1 (ja) * | 2008-04-18 | 2011-08-04 | 塩野義製薬株式会社 | Pi3k阻害活性を有する複素環化合物 |
JP2011518836A (ja) | 2008-04-24 | 2011-06-30 | インサイト・コーポレイション | 大環状化合物およびそれらのキナーゼ阻害剤としての使用 |
US20110224223A1 (en) * | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
BRPI0915231A2 (pt) | 2008-07-08 | 2018-06-12 | Intellikine Inc | compostos inibidores de quinase e métodos de uso |
TW201010984A (en) * | 2008-07-29 | 2010-03-16 | Boehringer Ingelheim Int | 5-alkynyl-pyrimidines |
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