DK1865986T3 - Anti-CTLA-4-antistofsammensætninger - Google Patents
Anti-CTLA-4-antistofsammensætninger Download PDFInfo
- Publication number
- DK1865986T3 DK1865986T3 DK06736812.6T DK06736812T DK1865986T3 DK 1865986 T3 DK1865986 T3 DK 1865986T3 DK 06736812 T DK06736812 T DK 06736812T DK 1865986 T3 DK1865986 T3 DK 1865986T3
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- DK
- Denmark
- Prior art keywords
- antibody
- amino acid
- ctla
- acid sequence
- composition
- Prior art date
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Claims (17)
1. Flydende sammensætning omfattende: EDTA eller EDTA-salte med en koncentration på 0,01 mM til 5,0 mM; histidin med en koncentration på 1mM til 100mM; og i det mindste ét humant IgG-antistof med en koncentration på 1 mg/ml til 200 mg/ml, hvor antistoffet omfatter: en aminosyresekvens, som er i det mindste 90% identisk med en tung kæde aminosyresekvens vist i SEQ ID NO: 2; og en aminosyresekvens, som er i det mindste 90% identisk med en let kæde aminosyresekvens vist i SEQ ID NO: 4; hvor antistoffet binder til humant CTLA-4.
2. Sammensætning ifølge krav 1, hvor antistoffet er et humant lgG2-antistof.
3. Sammensætning ifølge krav 1, hvor antistoffet omfatter en tung kæde aminosyresekvens med i det mindste 99% sekvensidentitet med SEQ ID NO: 2 og en let kæde aminosyresekvens med i det mindste 99% sekvensidentitet med SEQ ID NO: 4.
4. Sammensætning ifølge krav 1, hvor antistoffet omfatter en tung kæde, som omfatter aminosyresekvensen i det variable område i SEQ ID NO: 2, og en let kæde, som omfatter aminosyresekvensen i det variable område i SEQ ID NO: 4.
5. Sammensætning ifølge krav 1, hvor antistoffet er et monoklonalt lgG2 anti-CTLA-4-antistof med de tunge og lette kæde aminosyresekvenser i SEQ ID NO: 2 hhv. 4.
6. Sammensætning ifølge krav 1, hvor sammensætningen yderligere omfatter et overfladeaktivt stof.
7. Sammensætning ifølge krav 1, hvor sammensætningen yderligere omfatter et overfladeaktivt stof og et tonicitetsmiddel.
8. Sammensætning ifølge krav 1, hvor sammensætningen yderligere omfatter polysorbat 80 og et tonicitetsmiddel.
9. Sammensætning ifølge krav 1, hvor sammensætningen yderligere omfatter polysorbat 80 og trehalose.
10. Sammensætning ifølge krav 1, hvor sammensætningen omfatter: antistof med en koncentration på 1 mg/ml til 200 mg/ml; EDTA med en koncentration på 0,01 mM til 5,0 mM; og histidin med en koncentration på 1 mM til 100 mM.
11. Sammensætning ifølge krav 1, hvor sammensætningen omfatter: antistof med en koncentration på 1 mg/ml til 100 mg/ml; EDTA eller EDTA-salte med en koncentration på 0,01 mM til 1,0 mM; histidin med en koncentration på 1 mM til 100 mM; polysorbat 80 med en koncentration på 0,01 mg/ml til 10 mg/ml; og et tonicitetsmiddel med en koncentration på 100 mM til 300 mM.
12. Sammensætning ifølge krav 1, hvor sammensætningen omfatter: antistof med en koncentration på 0,1 mg/ml til 100 mg/ml; EDTA eller EDTA-salte med en koncentration på 0,001 mg/ml til 1,0 mg/ml; histidin med en koncentration på 1 mM til 50 mM; polysorbat 80 med en koncentration på 0,01 mg/ml til 5 mg/ml; og trehalose med en koncentration på 10 mg/ml til 200 mg/ml.
13. Sammensætning ifølge krav 1, hvor sammensætningen omfatter: 20 mg/ml antistof; 0,27 mM EDTA eller EDTA-salte; 20 mM histidin; 0,2 mg/ml polysorbat 80; og 222 mM trehalose.
14. Sammensætning ifølge krav 1, hvor sammensætningen omfatter: 20 mg/ml antistof; 0,1 mg/ml EDTA eller EDTA-salte; 20 mM histidin; 0,2 mg/ml polysorbat 80; og 84 mg/ml trehalose.
15. Sammensætning ifølge ethvert af de foregående krav, hvor reduktionen af et samlet chromatogramspidsareal for væskesammensætningen efter lagring over en periode på omkring 24 uger ved en temperatur på omkring 40°C, i forhold til et samlet chromatogramspidsareal for en i øvrigt identisk sammensætning, som ikke indeholder EDTA eller EDTA-salte, efter lagring over en periode på omkring 24 uger ved en temperatur på 40°C, er i det mindste omkring 2%.
16. Flydende sammensætning ifølge ethvert af kravene 1 til 15 til anvendelse ved behandling af en neoplasitilstand i et subjekt.
17. Fremgangsmåde til fremstilling af en sammensætning ifølge ethvert af kravene 1 til 15, som omfatter blanding af det nævnte antistof, som binder til humant CTLA-4 i opløsning med det nævnte EDTA eller EDTA-salte.
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US76245606P | 2006-01-26 | 2006-01-26 | |
PCT/US2006/007555 WO2006096491A2 (en) | 2005-03-08 | 2006-03-02 | Anti-ctla-4 antibody compositions |
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DK06736812.6T DK1865986T3 (da) | 2005-03-08 | 2006-03-02 | Anti-CTLA-4-antistofsammensætninger |
DK13155091.5T DK2620450T3 (da) | 2005-03-08 | 2006-03-02 | Antistofsammensætninger mod CTLA-4 |
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DK13155091.5T DK2620450T3 (da) | 2005-03-08 | 2006-03-02 | Antistofsammensætninger mod CTLA-4 |
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TWI445716B (zh) * | 2008-09-12 | 2014-07-21 | Rinat Neuroscience Corp | Pcsk9拮抗劑類 |
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