DK171118B1 - Syntetisk peptid udvisende den for VP1-proteinet fra mund-og-klovsygevirussen karakteristiske antigenicitet, vaccine samt diagnostisk testsystem omfattende samme - Google Patents

Syntetisk peptid udvisende den for VP1-proteinet fra mund-og-klovsygevirussen karakteristiske antigenicitet, vaccine samt diagnostisk testsystem omfattende samme Download PDF

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Publication number
DK171118B1
DK171118B1 DK532184A DK532184A DK171118B1 DK 171118 B1 DK171118 B1 DK 171118B1 DK 532184 A DK532184 A DK 532184A DK 532184 A DK532184 A DK 532184A DK 171118 B1 DK171118 B1 DK 171118B1
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Prior art keywords
peptide
replaced
amino acid
protein
peptides
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DK532184A
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Danish (da)
English (en)
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DK532184D0 (da
DK532184A (da
Inventor
Hendrik Mario Geysen
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Stichting Centr Diergeneeskund
Chiron Mimotopes Pty Ltd
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Priority claimed from PCT/AU1984/000038 external-priority patent/WO1984003506A1/en
Application filed by Stichting Centr Diergeneeskund, Chiron Mimotopes Pty Ltd filed Critical Stichting Centr Diergeneeskund
Publication of DK532184D0 publication Critical patent/DK532184D0/da
Publication of DK532184A publication Critical patent/DK532184A/da
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/125Picornaviridae, e.g. calicivirus
    • A61K39/135Foot- and mouth-disease virus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6081Albumin; Keyhole limpet haemocyanin [KLH]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32111Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32111Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/22Viral peptide or viral protein
    • Y10S930/222Foot and mouth disease related

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK532184A 1983-03-08 1984-11-08 Syntetisk peptid udvisende den for VP1-proteinet fra mund-og-klovsygevirussen karakteristiske antigenicitet, vaccine samt diagnostisk testsystem omfattende samme DK171118B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AUPF834783 1983-03-08
AUPF834783 1983-03-08
AU8400038 1984-03-08
PCT/AU1984/000038 WO1984003506A1 (en) 1983-03-08 1984-03-08 Antigenically active amino acid sequences

Publications (3)

Publication Number Publication Date
DK532184D0 DK532184D0 (da) 1984-11-08
DK532184A DK532184A (da) 1984-11-08
DK171118B1 true DK171118B1 (da) 1996-06-17

Family

ID=3770022

Family Applications (1)

Application Number Title Priority Date Filing Date
DK532184A DK171118B1 (da) 1983-03-08 1984-11-08 Syntetisk peptid udvisende den for VP1-proteinet fra mund-og-klovsygevirussen karakteristiske antigenicitet, vaccine samt diagnostisk testsystem omfattende samme

Country Status (5)

Country Link
US (1) US4708871A (de)
EP (1) EP0138854B1 (de)
JP (1) JPS60500673A (de)
CA (1) CA1247080A (de)
DK (1) DK171118B1 (de)

Families Citing this family (368)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5230888A (en) * 1982-05-06 1993-07-27 Massachusetts Institute Of Technology Production of neutralizing antibodies by polypeptide VP1 of enteroviruses and by oligopeptide fragments of polypeptide VP1
NZ207394A (en) * 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
DE3813821A1 (de) * 1988-04-22 1989-11-02 Hoechst Ag Synthetische vakzine gegen die maul- und klauenseuche und verfahren zu deren herstellung
US5866363A (en) 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
EP0251575B2 (de) * 1986-06-17 2002-11-13 Chiron Corporation Hepatitis-Delta-Diagnostika und Impfstoffe, ihre Herstellung und Verwendung
US5919665A (en) * 1989-10-31 1999-07-06 Ophidian Pharmaceuticals, Inc. Vaccine for clostridium botulinum neurotoxin
US6730305B1 (en) 2000-05-08 2004-05-04 The Uab Research Foundation Nucleotide sequences encoding bovine respiratory syncytial virus immunogenic proteins
US5674978A (en) * 1990-09-21 1997-10-07 The Regents Of The University Of California Peptides derived from glutamic acid decarboxylase
ATE176239T1 (de) * 1990-11-21 1999-02-15 Iterex Pharma Lp Synthese äquimolarer mischungen vielzähliger oligomere, speziell oligopeptidmischungen
US5243540A (en) * 1991-04-03 1993-09-07 The United States Of America As Represented By The Secretary Of The Army Computer-driven amino acid indexer for peptide synthesis
US5397703A (en) * 1992-07-09 1995-03-14 Cetus Oncology Corporation Method for generation of antibodies to cell surface molecules
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5919712A (en) 1993-05-18 1999-07-06 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5480971A (en) * 1993-06-17 1996-01-02 Houghten Pharmaceuticals, Inc. Peralkylated oligopeptide mixtures
US5846731A (en) * 1993-06-17 1998-12-08 Torry Pines Institute For Molecular Studies Peralkylated oligopeptide mixtures
US5380668A (en) * 1993-07-06 1995-01-10 University Of Utah Research Foundation Compounds having the antigenicity of hCG
US6287787B1 (en) 1993-11-24 2001-09-11 Torrey Pines Institute For Molecular Studies Dimeric oligopeptide mixture sets
US5645996A (en) * 1994-08-24 1997-07-08 Torrey Pines Institute For Molecular Studies Melittin-related polypeptides, mixture sets and libraries thereof
US5582997A (en) * 1994-08-24 1996-12-10 Torrey Pines Institute For Molecular Studies Lysine/leucine polypeptides, mixture sets and libraries thereof
US5747458A (en) * 1995-06-07 1998-05-05 Chiron Corporation Urokinase receptor ligands
US5756300A (en) * 1995-11-14 1998-05-26 Research Genetics, Inc. Oligodendrocyte-specific protein and method for diagnosing and treating disease
US6150136A (en) * 1995-11-14 2000-11-21 The Regents Of The University Of California Nucleotide sequence encoding oligodendrocyte-specific protein
US6323020B1 (en) 1996-08-23 2001-11-27 North Carolina State University Neutralization-sensitive epitopes of Cryptosporidium parvum
US20040161409A1 (en) * 1997-07-25 2004-08-19 Kurtzman Gary J. Induction of immune response to antigens expressed by recombinant adeno-associated virus
US6710036B2 (en) 1997-07-25 2004-03-23 Avigen, Inc. Induction of immune response to antigens expressed by recombinant adeno-associated virus
CA2301942C (en) 1997-08-27 2011-05-31 Chiron Corporation Molecular mimetics of meningococcal b epitopes
KR100879650B1 (ko) 1997-12-11 2009-01-20 유니버시티 오브 사스카췌완 돼지로부터의 이유후 다기관계작용성 소모 증후군 바이러스
US6369201B1 (en) 1998-02-19 2002-04-09 Metamorphix International, Inc. Myostatin multimers
US6500637B1 (en) 1998-03-31 2002-12-31 The Institute Of Physical And Chemical Research Neurogenesis inducing genes
US8206749B1 (en) 1999-02-26 2012-06-26 Novartis Vaccines And Diagnostics, Inc. Microemulsions with adsorbed macromolecules and microparticles
US9289487B2 (en) * 1999-09-14 2016-03-22 Antigen Express, Inc. II-key/antigenic epitope hybrid peptide vaccines
US6432409B1 (en) * 1999-09-14 2002-08-13 Antigen Express, Inc. Hybrid peptides modulate the immune response
US20030235594A1 (en) * 1999-09-14 2003-12-25 Antigen Express, Inc. Ii-Key/antigenic epitope hybrid peptide vaccines
US20040092712A1 (en) * 2000-03-31 2004-05-13 Shoji Furusako Tlr/cd14 binding inhibitor
US6686188B2 (en) * 2000-05-26 2004-02-03 Amersham Plc Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
US6656700B2 (en) 2000-05-26 2003-12-02 Amersham Plc Isoforms of human pregnancy-associated protein-E
EP1734050A3 (de) 2000-06-12 2012-12-05 University Of Saskatchewan Immunisation von Milchvieh mit GapC Protein gegen Streptococcusinfektion
US6783939B2 (en) * 2000-07-07 2004-08-31 Alphavax, Inc. Alphavirus vectors and virosomes with modified HIV genes for use in vaccines
AU2001296545A1 (en) 2000-10-02 2002-04-15 Chiron Corporation Methods of therapy for b-cell malignancies
ES2446984T3 (es) 2001-01-04 2014-03-11 University Of Saskatchewan Vacuna contra Escherichia coli enterohemorrágica
EP1351980B1 (de) 2001-01-18 2014-12-31 The Board Of Trustees Of The Leland Stanford Junior University Peptide zur aktivierung und inhibierung von delta-pkc
CA2658221C (en) 2001-04-27 2012-11-27 Kyowa Hakko Kirin Co., Ltd. Anti-cd40 monoclonal antibody
EP2332573A1 (de) 2001-05-31 2011-06-15 Novartis Vaccines and Diagnostics, Inc. Chimäre Alphavirus-Replikonpartikel
US20070160576A1 (en) 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
KR100628425B1 (ko) 2001-06-20 2006-09-28 제넨테크, 인크. 종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물
US7803915B2 (en) 2001-06-20 2010-09-28 Genentech, Inc. Antibody compositions for the diagnosis and treatment of tumor
ATE437222T1 (de) * 2001-09-06 2009-08-15 Alphavax Inc Alphavirus replikon-vektorsysteme
NZ573831A (en) 2001-09-18 2010-07-30 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor, particularly breast tumor - TAT193
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
MXPA04006554A (es) 2002-01-02 2005-03-31 Genentech Inc Composiciones y metodos para diagnostico y tratamiento de tumor.
US7501134B2 (en) 2002-02-20 2009-03-10 Novartis Vaccines And Diagnostics, Inc. Microparticles with adsorbed polypeptide-containing molecules
US8802618B2 (en) * 2002-03-08 2014-08-12 Board Of Regents, The University Of Texas System Controlled modulation of amino acid side chain length of peptide antigens
EP1571968A4 (de) 2002-04-16 2007-10-17 Genentech Inc Zusammensetzungen und verfahren zur diagnose und behandlung von tumoren
BR0308896A (pt) * 2002-05-07 2007-01-09 Chiron Corp complexos e hìbridos envelope do hiv-cd4
EP2305710A3 (de) 2002-06-03 2013-05-29 Genentech, Inc. Synthetische Antikörperphagenbibliotheken
JP4598518B2 (ja) 2002-06-19 2010-12-15 ユニバーシティー ヘルス ネットワーク 心臓、肺および腎臓疾患および高血圧症の治療のためのace2活性化
CA2496925A1 (en) * 2002-08-29 2004-03-11 Genentech, Inc. Achaete-scute like-2 polypeptides and encoding nucleic acids and methods for the diagnosis and treatment of tumor
AU2003252591A1 (en) 2002-08-30 2004-03-29 Japan Science And Technology Corporation Method of targeted gene disruption, genome of hyperthermostable bacterium and genome chip using the same
US7179645B2 (en) * 2002-09-24 2007-02-20 Antigen Express, Inc. Ii-Key/antigenic epitope hybrid peptide vaccines
CA2499123A1 (en) 2002-09-17 2004-04-15 Antigen Express, Inc. Ii-key/antigenic epitope hybrid peptide vaccines
ES2552687T3 (es) * 2002-12-13 2015-12-01 Alphavax, Inc. Partículas alfavíricas y métodos de preparación
DK1585812T3 (en) 2002-12-13 2017-04-10 Alphavax Inc MULTI-ANTI-ANTI-ANTI-VIRUS REPLICATE PARTICLES AND PROCEDURES
EP1585542B1 (de) 2002-12-27 2012-06-13 Novartis Vaccines and Diagnostics, Inc. Immunogene zusammensetzungen enthaltend phospholipid
WO2004085660A2 (en) * 2003-03-20 2004-10-07 Alphavax, Inc. Improved alphavirus replicons and helper constructs
CA2523875A1 (en) * 2003-04-28 2004-11-11 Public Health Agency Of Canada Sars virus nucleotide and amino acid sequences and uses thereof
EP1628680B1 (de) 2003-05-15 2012-10-24 Novartis Vaccines and Diagnostics, Inc. Hiv polynucleotide und polypeptide von botswana mj4
ES2424353T3 (es) 2003-07-08 2013-10-01 Genentech, Inc. Polipéptidos heterólogos IL-17 A/F y usos terapéuticos de los mismos
AU2004257214B2 (en) * 2003-07-11 2010-04-22 Alphavax, Inc. Alphavirus-based cytomegalovirus vaccines
US20060035242A1 (en) 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
CA2543763A1 (en) * 2003-10-31 2005-05-12 The University Of British Columbia Bacterial virulence factors and uses thereof
PT1680141E (pt) 2003-11-04 2010-12-20 Novartis Vaccines & Diagnostic Métodos terapêuticos para tumores sólidos que expressam o antigénio de superfície celular cd40
JP4746552B2 (ja) 2003-11-04 2011-08-10 ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗cd40抗体の使用
US20070218060A1 (en) 2003-11-04 2007-09-20 Chiron Corporation Use of Antagonist Anti-Cd40 Monoclonal Antibodies for Treatment of Multiple Myeloma
EP1844815B1 (de) 2003-11-04 2011-09-14 Novartis Vaccines and Diagnostics, Inc. Kombinationstherapie von anti-CD20 und anti-CD40 Antikörpern zur Behandlung von B-Zell-bedingtem Krebs
DK1682177T3 (da) 2003-11-04 2010-11-01 Novartis Vaccines & Diagnostic Anvendelse af antagonist-anti-CD40-antistoffer til behandling af kronisk lymfocytisk leukæmi
JP4901478B2 (ja) 2003-11-17 2012-03-21 ジェネンテック, インコーポレイテッド 造血系起源の腫瘍の治療のための組成物と方法
GB0330079D0 (en) * 2003-12-20 2004-02-04 Bioinvent Int Ab Vaccine
WO2005107789A1 (en) * 2004-04-30 2005-11-17 The Board Of Trustees Of The Leland Stanford Junior University Use of delta pkc peptides for modulation of reactive oxigen species
DE602005012382D1 (de) 2004-05-18 2009-03-05 Alphavax Inc Von tc-83 abgeleitete alphavirus-vektoren, partikel und verfahren
ES2647491T3 (es) 2004-05-21 2017-12-21 Novartis Vaccines And Diagnostics, Inc. Vectores del alfavirus para las vacunas del virus de la gripe
CA2569562C (en) * 2004-06-08 2013-12-03 Vega Masignani Fusion proteins comprising cd4 minimal modules and methods of use thereof
US7899623B2 (en) 2004-09-22 2011-03-01 Tripath Imaging, Inc. Methods and computer program products for analysis and optimization of marker candidates for cancer prognosis
EP2266602A3 (de) 2004-11-01 2011-08-10 Novartis Vaccines and Diagnostics, Inc. Kombinationswege zur Erzeugung von Immunantworten
AU2005313026B2 (en) 2004-12-06 2011-09-08 Kyowa Hakko Kirin Co., Ltd. Human monoclonal antibodies to influenza M2 protein and methods of making and using same
SG158155A1 (en) * 2004-12-29 2010-01-29 Mannkind Corp Methods to bypass cd+4 cells in the induction of an immune response
CA2592500A1 (en) * 2005-01-04 2006-07-27 The Board Of Trustees Of The Leland Stanford Junior University Methods of increasing cerebral blood flow
WO2006084179A2 (en) * 2005-02-03 2006-08-10 Novartis Vaccines And Diagnostics Inc. Hiv tat-cd4 hybried molecules and methods of use thereof
BRPI0607985A2 (pt) 2005-03-10 2009-10-27 Genentech Inc modulador da dscr1, métodos de tratamento, método de melhoria de efeitos colaterais e método de inibição do crescimento de tumores
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
US7595380B2 (en) 2005-04-27 2009-09-29 Tripath Imaging, Inc. Monoclonal antibodies and methods for their use in the detection of cervical disease
GB0508726D0 (en) * 2005-04-29 2005-06-08 Bioinvent Int Ab Polypeptide, vaccine and use thereof
DK1889065T3 (da) 2005-05-18 2013-09-02 Xoma Technology Ltd Metoder til diagnostisering og behandling af sygdomme med en autoimmun- og/eller inflammationskomponent
JP2008541781A (ja) 2005-06-06 2008-11-27 ジェネンテック・インコーポレーテッド 異なる遺伝子に対するトランスジェニック動物、および遺伝子の特徴づけのためのその使用
US7763460B2 (en) 2005-06-24 2010-07-27 Focus Diagnostics, Inc. Methods and compositions for detecting herpes simplex virus type 2
US8398994B2 (en) 2005-07-15 2013-03-19 Boehringer Ingelheim Vetmedica, Inc. Lawsonia vaccine and methods of use thereof
ZA200800970B (en) 2005-08-15 2009-10-28 Genentech Inc Gene disruptions, compositions and methods relating thereto
US20080241184A1 (en) 2005-08-25 2008-10-02 Jules Maarten Minke Canine influenza vaccines
US8945573B2 (en) 2005-09-08 2015-02-03 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Targeted identification of immunogenic peptides
EP2357000A1 (de) 2005-10-18 2011-08-17 Novartis Vaccines and Diagnostics, Inc. Mukosale und systemische Immunisierungen mit Alphavirus-Replikonpartikeln
ZA200804162B (en) 2005-11-21 2009-12-30 Genentech Inc Novel gene disruptions, compositions and methods relating thereto
ES2514316T3 (es) 2005-11-22 2014-10-28 Novartis Vaccines And Diagnostics, Inc. Partículas similares a virus (VLPs) de Norovirus y Sapovirus
TWI461436B (zh) 2005-11-25 2014-11-21 Kyowa Hakko Kirin Co Ltd 人類cd134(ox40)之人類單株抗體及其製造及使用方法
AU2006342792A1 (en) 2005-12-02 2007-11-08 Genentech, Inc. Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to IL-22 and IL-22R
US7632498B2 (en) 2005-12-19 2009-12-15 Tripath Imaging, Inc. MCM6 and MCM7 monoclonal antibodies and methods for their use in the detection of cervical disease
MY149398A (en) 2005-12-29 2013-08-30 Boehringer Ingelheim Vetmed Multivalent pcv2 immunogenic compositions and methods of producing such compositions
MX2008008311A (es) 2005-12-29 2009-03-04 Boehringer Ingelheim Vetmed Uso de una composicion inmunogenica de pcv2 para reducir los sintomas clinicos en cerdos.
EP2363711A1 (de) 2006-01-27 2011-09-07 Tripath Imaging, Inc. Verfahren zur Identifizierung von Patienten mit erhöhter Wahrscheinlichkeit des Auftretens eines Ovarialkarzinoms und Zusammensetzungen dafür
ZA200807714B (en) 2006-02-17 2010-01-27 Genentech Inc Gene disruptions, compositions and methods relating thereto
JP2009531464A (ja) 2006-03-29 2009-09-03 メリアル リミテッド 連鎖球菌に対するワクチン
WO2007126455A2 (en) 2006-04-05 2007-11-08 Genentech, Inc. Method for using boc/cdo to modulate hedgehog signaling
CA2649387A1 (en) 2006-04-19 2008-03-27 Genentech, Inc. Novel gene disruptions, compositions and methods relating thereto
GEP20125628B (en) 2006-04-21 2012-09-10 Novartis Ag Pharmaceutical compositions containing antagonist anti-cd40 antibody
US20090142259A1 (en) * 2006-05-12 2009-06-04 Genentech, Inc. Compositions and methods for the diagnosis and treatment of bladder and urinary tract tumors
CA2660286A1 (en) 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
JP2010503407A (ja) 2006-09-12 2010-02-04 ジェネンテック・インコーポレーテッド 癌の診断及び治療のための方法及び組成物
US8865183B2 (en) 2006-12-15 2014-10-21 Boehringer Ingelheim Vetmedica, Inc. Treatment of pigs with PCV2 antigent
EP1941903A1 (de) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxe und Behandlung von PRDC
EP1958644A1 (de) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Vorbeugung und Behandlung von subklinischer PCVD
MX2009008736A (es) 2007-02-22 2009-08-24 Genentech Inc Metodos para detectar la enfermedad inflamatoria intestinal.
EP2146743A2 (de) 2007-04-12 2010-01-27 Stichting Katholieke Universiteit, more particularly the Radboud University Nijmegen Medical Centre Neue virulenz-faktoren von streptococcus pneumoniae
US20100210708A1 (en) * 2007-04-13 2010-08-19 Cytopathfinder, Inc. Compound profiling method
AU2008266807B2 (en) * 2007-06-21 2012-08-16 Alphavax, Inc. Promoterless cassettes for expression of alphavirus structural proteins
US20090017064A1 (en) * 2007-07-10 2009-01-15 Wyeth Methods and Compositions for Immunizing Pigs Against Porcine Circovirus
AU2008307145B2 (en) * 2007-10-04 2014-07-10 Bionomics Limited Markers of endothelial cells and uses thereof
PE20091163A1 (es) 2007-11-01 2009-08-09 Wyeth Corp Anticuerpos para gdf8
DK2514436T3 (en) 2007-11-07 2018-03-12 Genentech Inc IL-22 FOR USE IN TREATMENT OF MICROBIAL DISEASES
WO2009064944A2 (en) 2007-11-16 2009-05-22 Nuvelo, Inc. Antibodies to lrp6
KR20100094587A (ko) * 2007-12-21 2010-08-26 와이어쓰 엘엘씨 돼지 써코바이러스에 대해 돼지를 면역시키는 방법 및 조성물
EP2077119A1 (de) * 2007-12-21 2009-07-08 Apeiron Biologics Forschungs- und Entwicklungsgesellschaft M.B.H. Behandlung von Fibrosen und Lebererkrankungen
US20090175906A1 (en) * 2007-12-21 2009-07-09 Wyeth Genetically Modified Attenuated Vesicular Stomatitis Virus, Compositions and Methods of use Thereof
NZ589795A (en) 2008-06-16 2013-02-22 Patrys Ltd Use of LM-1 antibody which binds to NONO/nmt55 protein to prevent metastasis
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
EP2174664A1 (de) 2008-10-07 2010-04-14 Stichting Katholieke Universiteit, more particularly the Radboud University Nijmegen Medical Centre Neue Virulenzfaktoren von Pneumokokken
MX2011005604A (es) 2008-11-28 2011-09-01 Merial Ltd Vacuna recombinante para influenza aviar y sus usos.
BRPI0923199B8 (pt) 2008-12-01 2021-07-27 Univ Leland Stanford Junior método para determinar a presença de anticorpos de fixação de complemento
EP2376535B9 (de) 2008-12-09 2017-09-13 F. Hoffmann-La Roche AG Anti-pd-l1-antikörper und deren verwendung zur verbesserung der t-zellen-funktion
CA2750922A1 (en) * 2009-01-28 2010-08-05 Antigen Express, Inc. Li-key hybrid peptides that modulate the immune response to influenza
EP2403880A1 (de) 2009-03-05 2012-01-11 Tripath Imaging, Inc. Monoklonale antikörper gegen matrixmetalloproteinase-7 (mmp-7) und verfahren zu ihrer verwendung beim nachweis von eierstockkrebs
JP2012524521A (ja) 2009-03-06 2012-10-18 トライパス イメージング インコーポレイテッド グリコデリンモノクローナル抗体および卵巣癌の検出におけるその使用のための方法
CN102428099B (zh) 2009-04-03 2016-03-16 梅里亚有限公司 运载新城疫病毒的禽疫苗
HUE036372T2 (hu) 2009-06-22 2018-07-30 Wyeth Llc Staphylococcus aureus antigének immunogén készítményei
CA2766418C (en) 2009-06-22 2016-03-29 Wyeth Llc Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
MX2012002114A (es) 2009-08-21 2012-08-08 Univ Georgia Vacuna de paramixovirus aviar recombinante y metodo para hacerla y usarla.
CN102597775A (zh) 2009-09-25 2012-07-18 佐马技术有限公司 筛选方法
US8926976B2 (en) 2009-09-25 2015-01-06 Xoma Technology Ltd. Modulators
ES2564207T3 (es) 2009-10-22 2016-03-18 F. Hoffmann-La Roche Ag Métodos y composiciones para modular la activación con hepsina de la proteína estimuladora de macrófagos
EP2501414B1 (de) 2009-11-17 2018-01-10 The Trustees Of The University Of Pennsylvania Smn-delta-7-degron: neuartige zusammensetzungen und verfahren zu ihrer verwendung
EP2507264A2 (de) 2009-11-30 2012-10-10 F. Hoffmann-La Roche AG Antikörper zur behandlung und diagnostizierung von slc34a2-exprimierenden tumoren (tat211 = seqid 2)
WO2011075379A1 (en) 2009-12-18 2011-06-23 Boehringer Ingelheim Vetmedica, Inc. Multivalent vaccine against porcine teschovirus and other disease causing organisms in swine
MX351643B (es) 2009-12-28 2017-10-23 Merial Ltd Antigeno ndv recombinante y usos del mismo.
RU2587619C2 (ru) 2010-02-18 2016-06-20 Дженентек, Инк. Антагонисты неурегулина и применение их в лечении злокачественного новообразования
US8877897B2 (en) 2010-02-23 2014-11-04 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US20130197612A1 (en) 2010-02-26 2013-08-01 Jack W. Lasersohn Electromagnetic Radiation Therapy
EP2544715A2 (de) 2010-03-09 2013-01-16 Board Of Regents, University Of Texas System Verfahren und zusammensetzung für chlamydia-antigen zur diagnose und behandlung einer chlamydieninfektion und -erkranung
MA34087B1 (fr) 2010-03-12 2013-03-05 Merial Ltd Vaccins recombinants contre le virus de la langue bleue et leurs utilisations
WO2011139985A1 (en) 2010-05-03 2011-11-10 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
MX2012012927A (es) 2010-05-06 2013-05-01 Novartis Ag Composiciones y metodos de uso para anticuerpos multivalentes terapeuticos de proteina relacionada con lipoproteina de baja densidad 6 (lrp6).
EA201291180A1 (ru) 2010-05-06 2013-05-30 Новартис Аг Композиции и способы применения терапевтических антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6)
EP2575988A1 (de) 2010-05-28 2013-04-10 Tetris Online, Inc. Interaktive, hybride und asynchrone computerspiel-infrastruktur
US9192661B2 (en) 2010-07-06 2015-11-24 Novartis Ag Delivery of self-replicating RNA using biodegradable polymer particles
KR102027011B1 (ko) 2010-08-20 2019-09-30 노파르티스 아게 표피 성장 인자 수용체 3 (her3)에 대한 항체
PL3246044T3 (pl) 2010-08-23 2021-08-23 Wyeth Llc Stabilne preparaty antygenów rLP2086 Neisseria meningitidis
EP2611460B1 (de) 2010-08-31 2016-10-05 Merial, Inc. Auf das virus der newcastle-krankheit gerichtete herpesvirus-impfstoffe
CA2809758C (en) 2010-09-10 2021-07-13 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
WO2012071436A1 (en) 2010-11-24 2012-05-31 Genentech, Inc. Method of treating autoimmune inflammatory disorders using il-23r loss-of-function mutants
EP2643353A1 (de) 2010-11-24 2013-10-02 Novartis AG Multispezifische moleküle
WO2012075111A1 (en) 2010-11-30 2012-06-07 Novartis Ag Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers
DK2654784T3 (en) 2010-12-22 2017-02-13 Wyeth Llc STABLE IMMUNOGENIC COMPOSITIONS OF STAPHYLOCOCCUS AUREUS ANTIGENES
CA2826229A1 (en) 2011-02-11 2012-08-16 Pioneer Hi-Bred International, Inc. Synthetic insecticidal proteins active against corn rootworm
US9428789B2 (en) 2011-03-21 2016-08-30 Biodesy, Inc. Classification of kinase inhibitors using nonlinear optical techniques
WO2012142526A1 (en) 2011-04-14 2012-10-18 Modiano Jaime Use of tumor fas expression to determine response to anti-cancer therapy
WO2012144546A1 (ja) * 2011-04-22 2012-10-26 ロート製薬株式会社 新規ペプチド
CN103945864A (zh) 2011-04-25 2014-07-23 先进生物学实验室股份有限公司 截短的hiv包膜蛋白(env)、其相关方法和组合物
EP2714722B1 (de) 2011-05-27 2019-09-11 Boehringer Ingelheim Animal Health USA Inc. Genetischer impfstoff gegen hendra- und nipah-virus
TW201840336A (zh) 2011-08-01 2018-11-16 美商建南德克公司 利用pd-1軸結合拮抗劑及mek抑制劑治療癌症之方法
WO2013024517A1 (ja) 2011-08-12 2013-02-21 国立感染症研究所 アスペルギルス フミガーツス感染症の検査、予防及び治療のための方法並びに組成物
HUE058855T2 (hu) 2011-08-16 2022-09-28 Morphosys Ag Kombinációs terápia, CD19 elleni ellenanyag és purinanalóg alkalmazásával
KR20200058583A (ko) 2011-08-16 2020-05-27 모르포시스 아게 항-cd19 항체 및 질소 머스타드를 사용한 조합 요법
WO2013033092A2 (en) 2011-09-03 2013-03-07 Boehringer Ingelheim Vetmedica Gmbh Streptococcus suis pilus antigens
KR20140068062A (ko) 2011-09-15 2014-06-05 제넨테크, 인크. 분화의 촉진 방법
JP6254087B2 (ja) 2011-10-15 2017-12-27 ジェネンテック, インコーポレイテッド 癌を治療するためのscd1アンタゴニスト
ES2666856T3 (es) 2011-11-04 2018-05-08 Novartis Ag Proteína 6 relacionada con lipoproteínas de baja densidad (LRP6) - constructos extensores de la vida media
MX361893B (es) 2011-11-30 2018-12-18 Merial Inc Vectores recombinantes de herpesvirus 3 galido (mdv serotipo 2) que expresan antigenos de patogenos de aves y sus usos.
EP3590538A1 (de) 2011-12-05 2020-01-08 Novartis AG Antikörper für den epidermalen wachstumsfaktorrezeptor 3 (her 3)
BR112014013568A8 (pt) 2011-12-05 2017-06-13 Novartis Ag anticorpos para o receptor do fator de crescimento epidermal 3 (her3) direcionados para o domínio ii do her3
WO2013093629A2 (en) 2011-12-20 2013-06-27 Netherlands Cancer Institute Modular vaccines, methods and compositions related thereto
WO2013094720A1 (ja) * 2011-12-22 2013-06-27 ロート製薬株式会社 細胞接着促進能を有する組成物
EP2804630B1 (de) 2012-01-18 2017-10-18 F. Hoffmann-La Roche AG Verfahren zur verwendung von fgf19-modulatoren
WO2013162654A1 (en) 2012-04-25 2013-10-31 Biodesy, Llc Methods for detecting allosteric modulators of proteins
JP6545959B2 (ja) 2012-02-11 2019-07-17 ジェネンテック, インコーポレイテッド Rスポンジン転位およびその使用方法
MX360415B (es) 2012-02-14 2018-10-31 Merial Inc Vectores poxvirales recombinantes que expresan proteinas tanto de rabia como de ox40, y vacunas hechas a partir de los mismos.
US9446117B2 (en) 2012-02-14 2016-09-20 Merial, Inc. Rotavirus subunit vaccines and methods of making and use thereof
WO2013129456A1 (ja) * 2012-02-29 2013-09-06 ロート製薬株式会社 線維芽細胞増殖促進能を有する組成物
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
CN104334187B (zh) 2012-03-09 2017-04-05 辉瑞公司 脑膜炎双球菌组合物及其方法
US9139863B2 (en) 2012-03-16 2015-09-22 Genentech, Inc. Engineered conformationally-stabilized proteins
JP2015511598A (ja) 2012-03-16 2015-04-20 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Pak1阻害剤を用いて黒色腫を治療する方法
WO2013137920A1 (en) 2012-03-16 2013-09-19 Genentech, Inc. Engineered conformationally-stabilized proteins
BR112014024612A2 (pt) 2012-04-02 2021-06-08 Univ North Carolina Chapel Hill ácido nucleico, polipeptídeo, glicoproteína e quimérica, epítopo de vírus da dengue, partícula semelhante a flavivírus quimérico (vlp), flavivírus quimérico, e métodos in vitro para identificar um anticorpo neutralizante e para identificar uma composição imunogênica contra um vírus da dengue
US9597386B2 (en) 2012-04-05 2017-03-21 Boehringer Ingelheim Vetmedica, Inc. Outer membrane proteins of Histophilus somni and methods thereof
CN104470950B (zh) 2012-05-11 2017-04-26 公益财团法人微生物化学研究会 抗cxadr抗体
WO2013170191A1 (en) 2012-05-11 2013-11-14 Genentech, Inc. Methods of using antagonists of nad biosynthesis from nicotinamide
KR102129636B1 (ko) 2012-05-31 2020-07-03 제넨테크, 인크. Pd-l1 축 결합 길항제 및 vegf 길항제를 사용하여 암을 치료하는 방법
CN104582724A (zh) 2012-06-13 2015-04-29 梅里亚有限公司 重配btv和ahsv疫苗
NZ703701A (en) 2012-06-27 2016-03-31 Merial Inc Attenuated streptococcus suis vaccines and methods of making and use thereof
JP6519851B2 (ja) 2012-07-06 2019-05-29 京都府公立大学法人 眼細胞の分化マーカーおよび分化制御
BR112015001020B1 (pt) 2012-07-17 2022-04-19 Merial, Inc. Vacinas de influenza suína atenuada e métodos de produção e utilização das mesmas
AU2013303826B2 (en) 2012-08-16 2017-06-29 Pfizer Inc. Glycoconjugation processes and compositions
EA031988B1 (ru) 2012-08-30 2019-03-29 Мериал, Инк. Гипербарическое устройство и способы получения инактивированных вакцин и повторно свернутых/солюбилизированных рекомбинантных белков
US9555098B2 (en) 2012-09-10 2017-01-31 Merial Inc. Attenuated parvovirus vaccine for Muscovy duck parvovirus and goose parvovirus (Derzsys disease)
EP2916863B1 (de) 2012-11-08 2018-05-30 Merial, Inc. Attenuierte mannheimia-haemolytica-impfstoffe sowie verfahren zur herstellung und verwendung
US20140170180A1 (en) 2012-12-17 2014-06-19 Boehringer Ingelheim Vetmedica, Inc. Porcine parvovirus 5a, methods of use and vaccine
KR20150110531A (ko) 2012-12-18 2015-10-02 메리얼 인코포레이티드 Ibv, csfv 및 ndv 의 고 해상도 용융 유전자형분석
EP4169929A1 (de) 2012-12-20 2023-04-26 Pfizer Inc. Immunogene zusammensetzungen mit pn-serotype 12f
BR112015018330A2 (pt) 2013-02-01 2017-07-18 Univ Auburn cepas de flavobacterium vivas modificadas, vacinas estabilizadas compreendendo as mesmas, e métodos de preparo e uso das mesmas
US20140234354A1 (en) 2013-02-15 2014-08-21 Boehringer Ingelheim Vetmedica, Inc. Porcine parvovirus 5b, methods of use and vaccine
BR112015018418A2 (pt) 2013-02-22 2017-07-18 Hoffmann La Roche métodos para tratar câncer, para aumentar a eficácia de um tratamento, para adiar e/ou prevenir o desenvolvimento de câncer, para aumentar a sensibilidade a um terapêutico direcionado, para estender o período de sensibilidade, para estender a duração de resposta a um terapêutico direcionado e produto farmacêutico
US9925240B2 (en) 2013-03-06 2018-03-27 Genentech, Inc. Methods of treating and preventing cancer drug resistance
JP6446377B2 (ja) 2013-03-08 2018-12-26 ファイザー・インク 免疫原性融合ポリペプチド
BR112015022844B1 (pt) 2013-03-14 2023-01-24 The Board Of Trustees Of The Leland Stanford Junior University Método para determinar a presença ou ausência de anticorpos específicos do doador em uma amostra biológica, sistema e kit para praticar o mesmo
RU2015139054A (ru) 2013-03-14 2017-04-19 Дженентек, Инк. Способы лечения рака и профилактики лекарственной резистентности рака
EP2970479B1 (de) 2013-03-14 2019-04-24 Novartis AG Antikörper gegen notch 3
JP6456356B2 (ja) 2013-03-15 2019-01-23 ジェネンテック, インコーポレイテッド IL−22ポリペプチド及びIL−22Fc融合タンパク質並びに使用方法
EP2968513A2 (de) 2013-03-15 2016-01-20 Boehringer Ingelheim Vetmedica, Inc. Prrs-virus, zusammensetzungen, impfstoff und verfahren zur verwendung
WO2014144850A1 (en) 2013-03-15 2014-09-18 Genentech, Inc. Methods of treating cancer and preventing cancer drug resistance
EP3633377A1 (de) 2013-03-15 2020-04-08 F. Hoffmann-La Roche AG Biomarker und verfahren zur behandlung von pd-1 und pd-l1-verwandten leiden
CA2918644A1 (en) 2013-06-26 2014-12-31 The University Of North Carolina At Chapel Hill Methods and compositions for dengue virus vaccines
RU2019129525A (ru) 2013-07-16 2019-11-05 Дженентек, Инк. Способы лечения рака с использованием антагонистов, связывающих с осью pd-1, и ингибиторов tigit
CN105492021B (zh) 2013-09-08 2018-12-04 辉瑞公司 脑膜炎奈瑟氏球菌组合物及其方法
JP6821429B2 (ja) 2013-09-25 2021-01-27 ゾエティス・サービシーズ・エルエルシー Pcv2b分岐ワクチン組成物及び使用方法
EP3062816B1 (de) 2013-11-01 2020-08-05 Boehringer Ingelheim Animal Health USA Inc. Attenuierte pasteurella-multocida-impfstoffe und verfahren zur herstellung und verwendung davon
WO2015095410A1 (en) 2013-12-17 2015-06-25 Genentech, Inc. Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody
WO2015116902A1 (en) 2014-01-31 2015-08-06 Genentech, Inc. G-protein coupled receptors in hedgehog signaling
JP2017505792A (ja) 2014-02-14 2017-02-23 ファイザー・インク 免疫原性糖タンパク質コンジュゲート
KR101924271B1 (ko) 2014-03-25 2019-02-22 메리얼 인코포레이티드 약독화된 히스토필러스 솜니를 함유하는 면역학적 조성물
CN106456784A (zh) 2014-04-16 2017-02-22 拜康有限公司 包含摩尔过量的山梨醇的稳定蛋白质制剂
WO2015171523A1 (en) 2014-05-05 2015-11-12 Regeneron Pharmaceuticals, Inc. Humanized c5 and c3 animals
JP2017524371A (ja) 2014-05-23 2017-08-31 ジェネンテック, インコーポレイテッド Mitバイオマーカーとその使用方法
WO2015191986A1 (en) 2014-06-13 2015-12-17 Genentech, Inc. Methods of treating and preventing cancer drug resistance
MX2017000546A (es) 2014-07-15 2017-03-08 Genentech Inc Composiciones para el tratamiento del cancer mediante el uso de antagonistas de union al eje de pd-1 e inhibidores de mek.
WO2016011167A1 (en) 2014-07-16 2016-01-21 Dana-Farber Cancer Institute, Inc., Et Al Her3 inhibition in low-grade serous ovarian cancers
EP3188746B1 (de) 2014-09-05 2024-06-19 The Johns Hopkins University Capn9-aktivität als ziel für eine therapeutische strategie zur behandlung von myofibroblastendifferenzierung und assoziierten erkrankungen
WO2016038550A1 (en) 2014-09-11 2016-03-17 Novartis Ag Inhibition of prmt5 to treat mtap-deficiency-related diseases
KR20170075775A (ko) 2014-11-02 2017-07-03 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 백신 및 진단제 개발을 위한 재조합 뎅기 바이러스에 대한 방법 및 조성물
BR112017010324A2 (pt) 2014-11-20 2018-05-15 F. Hoffmann-La Roche Ag método para tratar ou retardar a progressão de um câncer em um indivíduo, moléculas, métodos para aumentar a função imune em um indivíduo e para selecionar um paciente para tratamento, kits, composição farmacêutica e usos de uma combinação de uma molécula
EP3227446A1 (de) 2014-12-01 2017-10-11 Novartis AG Zusammensetzungen und verfahren zur diagnose und behandlung von prostatakrebs
US20160158360A1 (en) 2014-12-05 2016-06-09 Genentech, Inc. Methods and compositions for treating cancer using pd-1 axis antagonists and hpk1 antagonists
US10996222B2 (en) 2014-12-05 2021-05-04 Boehringer Ingelheim Animal Health USA Inc. Enzyme-linked immunosorbent assay (ELISA) for the detection of anti-mycoplasma hyorhinis IgG in swine serum
UY36449A (es) 2014-12-19 2016-07-29 Novartis Ag Composiciones y métodos para anticuerpos dirigidos a bmp6
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
WO2016132294A1 (en) 2015-02-19 2016-08-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
DK3258960T3 (da) 2015-02-20 2021-04-19 Boehringer Ingelheim Animal Health Usa Inc Leptospira-immunbeskyttende proteiner og fremgangsmåder til identifikation og anvendelse deraf
US10596247B2 (en) 2015-02-20 2020-03-24 Board Of Regents, The University Of Texas System Methods and compositions for attenuated chlamydia as vaccine and vector
US10376535B2 (en) 2015-03-26 2019-08-13 University Of Rochester Therapy for malignant disease
CA3155251A1 (en) 2015-05-01 2016-11-10 The Regents Of The University Of California Glycan-dependent immunotherapeutic molecules
EP3292146A1 (de) 2015-05-04 2018-03-14 Pfizer Inc Gruppe-b-streptococcus-polysaccharid-proteinkonjugate, verfahren zur herstellung von konjugaten, immunogene zusammensetzungen mit konjugaten und verwendungen davon
PT3297666T (pt) 2015-05-22 2019-09-06 Consejo Superior Investigacion Adjuvante e vacina molecular
CA3025145A1 (en) 2015-05-22 2016-12-01 Translational Drug Development Llc Benzamide and active compound compositions and methods of use
EP3603672A1 (de) 2015-05-26 2020-02-05 MorphoSys AG Kombination aus einem anti-cd19-antikörper und einem bruton-tyrosinkinase-inhibitor und verwendungen davon
WO2016191389A2 (en) 2015-05-27 2016-12-01 Merial, Inc. Compositions containing antimicrobial igy antibodies, for treatment and prevention of disorders and diseases caused by oral health compromising (ohc) microorganisms
US20180296537A1 (en) 2015-06-05 2018-10-18 Novartis Ag Methods and compositions for diagnosing, treating, and monitoring treatment of shank3 deficiency associated disorders
BR112017021484A2 (pt) 2015-06-05 2018-07-03 Novartis Ag anticorpos de direcionamento à proteína morfogenética óssea 9 (bmp9) e métodos para os mesmos
EP3311165B1 (de) 2015-06-19 2020-12-09 University Of Rochester Septinproteine als neuartige biomarker zur detektion und behandlung von müllerschen tumoren
AR105482A1 (es) 2015-06-23 2017-10-11 Merial Inc Vectores virales recombinantes que contienen la proteína menor del virus del síndrome reproductor y respiratorio porcino (prrsv) y sus métodos de elaboración y uso
CA2996143A1 (en) 2015-08-20 2017-02-23 Merial, Inc. Fcv recombinant vaccines and uses thereof
RS62260B1 (sr) 2015-08-21 2021-09-30 Morphosys Ag Kombinacije i njihova upotreba
CN108135993B (zh) 2015-08-31 2022-03-22 贝林格尔·英格海姆维特梅迪卡有限公司 用于先天性震颤的瘟病毒疫苗
UY36889A (es) 2015-09-09 2017-04-28 Novartis Ag Moléculas de unión a linfopoyetina estromal timica (tslp) y métodos de uso de las moléculas
EP3842457A1 (de) 2015-09-09 2021-06-30 Novartis AG Moleküle zur bindung von thymus-stroma-lymphopoietin (tslp) und verfahren zur verwendung der moleküle
SI3355915T1 (sl) 2015-09-29 2024-03-29 Boehringer Ingelheim Animal Health USA Inc. Cepiva z virusu podobnim delcem (vlp) pasjega parvovirusa (cpv) in njihove uporabe
JP2018529719A (ja) 2015-09-30 2018-10-11 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung Alk陰性がんを処置するためのpd−1系結合アンタゴニストおよびalk阻害剤の組合せ
US11273151B2 (en) 2015-11-04 2022-03-15 Icahn School Of Medicine At Mount Sinai Methods of treating tumors and cancer, and identifying candidate subjects for such treatment
US10527613B2 (en) 2015-11-10 2020-01-07 The Board Of Trustees Of The Leland Stanford Junior University Biomarker detection methods and systems and kits for practicing same
JP2019500025A (ja) 2015-11-18 2019-01-10 オービス ヘルス ソリューションズ エルエルシー T7アルファウイルスベクター系
MA42640B1 (fr) 2015-11-23 2021-06-30 Merial Inc Protéines de fusion de dmdv et e2 et leurs utilisations
US10188725B2 (en) 2015-12-14 2019-01-29 Elanco Us Inc. Hybrid core feline vaccines
WO2017103895A1 (en) 2015-12-18 2017-06-22 Novartis Ag Antibodies targeting cd32b and methods of use thereof
EP3405587A4 (de) 2015-12-23 2019-10-30 Moonshot Pharma LLC Verfahren zur auslösung einer immunreaktion durch read-through-förderung eines vorzeitigen terminationscodons
CA3009001A1 (en) 2016-01-11 2017-07-20 Universitat Zurich Immune-stimulating humanized monoclonal antibodies against human interleukin-2, and fusion proteins thereof
US20210198368A1 (en) 2016-01-21 2021-07-01 Novartis Ag Multispecific molecules targeting cll-1
TWI760322B (zh) 2016-01-29 2022-04-11 美商百靈佳殷格翰動物保健美國有限公司 重組腺病毒載體裝載之fmdv疫苗及其用途
EA037813B1 (ru) 2016-02-19 2021-05-24 МорфоСис АГ Антитела к il-17c
AU2017244108B2 (en) 2016-03-29 2021-03-18 University Of Southern California Chimeric antigen receptors targeting cancer
MA44624A (fr) 2016-04-07 2019-02-13 Merial Inc Vaccin contre le ver du c ur, procédés et utilisations associés
US11246868B2 (en) 2016-04-26 2022-02-15 Icahn School Of Medicine At Mount Sinai Treatment of hippo pathway mutant tumors and methods of identifying subjects as candidates for treatment
AU2017283787B2 (en) 2016-06-15 2020-09-17 Novartis Ag Methods for treating disease using inhibitors of bone morphogenetic protein 6 (BMP6)
RU2748024C2 (ru) 2016-06-27 2021-05-19 МорфоСис АГ Составы на основе антитела к CD19
AU2017292646A1 (en) 2016-07-05 2019-02-07 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
US11795202B2 (en) 2016-08-04 2023-10-24 Stichting Vumc Fusion polypeptide comprising a foreign antigen and self antigen
CA3153265A1 (en) 2016-08-17 2018-02-22 Pharmaq As Sea lice vaccine
AR109539A1 (es) 2016-09-20 2018-12-19 Boehringer Ingelheim Vetmedica Gmbh Sitio de inserción orf70 de ehv
AU2017329672B2 (en) 2016-09-20 2023-07-27 Boehringer Ingelheim Vetmedica Gmbh New promoters
AR109538A1 (es) 2016-09-20 2018-12-19 Boehringer Ingelheim Vetmedica Gmbh Vacuna contra la gripe porcina
AU2017332677B2 (en) 2016-09-20 2024-01-11 Boehringer Ingelheim Vetmedica Gmbh Canine adenovirus vectors
PE20191153A1 (es) 2016-09-28 2019-09-05 Blade Therapeutics Inc Moduladores de calpainas y usos terapeuticos de los mismos
PT3532098T (pt) 2016-10-28 2021-06-17 Morphosys Ag Combinação de anticorpo anti cd19 com um inibidor bcl-2 e suas utilizações
EP3535396A1 (de) 2016-11-01 2019-09-11 Novartis AG Verfahren und zusammensetzungen zur verbesserung der genbearbeitung
US10751402B2 (en) 2016-11-09 2020-08-25 Pfizer Inc. Immunogenic compositions and uses thereof
JP2020500020A (ja) 2016-11-14 2020-01-09 ノバルティス アーゲー 融合誘導性タンパク質minionに関連する組成物、方法、および治療上の使用
AU2017363337B2 (en) 2016-11-23 2021-07-01 Translational Drug Development, Llc Benzamide and active compound compositions and methods of use
KR20190099218A (ko) 2016-11-30 2019-08-26 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 약독화된 돼지 인플루엔자 백신 및 이의 제조 및 사용 방법
IL303108B1 (en) 2017-01-31 2024-03-01 Pfizer NEISSERIA MENINGITIDIS preparations and methods therefor
WO2018152496A1 (en) 2017-02-17 2018-08-23 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Compositions and methods for the diagnosis and treatment of zika virus infection
JP7169979B2 (ja) 2017-02-27 2022-11-11 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 補体関連腎症および肝線維症の候補治療剤の治療有効性を評価する方法
AU2018254586A1 (en) 2017-04-21 2019-10-17 Genentech, Inc. Use of KLK5 antagonists for treatment of a disease
US11236151B2 (en) 2017-04-25 2022-02-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibodies and methods for the diagnosis and treatment of Epstein Barr virus infection
WO2018229715A1 (en) 2017-06-16 2018-12-20 Novartis Ag Compositions comprising anti-cd32b antibodies and methods of use thereof
WO2018237326A1 (en) 2017-06-22 2018-12-27 1AlMOONSHOT PHARMA LLC METHODS OF TREATING CANCER USING COMPOSITIONS COMPRISING AMLEXANOX AND IMMUNOMODULATORS
US11179457B2 (en) 2017-07-12 2021-11-23 Boehringer Ingelheim Animal Health USA Inc. Senecavirus a immunogenic compositions and methods thereof
EP3655430A1 (de) 2017-07-19 2020-05-27 The U.S.A. as represented by the Secretary, Department of Health and Human Services Antikörper und verfahren zur diagnose und behandlung von hepatitis-b-virusinfektionen
AU2018325528A1 (en) 2017-08-31 2020-04-16 Newport Laboratories, Inc. Streptococcus suis vaccines to protect against reproductive, nursery-age, and growing pig diseases and methods of making and use thereof
TW201923084A (zh) 2017-09-23 2019-06-16 德商百靈佳殷格翰維美迪加股份有限公司 副黏液病毒科(paramyxoviridae)表現系統
EP3470429A1 (de) 2017-10-10 2019-04-17 Numab Innovation AG Auf pdl1 gerichtete antikörper und verfahren zur verwendung davon
EP3470428A1 (de) 2017-10-10 2019-04-17 Numab Innovation AG Anti cd137 antikörper und deren verwendung
MA50352A (fr) 2017-10-10 2020-08-19 Numab Therapeutics AG Anticorps multispécifiques
EP3470426A1 (de) 2017-10-10 2019-04-17 Numab Therapeutics AG Multispezifischer antikörper
WO2019081983A1 (en) 2017-10-25 2019-05-02 Novartis Ag CD32B TARGETING ANTIBODIES AND METHODS OF USE
WO2019092027A1 (en) 2017-11-09 2019-05-16 Boehringer Ingelheim Vetmedica Gmbh Sapelovirus immunogenic compositions and uses thereof
WO2019126472A1 (en) 2017-12-22 2019-06-27 Genentech, Inc. Use of pilra binding agents for treatment of a disease
KR20200124713A (ko) 2018-02-23 2020-11-03 베링거잉겔하임베트메디카게엠베하 외인성 펠라인 파라믹소바이러스 유전자를 발현하는 재조합 바이러스 벡터 시스템 및 이로부터 제조된 백신
EP3768307A1 (de) 2018-03-19 2021-01-27 Boehringer Ingelheim Vetmedica GmbH Neue ehv mit inaktiviertem ul18 und/oder ul8
US11596681B2 (en) 2018-03-19 2023-03-07 Boehringer Ingelheim Vetmedica Gmbh EHV insertion site UL43
EP3793596A1 (de) 2018-05-16 2021-03-24 MorphoSys AG Antikörper gegen glycoprotein vi
TW202015726A (zh) 2018-05-30 2020-05-01 瑞士商諾華公司 Entpd2抗體、組合療法、及使用該等抗體和組合療法之方法
EP3816186A4 (de) 2018-06-29 2022-04-06 Suzhou Smartnuclide Biopharmaceutical Co., Ltd. Pd-l1-bindende polypeptide und verwendung davon
TW202026010A (zh) 2018-09-20 2020-07-16 德商百靈佳殷格翰維美迪加股份有限公司 抗豬流行性下痢之鼻內載體疫苗
UY38407A (es) 2018-10-15 2020-05-29 Novartis Ag Anticuerpos estabilizadores de trem2
US20210387020A1 (en) 2018-10-19 2021-12-16 University Of Rochester Immune modulators in combination with radiation treatment for advanced pancreatic cancer
US20210363509A1 (en) 2018-10-22 2021-11-25 University Of Rochester Genome Editing by Directed Non-Homologous DNA Insertion Using a Retroviral Integrase-Cas9 Fusion Protein
US20220089670A1 (en) 2018-12-28 2022-03-24 University Of Rochester Gene Therapy for BEST1 Dominant Mutations
JP7416451B2 (ja) 2019-01-14 2024-01-17 ユニバーシティ オブ ロチェスター CRISPR-Casによる標的化された核内RNA切断及びポリアデニル化
US20220118089A1 (en) 2019-02-25 2022-04-21 The University Of Chicago Methods and compositions for treating inflammatory and autoimmune conditions with ecm-affinity peptides linked to anti-inflammatory agents
EP3946445A2 (de) 2019-03-27 2022-02-09 Boehringer Ingelheim Vetmedica GmbH Immunogene zusammensetzungen und impfstoffe mit peptiden und proteinen des afrikanischen schweinepestvirus und verwendungen davon
AU2020256283A1 (en) 2019-04-04 2021-11-18 Boehringer lngelheim Vetmedica GMBH Porcine circovirus type 3 (PCV3) vaccines, and production and uses thereof
AU2020281535A1 (en) 2019-05-24 2022-01-27 Merck Patent Gmbh Combination therapies using CDK inhibitors
CA3144533A1 (en) 2019-06-03 2020-12-10 The University Of Chicago Methods and compositions for treating cancer with cancer-targeted adjuvants
JP7315259B2 (ja) 2019-07-01 2023-07-26 スジョウ・アルファマブ・カンパニー・リミテッド 百日咳毒素結合タンパク質
US20220267773A1 (en) 2019-07-23 2022-08-25 University Of Rochester Targeted RNA cleavage with CRISPR-Cas
TW202124446A (zh) 2019-09-18 2021-07-01 瑞士商諾華公司 與entpd2抗體之組合療法
JP2022548881A (ja) 2019-09-18 2022-11-22 ノバルティス アーゲー Entpd2抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法
CN115175680A (zh) 2019-10-18 2022-10-11 加利福尼亚大学董事会 Plxdc激活剂及其用于治疗血管病症的用途
WO2021158982A2 (en) 2020-02-07 2021-08-12 University Of Rochester Targeted translation of rna with crispr-cas13 to enhance protein synthesis
CA3171831A1 (en) 2020-02-21 2021-08-26 Origimm Biotechnology Gmbh Propionibacterium acnes prophylactic and therapeutic immune treatment
KR20220154140A (ko) 2020-03-13 2022-11-21 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Pvrig 결합 단백질 및 이의 의학적 용도
JP2023519307A (ja) 2020-03-27 2023-05-10 ユニバーシティ オブ ロチェスター Crispr-cas13によるウイルスrnaの標的化破壊
JP2023519344A (ja) 2020-03-27 2023-05-10 ユニバーシティ オブ ロチェスター CRISPR-Cas13 crRNAアレイ
EP4143225A4 (de) 2020-04-27 2024-05-15 The Regents of the University of California Isoform-unabhängige antikörper gegen lipoprotein(a)
MX2022016337A (es) 2020-06-17 2023-04-10 Boehringer Ingelheim Vetmedica Gmbh Vectores de hvt recombinantes que expresan hemaglutinina de influenza y composiciones inmunogenicas, su produccion y usos.
WO2022002233A1 (zh) 2020-07-03 2022-01-06 苏州康宁杰瑞生物科技有限公司 凝血因子xi(fxi)结合蛋白
CA3185589A1 (en) 2020-07-15 2022-01-20 Douglas Matthew ANDERSON Targeted rna cleavage with dcasl3-rnase fusion proteins
WO2022013787A1 (en) 2020-07-16 2022-01-20 Novartis Ag Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules
WO2022017370A1 (zh) 2020-07-21 2022-01-27 苏州智核生物医药科技有限公司 Cd8结合多肽及其用途
WO2022043855A1 (en) 2020-08-26 2022-03-03 Pfizer Inc. Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof
MX2023004342A (es) 2020-10-20 2023-05-04 Hoffmann La Roche Politerapia de antagonistas de union al eje de pd-1 e inhibidores de lrrk2.
US20220168293A1 (en) 2020-12-02 2022-06-02 Pfizer Inc. Time to resolution of axitinib-related adverse events
KR20230157315A (ko) 2021-01-28 2023-11-16 리제너론 파마슈티칼스 인코포레이티드 사이토카인 방출 증후군을 치료하기 위한 조성물 및 방법
EP4284510A1 (de) 2021-01-29 2023-12-06 Novartis AG Dosierungsschemata für anti-cd73- und anti-enpd2-antikörper und verwendungen davon
EP4046652A1 (de) 2021-02-23 2022-08-24 Johann Wolfgang Goethe-Universität Frankfurt Zusammensetzungen und verfahren zur diagnose, behandlung und vorbeugung der carriðn-krankheit
AU2022261125A1 (en) 2021-04-23 2023-11-23 University Of Rochester Genome editing by directed non-homologous dna insertion using a retroviral integrase-cas fusion protein and methods of treatment
TW202313045A (zh) 2021-06-09 2023-04-01 瑞士商赫孚孟拉羅股份公司 用於癌症治療之組合療法
CA3231553A1 (en) 2021-09-15 2023-03-23 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition comprising anti-pvrig/tigit bispecific antibody
TW202327595A (zh) 2021-10-05 2023-07-16 美商輝瑞大藥廠 用於治療癌症之氮雜內醯胺化合物的組合
NL2031833B1 (en) 2022-05-11 2023-11-17 Univ Leiden Immunotherapeutic compositions and adjuvants
WO2023240458A1 (zh) * 2022-06-14 2023-12-21 中国医学科学院病原生物学研究所 一种口蹄疫病毒多肽抑制剂及其应用
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders
EP4316513A1 (de) 2022-08-02 2024-02-07 Consejo Superior de Investigaciones Científicas (CSIC) Neuer dna-sars-cov-2-impfstoff

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE436645C (sv) * 1976-04-29 1996-07-22 Bonnierfoeretagen Ab Antigeniskt aktiv polypeptid, som kan användas vid cancerdiagnosticering och vid framställning av antikroppar
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
JPS5849321A (ja) * 1981-06-16 1983-03-23 ジエネンテツク・インコ−ポレイテツド 口蹄病ワクチン
ZA831854B (en) * 1982-03-26 1984-01-25 Biogen Nv Small peptides with the specificity of foot and mouth disease viral antigens
US4544500A (en) * 1982-04-14 1985-10-01 Scripps Clinic And Research Foundation Synthetic foot and mouth disease antigen
DE3382459D1 (de) * 1982-04-14 1991-12-19 James L Bittle Kuenstliches pikornavirusantigen.
JPS59501866A (ja) * 1982-10-11 1984-11-08 ナショナル・リサ−チ・ディベロップメント・コ−ポレイション 腸内ウイルスに対するワクチン接種に有用なポリペプチド

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