MA34087B1 - Vaccins recombinants contre le virus de la langue bleue et leurs utilisations - Google Patents

Vaccins recombinants contre le virus de la langue bleue et leurs utilisations

Info

Publication number
MA34087B1
MA34087B1 MA35244A MA35244A MA34087B1 MA 34087 B1 MA34087 B1 MA 34087B1 MA 35244 A MA35244 A MA 35244A MA 35244 A MA35244 A MA 35244A MA 34087 B1 MA34087 B1 MA 34087B1
Authority
MA
Morocco
Prior art keywords
btv
vaccines against
recombinant vaccines
against blue
viruses
Prior art date
Application number
MA35244A
Other languages
Arabic (ar)
English (en)
Inventor
Jean-Christophe Audonnet
Xuan Guo
Kevin Cox
Original Assignee
Merial Ltd
Biolex Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Ltd, Biolex Therapeutics filed Critical Merial Ltd
Publication of MA34087B1 publication Critical patent/MA34087B1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/15Reoviridae, e.g. calf diarrhea virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/517Plant cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5252Virus inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55577Saponins; Quil A; QS21; ISCOMS
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011Details
    • C12N2720/12011Reoviridae
    • C12N2720/12111Orbivirus, e.g. bluetongue virus
    • C12N2720/12134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne des vaccins ou des compositions contre le BTV. Il peut s'agir d'un vaccin ou d'une composition contenant des antigènes du BTV. L'invention concerne également des vecteurs recombinants codant pour et exprimant des antigènes, des épitopes ou des immunogènes du BTV qui peuvent être utilisés pour protéger des animaux tels que des ovins, des bovins ou des caprins contre le BTV.
MA35244A 2010-03-12 2011-03-11 Vaccins recombinants contre le virus de la langue bleue et leurs utilisations MA34087B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31316410P 2010-03-12 2010-03-12
US36636310P 2010-07-21 2010-07-21
PCT/US2011/028131 WO2011112955A1 (fr) 2010-03-12 2011-03-11 Vaccins recombinants contre le virus de la langue bleue et leurs utilisations

Publications (1)

Publication Number Publication Date
MA34087B1 true MA34087B1 (fr) 2013-03-05

Family

ID=43923659

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35244A MA34087B1 (fr) 2010-03-12 2011-03-11 Vaccins recombinants contre le virus de la langue bleue et leurs utilisations

Country Status (15)

Country Link
US (3) US20110236416A1 (fr)
EP (4) EP2944322B1 (fr)
JP (1) JP2013522300A (fr)
CN (2) CN103492410A (fr)
AR (1) AR080515A1 (fr)
AU (1) AU2011224188B2 (fr)
BR (2) BR112012023852B1 (fr)
CA (2) CA2792118C (fr)
ES (2) ES2795148T3 (fr)
IL (3) IL221781B (fr)
MA (1) MA34087B1 (fr)
NZ (2) NZ602278A (fr)
RU (1) RU2575599C2 (fr)
WO (2) WO2011112945A2 (fr)
ZA (1) ZA201206619B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2132312B1 (fr) 2007-03-27 2016-01-27 Sea Lane Biotechnologies,llc. Constructions et bibliothèques comprenant des séquences de chaînes légères de substitution d'anticorps
CN102482345A (zh) 2009-05-13 2012-05-30 航道生物技术有限责任公司 针对流感病毒的中和分子
JP2013509203A (ja) 2009-11-02 2013-03-14 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 口蹄疫ウイルス(fmdv)コンセンサスタンパク質、そのコード配列およびそれから生成されるワクチン
EP2736928B1 (fr) * 2011-07-28 2019-01-09 i2 Pharmaceuticals, Inc. Proteines "sur"-liantes dirigees contre erbb3
EP2793940B1 (fr) 2011-12-22 2018-11-14 i2 Pharmaceuticals, Inc. Protéines substitutives de liaison
ES2911774T3 (es) 2012-09-05 2022-05-20 Medicago Inc Producción de partículas similares a enterovirus 71 en plantas
US20140090108A1 (en) * 2012-09-18 2014-03-27 Freydoun Garabagi Vectors and Methods For Enhancing Recombinant Protein Expression in Plants
CA2895806C (fr) * 2013-03-15 2023-02-21 The Trustees Of The University Of Pennsylvania Proteines consensus du virus de la fievre aphteuse (fmdv), sequences codant pour celles-ci et vaccins obtenus de celles-ci
AU2014243149B2 (en) * 2013-03-26 2017-11-23 The Pirbright Institute Stabilised FMDV capsids
US10872313B2 (en) 2015-06-02 2020-12-22 ROCA Medical Ltd. Method for repurposing NDC codes in a pharmaceutical database for venom derived allergens involved in venom immunotherapy
AR102006A1 (es) 2014-09-23 2017-01-25 Merial Inc Vacunas recombinantes contra el virus de la fiebre aftosa (fmdv) y sus usos
CN105624124B (zh) * 2014-11-07 2020-09-29 普莱柯生物工程股份有限公司 一种抗o型口蹄疫的疫苗组合物及其制备方法和应用
US10548974B2 (en) * 2015-06-02 2020-02-04 ROCA Medical Ltd. Therapeutic treatment kit for allergies based on DNA profiles
US10369215B2 (en) 2015-06-02 2019-08-06 ROCA Medical Ltd. Predilution sets for distributing antigens
WO2016202828A1 (fr) * 2015-06-15 2016-12-22 Bavarian Nordic A/S Vaccin recombinant contre le virus de la fièvre aphteuse (fmdv) basé sur le virus de la vaccine ankara modifié (mva)
CA3006078A1 (fr) * 2015-11-23 2017-06-01 Merial, Inc. Proteines de fusion de dmdv et e2 et leurs utilisations
WO2017097875A1 (fr) * 2015-12-08 2017-06-15 Danmarks Tekniske Universitet Kit d'éléments pour utilisation dans le cadre d'une stratégie de primo-vaccination/rappel visant à protéger des animaux biongulés contre une infection par le virus de la fièvre aphteuse
TWI730037B (zh) * 2016-01-26 2021-06-11 日商富士軟片和光純藥股份有限公司 光硬化方法,及用於該光硬化方法之化合物和組成物
TWI760322B (zh) * 2016-01-29 2022-04-11 美商百靈佳殷格翰動物保健美國有限公司 重組腺病毒載體裝載之fmdv疫苗及其用途
US11053509B2 (en) 2016-04-19 2021-07-06 Csir Plant-produced chimaeric Orbivirus VLPs
US10385319B2 (en) 2016-09-08 2019-08-20 The Governement of the United States of America, as represented by the Secretary of Homeland Security Modified foot-and-mouth disease virus 3C proteases, compositions and methods thereof
US10435695B2 (en) 2016-09-08 2019-10-08 The Government of the United States of America, as represented by the Secretary of Homeland Security Fusion protein comprising Gaussia luciferase, translation interrupter sequence, and interferon amino acid sequences
KR102132730B1 (ko) * 2017-08-01 2020-07-10 지프로안 바이오테크놀로지즈 (스저우), 아이엔씨. 구제역 바이러스 유사 입자 백신 및 그 제조방법
KR102165358B1 (ko) * 2017-12-29 2020-10-14 (주)플럼라인생명과학 구제역 바이러스 a형 백신 조성물
CN108273054B (zh) * 2018-01-25 2020-11-17 中国农业科学院兰州兽医研究所 猪口蹄疫病毒O型、A型Fc多肽双价疫苗及其制备方法和应用
CN111233984B (zh) * 2018-11-29 2022-08-12 普莱柯生物工程股份有限公司 一种o型口蹄疫病毒样颗粒抗原、及其疫苗组合物、制备方法和应用
AU2021282245A1 (en) * 2020-05-27 2023-01-19 Codagenix Inc. Live attenuated strains of foot and mouth disease modified by deoptimization and uses thereof
CN117801099B (zh) * 2023-12-11 2024-08-30 中国农业科学院兰州兽医研究所 一株抗蓝舌病毒vp7蛋白的重组单克隆抗体

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
US5110587A (en) 1981-12-24 1992-05-05 Health Research, Incorporated Immunogenic composition comprising synthetically modified vaccinia virus
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
US5174993A (en) 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
US5505941A (en) 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
US5380831A (en) 1986-04-04 1995-01-10 Mycogen Plant Science, Inc. Synthetic insecticidal crystal protein gene
US4761373A (en) 1984-03-06 1988-08-02 Molecular Genetics, Inc. Herbicide resistance in plants
DE3584341D1 (de) 1984-08-24 1991-11-14 Upjohn Co Rekombinante dna-verbindungen und expression von polypeptiden wie tpa.
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4963481A (en) 1985-12-18 1990-10-16 Genetics Institute Inc Promoter system
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
WO1987004181A1 (fr) 1986-01-08 1987-07-16 Rhone-Poulenc Agrochimie Gene decomposant l'haloarylnitrile, son utilisation et cellules le contenant
NZ221790A (en) 1986-09-12 1990-07-26 Genentech Inc Method for the continuous production of a heterologous protein in a eukaryotic host cell
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
DE3743138A1 (de) 1987-12-18 1989-09-14 Mayr Christian Gmbh & Co Kg Schleifringlose, elektromagnetische ueberlastkupplung
CA1341245C (fr) 1988-01-12 2001-06-05 F. Hoffmann-La Roche Ag Virus recombinant de la vaccine derive du virus modifie ankara
US5990387A (en) 1988-06-10 1999-11-23 Pioneer Hi-Bred International, Inc. Stable transformation of plant cells
NZ230375A (en) 1988-09-09 1991-07-26 Lubrizol Genetics Inc Synthetic gene encoding b. thuringiensis insecticidal protein
DK0413019T3 (da) 1989-02-24 2001-11-12 Monsanto Technology Llc Syntetiske plantegener og fremgangsmåde til fremstilling af disse
US5879918A (en) 1989-05-12 1999-03-09 Pioneer Hi-Bred International, Inc. Pretreatment of microprojectiles prior to using in a particle gun
GB8915572D0 (en) * 1989-07-07 1989-08-23 Natural Environment Res Use of bluetongue virus proteins as vaccine components
US5690938A (en) * 1989-07-07 1997-11-25 Oravax, Inc. Oral immunization with multiple particulate antigen delivery system
EP0528819A1 (fr) 1990-04-18 1993-03-03 Plant Genetic Systems, N.V. GENES MODIFIES DU $i(BACILLUS THURINGIENSIS) CODANT UNE PROTEINE CRISTALLINE INSECTICIDE ET LEUR EXPRESSION DANS DES CELLULES DE PLANTES
US5932782A (en) 1990-11-14 1999-08-03 Pioneer Hi-Bred International, Inc. Plant transformation method using agrobacterium species adhered to microprojectiles
JP3602530B2 (ja) 1991-03-07 2004-12-15 ヴァイロジェネティクス コーポレイション 遺伝子操作したワクチン菌株
TW261517B (fr) 1991-11-29 1995-11-01 Mitsubishi Shozi Kk
BR9306802A (pt) 1992-07-27 1998-12-08 Pioneer Hi Bred Int Processo independente de genótipos para produção de planta de soja transgénica e processo de regeneração de plantas de soja a partir de nodos cotiledonais
CN1061376C (zh) 1993-11-19 2001-01-31 生物技术研究及发展有限公司 用于植物体内基因表达的嵌合调节区和基因盒
EP0826063A1 (fr) 1995-04-25 1998-03-04 Vical Incorporated Formulations en ampoule unidose de complexes adn/lipides
US5846946A (en) 1996-06-14 1998-12-08 Pasteur Merieux Serums Et Vaccins Compositions and methods for administering Borrelia DNA
FR2751225B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique aviaire
FR2751227B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique contre les pathologies canines, notamment les pathologies respiratoires et digestives
FR2751226B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique contre les pathologies du cheval
FR2751224B1 (fr) 1996-07-19 1998-11-20 Rhone Merieux Formule de vaccin polynucleotidique contre les pathologies respiratoires et de reproduction des porcs
FR2751228B1 (fr) 1996-07-19 1998-11-20 Rhone Merieux Vaccin polynucleotidique bovin pour voie intradermique
FR2751229B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique notamment contre la pathologie respiratoire des bovins
EP0930893B1 (fr) 1996-10-11 2005-04-13 The Regents of The University of California Conjugues polynucleotide immunostimulateur/molecule immunomodulatrice
US6045774A (en) 1997-01-10 2000-04-04 Epicyte Pharmaceutical Inc. J chain polypeptide targeting molecule linked to an imaging agent
US5981840A (en) 1997-01-24 1999-11-09 Pioneer Hi-Bred International, Inc. Methods for agrobacterium-mediated transformation
HUP0004589A3 (en) 1997-06-30 2003-08-28 Centre Nat Rech Scient Improved method for transferring nucleic acid into the striped muscle and combination therefor
US7161064B2 (en) 1997-08-12 2007-01-09 North Carolina State University Method for producing stably transformed duckweed using microprojectile bombardment
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
FR2778858B1 (fr) 1998-05-20 2000-06-16 Oreal Emulsion e/h/e stable et son utilisation comme composition cosmetique et/ou dermatologique
US8003772B2 (en) 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
FR2801607B1 (fr) 1999-11-26 2001-12-28 Merial Sas Pneumovirus du canard et vaccins correspondants
US6852705B2 (en) 2000-01-21 2005-02-08 Merial DNA vaccines for farm animals, in particular bovines and porcines
FR2810888B1 (fr) * 2000-06-29 2004-07-30 Merial Sas Vaccin contre la fievre aphteuse
DK1305437T3 (da) 2000-07-31 2010-12-13 Biolex Therapeutics Inc Ekspression af biologisk aktive polypeptider i andemad
US7632983B2 (en) * 2000-07-31 2009-12-15 Biolex Therapeutics, Inc. Expression of monoclonal antibodies in duckweed
US8022270B2 (en) * 2000-07-31 2011-09-20 Biolex Therapeutics, Inc. Expression of biologically active polypeptides in duckweed
US7018164B2 (en) 2000-09-06 2006-03-28 The Charles Machine Works, Inc. Auxiliary pipe loading device
TWI377253B (en) 2001-04-16 2012-11-21 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
MXPA03010832A (es) 2001-05-30 2004-11-22 Biolex Inc Uso de planta acuatica en clasificacion de alto rendimiento.
RU2207877C1 (ru) * 2001-11-09 2003-07-10 Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. Я.Р. Коваленко Вакцина для профилактики и лечения трихофитии крупного, мелкого рогатого скота и оленей
US6680200B2 (en) 2002-02-22 2004-01-20 Biolex, Inc. Led array for illuminating cell well plates and automated rack system for handling the same
NZ534881A (en) * 2002-03-19 2006-09-29 Plant Res Internat B Mammalian GnTIII expression in plants
US7176024B2 (en) 2003-05-30 2007-02-13 Biolex, Inc. Bioreactor for growing biological materials supported on a liquid surface
HRP20080235T3 (hr) 2003-07-24 2008-07-31 Merial Limited Formulacija vakcine koja sadrži emulziju ulje-u-vodi
ES2424847T3 (es) 2004-06-25 2013-10-09 Merial Ltd. Genes del virus de la fiebre aftosa que expresan avipox recombinantes
CN100582122C (zh) * 2006-05-12 2010-01-20 北京宝麦德生物医药科技有限责任公司 O型口蹄疫病毒多表位粘膜免疫疫苗及其应用
US7862821B2 (en) * 2006-06-01 2011-01-04 Merial Limited Recombinant vaccine against bluetongue virus
CN101082051A (zh) * 2006-06-02 2007-12-05 广东出入境检验检疫局检验检疫技术中心 重组口蹄疫病毒多肽片段及其应用
CN101121938B (zh) * 2007-03-23 2010-10-06 中国农业科学院兰州兽医研究所 一种口蹄疫抗原的制备方法
CN101970645B (zh) * 2007-11-26 2018-11-30 伦敦卫生及热带医学学院 呼肠弧病毒家族病毒的疫苗病毒株的制造方法
PT2610345E (pt) 2007-11-27 2016-01-11 Medicago Inc Partículas semelhantes ao vírus (vlps) da gripe recombinantes produzidas em plantas transgénicas que expressam hemaglutinina
EP2280729A1 (fr) * 2008-04-16 2011-02-09 Onderstepoort Biological Products Ltd Vaccin contre le virus vivant atténué inactivé de la fièvre catarrhale ovine
TW201010719A (en) * 2008-08-19 2010-03-16 Wyeth Corp Immunological composition
CN102271704A (zh) * 2008-11-28 2011-12-07 梅里亚有限公司 重组禽流感疫苗及其用途
CN102648207A (zh) 2009-03-16 2012-08-22 马太克生物科学公司 在网粘菌门微生物中产生蛋白质

Also Published As

Publication number Publication date
ES2617743T3 (es) 2017-06-19
US20170022255A1 (en) 2017-01-26
ZA201206619B (en) 2013-05-29
IL221781B (en) 2018-12-31
EP2545067A1 (fr) 2013-01-16
RU2575599C2 (ru) 2016-02-20
WO2011112945A3 (fr) 2011-11-10
BR112012023852B1 (pt) 2020-11-10
US9345759B2 (en) 2016-05-24
CA2792118A1 (fr) 2011-09-15
AU2011224188A1 (en) 2012-09-27
EP2944322B1 (fr) 2018-01-17
CN103492410A (zh) 2014-01-01
AR080515A1 (es) 2012-04-11
BR112012023852A2 (pt) 2017-03-21
IL263249A (en) 2018-12-31
BR112012023046A2 (pt) 2017-07-18
CA2792117A1 (fr) 2011-09-15
US20110236420A1 (en) 2011-09-29
WO2011112945A2 (fr) 2011-09-15
EP2944322A2 (fr) 2015-11-18
NZ602278A (en) 2014-12-24
CA2792118C (fr) 2022-07-12
NZ702145A (en) 2016-03-31
CA2792117C (fr) 2016-09-20
EP2544716A2 (fr) 2013-01-16
RU2012143624A (ru) 2014-04-20
CN103687614B (zh) 2018-06-08
US20110236416A1 (en) 2011-09-29
ES2795148T3 (es) 2020-11-20
AU2011224188B2 (en) 2015-01-22
IL263253B (en) 2020-07-30
EP2944322A3 (fr) 2015-12-16
IL263249B (en) 2020-05-31
IL263253A (en) 2018-12-31
EP3093025B1 (fr) 2018-08-01
EP2545067B1 (fr) 2016-11-30
EP2544716B1 (fr) 2020-01-01
WO2011112955A1 (fr) 2011-09-15
JP2013522300A (ja) 2013-06-13
EP3093025A1 (fr) 2016-11-16
CN103687614A (zh) 2014-03-26
BR112012023046B1 (pt) 2020-04-07

Similar Documents

Publication Publication Date Title
MA34087B1 (fr) Vaccins recombinants contre le virus de la langue bleue et leurs utilisations
MA40151B2 (fr) Vaccins de recombinaison fmdv et leurs utilisations
JOP20170022B1 (ar) لقاحات التهاب العين الفيروسي المهجنة المنقولة بواسطة اف ام دي في و استخداماتها
WO2012027365A3 (fr) Formes pharmaceutiques multi-épitopes ciblées servant à l'induction d'une réponse immunitaire dirigée contre des antigènes
MY169331A (en) Vaccine against rsv
EA201001491A1 (ru) Репликационно-дефектные вакцины и вакцинные векторы против флавивирусов
MX344103B (es) Vacunas de virus herpes vectorizado con virus de enfermedad de newcastle.
EA201400912A1 (ru) Рекомбинантные поксвирусные векторы, экспрессирующие белки вируса бешенства и ox40, и вакцины, созданные на их основе
MX2013004159A (es) Proteina vp6 de la capside de norovirus y de rotavirus para el uso como vacuna combinada.
PH12017501370A1 (en) Bivalent swine influenza virus vaccine
MA37749B1 (fr) Vaccins contre les virus réassortis de la fièvre catarrhale et de la peste équine
MX2017005687A (es) Metodos para usar formulaciones para vacuna con microagujas para elicitar en animales inmunidad protectora contra virus de la rabia.
MY179251A (en) Methods and compositions for recombinant dengue viruses for vaccine and diagnostic development
WO2007024947A3 (fr) Vaccins contre la grippe canine
CO6700818A2 (es) Vectores de parapoxvirus
MX2010008170A (es) Vacunas para influenza canina.
PH12018500372A1 (en) Fcv recombinant vaccines and uses thereof
IL259451B (en) A live virus containing an attenuated dengue virus and a dengue vaccine containing identical antigens
EA202090236A1 (ru) Иммуногенные композиции senecavirus a и способы с ними
PH12014502086A1 (en) Vaccine against rsv