EA201400912A1 - Рекомбинантные поксвирусные векторы, экспрессирующие белки вируса бешенства и ox40, и вакцины, созданные на их основе - Google Patents

Рекомбинантные поксвирусные векторы, экспрессирующие белки вируса бешенства и ox40, и вакцины, созданные на их основе

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EA201400912A1
EA201400912A1 EA201400912A EA201400912A EA201400912A1 EA 201400912 A1 EA201400912 A1 EA 201400912A1 EA 201400912 A EA201400912 A EA 201400912A EA 201400912 A EA201400912 A EA 201400912A EA 201400912 A1 EA201400912 A1 EA 201400912A1
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virus
rabor
vaccines
vectors
established
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EA201400912A
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English (en)
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EA032389B1 (ru
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Тезом Мебатсьон
Жюль Мартен Минке
Фредерик Дейвид
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Мериал Лимитед
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Publication of EA201400912A1 publication Critical patent/EA201400912A1/ru
Publication of EA032389B1 publication Critical patent/EA032389B1/ru

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Abstract

В изобретении предлагаются векторы, обеспечивающие экспрессию in vivo и in vitro иммуногенных полипептидов или антигенов вместе с полипептидом OX40L, который служит генетическим адъювантом. У животного или человека иммуногенный полипептид и OX40L, действуя совместно, вызывают более выраженный иммунный ответ, нежели данный иммуногенный полипептид в отдельности. В одном из конкретных примеров данного изобретения предлагаются векторы, кодирующие иммуногенный полипептид G вируса бешенства и собачий OX40L, служащий генетическим адъювантом; эти векторы вызывают у представителей семейства псовых сильный иммунный ответ против бешенства.
EA201400912A 2012-02-14 2013-02-14 Рекомбинантные поксвирусные векторы, кодирующие и экспрессирующие гликопротеин g вируса бешенства и полипептид oxl, и вакцины, созданные на их основе, используемые в способе вакцинации животных против бешенства EA032389B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261598610P 2012-02-14 2012-02-14
PCT/US2013/026206 WO2013123242A1 (en) 2012-02-14 2013-02-14 Recombinant poxviral vectors expressing both rabies and ox40 proteins, and vaccines made therefrom

Publications (2)

Publication Number Publication Date
EA201400912A1 true EA201400912A1 (ru) 2015-01-30
EA032389B1 EA032389B1 (ru) 2019-05-31

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EA201400912A EA032389B1 (ru) 2012-02-14 2013-02-14 Рекомбинантные поксвирусные векторы, кодирующие и экспрессирующие гликопротеин g вируса бешенства и полипептид oxl, и вакцины, созданные на их основе, используемые в способе вакцинации животных против бешенства

Country Status (13)

Country Link
US (2) US9567606B2 (ru)
EP (2) EP3466443B1 (ru)
JP (1) JP6260972B2 (ru)
CN (1) CN104203271B (ru)
AU (1) AU2013221502C1 (ru)
BR (1) BR112014020019A8 (ru)
CA (1) CA2864119C (ru)
EA (1) EA032389B1 (ru)
ES (2) ES2723273T3 (ru)
HK (1) HK1200327A1 (ru)
MX (1) MX360415B (ru)
NZ (2) NZ628270A (ru)
WO (1) WO2013123242A1 (ru)

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Publication number Publication date
EP2814506B1 (en) 2018-11-28
BR112014020019A2 (pt) 2017-07-04
HK1200327A1 (en) 2015-08-07
CA2864119A1 (en) 2013-08-22
JP2015511948A (ja) 2015-04-23
AU2013221502B2 (en) 2017-10-26
CN104203271A (zh) 2014-12-10
ES2866108T3 (es) 2021-10-19
US20130209511A1 (en) 2013-08-15
EA032389B1 (ru) 2019-05-31
US20170137843A1 (en) 2017-05-18
EP3466443A1 (en) 2019-04-10
JP6260972B2 (ja) 2018-01-17
MX360415B (es) 2018-10-31
AU2013221502C1 (en) 2018-03-01
CN104203271B (zh) 2017-08-25
EP2814506A1 (en) 2014-12-24
WO2013123242A1 (en) 2013-08-22
AU2013221502A1 (en) 2014-08-28
US9567606B2 (en) 2017-02-14
NZ628270A (en) 2016-09-30
MX2014009845A (es) 2015-03-10
EP3466443B1 (en) 2020-12-16
CA2864119C (en) 2022-05-24
ES2723273T3 (es) 2019-08-23
NZ722700A (en) 2017-12-22
US10006050B2 (en) 2018-06-26
BR112014020019A8 (pt) 2022-07-12

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