WO2014153168A3 - Porcine astrovirus sequences and uses thereof - Google Patents

Porcine astrovirus sequences and uses thereof Download PDF

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Publication number
WO2014153168A3
WO2014153168A3 PCT/US2014/029394 US2014029394W WO2014153168A3 WO 2014153168 A3 WO2014153168 A3 WO 2014153168A3 US 2014029394 W US2014029394 W US 2014029394W WO 2014153168 A3 WO2014153168 A3 WO 2014153168A3
Authority
WO
WIPO (PCT)
Prior art keywords
porcine
astroviruses
relates
animal
disease
Prior art date
Application number
PCT/US2014/029394
Other languages
French (fr)
Other versions
WO2014153168A2 (en
WO2014153168A4 (en
Inventor
W. Ian Lipkin
Cadhla FIRTH
Richard A. Hesse
John Morgan Hardham
Sudhir Keesara REDDY
Tanja I. OPRIESSNIG
Patrick G. Halbur
Jacqueline Gayle Marx
Original Assignee
The Trustees Of Columbia University In The City Of New York
Iowa State University Research Foundation, Inc.
Kansas State University Research Foundation
Zoetis Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of Columbia University In The City Of New York, Iowa State University Research Foundation, Inc., Kansas State University Research Foundation, Zoetis Llc filed Critical The Trustees Of Columbia University In The City Of New York
Publication of WO2014153168A2 publication Critical patent/WO2014153168A2/en
Publication of WO2014153168A3 publication Critical patent/WO2014153168A3/en
Publication of WO2014153168A4 publication Critical patent/WO2014153168A4/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/12011—Astroviridae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/12011—Astroviridae
    • C12N2770/12034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

The invention is directed to isolated porcine astroviruses associated with porcine periweaning failure to thrive syndrome, high morbidity and mortality syndrome in growing pigs, mulberry heart disease, porcine respiratory disease, porcine gastrointestinal disease, or reproductive failure. The invention also relates to isolated nucleic acids sequences and polypeptides derived from porcine astroviruses. Additionally, the invention relates to antibodies against antigens from porcine astroviruses. The invention also relates to iRNAs which target nucleic acid sequences of the porcine astrovirus. The invention is further related to methods for detecting the presence or absence of porcine astroviruses in an animal. The invention is also related to immunogenic compositions for inducing an immune response against porcine astroviruses in an animal.
PCT/US2014/029394 2013-03-14 2014-03-14 Porcine astrovirus sequences and uses thereof WO2014153168A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361782256P 2013-03-14 2013-03-14
US61/782,256 2013-03-14
US201361912757P 2013-12-06 2013-12-06
US61/912,757 2013-12-06

Publications (3)

Publication Number Publication Date
WO2014153168A2 WO2014153168A2 (en) 2014-09-25
WO2014153168A3 true WO2014153168A3 (en) 2015-02-12
WO2014153168A4 WO2014153168A4 (en) 2015-03-26

Family

ID=51581770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/029394 WO2014153168A2 (en) 2013-03-14 2014-03-14 Porcine astrovirus sequences and uses thereof

Country Status (1)

Country Link
WO (1) WO2014153168A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3460053A1 (en) * 2017-09-25 2019-03-27 Ceva Sante Animale Porcine astroviruses and the uses thereof
CN111551750B (en) * 2020-06-17 2023-10-10 广西大学 Indirect ELISA (enzyme-linked immunosorbent assay) detection kit for porcine astrovirus
CN112048483B (en) * 2020-08-26 2022-09-02 广西大学 Epitope of 1-type PAStV capsid protein, monoclonal antibody and preparation thereof
CN112458060B (en) * 2020-08-26 2022-09-02 广西大学 Monoclonal antibody of type 1 PAStV, preparation and ELISA application thereof
CN112831606A (en) * 2021-03-03 2021-05-25 广西大学 Multiplex RT-PCR (reverse transcription-polymerase chain reaction) primer group of porcine astrovirus, kit and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070099181A1 (en) * 1997-12-11 2007-05-03 Merial Sas Postweaning multisystemic wasting syndrome virus from pigs
US20090305232A1 (en) * 2005-02-25 2009-12-10 Idexx Laboratoires, Inc. Peptides for Detection of Antibody to Porcine Reproductive Respiratory Syndrome Virus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070099181A1 (en) * 1997-12-11 2007-05-03 Merial Sas Postweaning multisystemic wasting syndrome virus from pigs
US20090305232A1 (en) * 2005-02-25 2009-12-10 Idexx Laboratoires, Inc. Peptides for Detection of Antibody to Porcine Reproductive Respiratory Syndrome Virus

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FRIENDSHIP ET AL.: "Periweaning Failure to Thrive Syndrome (PFTS): difficulties of investigating an emerging clinical problem", AD LEMAN CONFERENCE, 2010, pages 1 - 8., Retrieved from the Internet <URL:www.prairieswine.com/wp-content/uploads/2012/08/Periweaning-Failure-to-Thrive-Syndrome-PFTS.pdf> [retrieved on 20141017] *
HUANG ET AL.: "Diagnostic investigation of porcine periweaning failure-to-thrive syndrome: lack of compelling evidence linking to common porcine pathogens", JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, vol. 24, 6 December 2011 (2011-12-06), pages 96 - 106 *
MOR ET AL.: "Detection and molecular characterization of Porcine astrovirus strains associated with swine diarrhea", JOUMAL OF VETERINARY DIAGNOSTIC INVESTIGATION, vol. 24, 5 September 2012 (2012-09-05), pages 1064 - 1067 *

Also Published As

Publication number Publication date
WO2014153168A2 (en) 2014-09-25
WO2014153168A4 (en) 2015-03-26

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