WO2016022958A3 - Tick-associated virus sequences and uses thereof - Google Patents

Tick-associated virus sequences and uses thereof Download PDF

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Publication number
WO2016022958A3
WO2016022958A3 PCT/US2015/044284 US2015044284W WO2016022958A3 WO 2016022958 A3 WO2016022958 A3 WO 2016022958A3 US 2015044284 W US2015044284 W US 2015044284W WO 2016022958 A3 WO2016022958 A3 WO 2016022958A3
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WO
WIPO (PCT)
Prior art keywords
tick
associated viruses
associated virus
animal
virus sequences
Prior art date
Application number
PCT/US2015/044284
Other languages
French (fr)
Other versions
WO2016022958A2 (en
Inventor
W. Ian Lipkin
Rafal TOKARZ
Original Assignee
The Trustees Of Columbia University In The City Of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of Columbia University In The City Of New York filed Critical The Trustees Of Columbia University In The City Of New York
Publication of WO2016022958A2 publication Critical patent/WO2016022958A2/en
Publication of WO2016022958A3 publication Critical patent/WO2016022958A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/12011—Bunyaviridae
    • C12N2760/12021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/12011—Bunyaviridae
    • C12N2760/12211—Phlebovirus, e.g. Rift Valley fever virus
    • C12N2760/12221—Viruses as such, e.g. new isolates, mutants or their genomic sequences

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention is directed to isolated tick-associated viruses and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to antibodies against antigens from tick- associated viruses. The invention also relates to iRNAs which target nucleic acid sequences of the tick-associated virus. The invention is related to methods for detecting the presence or absence of tick-associated viruses in an animal. The invention is also related to immunogenic compositions for inducing an immune response against tick-associated viruses in an animal.
PCT/US2015/044284 2014-08-07 2015-08-07 Tick-associated virus sequences and uses thereof WO2016022958A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462034722P 2014-08-07 2014-08-07
US62/034,722 2014-08-07

Publications (2)

Publication Number Publication Date
WO2016022958A2 WO2016022958A2 (en) 2016-02-11
WO2016022958A3 true WO2016022958A3 (en) 2016-03-31

Family

ID=55264779

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/044284 WO2016022958A2 (en) 2014-08-07 2015-08-07 Tick-associated virus sequences and uses thereof

Country Status (1)

Country Link
WO (1) WO2016022958A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3530668A1 (en) * 2018-02-22 2019-08-28 Euroimmun Medizinische Labordiagnostika AG A novel assay for the diagnosis of viral infections
US11292816B2 (en) 2018-02-22 2022-04-05 Euroimmun Medizinische Labordiagnostika Ag Assay for the diagnosis of viral infections
US20220054620A1 (en) * 2018-12-20 2022-02-24 The Wistar Institute Of Anatomy And Biology Vaccines against powassan virus, and methods of using same
CN116716437A (en) * 2023-06-05 2023-09-08 昆明理工大学 Tick-derived vitex virus genome amplification primer group, amplification method and application

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030165539A1 (en) * 1997-10-08 2003-09-04 Alexander Pletnev Chimeric vaccine against tick-borne encephalitis virus
WO2007130519A2 (en) * 2006-05-02 2007-11-15 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Viral nucleic acid microarray and method of use
US20120076821A1 (en) * 2009-05-28 2012-03-29 Pletnev Alexander G Antigenic chimeric tick-borne encephalitis virus/dengue virus type 4 recombinant viruses
WO2014006226A1 (en) * 2012-07-06 2014-01-09 Intercell Austria Ag MUTANT FRAGMENTS OF OspA AND METHODS AND USES RELATING THERETO

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030165539A1 (en) * 1997-10-08 2003-09-04 Alexander Pletnev Chimeric vaccine against tick-borne encephalitis virus
WO2007130519A2 (en) * 2006-05-02 2007-11-15 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Viral nucleic acid microarray and method of use
US20120076821A1 (en) * 2009-05-28 2012-03-29 Pletnev Alexander G Antigenic chimeric tick-borne encephalitis virus/dengue virus type 4 recombinant viruses
WO2014006226A1 (en) * 2012-07-06 2014-01-09 Intercell Austria Ag MUTANT FRAGMENTS OF OspA AND METHODS AND USES RELATING THERETO

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE GenBank [o] 15 November 2007 (2007-11-15), Database accession no. GN351178 *
DATABASE GenBank [o] 15 November 2007 (2007-11-15), Database accession no. GN351179 *
DATABASE GenBank [o] 24 July 2014 (2014-07-24), "Powassan virus isolate LI-1 polyprotein gene", Database accession no. KJ746872 *
KUNO ET AL.: "Genomic sequencing of deer tick virus and phylogeny of powassan-related viruses of North America", AM. J. TROP. HYG., vol. 65, no. 5, 1 November 2001 (2001-11-01), pages 671 - 676, XP002982318 *
MANDL ET AL.: "Complete Genomic Sequence of Powassan Virus: Evaluation of Genetic Elements in Tick-Borne Versus Mosquito-Borne Flaviviruses", VIROLOGY, vol. 194, 1993, pages 173 - 184, XP025635728, DOI: doi:10.1006/viro.1993.1247 *
TOKARZ ET AL.: "Virome Analysis of Amblyomma american um, Dermacentor variabilis, and Ixodes scapularis Ticks Reveals Novel Highly Divergent Vertebrate and Invertebrate Viruses", JOURNAL OF VIROLOGY, vol. 88, no. 19, 23 July 2014 (2014-07-23), pages 11480 - 11492 *

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Publication number Publication date
WO2016022958A2 (en) 2016-02-11

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