DE60143287D1 - Lösungsmittelfreies extraktionsverfahren - Google Patents

Lösungsmittelfreies extraktionsverfahren

Info

Publication number
DE60143287D1
DE60143287D1 DE60143287T DE60143287T DE60143287D1 DE 60143287 D1 DE60143287 D1 DE 60143287D1 DE 60143287 T DE60143287 T DE 60143287T DE 60143287 T DE60143287 T DE 60143287T DE 60143287 D1 DE60143287 D1 DE 60143287D1
Authority
DE
Germany
Prior art keywords
solvent
extraction process
microorganisms
provides
free extraction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60143287T
Other languages
English (en)
Inventor
Craig M Ruecker
Swithin Patrick Adu-Peasah
Brian S Engelhardt
George T Veeder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Martek Biosciences Corp
Original Assignee
Martek Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22647287&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60143287(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Martek Biosciences Corp filed Critical Martek Biosciences Corp
Application granted granted Critical
Publication of DE60143287D1 publication Critical patent/DE60143287D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/006—Refining fats or fatty oils by extraction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/02—Pretreatment
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/001—Refining fats or fatty oils by a combination of two or more of the means hereafter
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6463—Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)
DE60143287T 2000-01-19 2001-01-19 Lösungsmittelfreies extraktionsverfahren Expired - Lifetime DE60143287D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17712500P 2000-01-19 2000-01-19
PCT/US2001/001806 WO2001053512A1 (en) 2000-01-19 2001-01-19 Solventless extraction process

Publications (1)

Publication Number Publication Date
DE60143287D1 true DE60143287D1 (de) 2010-12-02

Family

ID=22647287

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60143287T Expired - Lifetime DE60143287D1 (de) 2000-01-19 2001-01-19 Lösungsmittelfreies extraktionsverfahren

Country Status (24)

Country Link
US (8) US6750048B2 (de)
EP (4) EP1252324B1 (de)
JP (5) JP4020642B2 (de)
KR (8) KR20140079870A (de)
CN (1) CN100460513C (de)
AT (1) ATE485385T1 (de)
AU (7) AU780619B2 (de)
BR (1) BR0107699B1 (de)
CA (2) CA2772540A1 (de)
CZ (1) CZ303446B6 (de)
DE (1) DE60143287D1 (de)
DK (1) DK1252324T3 (de)
ES (3) ES2352001T3 (de)
HK (1) HK1050716A1 (de)
HU (1) HUP0300556A3 (de)
IL (5) IL150772A0 (de)
MX (4) MX350779B (de)
NO (2) NO20023449L (de)
NZ (1) NZ520287A (de)
PL (1) PL356587A1 (de)
PT (1) PT1252324E (de)
RU (1) RU2336307C2 (de)
WO (1) WO2001053512A1 (de)
ZA (1) ZA200205790B (de)

Families Citing this family (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000516480A (ja) 1998-03-17 2000-12-12 コンリンコ，インコーポレイテッド 共役リノール酸組成物
US7776353B1 (en) 1998-03-17 2010-08-17 Aker Biomarine Asa Conjugated linoleic acid compositions
US7078051B1 (en) 1998-08-11 2006-07-18 Natural Asa Conjugated linoleic acid alkyl esters in feedstuffs and food
US7101914B2 (en) 1998-05-04 2006-09-05 Natural Asa Isomer enriched conjugated linoleic acid compositions
CZ303446B6 (cs) * 2000-01-19 2012-09-19 Martek Biosciences Corporation Zpusob získávání lipidu z mikroorganismu
AU2001251449B2 (en) 2000-04-06 2005-04-07 Conlinco, Inc. Conjugated linoleic acid compositions
JP5258134B2 (ja) 2000-04-18 2013-08-07 エイカー バイオマリン アーエスアー 共役リノール酸粉末
EP1178118A1 (de) * 2000-08-02 2002-02-06 Dsm N.V. Isolation von mikrobiellen Ölen
US6677470B2 (en) 2001-11-20 2004-01-13 Natural Asa Functional acylglycerides
EP2239028A1 (de) * 2001-12-12 2010-10-13 Martek Biosciences Corporation Extraktion und Winterisierung von Lipiden aus Ölsaat und mikrobiellen Quellen
CA2484334C (en) 2002-05-03 2013-01-22 Martek Biosciences Corporation High-quality lipids and methods for producing by enzymatic liberation from biomass
US6743931B2 (en) 2002-09-24 2004-06-01 Natural Asa Conjugated linoleic acid compositions
JP4733043B2 (ja) 2003-10-02 2011-07-27 マーテック バイオサイエンシーズ コーポレーション 改変された量の塩化物およびカリウムを使用した微細藻類における高レベルのｄｈａの産生法
US7566570B2 (en) 2004-01-26 2009-07-28 Martek Biosciences Corporation Method for the separation of phospholipids from phospholipid-containing materials
UA94038C2 (ru) 2005-03-18 2011-04-11 Майкробиа, Инк. Продуцирование каротиноидов в маслянистых дрожжах и грибах
EA200870001A1 (ru) * 2005-05-12 2009-10-30 Мартек Байосайенсиз Корпорейшн Гидролизат биомассы, его применение и производство
EP1899453B1 (de) * 2005-06-07 2013-12-18 Ocean Nutrition Canada Limited Eukaryotische mikroorganismen zur herstellung von lipiden und antioxidantien
WO2007005725A2 (en) 2005-07-01 2007-01-11 Martek Biosciences Corporation Polyunsaturated fatty acid-containing oil product and uses and production thereof
US8277849B2 (en) 2006-01-19 2012-10-02 Solazyme, Inc. Microalgae-derived compositions for improving the health and appearance of skin
US8298548B2 (en) 2007-07-18 2012-10-30 Solazyme, Inc. Compositions for improving the health and appearance of skin
US20100242345A1 (en) * 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
US8877465B2 (en) * 2006-07-05 2014-11-04 Photonz Corporation Limited Production of ultrapure EPA and polar lipids from largely heterotrophic culture
JP4854418B2 (ja) * 2006-07-28 2012-01-18 花王株式会社 ドデカヒドロ−３ａ，６，６，９ａ−テトラメチルナフト［２，１−ｂ］フラン原料の製造方法
US9023616B2 (en) * 2006-08-01 2015-05-05 Dsm Nutritional Products Ag Oil producing microbes and method of modification thereof
WO2008042338A2 (en) 2006-09-28 2008-04-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
US8262776B2 (en) * 2006-10-13 2012-09-11 General Atomics Photosynthetic carbon dioxide sequestration and pollution abatement
WO2008060571A2 (en) * 2006-11-13 2008-05-22 Aurora Biofuels, Inc. Methods and compositions for production and purification of biofuel from plants and microalgae
JP2010523113A (ja) * 2007-04-03 2010-07-15 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー マルチザイム（ｍｕｌｔｉｚｙｍｅ）および多価不飽和脂肪酸の製造におけるその使用
US20090004715A1 (en) * 2007-06-01 2009-01-01 Solazyme, Inc. Glycerol Feedstock Utilization for Oil-Based Fuel Manufacturing
WO2008155410A1 (en) * 2007-06-21 2008-12-24 Novozymes A/S Production of lipids containing poly-unsaturated fatty acids
CA2692355C (en) * 2007-06-29 2018-09-11 Martek Biosciences Corporation Production and purification of esters of polyunsaturated fatty acids
AU2008300002B2 (en) * 2007-09-12 2014-04-10 Dsm Ip Assets B.V. Biological oils and production and uses thereof
AU2008304180B2 (en) * 2007-09-27 2014-02-27 Genomatica, Inc. Reduction of the toxic effect of impurities from raw materials by extractive fermentation
EP2211881A4 (de) * 2007-11-01 2012-01-04 Wake Forest University School Of Medicine Zusammensetzungen und verfahren zur prävention und behandlung von krankheiten von säugetieren
US8343753B2 (en) * 2007-11-01 2013-01-01 Wake Forest University School Of Medicine Compositions, methods, and kits for polyunsaturated fatty acids from microalgae
WO2009149470A1 (en) 2008-06-06 2009-12-10 Aurora Biofuels, Inc. Vcp-based vectors for algal cell transformation
US20100022393A1 (en) * 2008-07-24 2010-01-28 Bertrand Vick Glyphosate applications in aquaculture
US20100077654A1 (en) * 2008-09-23 2010-04-01 LiveFuels, Inc. Systems and methods for producing biofuels from algae
US20100236137A1 (en) * 2008-09-23 2010-09-23 LiveFuels, Inc. Systems and methods for producing eicosapentaenoic acid and docosahexaenoic acid from algae
US9896642B2 (en) 2008-10-14 2018-02-20 Corbion Biotech, Inc. Methods of microbial oil extraction and separation
US20100303957A1 (en) * 2008-10-14 2010-12-02 Solazyme, Inc. Edible Oil and Processes for Its Production from Microalgae
US20100297331A1 (en) * 2008-10-14 2010-11-25 Solazyme, Inc. Reduced Fat Foods Containing High-Lipid Microalgae with Improved Sensory Properties
US20100303989A1 (en) * 2008-10-14 2010-12-02 Solazyme, Inc. Microalgal Flour
US20100297323A1 (en) * 2008-10-14 2010-11-25 Solazyme, Inc. Gluten-free Foods Containing Microalgae
US20100297325A1 (en) * 2008-10-14 2010-11-25 Solazyme, Inc. Egg Products Containing Microalgae
US20100297295A1 (en) * 2008-10-14 2010-11-25 Solazyme, Inc. Microalgae-Based Beverages
US20100303961A1 (en) * 2008-10-14 2010-12-02 Solazyme, Inc. Methods of Inducing Satiety
US20100303990A1 (en) * 2008-10-14 2010-12-02 Solazyme, Inc. High Protein and High Fiber Algal Food Materials
CN102271525B (zh) * 2008-10-14 2015-01-07 索拉兹米公司 微藻生物质的食品组合物
US8927522B2 (en) 2008-10-14 2015-01-06 Solazyme, Inc. Microalgal polysaccharide compositions
US8809037B2 (en) 2008-10-24 2014-08-19 Bioprocessh20 Llc Systems, apparatuses and methods for treating wastewater
WO2010054322A1 (en) 2008-11-07 2010-05-14 Solazyme, Inc. Cosmetic compositions comprising microalgal components
WO2010059598A1 (en) * 2008-11-18 2010-05-27 LiveFuels, Inc. Methods for producing fish with high lipid content
ES2714096T3 (es) 2008-11-28 2019-05-27 Corbion Biotech Inc Producción de aceites adaptados en microorganismos heterotróficos
AU2009333461B2 (en) * 2008-12-08 2015-10-15 Sapphire Energy, Inc. Removal of nitrogen from a chlorophyll or pheophytin containing biomass
US8940340B2 (en) * 2009-01-22 2015-01-27 Aurora Algae, Inc. Systems and methods for maintaining the dominance of Nannochloropsis in an algae cultivation system
CA2751275A1 (en) 2009-02-02 2010-08-05 Martek Biosciences Corporation Use of docosahexaenoic acid in treating mild cognitive impairment
US8143051B2 (en) * 2009-02-04 2012-03-27 Aurora Algae, Inc. Systems and methods for maintaining the dominance and increasing the biomass production of nannochloropsis in an algae cultivation system
SE534278C2 (sv) * 2009-02-17 2011-06-28 Alfa Laval Corp Ab Ett kontinuerligt förfarande för isolering av oljor från alger eller mikroorganismer
US8207363B2 (en) * 2009-03-19 2012-06-26 Martek Biosciences Corporation Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
CA2754952C (en) 2009-03-19 2018-11-06 Martek Biosciences Corporation Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
US8476060B2 (en) * 2009-04-13 2013-07-02 Board Of Regents, The University Of Texas System Process for separating lipids from a biomass
WO2010121094A1 (en) 2009-04-17 2010-10-21 Livefuels. Inc. Systems and methods for culturing algae with bivalves
US20100297749A1 (en) * 2009-04-21 2010-11-25 Sapphire Energy, Inc. Methods and systems for biofuel production
CN102612550A (zh) * 2009-04-22 2012-07-25 R·富尔顿三世 可流化的基于藻类的粉末状燃料及其制造和使用方法
EP2425007A4 (de) 2009-04-27 2013-01-02 Ls9 Inc Herstellung von fettsäureestern
US9187778B2 (en) 2009-05-04 2015-11-17 Aurora Algae, Inc. Efficient light harvesting
US8580540B2 (en) 2009-05-26 2013-11-12 Solazyme, Inc. Fractionation of oil-bearing microbial biomass
US8865468B2 (en) * 2009-10-19 2014-10-21 Aurora Algae, Inc. Homologous recombination in an algal nuclear genome
US8809046B2 (en) 2011-04-28 2014-08-19 Aurora Algae, Inc. Algal elongases
US8865452B2 (en) * 2009-06-15 2014-10-21 Aurora Algae, Inc. Systems and methods for extracting lipids from wet algal biomass
US9101942B2 (en) * 2009-06-16 2015-08-11 Aurora Algae, Inc. Clarification of suspensions
US8769867B2 (en) * 2009-06-16 2014-07-08 Aurora Algae, Inc. Systems, methods, and media for circulating fluid in an algae cultivation pond
US8747930B2 (en) * 2009-06-29 2014-06-10 Aurora Algae, Inc. Siliceous particles
US20100325948A1 (en) * 2009-06-29 2010-12-30 Mehran Parsheh Systems, methods, and media for circulating and carbonating fluid in an algae cultivation pond
CN101585759B (zh) * 2009-07-08 2012-05-23 内蒙古金达威药业有限公司 从双鞭甲藻发酵液中提取dha不饱和脂肪酸的方法
WO2011006144A1 (en) 2009-07-10 2011-01-13 Martek Biosciences Corporation Methods of treating and preventing neurological disorders using docosahexaenoic acid
WO2011011463A2 (en) * 2009-07-20 2011-01-27 Aurora Biofuels, Inc. Manipulation of an alternative respiratory pathway in photo-autotrophs
US20110082205A1 (en) 2009-10-01 2011-04-07 Panker Cynthia A Docosahexaenoic Acid Gel Caps
US8765983B2 (en) * 2009-10-30 2014-07-01 Aurora Algae, Inc. Systems and methods for extracting lipids from and dehydrating wet algal biomass
US8748160B2 (en) * 2009-12-04 2014-06-10 Aurora Alage, Inc. Backward-facing step
EP2519642B1 (de) * 2009-12-28 2017-10-25 DSM IP Assets B.V. Auf xylose wachsende rekombinante thraustochytride sowie zusammensetzungen, herstellungsverfahren und verwendungen davon
CN107858297A (zh) 2009-12-28 2018-03-30 Dsm Ip资产公司 在蔗糖上生长的重组破囊壶菌和其组合物、制备方法及用途
JP5920890B2 (ja) * 2010-01-19 2016-05-18 ディーエスエム アイピー アセッツ ビー．ブイ． エイコサペンタエン酸生成微生物、脂肪酸組成物、ならびにそれらを作る方法およびそれらの使用
US8303818B2 (en) * 2010-06-24 2012-11-06 Streamline Automation, Llc Method and apparatus using an active ionic liquid for algae biofuel harvest and extraction
US8313648B2 (en) 2010-04-06 2012-11-20 Heliae Development, Llc Methods of and systems for producing biofuels from algal oil
US8115022B2 (en) 2010-04-06 2012-02-14 Heliae Development, Llc Methods of producing biofuels, chlorophylls and carotenoids
US8211308B2 (en) 2010-04-06 2012-07-03 Heliae Development, Llc Extraction of polar lipids by a two solvent method
AU2011237703A1 (en) * 2010-04-06 2012-10-11 Heliae Development, Llc Selective extraction of proteins from freshwater or saltwater algae
US8211309B2 (en) 2010-04-06 2012-07-03 Heliae Development, Llc Extraction of proteins by a two solvent method
US8475660B2 (en) 2010-04-06 2013-07-02 Heliae Development, Llc Extraction of polar lipids by a two solvent method
WO2011127127A2 (en) 2010-04-06 2011-10-13 Arizona Board Of Regents For And On Behalf Of Arizona State University Extraction with fractionation of oil and co-products from oleaginous material
US8273248B1 (en) 2010-04-06 2012-09-25 Heliae Development, Llc Extraction of neutral lipids by a two solvent method
US8202425B2 (en) 2010-04-06 2012-06-19 Heliae Development, Llc Extraction of neutral lipids by a two solvent method
US8308951B1 (en) 2010-04-06 2012-11-13 Heliae Development, Llc Extraction of proteins by a two solvent method
US10125331B2 (en) * 2010-04-29 2018-11-13 Advanced Energy Development Renewable oil refining processes
CA2801057C (en) 2010-05-28 2019-06-18 Solazyme, Inc. Tailored oils produced from recombinant heterotrophic microorganisms
AU2011261455B2 (en) 2010-06-01 2016-03-24 Dsm Ip Assets B.V. Extraction of lipid from cells and products therefrom
NL2004832C2 (en) * 2010-06-07 2011-12-08 Evodos B V Separating biomass from an aqueous medium.
MY163938A (en) 2010-06-14 2017-11-15 Io-Mega Holding Corp Method for the production of algae derived oils
EP2598641B1 (de) 2010-07-26 2014-05-21 Sapphire Energy, Inc. Verfahren zur gewinnung von ölhaltigen verbindungen aus biomasse
US9028696B2 (en) 2010-07-26 2015-05-12 Sapphire Energy, Inc. Process for the recovery of oleaginous compounds from biomass
US8906236B2 (en) 2010-07-26 2014-12-09 Sapphire Energy, Inc. Process for the recovery of oleaginous compounds and nutrients from biomass
CN103180422A (zh) 2010-09-21 2013-06-26 国际壳牌研究有限公司 含微生物油和微生物物质的混合物的分离方法
CA3024641A1 (en) 2010-11-03 2012-05-10 Corbion Biotech, Inc. Microbial oils with lowered pour points, dielectric fluids produced therefrom, and related methods
US20120329138A1 (en) 2010-12-23 2012-12-27 Shell Oil Company Process for separation of a mixture containing a microbial substance and a liquid
US8722359B2 (en) 2011-01-21 2014-05-13 Aurora Algae, Inc. Genes for enhanced lipid metabolism for accumulation of lipids
CN102617431B (zh) * 2011-01-28 2013-09-25 天津滨海索尔特生物技术中心有限公司 用无机碱提取盐藻中的β-胡萝卜素的方法
MX351063B (es) 2011-02-02 2017-09-29 Terravia Holdings Inc Aceites adaptados producidos a partir de microorganismos oleaginosos recombinantes.
RU2605328C2 (ru) * 2011-02-16 2016-12-20 Соликс Алгредиентс, Инк. Композиция, набор и способ извлечения целевых соединений из биомассы
US8926844B2 (en) 2011-03-29 2015-01-06 Aurora Algae, Inc. Systems and methods for processing algae cultivation fluid
US8569530B2 (en) 2011-04-01 2013-10-29 Aurora Algae, Inc. Conversion of saponifiable lipids into fatty esters
AU2012249377A1 (en) 2011-04-28 2013-11-14 Aurora Algae, Inc. Algal desaturases
US8752329B2 (en) 2011-04-29 2014-06-17 Aurora Algae, Inc. Optimization of circulation of fluid in an algae cultivation pond
JP2014513964A (ja) 2011-05-06 2014-06-19 ソラザイム、インク キシロースを代謝する遺伝子操作微生物
US9487716B2 (en) 2011-05-06 2016-11-08 LiveFuels, Inc. Sourcing phosphorus and other nutrients from the ocean via ocean thermal energy conversion systems
US20140099684A1 (en) * 2011-05-26 2014-04-10 Council Of Scientific & Industrial Research Engine worthy fatty acid methyl ester (biodiesel) from naturally occuring marine microalgal mats and marine microalgae cultured in open salt pans together with value addition of co-products
FR2975705B1 (fr) * 2011-05-27 2014-12-26 Roquette Freres Procede d'extraction du squalene a partir de microalgues
US8365462B2 (en) 2011-05-31 2013-02-05 Heliae Development, Llc V-Trough photobioreactor systems
USD682637S1 (en) 2011-06-10 2013-05-21 Heliae Development, Llc Aquaculture vessel
USD679965S1 (en) 2011-06-10 2013-04-16 Heliae Development, Llc Aquaculture vessel
USD661164S1 (en) 2011-06-10 2012-06-05 Heliae Development, Llc Aquaculture vessel
AU2012285803B2 (en) 2011-07-21 2016-08-25 Dsm Ip Assets B.V. Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof
US9222112B2 (en) 2011-07-21 2015-12-29 Dsm Ip Assets B.V. Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof
WO2013024174A1 (en) 2011-08-18 2013-02-21 Dsm Ip Assets B.V. Dha triglyceride, dha free fatty acid, and dha ethyl ester emulsions, and methods of treating spinal cord injury
AU2012333227B2 (en) 2011-11-01 2016-08-11 Dsm Ip Assets B.V. Oxidatively stable polyunsaturated fatty acid containing oil
WO2013075116A2 (en) 2011-11-17 2013-05-23 Heliae Development, Llc Omega 7 rich compositions and methods of isolating omega 7 fatty acids
CN103131529B (zh) * 2011-11-23 2016-02-24 丰益(上海)生物技术研发中心有限公司 一种提取微生物油脂的方法
ES2744868T3 (es) 2012-04-18 2020-02-26 Corbion Biotech Inc Aceites hechos a medida
WO2013166065A1 (en) 2012-04-30 2013-11-07 Aurora Algae, Inc. ACP Promoter
CN103421595A (zh) * 2012-05-25 2013-12-04 丰益(上海)生物技术研发中心有限公司 一种提取微生物油脂的方法
CA2877937A1 (en) 2012-06-29 2014-01-03 BP Biofuels UK Limited Process for separation of renewable materials from microorganisms
CN103589503B (zh) * 2012-08-13 2015-09-30 丰益(上海)生物技术研发中心有限公司 一种高效提取微生物油脂的方法
KR101470078B1 (ko) * 2012-08-21 2014-12-08 현대자동차주식회사 이산화탄소 포집ㆍ고정ㆍ전환을 통한 온실가스 감축 및 부가가치화 방법
US10098371B2 (en) 2013-01-28 2018-10-16 Solazyme Roquette Nutritionals, LLC Microalgal flour
US9816079B2 (en) 2013-01-29 2017-11-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9567615B2 (en) 2013-01-29 2017-02-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
EP2953480B1 (de) * 2013-02-05 2020-06-03 Evonik Operations GmbH Verbesserung der bioverfügbarkeit von wertstoffen aus mikroorganismen
EP2762009A1 (de) * 2013-02-05 2014-08-06 Evonik Industries AG Verbesserung der Bioverfügbarkeit von Wertstoffen aus Mikroorganismen
PT2970926T (pt) 2013-03-13 2018-03-22 Dsm Nutritional Products Ag Modificação genética de microrganismos
US9290749B2 (en) 2013-03-15 2016-03-22 Solazyme, Inc. Thioesterases and cells for production of tailored oils
US9266973B2 (en) 2013-03-15 2016-02-23 Aurora Algae, Inc. Systems and methods for utilizing and recovering chitosan to process biological material
US9783836B2 (en) 2013-03-15 2017-10-10 Terravia Holdings, Inc. Thioesterases and cells for production of tailored oils
WO2014186395A1 (en) 2013-05-15 2014-11-20 Solazyme, Inc. Cosmetic compositions comprising microalgal oil
EP2826384A1 (de) 2013-07-16 2015-01-21 Evonik Industries AG Verfahren zur Trocknung von Biomasse
FR3009619B1 (fr) 2013-08-07 2017-12-29 Roquette Freres Compositions de biomasse de microalgues riches en proteines de qualite sensorielle optimisee
EP3052636A2 (de) 2013-10-04 2016-08-10 Solazyme, Inc. Massgeschneiderte öle
KR102143001B1 (ko) * 2013-11-01 2020-08-11 에스케이이노베이션 주식회사 초음속 분산기를 이용한 유질 미생물 파쇄 공정 및 이를 이용한 바이오 오일의 제조방법
MX2016008228A (es) 2013-12-20 2016-11-28 Dsm Ip Assets Bv Procedimiento para la obtención de aceite microbiano a partir de células microbianas.
BR112016014208B1 (pt) 2013-12-20 2022-09-20 Dsm Nutricional Products Ag Método de extração de lipídeos a partir de uma população de micro-organismos
PT3626806T (pt) 2013-12-20 2024-07-31 Mara Renewables Corp Métodos para recuperar óleo de microrganismos
TWI646189B (zh) * 2013-12-20 2019-01-01 荷蘭商Ｄｓｍ智慧財產有限公司 用於從微生物細胞獲得微生物油之方法（五）
CA2934491C (en) 2013-12-20 2023-09-26 Dsm Ip Assets B.V. Processes for obtaining microbial oil from microbial cells
NZ721417A (en) 2013-12-20 2022-07-01 Dsm Ip Assets Bv Processes for obtaining microbial oil from microbial cells
EP3083545B1 (de) 2013-12-20 2023-08-02 DSM IP Assets B.V. Verfahren zur gewinnung von mikrobiellem öl aus mikrobiellen zellen
ES2764273T3 (es) 2014-07-10 2020-06-02 Corbion Biotech Inc Nuevos genes de cetoacil ACP sintasa y uso de los mismos
EP3660149A1 (de) 2014-07-24 2020-06-03 Corbion Biotech, Inc. Variante thioesterasen und verfahren zur verwendung
BR112017005370A2 (pt) 2014-09-18 2017-12-12 Terravia Holdings Inc acil-acp tioesterases e mutantes das mesmas
US11464244B2 (en) 2014-10-02 2022-10-11 Evonik Operations Gmbh Feedstuff of high abrasion resistance and good stability in water, containing PUFAs
CN106793803B (zh) 2014-10-02 2021-03-09 赢创运营有限公司 通过挤压含pufa的生物质来制备含pufa的饲料的方法
EP3200604B1 (de) 2014-10-02 2021-11-03 Evonik Operations GmbH Verfahren zur herstellung eines futtermittels
CA2958457C (en) 2014-10-02 2022-10-25 Evonik Industries Ag Process for producing a pufa-containing biomass which has high cell stability
BR112017012648B1 (pt) 2014-12-22 2020-12-08 Unilever N.V composição oral ou tópica e uso de um agonista de fator nuclear eritróide 2 relacionado ao fator 2 e um agonista do receptor hepático x como agentes ativos em uma composição oral ou tópica para beneficiar o crescimento da fibra capilar e/ou induzir o elemento de resposta antioxidante (are)
KR20160096478A (ko) * 2015-02-05 2016-08-16 주식회사 이코원 탄소 발열 모듈 및 이를 이용한 탄소 발열 튀김기
AR104042A1 (es) 2015-03-26 2017-06-21 Mara Renewables Corp Producción de alta densidad de biomasa y aceite utilizando glicerol en bruto
WO2016156528A1 (en) 2015-03-31 2016-10-06 Fresenius Kabi Deutschland Gmbh Emulsions for parenteral administration
US20160298104A1 (en) * 2015-04-07 2016-10-13 Decant Treatment Systems, Llc Method for electrical treatment of fluid medium containing biological matter and a system for its implementation
CN107750155A (zh) 2015-05-22 2018-03-02 费森尤斯卡比德国有限公司 用于肠胃外给药的维生素a
WO2016188876A1 (en) 2015-05-22 2016-12-01 Fresenius Kabi Deutschland Gmbh Vitamin a for parenteral administration
CN107849514A (zh) 2015-07-13 2018-03-27 玛拉可再生能源公司 增强木糖的微藻代谢
ITUB20152958A1 (it) 2015-08-06 2017-02-06 Eni Spa Metodo per concentrare una sospensione cellulare comprendente una biomassa mucillaginosa di lieviti oleaginosi.
KR102680258B1 (ko) * 2016-04-18 2024-07-02 서울바이오시스 주식회사 공기 청정기
CN109477079A (zh) 2016-05-12 2019-03-15 帝斯曼知识产权资产管理有限公司 增加微藻中ω-3多不饱和脂肪酸产量的方法
US10851395B2 (en) 2016-06-10 2020-12-01 MARA Renewables Corporation Method of making lipids with improved cold flow properties
US11419350B2 (en) 2016-07-01 2022-08-23 Corbion Biotech, Inc. Feed ingredients comprising lysed microbial cells
JP6947810B2 (ja) * 2016-07-13 2021-10-13 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． 油糧微生物を含む発酵ブロスから多価不飽和脂肪酸を含む微生物油を抽出するための方法
US11946017B2 (en) 2016-07-13 2024-04-02 Evonik Operations Gmbh Method of separating lipids from a lysed lipids containing biomass
US11406614B2 (en) 2016-10-11 2022-08-09 Fresenius Kabi Deutschland Gmbh Composition comprising EPA and DHA for an enhanced efficacy of anticancer agents
WO2018122057A1 (en) * 2016-12-27 2018-07-05 Evonik Degussa Gmbh Method of isolating lipids from a lipids containing biomass
US11352651B2 (en) 2016-12-27 2022-06-07 Evonik Operations Gmbh Method of isolating lipids from a lipids containing biomass
CN111356767A (zh) 2017-08-17 2020-06-30 赢创运营有限公司 通过限制至少两种限制性营养源增强脂质的产生
EP3470502A1 (de) * 2017-10-13 2019-04-17 Evonik Degussa GmbH Verfahren zum trennen von lipiden aus einer lysierten lipidhaltigen biomasse
EA202090440A1 (ru) 2017-09-21 2020-07-17 Эвоник Оперейшенс ГмбХ Улучшенное получение липидов путем ограничения по меньшей мере двух источников лимитирующих питательных веществ
EP3527664A1 (de) 2018-02-15 2019-08-21 Evonik Degussa GmbH Verfahren zur isolierung von lipiden von einer lipidhaltigen biomasse
WO2019122030A1 (en) * 2017-12-22 2019-06-27 Dsm Ip Assets B.V. Method of separating lipids from a lysed lipids containing biomass
CN112004919A (zh) * 2018-03-30 2020-11-27 帝斯曼知识产权资产管理有限公司 通过肉汤洗涤减少乳液的方法
US20210024966A1 (en) * 2018-03-30 2021-01-28 Dsm Ip Assets B.V. Method of obtaining a microbial oil and a method of reducing emulsion by maintaining a low concentration of carbohydrate
RU2760575C1 (ru) 2018-05-15 2021-11-29 Эвоник Оперейшнс Гмбх Способ выделения липидов из содержащей липиды биомассы с помощью гидрофобного диоксида кремния
US11976253B2 (en) 2018-05-15 2024-05-07 Evonik Operations Gmbh Method of isolating lipids from a lysed lipids containing biomass by emulsion inversion
US20210290526A1 (en) 2018-07-03 2021-09-23 Fresenius Kabi Deutschland Gmbh Lipid emulsion for parenteral administration
FR3085825B1 (fr) 2018-09-14 2021-07-16 Fermentalg Huile de microorganismes riche en acide docosahexaenoique
FR3085962B1 (fr) * 2018-09-14 2021-06-18 Fermentalg Procede d'extracton d'une huile riche en pufa
CN112969796A (zh) 2018-11-09 2021-06-15 赢创运营有限公司 用于生产具有增加的多不饱和脂肪酸含量的生物质的方法
EP3877535A1 (de) * 2018-11-09 2021-09-15 Evonik Operations GmbH Verfahren zur herstellung einer leicht aufschliessbaren biomasse mit erhöhtem gehalt an polyungesättigten fettsäuren
CN113543653A (zh) 2018-12-14 2021-10-22 帝斯曼知识产权资产管理有限公司 具有增强的适口性的含有多不饱和脂肪酸的食品成分及其制造方法
BR112022005497A2 (pt) 2019-12-20 2022-06-21 Fresenius Kabi Austria Gmbh Método para produzir emulsões de óleo em água
CN111235035A (zh) * 2019-12-30 2020-06-05 嘉必优生物技术（武汉）股份有限公司 一种裂殖壶菌突变株及其用于制备二十二碳六烯酸油脂的方法和应用
FR3111912A1 (fr) 2020-06-24 2021-12-31 Fermentalg Procédé de culture de microorganismes pour l’accumulation de lipides
FR3130842A1 (fr) 2021-12-22 2023-06-23 CarbonWorks Procede de captation des phytotoxines dans un reacteur biologique
WO2023175141A1 (en) * 2022-03-18 2023-09-21 Purac Biochem B.V. Method for reducing fermentation broth viscosity
WO2023220060A1 (en) * 2022-05-11 2023-11-16 C16 Biosciences, Inc. Enzymatic lysis for extraction of bioproducts from yeast
WO2024119170A2 (en) 2022-12-02 2024-06-06 Dsm Ip Assets B.V. Fermentatively-produced retinoid containing compositions, and the methdos of making and using the same
KR20240109876A (ko) * 2023-01-05 2024-07-12 주식회사 밤비콜라 커피박을 이용한 칸디다 봄비콜라의 배양방법 및 이로부터의 배양물

Family Cites Families (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2753362A (en) * 1951-05-18 1956-07-03 Standard Brands Inc Process of extracting lipids from plant and animal tissue
GB808128A (en) * 1955-12-01 1959-01-28 Nat Res Dev A method of increasing the fatty contents of such micro-organisms as yeasts, bacteria and moulds
US3089821A (en) 1959-10-28 1963-05-14 Merck & Co Inc Process for the preparation of lipids
DE2056896B2 (de) * 1970-02-18 1979-12-06 Veb Schwermaschinenbau Kombinat Ernst Thaelmann Magdeburg, Ddr 3011 Magdeburg Verfahren zur gleichzeitigen Gewinnung von Fett und Protein aus pflanzlichen, ölhaltigen Rohstoffen und Zwischenprodukten
US3878232A (en) * 1970-09-28 1975-04-15 Staley Mfg Co A E Extraction process to improve the quality and yield of crude vegetable oils
US4504473A (en) * 1982-06-30 1985-03-12 Ribi Immunochem Research, Inc. Pyridine soluble extract of a microorganism
DE3248167A1 (de) * 1982-12-27 1984-06-28 Wintershall Ag, 3100 Celle Trehaloselipidtetraester
US4792418A (en) 1985-08-14 1988-12-20 Century Laboratories, Inc. Method of extraction and purification of polyunsaturated fatty acids from natural sources
JPS6244170A (ja) 1985-08-19 1987-02-26 Agency Of Ind Science & Technol モルテイエレラ属糸状菌体の超臨界流体による抽出方法
US4680314A (en) 1985-08-30 1987-07-14 Microbio Resources, Inc. Process for producing a naturally-derived carotene/oil composition by direct extraction from algae
JPH0634730B2 (ja) * 1986-06-16 1994-05-11 鐘淵化学工業株式会社 パルミトレイン酸の製造法
DK199887D0 (da) 1987-04-15 1987-04-15 Danisco Bioteknologi As Gaerstamme
FR2621327B1 (fr) 1987-10-06 1990-01-05 Commissariat Energie Atomique Procede de production et d'extraction de polysaccharides a partir d'une culture de porphyridium cruentum et dispositif pour la mise en oeuvre du procede
JPH0198494A (ja) 1987-10-09 1989-04-17 Agency Of Ind Science & Technol バイオリアクター
US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US6451567B1 (en) 1988-09-07 2002-09-17 Omegatech, Inc. Fermentation process for producing long chain omega-3 fatty acids with euryhaline microorganisms
US5130242A (en) * 1988-09-07 1992-07-14 Phycotech, Inc. Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US5340594A (en) 1988-09-07 1994-08-23 Omegatech Inc. Food product having high concentrations of omega-3 highly unsaturated fatty acids
US5173409A (en) 1989-12-08 1992-12-22 Ecogen Inc. Recovery of bt endotoxin protein from lysed cell mixtures
FR2656874B1 (fr) * 1990-01-11 1992-04-03 Commissariat Energie Atomique Procede de production et d'extraction d'anti-oxydants a partir d'une culture de micro-organismes et photobioreacteur pour la mise en óoeuvre de ce procede.
US5407957A (en) 1990-02-13 1995-04-18 Martek Corporation Production of docosahexaenoic acid by dinoflagellates
US5658767A (en) * 1991-01-24 1997-08-19 Martek Corporation Arachidonic acid and methods for the production and use thereof
US6270828B1 (en) 1993-11-12 2001-08-07 Cargrill Incorporated Canola variety producing a seed with reduced glucosinolates and linolenic acid yielding an oil with low sulfur, improved sensory characteristics and increased oxidative stability
FR2686619B1 (fr) * 1992-01-28 1995-07-13 Commissariat Energie Atomique Procede de production selective de lipides poly-insatures a partir d'une culture de micro-algues du type porphyridium et cuve utilisee dans ce procede.
US5476787A (en) 1992-04-24 1995-12-19 Director-General Of Agency Of Industrial Science And Technology Method of removing nitrogen impurities from water using hydrocarbon-producing microalga
DE4219360C2 (de) * 1992-06-12 1994-07-28 Milupa Ag Verfahren zur Gewinnung von Lipiden mit einem hohen Anteil von langkettig-hochungesättigten Fettsäuren
JPH072724A (ja) * 1993-03-24 1995-01-06 Nippon Sanso Kk １３ｃ標識アラキドン酸とその誘導体及び製造方法
JPH06340577A (ja) * 1993-03-24 1994-12-13 Nippon Sanso Kk １３ｃ標識イコサペンタエン酸とその誘導体及び製造方法
FR2719222B1 (fr) * 1994-05-02 1996-06-21 Rocher Yves Biolog Vegetale Vésicules lipidiques, leur procédé de fabrication et leurs applications.
DE59506314D1 (de) 1994-08-16 1999-08-05 Frische Gmbh Verfahren zur gewinnung von nicht wasserlöslichen, nativen produkten aus nativen stoffgemengen mit hilfe der zentrifugalkraft
US5583019A (en) 1995-01-24 1996-12-10 Omegatech Inc. Method for production of arachidonic acid
JP2764572B2 (ja) * 1995-04-17 1998-06-11 工業技術院長 ドコサヘキサエン酸生産能を有する新規微生物及びそれを用いたドコサヘキサエン酸の製造方法
EP0823475B1 (de) 1995-04-17 2009-06-17 National Institute of Advanced Industrial Science and Technology Hoch ungesättigte fettsäurenproduzierende mikroorganismen und verfahren zur herstellung von hoch ungesättigten fettsäuren durch verwendung dieser mikroorganismen
DE69508558T2 (de) * 1995-05-04 1999-08-26 Societe Des Produits Nestle S.A. Verfahren zur Fraktionierung von Fettsäuren
GB9514649D0 (en) 1995-07-18 1995-09-13 Zeneca Ltd Extraction of triglycerides from microorganisms
JP3985035B2 (ja) * 1995-09-14 2007-10-03 独立行政法人産業技術総合研究所 （ｎ−６）系ドコサペンタエン酸含有油脂ならびに該油脂の製造方法および用途
US6255505B1 (en) 1996-03-28 2001-07-03 Gist-Brocades, B.V. Microbial polyunsaturated fatty acid containing oil from pasteurised biomass
EP0969086A1 (de) 1996-07-03 2000-01-05 Sagami Chemical Research Center Docosahexaensäure produzierende mikroorganismen sowie herstellungsverfahren f!ur docosahexaensäure
CA2261231C (en) * 1996-07-23 2012-11-27 Nagase Biochemicals, Ltd. Process using ulkenia sp. to prepare docosahexaenoic acid and docosapentaenoic acid
US5951875A (en) 1996-12-20 1999-09-14 Eastman Chemical Company Adsorptive bubble separation methods and systems for dewatering suspensions of microalgae and extracting components therefrom
WO1998039468A1 (fr) * 1997-03-04 1998-09-11 Suntory Limited Procede pour preparer un acide gras hautement insature (aghi) et lipide contenant cet aghi
UA67742C2 (uk) 1997-05-02 2004-07-15 Дсм Іп Ассетс Б.В. Спосіб виділення кристалічної каротиноїдної сполуки з мікробної каротиноїдвмісної біомаси
US7585645B2 (en) 1997-05-27 2009-09-08 Sembiosys Genetics Inc. Thioredoxin and thioredoxin reductase containing oil body based products
EP1905309A1 (de) 1997-05-27 2008-04-02 SemBioSys Genetics Inc. Verwendung von Ölkörpern
US6566583B1 (en) 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
JP3836231B2 (ja) * 1997-10-17 2006-10-25 日本化学飼料株式会社 ホタテガイ中腸腺から得られる高度不飽和脂肪酸含有油及びその製造方法
WO1999025157A1 (fr) 1997-11-12 1999-05-20 Mitsubishi Denki Kabushiki Kaisha Dispositif electroluminescent et structure destinee au blindage de celui-ci
JP2000041684A (ja) 1998-07-29 2000-02-15 Daicel Chem Ind Ltd 新規なｄ−アミノアシラーゼおよびその製造方法、並びに該ｄ−アミノアシラーゼを利用したｄ−アミノ酸の製造方法
FR2782921B1 (fr) 1998-09-09 2002-09-20 Dior Christian Parfums Extrait lipidique de l'algue skeletonema, procede de preparation et utilisation dans des domaines cosmetique et pharmaceutique, notamment dermatologique
US6166231A (en) 1998-12-15 2000-12-26 Martek Biosciences Corporation Two phase extraction of oil from biomass
JP2000245492A (ja) 1999-03-02 2000-09-12 Kyowa Hakko Kogyo Co Ltd 微生物抽出脂質
US6344349B1 (en) 1999-12-06 2002-02-05 Decant Technologies Llc Process and system for electrical extraction of intracellular matter from biological matter
CZ303446B6 (cs) 2000-01-19 2012-09-19 Martek Biosciences Corporation Zpusob získávání lipidu z mikroorganismu
CA2398053C (en) 2000-04-12 2011-02-01 Westfalia Separator Industry Gmbh Method for the fractionation of oil and polar lipid-containing native raw materials
DE10018213A1 (de) 2000-04-12 2001-10-25 Westfalia Separator Ind Gmbh Verfahren zur Fraktionierung von öl-und lecithinhaltigen nativen Rohstoffen
EP1178118A1 (de) 2000-08-02 2002-02-06 Dsm N.V. Isolation von mikrobiellen Ölen
US20060060520A1 (en) 2001-06-25 2006-03-23 Bomberger David C Systems and methods using a solvent for the removal of lipids from fluids
AU2002323409A1 (en) 2001-08-24 2003-03-10 Martek Biosciences Boulder Corporation Products containing highly unsaturated fatty acids for use by women and their children during stages of preconception, pregnancy and lactation/post-partum
EP2239028A1 (de) 2001-12-12 2010-10-13 Martek Biosciences Corporation Extraktion und Winterisierung von Lipiden aus Ölsaat und mikrobiellen Quellen
CA2484334C (en) 2002-05-03 2013-01-22 Martek Biosciences Corporation High-quality lipids and methods for producing by enzymatic liberation from biomass
ES2712854T3 (es) 2002-06-19 2019-05-16 Dsm Ip Assets Bv Aceite microbiano y procedimientos para su procesamiento
JP4733043B2 (ja) 2003-10-02 2011-07-27 マーテック バイオサイエンシーズ コーポレーション 改変された量の塩化物およびカリウムを使用した微細藻類における高レベルのｄｈａの産生法
KR101194235B1 (ko) 2004-03-01 2012-10-29 산토리 홀딩스 가부시키가이샤 장쇄 고도 불포화 지방산을 구성요소로서 포함하는 인지질의 제조방법, 및 그 이용
US20050239198A1 (en) 2004-04-27 2005-10-27 Baxter International, Inc. Stirred-tank reactor system
EP1597976B1 (de) 2004-05-21 2013-01-30 Nestec S.A. Verwendung von Polyolestern von Fettsäuren in gefrorenen und durchlüfteten Konfektzubereitungen mit verbesserten Nutritional-Eigenschaften
DE102004062141A1 (de) 2004-12-23 2006-07-06 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Verfahren zur Herstellung eines Rohöls aus Gemischen von Mikroorganismen und Pflanzen, das so hergestellte Öl sowie die spezifischen Verwendungen des so hergestellten und gegebenenfalls zusätzlich raffinierten Öls
DE102005003624A1 (de) 2005-01-26 2006-07-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Herstellung und Anwendung eines antioxidativ wirksamen Extraktes aus Crypthecodinium sp.
NZ563125A (en) 2005-06-03 2009-11-27 Mcfarlane Marketing Aust Pty L Lipid extract of mussels and method for preparation thereof
EP1899453B1 (de) 2005-06-07 2013-12-18 Ocean Nutrition Canada Limited Eukaryotische mikroorganismen zur herstellung von lipiden und antioxidantien
WO2007005725A2 (en) 2005-07-01 2007-01-11 Martek Biosciences Corporation Polyunsaturated fatty acid-containing oil product and uses and production thereof
US7527734B1 (en) 2005-11-15 2009-05-05 Shepherd Samuel L Rapid non-equilibrium decompression of microorganism-containing waste streams
EP1996686A1 (de) 2006-02-07 2008-12-03 Universitetet I Oslo Omega 3
US8877465B2 (en) 2006-07-05 2014-11-04 Photonz Corporation Limited Production of ultrapure EPA and polar lipids from largely heterotrophic culture
EP1887011A1 (de) 2006-08-09 2008-02-13 Thermphos Trading GmbH Alpha-Aminosäurephosphonsäure-Verbindungen, Verfahren zur Herstellung und Verwendung
EP2074214A2 (de) 2006-09-28 2009-07-01 Microbia, Inc. Produktion von sterolen in öligen hefen und pilzen
US20080083352A1 (en) 2006-10-10 2008-04-10 Ernest Peter Tovani Vehicle Table System
KR100810314B1 (ko) 2006-10-11 2008-03-04 삼성전자주식회사 휴대 단말기의 키 입력 장치
WO2008060571A2 (en) 2006-11-13 2008-05-22 Aurora Biofuels, Inc. Methods and compositions for production and purification of biofuel from plants and microalgae
EA200900728A1 (ru) 2006-12-01 2009-12-30 Норт Каролина Стейт Юниверсити Способ превращения биомассы в топливо
US20100227042A1 (en) 2006-12-22 2010-09-09 Christopher Penet Enzyme-Assisted De-Emulsification of Aqueous Lipid Extracts
KR20100039846A (ko) 2007-06-14 2010-04-16 닉콜라오스 미트로포울로스 바이오연료용 조류의 성장
US20100226977A1 (en) 2007-08-29 2010-09-09 Aker Biomarine Asa Low viscosity phospholipid compositions
AU2008300002B2 (en) 2007-09-12 2014-04-10 Dsm Ip Assets B.V. Biological oils and production and uses thereof
JP4594998B2 (ja) * 2008-05-21 2010-12-08 株式会社日立製作所 エレベーターかごの速度検出装置の検査方法。
ITMI20081203A1 (it) 2008-06-30 2010-01-01 Eni Spa Procedimento per l'estrazione di acidi grassi da biomassa algale
EP2145942A1 (de) 2008-07-15 2010-01-20 Lonza Ltd. Verfahren zur Isolierung von Ölen aus Zellen und Biomasse
US20120036767A1 (en) 2008-08-04 2012-02-16 Larach Mario C Continuous cultivation, harvesting, and extraction of photosynthetic cultures
DK2337857T3 (en) 2008-10-02 2017-05-22 Ramon Nieves Gonzalez MICROALGE EXTRACT CONTAINING POLYUM Saturated W3 FAT ACIDS AND PROCEDURE FOR EXTRACING OIL FROM MICRO-ORGANISMS
CN102271525B (zh) 2008-10-14 2015-01-07 索拉兹米公司 微藻生物质的食品组合物
SE534278C2 (sv) 2009-02-17 2011-06-28 Alfa Laval Corp Ab Ett kontinuerligt förfarande för isolering av oljor från alger eller mikroorganismer
US9296985B2 (en) 2009-03-10 2016-03-29 Valicor, Inc. Algae biomass fractionation
US8207363B2 (en) 2009-03-19 2012-06-26 Martek Biosciences Corporation Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
US8476060B2 (en) 2009-04-13 2013-07-02 Board Of Regents, The University Of Texas System Process for separating lipids from a biomass
US8580540B2 (en) 2009-05-26 2013-11-12 Solazyme, Inc. Fractionation of oil-bearing microbial biomass
KR101659765B1 (ko) 2009-09-28 2016-09-27 삼성전자주식회사 다중 모드 휴대용 단말기에서 전력 소모를 줄이기 위한 장치 및 방법
US20110256268A1 (en) 2010-04-14 2011-10-20 Solazyme, Inc. Oleaginous Yeast Food Compositions
AU2011261455B2 (en) 2010-06-01 2016-03-24 Dsm Ip Assets B.V. Extraction of lipid from cells and products therefrom
MY163938A (en) 2010-06-14 2017-11-15 Io-Mega Holding Corp Method for the production of algae derived oils
EP2598641B1 (de) 2010-07-26 2014-05-21 Sapphire Energy, Inc. Verfahren zur gewinnung von ölhaltigen verbindungen aus biomasse
US9028696B2 (en) 2010-07-26 2015-05-12 Sapphire Energy, Inc. Process for the recovery of oleaginous compounds from biomass
US8192627B2 (en) 2010-08-06 2012-06-05 Icm, Inc. Bio-oil recovery methods
US20120040428A1 (en) 2010-08-13 2012-02-16 Paul Reep Procedure for extracting of lipids from algae without cell sacrifice
US20120129244A1 (en) 2010-10-17 2012-05-24 Michael Phillip Green Systems, methods and apparatuses for dewatering, flocculating and harvesting algae cells
CN101985637B (zh) 2010-11-02 2014-05-07 嘉必优生物工程（武汉）有限公司 一种微生物油脂的提取方法
DK2450425T3 (da) 2010-11-08 2014-07-07 Neste Oil Oyj Fremgangsmåde til lipidekstraktion fra biomasse
AU2012214187A1 (en) 2011-02-12 2013-05-02 Phycal, Inc. Aqueous extraction methods for high lipid microorganisms
CN103649313B (zh) 2011-03-07 2017-10-24 Dsm营养产品股份公司 工程化破囊壶菌属微生物
WO2012125611A2 (en) 2011-03-15 2012-09-20 Iowa State University Research Foundation Oil extraction from microalgae
FR2975705B1 (fr) 2011-05-27 2014-12-26 Roquette Freres Procede d'extraction du squalene a partir de microalgues
CN102433215A (zh) 2011-09-22 2012-05-02 厦门汇盛生物有限公司 一种从真菌或藻类中物理破壁提取油脂的方法
CN102388988B (zh) 2011-11-08 2013-01-23 中国农业科学院油料作物研究所 一种微生物油的分提方法
WO2013075116A2 (en) 2011-11-17 2013-05-23 Heliae Development, Llc Omega 7 rich compositions and methods of isolating omega 7 fatty acids
WO2013156720A2 (fr) 2012-04-16 2013-10-24 Roquette Freres Procédé de raffinage du squalène produit par microalgues
CA2877937A1 (en) 2012-06-29 2014-01-03 BP Biofuels UK Limited Process for separation of renewable materials from microorganisms
EP3083545B1 (de) 2013-12-20 2023-08-02 DSM IP Assets B.V. Verfahren zur gewinnung von mikrobiellem öl aus mikrobiellen zellen
SG10201911379QA (en) 2013-12-20 2020-01-30 Dsm Ip Assets Bv Process for extracting lipids for use in production of biofuels
NZ721417A (en) 2013-12-20 2022-07-01 Dsm Ip Assets Bv Processes for obtaining microbial oil from microbial cells
TWI646189B (zh) 2013-12-20 2019-01-01 荷蘭商Ｄｓｍ智慧財產有限公司 用於從微生物細胞獲得微生物油之方法（五）
CA2934491C (en) 2013-12-20 2023-09-26 Dsm Ip Assets B.V. Processes for obtaining microbial oil from microbial cells
MX2016008228A (es) 2013-12-20 2016-11-28 Dsm Ip Assets Bv Procedimiento para la obtención de aceite microbiano a partir de células microbianas.
PT3626806T (pt) 2013-12-20 2024-07-31 Mara Renewables Corp Métodos para recuperar óleo de microrganismos
BR112016014208B1 (pt) 2013-12-20 2022-09-20 Dsm Nutricional Products Ag Método de extração de lipídeos a partir de uma população de micro-organismos
MX2017000109A (es) 2014-07-07 2017-05-23 Commw Scient Ind Res Org Procesos para producir productos industriales de lipidos vegetales.

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