DE3887085T2 - Herstellung von schimären Antikörpern durch homologe Rekombination. - Google Patents

Herstellung von schimären Antikörpern durch homologe Rekombination.

Info

Publication number
DE3887085T2
DE3887085T2 DE3887085T DE3887085T DE3887085T2 DE 3887085 T2 DE3887085 T2 DE 3887085T2 DE 3887085 T DE3887085 T DE 3887085T DE 3887085 T DE3887085 T DE 3887085T DE 3887085 T2 DE3887085 T2 DE 3887085T2
Authority
DE
Germany
Prior art keywords
production
homologous recombination
chimeric antibodies
chimeric
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3887085T
Other languages
English (en)
Other versions
DE3887085D1 (de
Inventor
Kim R Folger Bruce
H Perry Fell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DE3887085D1 publication Critical patent/DE3887085D1/de
Publication of DE3887085T2 publication Critical patent/DE3887085T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
DE3887085T 1987-10-27 1988-10-27 Herstellung von schimären Antikörpern durch homologe Rekombination. Expired - Lifetime DE3887085T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11380087A 1987-10-27 1987-10-27
US07/243,873 US5204244A (en) 1987-10-27 1988-09-14 Production of chimeric antibodies by homologous recombination

Publications (2)

Publication Number Publication Date
DE3887085D1 DE3887085D1 (de) 1994-02-24
DE3887085T2 true DE3887085T2 (de) 1994-05-19

Family

ID=26811495

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3887085T Expired - Lifetime DE3887085T2 (de) 1987-10-27 1988-10-27 Herstellung von schimären Antikörpern durch homologe Rekombination.

Country Status (17)

Country Link
US (1) US5204244A (de)
EP (1) EP0315062B1 (de)
JP (1) JP2624314B2 (de)
CN (1) CN1033290A (de)
AU (1) AU607013B2 (de)
CA (1) CA1334177C (de)
CY (1) CY1778A (de)
DE (1) DE3887085T2 (de)
DK (1) DK174339B1 (de)
ES (1) ES2061598T3 (de)
FI (1) FI97303C (de)
HK (1) HK63094A (de)
IE (1) IE61733B1 (de)
IL (1) IL88149A (de)
NO (1) NO178234C (de)
NZ (1) NZ226695A (de)
PT (1) PT88858B (de)

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NO178234C (no) 1996-02-14
FI97303B (fi) 1996-08-15
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IL88149A (en) 1993-06-10
JPH02477A (ja) 1990-01-05
DK594588D0 (da) 1988-10-26
ES2061598T3 (es) 1994-12-16
AU607013B2 (en) 1991-02-21
US5204244A (en) 1993-04-20
NO884771D0 (no) 1988-10-26
FI884907A0 (fi) 1988-10-24
NO178234B (no) 1995-11-06
CA1334177C (en) 1995-01-31
IE883244L (en) 1989-04-27
FI884907A (fi) 1989-04-28
NO884771L (no) 1989-04-28
HK63094A (en) 1994-07-01
DK174339B1 (da) 2002-12-16
DE3887085D1 (de) 1994-02-24
IL88149A0 (en) 1989-06-30
AU2444688A (en) 1989-04-27
FI97303C (fi) 1996-11-25
JP2624314B2 (ja) 1997-06-25
IE61733B1 (en) 1994-11-30
PT88858B (pt) 1993-01-29
EP0315062B1 (de) 1994-01-12
CN1033290A (zh) 1989-06-07
EP0315062A3 (en) 1990-03-28
DK594588A (da) 1989-04-28

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