DE3322574A1 - Benzoesaeurepiperidylester-derivate bzw. verfahren zu deren herstellung und deren verwendung - Google Patents
Benzoesaeurepiperidylester-derivate bzw. verfahren zu deren herstellung und deren verwendungInfo
- Publication number
- DE3322574A1 DE3322574A1 DE19833322574 DE3322574A DE3322574A1 DE 3322574 A1 DE3322574 A1 DE 3322574A1 DE 19833322574 DE19833322574 DE 19833322574 DE 3322574 A DE3322574 A DE 3322574A DE 3322574 A1 DE3322574 A1 DE 3322574A1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- compounds
- group
- hydrogen
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Description
. Formel V bedeutet,
Ry für Wasserstoff oder Halogen,
Beisp. | A | B | η | R8 | KONF. | Smp. | o3) | Herst. |
B-I | 5-Chlor- indol-3-yl |
0 | 2 | CH3 | endo | 235-237 | O | 2 |
B-2 | 4-Methoxy- indol-3-yl |
0 | 2 | CH3 | endo | 193-194 | O | 2 |
B-3 | 5-Methoxy- indol-3-yl |
0 | 2 | CH3 | endo | 214-216 | O | 2 |
B-4 | 1-Methyl - indol-3-yl |
0 | 2 | CH3 | endo | 143-144 | o3) | 3 |
B-5 | Indol-3-yl | 0 | 2 | CH3 | exo | 239-240 | o3) | 2 |
B-6 | Indol-3-yl | 0 | 3 | CH3 | endo | 208-209 | O | 2 |
B-7 | Indol-3-yl | 0 | 2 | n-C3H7 | endo. | 158-159 | o8) | 2 |
B-8 | Indol-3-yl | 0 | 2 | benzyl | exo | 164-155 | o8) | 2 |
B-9 | Indol-3-yl | 0 | 2 | benzyl | endo | 162-163 | o3) | 2 |
B-IO | Indol~3-yl | 0 | 2 | H | endo | 261-263 | o3) | 8f |
B-Il | 5-Fluor- indol-3-yl |
0 | 3 | H | endo | 247-248 | O | 4 |
B-12 | 1-Methyl- indol-3-yl |
0 | 3 | H | endo | 147-148 | o3) | 4 |
B-13 | Indol-3-yl | 0 | 3 | H | endo | 234-235 | 4 | |
endo | 210-212° | 1 |
endo | 234-235° | 1 |
endo | 147-148° | 2 |
endo | 193-194°.. | 2 |
endo | 129-130° | 2 |
endo | 225-226° | I7) |
endo | 199-201° | 1 |
endo | 77-78° | 2 |
endo | 181-183° | 1 |
exo | 264-266°3) | ilc |
exo | 264-267°3) | 2 |
Beisp. | A | B | η | R7 | KONF. | Smp. | Herst. |
D-I | Hl-I | 0 | 2 | CH3 | endo | 193-195o1) | 7 |
D-2 | III-II | 0 | 2 | Benzyl | exo | 112-114o2) | 7 |
D-3 | III-III | 0 | 2 | CH3 | endo | 148-151o2) | 7 |
D-4 | III-III | 0 | 2 | H | endo | 168-169°2) | 9 |
D-5 | III-IV | 0 | 2 | H | endo | 184-185ol) | 9 |
D-6 | III-IV | 0 | 2 | H | exo | 166~167°2) | 9 |
D-7 | IH-IV | 0 | 2 | CH3 | endo | 245-246°4) | 7 |
D-8 | III-VI | 0 | 2 | CH3 | endo | 146-147°2) | 7 |
D-9 | III-VII | 0 | 2 | CH3 | endo | 210-211°5) | 7 |
D-IO | III-VIII | 0 | 2 | CH3 | endo | 216°6> | 7 |
D-Il | IH-V | 0 | 3 | CH3 | endo | 164-166° | 7 |
D-12 | III-IX | 0 | 3 | CH3 | endo | 163-154° | 7 |
D-13 | IH-X | 0 | 2 | CH3 | endo | 132-133 | 7 |
D-14 | IH-XI | 0 | 2 | CH3 | endo | 91- 92° | 7 |
D-15 | III-XII | 0 | 3 | CH3 | endo | 170-171 | 7 |
D-16 | HI-XIII | 0 | 2 | CH3 | endo | I58-159°2) | 7 |
D-17 | IH-XIV | 0 | 2 | CH. | endo | 159-160°2) | 7 |
Beisp. | A | B | D Substitution | .. .. Srnp. - - . | . Herst |
E-I | Indol-3-yl | O | 3 | 219-221o4)3) | 7 |
E-2 | IH-I | NH | 3 | 145-147V 154-156°^ |
7* |
E-3 | IU-XII | O | 3 | 159-160 | 7 |
a) | 2 | CH3 |
b) | 2 | CH3 |
c) | 2 | CH, |
d) | 2 | CH3 |
e) | 3 | CH3 |
f) | 3 | CH3 |
g) | 3 | Ben |
h) | 2 | n-C |
10 M vorinkubiert, bevor unterschiedliche Konzentrationen von Serotonin verabreicht werden. Die pHA^-Werte können daraus auf an sich bekannte Weise erhalten werden.
Claims (15)
eine Gruppe der Formel V,
worin B NH bedeutet und D für eine Gruppe der Formel IV
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH397982 | 1982-06-29 | ||
CH426782 | 1982-07-13 | ||
CH695182 | 1982-11-30 | ||
CH695082 | 1982-11-30 | ||
CH749582 | 1982-12-22 | ||
CH749482 | 1982-12-22 | ||
CH125683 | 1983-03-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3322574A1 true DE3322574A1 (de) | 1983-12-29 |
DE3322574C2 DE3322574C2 (de) | 1992-07-30 |
Family
ID=27561049
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19833322574 Granted DE3322574A1 (de) | 1982-06-29 | 1983-06-23 | Benzoesaeurepiperidylester-derivate bzw. verfahren zu deren herstellung und deren verwendung |
DE3348332A Expired - Lifetime DE3348332C2 (de) | 1982-06-29 | 1983-06-23 | |
DE3348333A Expired - Lifetime DE3348333C2 (de) | 1982-06-29 | 1983-06-23 | |
DE1994175004 Active DE19475004I2 (de) | 1982-06-29 | 1983-06-23 | Indolylcarbonsaeuretropyl- und- chinuclidinylester |
DE3348331A Expired - Lifetime DE3348331C2 (de) | 1982-06-29 | 1983-06-23 | |
DE3348334A Expired - Lifetime DE3348334C2 (de) | 1982-06-29 | 1983-06-23 |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3348332A Expired - Lifetime DE3348332C2 (de) | 1982-06-29 | 1983-06-23 | |
DE3348333A Expired - Lifetime DE3348333C2 (de) | 1982-06-29 | 1983-06-23 | |
DE1994175004 Active DE19475004I2 (de) | 1982-06-29 | 1983-06-23 | Indolylcarbonsaeuretropyl- und- chinuclidinylester |
DE3348331A Expired - Lifetime DE3348331C2 (de) | 1982-06-29 | 1983-06-23 | |
DE3348334A Expired - Lifetime DE3348334C2 (de) | 1982-06-29 | 1983-06-23 |
Country Status (20)
Country | Link |
---|---|
US (3) | US4803199A (de) |
AT (1) | AT391136B (de) |
AU (2) | AU570002B2 (de) |
CH (2) | CH669792A5 (de) |
CY (1) | CY1500A (de) |
DE (6) | DE3322574A1 (de) |
DK (1) | DK172475B1 (de) |
FI (1) | FI74707C (de) |
FR (1) | FR2531083B1 (de) |
GB (4) | GB2125398B (de) |
HK (1) | HK60690A (de) |
HU (1) | HU191053B (de) |
IL (1) | IL69081A (de) |
IT (1) | IT1173724B (de) |
NL (2) | NL191991C (de) |
NZ (1) | NZ204714A (de) |
PT (1) | PT76937B (de) |
SE (1) | SE463210B (de) |
SG (1) | SG53789G (de) |
WO (1) | WO1984000166A1 (de) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0189002A2 (de) * | 1984-12-20 | 1986-07-30 | Sandoz Ag | Behandlung von Gastrointestinalkrankheiten durch Anwendung von 5-HT3-Antagonisten |
EP0190920A2 (de) * | 1985-02-04 | 1986-08-13 | Synthelabo | Verfahren zur Verbesserung des Gedächnisses oder zur Beseitigung des Gedächnis-Mangels mit Arylamido-(und Arylthioamido)-Azabicycloalkanen |
EP0215545A2 (de) * | 1985-06-22 | 1987-03-25 | Beecham Group Plc | Verwendung von Benzamido-Azabicyclo-Verbindungen für Behandlungen von Migräne, Übelkeit, Erbrechen und Herzarhythmie |
FR2602142A1 (fr) * | 1986-07-30 | 1988-02-05 | Sandoz Sa | Utilisation en therapeutique des antagonistes des recepteurs serotoninergiques 5ht3 |
US4789673A (en) * | 1982-07-13 | 1988-12-06 | Peter Donatsch | Heterocyclic carboxylic acid amides and esters |
US4803199A (en) * | 1982-06-29 | 1989-02-07 | Peter Donatsch | Pharmaceutically useful heterocyclic and carbocyclic acid esters and amides of alkylene bridged piperidines |
EP0329932A2 (de) * | 1988-02-23 | 1989-08-30 | Merrell Pharmaceuticals Inc. | Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln |
US4892872A (en) * | 1987-10-22 | 1990-01-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzoxazine compounds and pharmaceutical use thereof |
WO1996003401A2 (en) * | 1994-07-23 | 1996-02-08 | Smithkline Beecham Plc | Process for the production of aminoazobicycloalkanes from oximes |
WO2003015517A1 (en) * | 2001-08-14 | 2003-02-27 | Commonwealth Scientific And Industrial Research Organisation | Agonists and antagonists of 5h3-like receptors of invertebrate s as pesticides |
WO2004039815A2 (en) * | 2002-11-01 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases |
US7358248B2 (en) | 2003-04-30 | 2008-04-15 | The Institute For Pharmaceutical Discovery Llc | Substituted amino carboxylic acids |
CN100390172C (zh) * | 2004-09-10 | 2008-05-28 | 成都欣捷高新技术开发有限公司 | 一种甲磺酸多拉司琼晶型及其制备方法 |
US7498356B2 (en) | 2004-11-18 | 2009-03-03 | The Institutes For Pharmaceutical Discovery Llc | Substituted amino carboxylic acids |
Families Citing this family (128)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0135545A1 (de) * | 1983-02-19 | 1985-04-03 | Beecham Group Plc | Azabicycloalkyl-derivate von benzamid und anilid |
GB8315495D0 (en) * | 1983-06-06 | 1983-07-13 | Sumitomo Chemical Co | Fungicidal aniline derivatives |
DE3429830A1 (de) * | 1983-08-26 | 1985-03-07 | Sandoz-Patent-GmbH, 7850 Lörrach | Automatische carbonsaeure- und sulfonsaeureester oder -amide |
JPS6084281A (ja) * | 1983-09-14 | 1985-05-13 | Yoshitomi Pharmaceut Ind Ltd | 3−インド−ルカルボキサミド類 |
US4888353A (en) * | 1986-02-28 | 1989-12-19 | Erbamont, Inc. | Carboxamides useful as antiemetic or antipsychotic agents |
US5175173A (en) * | 1983-12-22 | 1992-12-29 | Sun Jung Hui | Carboxamides useful as antiemetic or antipsychotic agents |
FR2557110B1 (fr) * | 1983-12-23 | 1989-11-24 | Sandoz Sa | Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments |
US4593034A (en) * | 1984-04-06 | 1986-06-03 | A. H. Robins Company, Inc. | 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides |
CH667657A5 (de) * | 1985-01-07 | 1988-10-31 | Sandoz Ag | Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine. |
EP0201165B1 (de) * | 1985-03-14 | 1994-07-20 | Beecham Group Plc | Arzneimittel zur Behandlung von Emesis |
EP0200444B1 (de) * | 1985-04-27 | 1992-11-11 | Beecham Group Plc | Azabicyclononyl-indazol-carboxamid mit 5-HT-antagonistischer Wirkung |
GB8623142D0 (en) * | 1986-09-26 | 1986-10-29 | Beecham Group Plc | Compounds |
US4937247A (en) * | 1985-04-27 | 1990-06-26 | Beecham Group P.L.C. | 1-acyl indazoles |
GB8525913D0 (en) * | 1985-10-21 | 1985-11-27 | Beecham Group Plc | Compounds |
GB8511988D0 (en) * | 1985-05-11 | 1985-06-19 | Beecham Group Plc | Compounds |
US5204356A (en) * | 1985-07-24 | 1993-04-20 | Glaxo Group Limited | Treatment of anxiety |
GB8518658D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Medicaments |
GB8520616D0 (en) * | 1985-08-16 | 1985-09-25 | Beecham Group Plc | Compounds |
GB8525844D0 (en) * | 1985-10-19 | 1985-11-20 | Beecham Group Plc | Compounds |
ES2053451T3 (es) * | 1986-01-07 | 1994-08-01 | Beecham Group Plc | Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles. |
EP0235878A3 (de) * | 1986-01-16 | 1989-06-14 | Beecham Group Plc | Neue Verbindungen |
US4722834A (en) * | 1986-03-05 | 1988-02-02 | A. H. Robins Company, Incorporated | Method of using 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide-N-oxides to control emesis caused by anticancer drugs |
US4717563A (en) * | 1986-03-05 | 1988-01-05 | A. H. Robins Company, Inc. | 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs |
EP0254584B1 (de) * | 1986-07-25 | 1992-10-07 | Beecham Group Plc | Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
EP0255297B1 (de) * | 1986-07-31 | 1993-04-21 | Beecham Group Plc | Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
AT396870B (de) * | 1986-08-07 | 1993-12-27 | Sandoz Ag | Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten |
US4772459A (en) * | 1986-09-09 | 1988-09-20 | Erbamont, Inc. | Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein |
EP0268309B1 (de) * | 1986-09-22 | 1996-12-11 | Janssen Pharmaceutica N.V. | Serotonin-Antagonisten zur Behandlung von Wunden |
US4906755A (en) * | 1986-11-03 | 1990-03-06 | Merrell Dow Pharmaceuticals Inc. | Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds |
ZA878096B (en) * | 1986-11-03 | 1988-04-26 | Merrell Dow Pharmaceuticals Inc. | Esters of hexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one and related compounds |
US5198447A (en) * | 1986-11-21 | 1993-03-30 | Glaxo Group Limited | Medicaments |
WO1988003801A1 (en) * | 1986-11-21 | 1988-06-02 | Glaxo Group Limited | Medicaments for treatment or prevention of withdrawal syndrome |
ES2051753T3 (es) * | 1986-12-16 | 1994-07-01 | Robins Co Inc A H | N-(1-azabiciclo(2.2.2)octo-3-il) benzamidas y tiobenzamidas ansioliticas. |
US5244909A (en) * | 1986-12-17 | 1993-09-14 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
PH25025A (en) * | 1986-12-17 | 1991-01-28 | Glaxo Group Ltd | A method of treating dementia and other cognitive disorders using 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazol-4-one |
US5246941A (en) * | 1986-12-17 | 1993-09-21 | Glaxo Group Limited | Method for the treatment of depression |
JPS63277622A (ja) * | 1986-12-17 | 1988-11-15 | グラクソ、グループ、リミテッド | 医薬 |
US5190954A (en) * | 1986-12-17 | 1993-03-02 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
ES2074981T3 (es) * | 1986-12-17 | 1995-10-01 | Glaxo Group Ltd | Uso de derivados heterociclicos en el tratamiento de trastornos cognoscitivos. |
US5200414A (en) * | 1986-12-17 | 1993-04-06 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
GB8806990D0 (en) * | 1988-03-23 | 1988-04-27 | Beecham Group Plc | Novel compounds |
GB8701022D0 (en) * | 1987-01-19 | 1987-02-18 | Beecham Group Plc | Treatment |
DE3852145T2 (de) * | 1987-02-18 | 1995-04-06 | Beecham Group Plc | Indolderivate, Verfahren zu deren Herstellung und pharmazeutische Präparate, die diese enthalten. |
EP0289170B1 (de) * | 1987-04-25 | 1993-06-23 | Beecham Group Plc | Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
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EP0190920A2 (de) * | 1985-02-04 | 1986-08-13 | Synthelabo | Verfahren zur Verbesserung des Gedächnisses oder zur Beseitigung des Gedächnis-Mangels mit Arylamido-(und Arylthioamido)-Azabicycloalkanen |
EP0215545A2 (de) * | 1985-06-22 | 1987-03-25 | Beecham Group Plc | Verwendung von Benzamido-Azabicyclo-Verbindungen für Behandlungen von Migräne, Übelkeit, Erbrechen und Herzarhythmie |
EP0215545A3 (de) * | 1985-06-22 | 1990-04-11 | Beecham Group Plc | Verwendung von Benzamido-Azabicyclo-Verbindungen für Behandlungen von Migräne, Übelkeit, Erbrechen und Herzarhythmie |
FR2602142A1 (fr) * | 1986-07-30 | 1988-02-05 | Sandoz Sa | Utilisation en therapeutique des antagonistes des recepteurs serotoninergiques 5ht3 |
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US4892872A (en) * | 1987-10-22 | 1990-01-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzoxazine compounds and pharmaceutical use thereof |
EP0329932A2 (de) * | 1988-02-23 | 1989-08-30 | Merrell Pharmaceuticals Inc. | Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln |
EP0329932A3 (de) * | 1988-02-23 | 1992-08-05 | Merrell Pharmaceuticals Inc. | Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln |
WO1996003401A2 (en) * | 1994-07-23 | 1996-02-08 | Smithkline Beecham Plc | Process for the production of aminoazobicycloalkanes from oximes |
WO1996003401A3 (en) * | 1994-07-23 | 1996-07-04 | Smithkline Beecham Plc | Process for the production of aminoazobicycloalkanes from oximes |
US5856489A (en) * | 1994-07-23 | 1999-01-05 | Smithkline Beecham P.L.C. | Process for the production of aminoazobicycloalkanes from oximes |
WO2003015517A1 (en) * | 2001-08-14 | 2003-02-27 | Commonwealth Scientific And Industrial Research Organisation | Agonists and antagonists of 5h3-like receptors of invertebrate s as pesticides |
WO2004039815A2 (en) * | 2002-11-01 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases |
WO2004039815A3 (en) * | 2002-11-01 | 2004-07-22 | Upjohn Co | Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases |
US7358248B2 (en) | 2003-04-30 | 2008-04-15 | The Institute For Pharmaceutical Discovery Llc | Substituted amino carboxylic acids |
CN100390172C (zh) * | 2004-09-10 | 2008-05-28 | 成都欣捷高新技术开发有限公司 | 一种甲磺酸多拉司琼晶型及其制备方法 |
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